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Search results 101 to 183 out of 183 for Hcar2

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Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:4422398
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2826026
Stage: TS26
Assay Id: MGI:5540576
Age: embryonic day 17.5
Image: GUDMAP:14903
Specimen Label: GUDMAP:14903
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4422398
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2826028
Stage: TS28
Assay Id: MGI:5540576
Age: postnatal day 84
Image: GUDMAP:14904
Specimen Label: GUDMAP:14904
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4422398
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2814226
Stage: TS26
Assay Id: MGI:5540576
Age: embryonic day 17.5
Image: GUDMAP:14903
Specimen Label: GUDMAP:14903
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4422398
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2814228
Stage: TS28
Assay Id: MGI:5540576
Age: postnatal day 84
Image: GUDMAP:14904
Specimen Label: GUDMAP:14904
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4422398
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1897626
Stage: TS26
Assay Id: MGI:5540576
Age: embryonic day 17.5
Image: GUDMAP:14903
Specimen Label: GUDMAP:14903
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4422398
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1897628
Stage: TS28
Assay Id: MGI:5540576
Age: postnatal day 84
Image: GUDMAP:14904
Specimen Label: GUDMAP:14904
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4422398
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2969128
Stage: TS28
Assay Id: MGI:5540576
Age: postnatal day 84
Image: GUDMAP:14904
Specimen Label: GUDMAP:14904
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4422398
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2826626
Stage: TS26
Assay Id: MGI:5540576
Age: embryonic day 17.5
Image: GUDMAP:14903
Specimen Label: GUDMAP:14903
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4422398
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2826628
Stage: TS28
Assay Id: MGI:5540576
Age: postnatal day 84
Image: GUDMAP:14904
Specimen Label: GUDMAP:14904
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4422398
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2772126
Stage: TS26
Assay Id: MGI:5540576
Age: embryonic day 17.5
Image: GUDMAP:14903
Specimen Label: GUDMAP:14903
Detected: false
Specimen Num: 1
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Publication
- | J:68733
   
First Author: Schaub A
Year: 2000
Journal: GenBank Submission
Title: Mus musculus mRNA for putative seven transmembrane spanning receptor (Puma-g gene)
Pages: AJ300198
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Publication
24845831 | J:274128
 
First Author: Rahman M
Year: 2014
Journal: Nat Commun
Title: The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages.
Volume: 5
Pages: 3944
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Publication
31710686 | J:313803
First Author: Horimatsu T
Year: 2020
Journal: Cardiovasc Res
Title: Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide.
Volume: 116
Issue: 14
Pages: 2226-2238
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Publication
21317532 | J:172039
First Author: Lukasova M
Year: 2011
Journal: J Clin Invest
Title: Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells.
Volume: 121
Issue: 3
Pages: 1163-73
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Publication
22914621 | J:187220
First Author: Lauring B
Year: 2012
Journal: Sci Transl Med
Title: Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression.
Volume: 4
Issue: 148
Pages: 148ra115
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Publication
32358041 | J:346180
First Author: Li YJ
Year: 2020
Journal: J Am Soc Nephrol
Title: Dietary Fiber Protects against Diabetic Nephropathy through Short-Chain Fatty Acid-Mediated Activation of G Protein-Coupled Receptors GPR43 and GPR109A.
Volume: 31
Issue: 6
Pages: 1267-1281
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Publication
37215085 | J:346135
 
First Author: Li YJ
Year: 2023
Journal: Front Cell Dev Biol
Title: Short-chain fatty acids directly exert anti-inflammatory responses in podocytes and tubular epithelial cells exposed to high glucose.
Volume: 11
Pages: 1182570
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Publication
23579073 | J:202401
First Author: Sonne SR
Year: 2013
Journal: Biochim Biophys Acta
Title: Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth.
Volume: 1832
Issue: 8
Pages: 1149-58
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Publication
33597149 | J:303901
First Author: Hayashi A
Year: 2021
Journal: J Immunol
Title: The Butyrate-Producing Bacterium Clostridium butyricum Suppresses Clostridioides difficile Infection via Neutrophil- and Antimicrobial Cytokine-Dependent but GPR43/109a-Independent Mechanisms.
Volume: 206
Issue: 7
Pages: 1576-1585
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Publication
23404113 | J:214918
First Author: Ananth S
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: Induction of the cystine/glutamate exchanger SLC7A11 in retinal pigment epithelial cells by the antipsoriatic drug monomethylfumarate.
Volume: 54
Issue: 3
Pages: 1592-602
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Publication
17008386 | J:274238
First Author: Benyó Z
Year: 2006
Journal: Mol Pharmacol
Title: Nicotinic acid-induced flushing is mediated by activation of epidermal langerhans cells.
Volume: 70
Issue: 6
Pages: 1844-9
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Publication
20664170 | J:274141
First Author: Hanson J
Year: 2010
Journal: J Clin Invest
Title: Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice.
Volume: 120
Issue: 8
Pages: 2910-9
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Publication
24226773 | J:207759
First Author: Arpaia N
Year: 2013
Journal: Nature
Title: Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.
Volume: 504
Issue: 7480
Pages: 451-5
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Publication
27570060 | J:326073
 
