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Search results 1 to 100 out of 272 for Irf5

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Hits by Strain

Hits by Category

Type Details Score
Gene
3663 | IRF5
Type: gene
Organism: human
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Gene
472512 | IRF5
Type: gene
Organism: chimpanzee
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Gene
615340 | IRF5
Type: gene
Organism: cattle
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Gene
430409 | IRF5
Type: gene
Organism: chicken
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Gene
405811 | irf5
Type: gene
Organism: zebrafish
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Gene
700725 | IRF5
Type: gene
Organism: macaque, rhesus
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Gene
734065 | irf5
Type: gene
Organism: frog, western clawed
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Gene
296953 | Irf5
Type: gene
Organism: rat
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Gene
482264 | IRF5
Type: gene
Organism: dog, domestic
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Protein Domain
IPR029838 | IRF5
Type: Family
Description: Interferon regulatory factor 5 (IRF5) is a transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection []. It is activated by TLR7 or TLR8 signalling []. Its structure has been revealed []. Variations of the IRF5 gene affects the susceptibility of a few diseases, such as inflammatory bowel disease 14 (IBD14) [], systemic lupus erythematosus 10 (SLEB10) []and Rheumatoid arthritis (RA).
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Protein Coding Gene
MGI:1350924 | Irf5
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
21240265 | J:169233
First Author: Krausgruber T
Year: 2011
Journal: Nat Immunol
Title: IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses.
Volume: 12
Issue: 3
Pages: 231-8
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Publication
26283380 | J:226709
First Author: Weiss M
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: IRF5 controls both acute and chronic inflammation.
Volume: 112
Issue: 35
Pages: 11001-6
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Publication
32897883 | J:300276
First Author: Song S
Year: 2020
Journal: J Clin Invest
Title: Inhibition of IRF5 hyperactivation protects from lupus onset and severity.
Volume: 130
Issue: 12
Pages: 6700-6717
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Publication
33991749 | J:317327
 
First Author: Leipner J
Year: 2021
Journal: Mol Metab
Title: Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe-/- mice.
Volume: 53
Pages: 101250
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Publication
34197340 | J:313965
 
First Author: Pellerin A
Year: 2021
Journal: JCI Insight
Title: Monoallelic IRF5 deficiency in B cells prevents murine lupus.
Volume: 6
Issue: 15
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Publication
25326420 | J:216669
First Author: Ren J
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: IKKβ is an IRF5 kinase that instigates inflammation.
Volume: 111
Issue: 49
Pages: 17438-43
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Publication
29483597 | J:281492
First Author: Manni M
Year: 2018
Journal: Nat Immunol
Title: Regulation of age-associated B cells by IRF5 in systemic autoimmunity.
Volume: 19
Issue: 4
Pages: 407-419
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Publication
27545875 | J:238932
First Author: Hedl M
Year: 2016
Journal: Cell Rep
Title: IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation.
Volume: 16
Issue: 9
Pages: 2442-55
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Publication
34282144 | J:320542
First Author: Ban T
Year: 2021
Journal: Nat Commun
Title: Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease.
Volume: 12
Issue: 1
Pages: 4379
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Publication
23251680 | J:195662
First Author: Xu H
Year: 2012
Journal: PLoS One
Title: 4F decreases IRF5 expression and activation in hearts of tight skin mice.
Volume: 7
Issue: 12
Pages: e52046
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Publication
28746869 | J:254231
First Author: Kim D
Year: 2017
Journal: Cell Rep
Title: Cytosolic Pellino-1-Mediated K63-Linked Ubiquitination of IRF5 in M1 Macrophages Regulates Glucose Intolerance in Obesity.
Volume: 20
Issue: 4
Pages: 832-845
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Publication
30457675 | J:270353
First Author: Chow KT
Year: 2019
Journal: J Leukoc Biol
Title: IRF5 regulates unique subset of genes in dendritic cells during West Nile virus infection.
Volume: 105
Issue: 2
Pages: 411-425
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Publication
31053739 | J:289729
First Author: Pandey SP
Year: 2019
Journal: Mucosal Immunol
Title: Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens.
Volume: 12
Issue: 4
Pages: 874-887
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Publication
31086271 | J:294432
First Author: Wei J
Year: 2019
Journal: Mucosal Immunol
Title: Irf5 deficiency in myeloid cells prevents necrotizing enterocolitis by inhibiting M1 macrophage polarization.
Volume: 12
Issue: 4
Pages: 888-896
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Publication
32610123 | J:302001
First Author: Yan J
Year: 2020
Journal: Cell Rep
Title: T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation.
Volume: 31
Issue: 13
Pages: 107820
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Publication
25939064 | J:228467
First Author: Dalmas E
Year: 2015
Journal: Nat Med
Title: Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity.
Volume: 21
Issue: 6
Pages: 610-8
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Publication
27942586 | J:290302
First Author: Alzaid F
Year: 2016
Journal: JCI Insight
Title: IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans.
Volume: 1
Issue: 20
Pages: e88689
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Publication
28515358 | J:287898
 
