TYRO protein tyrosine kinase-binding protein (Tyrobp), also called DNAX-activation protein 12 (DAP12), is expressed by NK cells and myeloid cells and mediates signalling for numerous cell-surface receptors expressedby these cells. It has been shown to both potentiate and attenuate the activation of these cells [, ]. More than 20receptor chains have been shown to associate with DAP12. It is involved for instance in neutrophil activation mediated by integrin [].