First Author: Wang N
Year: 2016
Journal: Gen Comp Endocrinol
Title: Niacin receptor GPR109A inhibits insulin secretion and is down-regulated in type 2 diabetic islet beta-cells.
Volume: 237
Pages: 98-108
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Publication
35189149 | J:325745
     
First Author: Suhrkamp I
Year: 2022
Journal: J Invest Dermatol
Title: Oral Dimethyl Fumarate Targets HCA2-Expressing Skin Cells in the Imiquimod Mouse Model.
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Publication
34919284 | J:326075
First Author: Viatchenko-Karpinski V
Year: 2022
Journal: Glia
Title: Activation of microglial GPR109A alleviates thermal hyperalgesia in female lupus mice by suppressing IL-18 and glutamatergic synaptic activity.
Volume: 70
Issue: 4
Pages: 634-649
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Publication
32093510 | J:304343
First Author: Kaye DM
Year: 2020
Journal: Circulation
Title: Deficiency of Prebiotic Fiber and Insufficient Signaling Through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease.
Volume: 141
Issue: 17
Pages: 1393-1403
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Publication
27332875 | J:238365
First Author: Tan J
Year: 2016
Journal: Cell Rep
Title: Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways.
Volume: 15
Issue: 12
Pages: 2809-24
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Publication
29514953 | J:261310
First Author: Bhatt B
Year: 2018
Journal: J Immunol
Title: Gpr109a Limits Microbiota-Induced IL-23 Production To Constrain ILC3-Mediated Colonic Inflammation.
Volume: 200
Issue: 8
Pages: 2905-2914
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Publication
24412617 | J:209390
First Author: Singh N
Year: 2014
Journal: Immunity
Title: Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.
Volume: 40
Issue: 1
Pages: 128-39
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Publication
22427566 | J:196849
First Author: Gambhir D
Year: 2012
Journal: Invest Ophthalmol Vis Sci
Title: GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy.
Volume: 53
Issue: 4
Pages: 2208-17
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Publication
25686106 | J:227935
First Author: Youm YH
Year: 2015
Journal: Nat Med
Title: The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.
Volume: 21
Issue: 3
Pages: 263-9
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Publication
25828455 | J:222745
 
First Author: Macia L
Year: 2015
Journal: Nat Commun
Title: Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.
Volume: 6
Pages: 6734
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Publication
34626852 | J:326072
 
First Author: Cook TM
Year: 2021
Journal: Mol Metab
Title: Vagal neuron expression of the microbiota-derived metabolite receptor, free fatty acid receptor (FFAR3), is necessary for normal feeding behavior.
Volume: 54
Pages: 101350
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Publication
25375133 | J:326070
First Author: Sun H
Year: 2014
Journal: PLoS One
Title: Niacin activates the PI3K/Akt cascade via PKC- and EGFR-transactivation-dependent pathways through hydroxyl-carboxylic acid receptor 2.
Volume: 9
Issue: 11
Pages: e112310
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Publication
32901017 | J:338010
First Author: Yang W
Year: 2020
Journal: Nat Commun
Title: Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity.
Volume: 11
Issue: 1
Pages: 4457
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Publication
29937375 | J:266038
First Author: Tumurkhuu G
Year: 2018
Journal: Cell Metab
Title: Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1β Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis.
Volume: 28
Issue: 3
Pages: 432-448.e4
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Publication
32641826 | J:291327
First Author: Muller PA
Year: 2020
Journal: Nature
Title: Microbiota modulate sympathetic neurons via a gut-brain circuit.
Volume: 583
Issue: 7816
Pages: 441-446
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Publication
20178780 | J:160012
First Author: Jerome-Majewska LA
Year: 2010
Journal: Dev Biol
Title: The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta.
Volume: 341
Issue: 1
Pages: 154-66
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Publication
- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:237616
     