First Author: Oriss TB
Year: 2017
Journal: JCI Insight
Title: IRF5 distinguishes severe asthma in humans and drives Th1 phenotype and airway hyperreactivity in mice.
Volume: 2
Issue: 10
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Publication
26598674 | J:228133
First Author: Saigusa R
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Multifaceted contribution of the TLR4-activated IRF5 transcription factor in systemic sclerosis.
Volume: 112
Issue: 49
Pages: 15136-41
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Publication
32444476 | J:318045
 
First Author: Corbin AL
Year: 2020
Journal: Sci Immunol
Title: IRF5 guides monocytes toward an inflammatory CD11c+ macrophage phenotype and promotes intestinal inflammation.
Volume: 5
Issue: 47
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Publication
23912454 | J:212615
First Author: Bi X
Year: 2014
Journal: Oncogene
Title: Deletion of Irf5 protects hematopoietic stem cells from DNA damage-induced apoptosis and suppresses γ-irradiation-induced thymic lymphomagenesis.
Volume: 33
Issue: 25
Pages: 3288-97
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Publication
22422888 | J:184062
First Author: Xu Y
Year: 2012
Journal: J Immunol
Title: Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus.
Volume: 188
Issue: 8
Pages: 4113-21
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Publication
27521268 | J:259269
First Author: Ban T
Year: 2016
Journal: Immunity
Title: Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity.
Volume: 45
Issue: 2
Pages: 319-32
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Publication
18836453 | -
First Author: Chen W
Year: 2008
Journal: Nat Struct Mol Biol
Title: Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5.
Volume: 15
Issue: 11
Pages: 1213-20
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Publication
11303025 | -
First Author: Barnes BJ
Year: 2001
Journal: J Biol Chem
Title: Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes.
Volume: 276
Issue: 26
Pages: 23382-90
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Publication
17881657 | -
First Author: Dideberg V
Year: 2007
Journal: Hum Mol Genet
Title: An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases.
Volume: 16
Issue: 24
Pages: 3008-16
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Publication
15657875 | -
First Author: Sigurdsson S
Year: 2005
Journal: Am J Hum Genet
Title: Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.
Volume: 76
Issue: 3
Pages: 528-37
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Publication
15695821 | -
First Author: Schoenemeyer A
Year: 2005
Journal: J Biol Chem
Title: The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
Volume: 280
Issue: 17
Pages: 17005-12
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Publication
32690658 | J:300671
First Author: Yan J
Year: 2020
Journal: J Immunol
Title: Myeloid Cell-Intrinsic IRF5 Promotes T Cell Responses through Multiple Distinct Checkpoints In Vivo, and IRF5 Immune-Mediated Disease Risk Variants Modulate These Myeloid Cell Functions.
Volume: 205
Issue: 4
Pages: 1024-1038
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Publication
25288773 | J:216591
First Author: Kreher S
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma.
Volume: 111
Issue: 42
Pages: E4513-22
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Publication
25326418 | J:216670
First Author: Lopez-Pelaez M
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells.
Volume: 111
Issue: 49
Pages: 17432-7
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Publication
27050551 | J:248755
First Author: Weihrauch D
Year: 2016
Journal: PLoS One
Title: An IRF5 Decoy Peptide Reduces Myocardial Inflammation and Fibrosis and Improves Endothelial Cell Function in Tight-Skin Mice.
Volume: 11
Issue: 4
Pages: e0151999
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Publication
25595782 | J:296060
First Author: Watkins AA
Year: 2015
Journal: J Immunol
Title: IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosis.
Volume: 194
Issue: 4
Pages: 1467-79
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Publication
17275788 | J:120351
First Author: Ouyang X
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation.
Volume: 354
Issue: 4
Pages: 1045-51
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Protein
E9Q5T2
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
A0A0N4SVY5
Organism: Mus musculus/domesticus
Length: 134  
Fragment?: true
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Protein
P56477
Organism: Mus musculus/domesticus
Length: 497  
Fragment?: false
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Protein
Q3U169
Organism: Mus musculus/domesticus
Length: 497  
Fragment?: false
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Protein
F6Z6C6
Organism: Mus musculus/domesticus
Length: 494  
Fragment?: false
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Protein
B2CC69
Organism: Mus musculus/domesticus
Length: 401  
Fragment?: false
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Publication
31799619 | J:285166
First Author: Csumita M
Year: 2020
Journal: Nucleic Acids Res
Title: Specific enhancer selection by IRF3, IRF5 and IRF9 is determined by ISRE half-sites, 5' and 3' flanking bases, collaborating transcription factors and the chromatin environment in a combinatorial fashion.
Volume: 48
Issue: 2
Pages: 589-604
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Publication
22933628 | J:190349
First Author: Yang L
Year: 2012
Journal: J Immunol
Title: Monocytes from Irf5-/- mice have an intrinsic defect in their response to pristane-induced lupus.
Volume: 189
Issue: 7
Pages: 3741-50
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Publication
32456211 | J:302405
 
First Author: Nakao M
Year: 2020
Journal: Int J Mol Sci
Title: Exacerbated Imiquimod-Induced Psoriasis-Like Skin Inflammation in IRF5-Deficient Mice.
Volume: 21
Issue: 10
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Publication
20935208 | J:165641
First Author: Feng D
Year: 2010
Journal: J Immunol
Title: Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression.
Volume: 185
Issue: 10
Pages: 6003-12
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Publication
22678902 | J:187760
First Author: Feng D
Year: 2012
Journal: Eur J Immunol
Title: Irf5-deficient mice are protected from pristane-induced lupus via increased Th2 cytokines and altered IgG class switching.
Volume: 42
Issue: 6
Pages: 1477-87
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Publication
36042203 | J:327966
First Author: Orliaguet L
Year: 2022
Journal: Nat Commun
Title: Early macrophage response to obesity encompasses Interferon Regulatory Factor 5 regulated mitochondrial architecture remodelling.
Volume: 13
Issue: 1
Pages: 5089
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Publication
31420465 | J:279281
First Author: Kobayashi S
Year: 2019
Journal: J Immunol
Title: TNF Receptor-Associated Factor 5 Limits Function of Plasmacytoid Dendritic Cells by Controlling IFN Regulatory Factor 5 Expression.
Volume: 203
Issue: 6
Pages: 1447-1456
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Publication
25031348 | J:214624
First Author: Thackray LB
Year: 2014
Journal: J Virol
Title: Interferon regulatory factor 5-dependent immune responses in the draining lymph node protect against West Nile virus infection.
Volume: 88
Issue: 19
Pages: 11007-21
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Publication
30902986 | J:273264
First Author: Zhao Y
Year: 2019
Journal: Nat Commun
Title: Microbial recognition by GEF-H1 controls IKKε mediated activation of IRF5.
Volume: 10
Issue: 1
Pages: 1349
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Publication
28698173 | J:266953
First Author: Seneviratne AN
Year: 2017
Journal: Circulation
Title: Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis.
Volume: 136
Issue: 12
Pages: 1140-1154
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Publication
33490963 | J:346469
First Author: Zimmerman KA
Year: 2020
Journal: Kidney360
Title: Interferon Regulatory Factor-5 in Resident Macrophage Promotes Polycystic Kidney Disease.
Volume: 1
Issue: 3
Pages: 179-190
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Publication
25149452 | J:291649
 
First Author: Chiba S
Year: 2014
Journal: Elife
Title: Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.
Volume: 3
Pages: e04177
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Publication
32038622 | J:297925
 