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q0VBA6
Organism: Mus musculus/domesticus
Length: 360  
Fragment?: false
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Protein Domain
IPR028017 | HCAR2/3_rcpt
Type: Family
Description: The hydroxycarboxylic acid receptors []are members of the rhodopsin-like G protein-coupled receptor (GPCR) family. There are three hydroxycarboxylic acid receptors, termed HCAR1-3. The family was formerly known as nicotinic acid receptor family, although nicotinic acid only shows submicromolar potency at HCAR2 [, ].The receptors respond to organic acids, including the endogenous short chain fatty acids, butyric acid and L-lactic acid, as well as the lipid lowering agents nicotinic acid (niacin), acipimox and acifran [, , ]. There is an increasing number of synthetic ligands mainly targeted at HCAR2 and HCAR3 receptors [, ]. All three receptors are expressed in adipocytes, and are coupled to Gi type G-proteins mediating antilipolytic effects in fat cells [, , , ]. HCAR2 and HCAR3 are also expressed in a variety of immune cells including monocytes, macrophages, neutrophils and Langerhans cells [, ]. HCAR1 and HCAR2 are found in most mammalian species, whereas HCAR3 is only present in higher primates []. There is evidence that these receptors can mediate anti-inflammatory effects. HCAR2 has been shown to be a receptor for the anti-dyslipidemic drug nicotinic acid (niacin) as well as for the anti-psoriatic drug monomethyl-fumarate [, ]. This entry represents two members of hydroxycarboxylic acid receptor family, hydroxycarboxylic acid receptor 2 (also known as niacin receptor 1, G protein-coupled receptor 109A, nicotinic acid receptor, HM74A) and hydroxycarboxylic acid receptor 3 (also known as niacin receptor 2, G protein-coupled receptor 109B, low affinity nicotinic acid receptor). The endogenous ligands of HCAR2 and HCAR3 are beta-D-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively [].
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Protein Domain
IPR028016 | HCAR1_rcpt
Type: Family
Description: The hydroxycarboxylic acid receptors []are members of the rhodopsin-like G protein-coupled receptor (GPCR) family. There are three hydroxycarboxylic acid receptors, termed HCAR1-3. The family was formerly known as nicotinic acid receptor family, although nicotinic acid only shows submicromolar potency at HCAR2 [, ].The receptors respond to organic acids, including the endogenous short chain fatty acids, butyric acid and L-lactic acid, as well as the lipid lowering agents nicotinic acid (niacin), acipimox and acifran [, , ]. There is an increasing number of synthetic ligands mainly targeted at HCAR2 and HCAR3 receptors [, ]. All three receptors are expressed in adipocytes, and are coupled to Gi type G-proteins mediating antilipolytic effects in fat cells [, , , ]. HCAR2 and HCAR3 are also expressed in a variety of immune cells including monocytes, macrophages, neutrophils and Langerhans cells [, ]. HCAR1 and HCAR2 are found in most mammalian species, whereas HCAR3 is only present in higher primates []. There is evidence that these receptors can mediate anti-inflammatory effects. HCAR2 has been shown to be a receptor for the anti-dyslipidemic drug nicotinic acid (niacin) as well as for the anti-psoriatic drug monomethyl-fumarate [, ]. This entry represents hydroxycarboxylic acid receptor 1, also known as lactate receptor 1, G protein coupled receptor 104 and G-protein coupled receptor 81. The endogenous ligand for HCAR1 is L-lactic acid [].
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Publication
21454438 | -
First Author: Offermanns S
Year: 2011
Journal: Pharmacol Rev
Title: International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B).
Volume: 63
Issue: 2
Pages: 269-90
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Publication
12522134 | -
First Author: Wise A
Year: 2003
Journal: J Biol Chem
Title: Molecular identification of high and low affinity receptors for nicotinic acid.
Volume: 278
Issue: 11
Pages: 9869-74
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Publication
19524438 | -
First Author: Skinner PJ
Year: 2009
Journal: Bioorg Med Chem Lett
Title: 5-N,N-Disubstituted 5-aminopyrazole-3-carboxylic acids are highly potent agonists of GPR109b.
Volume: 19
Issue: 15
Pages: 4207-9
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Publication
19309152 | -
First Author: Shen HC
Year: 2009
Journal: J Med Chem
Title: Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.
Volume: 52
Issue: 8
Pages: 2587-602
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Publication
17008871 | -
First Author: Maciejewski-Lenoir D
Year: 2006
Journal: J Invest Dermatol
Title: Langerhans cells release prostaglandin D2 in response to nicotinic acid.
Volume: 126
Issue: 12
Pages: 2637-46
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Publication
19237584 | -
First Author: Irukayama-Tomobe Y
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B.
Volume: 106
Issue: 10
Pages: 3930-4
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Publication
22654812 | -
 
First Author: Ahmed K
Year: 2011
Journal: Front Endocrinol (Lausanne)
Title: Biological roles and therapeutic potential of hydroxy-carboxylic Acid receptors.
Volume: 2
Pages: 51
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Protein
Q8C131
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
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•
•
Protein
E9PZR8
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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•
•
•
•
Protein
A0A4Y1JWM1
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
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•
•
•
•
Protein
B9UM22
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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•
•
•
•
Publication
30924852 | J:274772
First Author: Jiang D
Year: 2019
Journal: Invest Ophthalmol Vis Sci
Title: Monomethyl Fumarate Protects the Retina From Light-Induced Retinopathy.
Volume: 60
Issue: 4
Pages: 1275-1285
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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