First Author: Mai LT
Year: 2019
Journal: Front Immunol
Title: IRF-5 Expression in Myeloid Cells Is Required for Splenomegaly in L. donovani Infected Mice.
Volume: 10
Pages: 3071
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Publication
31892541 | J:286738
First Author: Al Mamun A
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Microglial IRF5-IRF4 regulatory axis regulates neuroinflammation after cerebral ischemia and impacts stroke outcomes.
Volume: 117
Issue: 3
Pages: 1742-1752
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Publication
35963621 | J:332338
First Author: Ngwa C
Year: 2022
Journal: Aging (Albany NY)
Title: Regulation of microglial activation in stroke in aged mice: a translational study.
Volume: 14
Issue: 15
Pages: 6047-6065
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Publication
20007534 | J:159416
First Author: Richez C
Year: 2010
Journal: J Immunol
Title: IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus.
Volume: 184
Issue: 2
Pages: 796-806
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Publication
25076492 | J:218999
First Author: Yasuda K
Year: 2014
Journal: PLoS One
Title: Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2.
Volume: 9
Issue: 7
Pages: e103478
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Publication
23291967 | J:199969
First Author: Yasuda K
Year: 2013
Journal: Int Immunol
Title: Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2.
Volume: 25
Issue: 5
Pages: 295-306
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Publication
22116829 | J:180587
First Author: Panchanathan R
Year: 2012
Journal: J Immunol
Title: Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis.
Volume: 188
Issue: 1
Pages: 270-8
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Publication
18268344 | J:132168
First Author: Couzinet A
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis.
Volume: 105
Issue: 7
Pages: 2556-61
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Publication
15665823 | J:97567
First Author: Takaoka A
Year: 2005
Journal: Nature
Title: Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.
Volume: 434
Issue: 7030
Pages: 243-9
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Publication
17513736 | J:147844
First Author: Yasuda K
Year: 2007
Journal: J Immunol
Title: Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production.
Volume: 178
Issue: 11
Pages: 6876-85
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Publication
17360658 | J:125934
First Author: Yanai H
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression.
Volume: 104
Issue: 9
Pages: 3402-7
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Publication
26468541 | J:227923
First Author: Proenca-Modena JL
Year: 2015
Journal: J Virol
Title: Interferon-Regulatory Factor 5-Dependent Signaling Restricts Orthobunyavirus Dissemination to the Central Nervous System.
Volume: 90
Issue: 1
Pages: 189-205
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Protein Coding Gene
MGP_CAROLIEiJ_G0028175 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030527 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030500 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030427 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030510 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0030223 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1350924 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030964 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029625 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0030201 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0030345 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0030299 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0030432 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0030335 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030994 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0029339 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029701 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021933 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0029175 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
18332133 | J:137585
First Author: Paun A
Year: 2008
Journal: J Biol Chem
Title: Functional characterization of murine interferon regulatory factor 5 (IRF-5) and its role in the innate antiviral response.
Volume: 283
Issue: 21
Pages: 14295-308
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Publication
- | J:176418
     
First Author: Pitha-Rowe P
Year: 2011
Journal: MGI Direct Data Submission
Title: Creation of a conditional targeted mutation in interferon regulatory factor 5 (Irf5)
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Publication
20176957 | J:158769
First Author: Lien C
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Critical role of IRF-5 in regulation of B-cell differentiation.
Volume: 107
Issue: 10
Pages: 4664-8
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Publication
19028697 | J:147231
First Author: Hu G
Year: 2009
Journal: J Biol Chem
Title: IRF-5 is a mediator of the death receptor-induced apoptotic signaling pathway.
Volume: 284
Issue: 5
Pages: 2767-77
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GXD Expression
GXD Expression
     
Probe: MGI:5751597
Assay Type: Western blot
Annotation Date: 2016-03-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754421
Stage: TS21
Assay Id: MGI:5751768
Age: embryonic day 13.0
Specimen Label: E13
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5751597
Assay Type: Western blot
Annotation Date: 2016-03-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754423
Stage: TS23
Assay Id: MGI:5751768
Age: embryonic day 15.0
Specimen Label: E15
Detected: true
Specimen Num: 3
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