GPN-loop GTPase 2 (Gpn2) belongs to the GPN-loop GTPase family []. It is also known as ATPBD1B in humans. In budding yeasts, Gpn2 is a putative GTPase that has a role in biogenesis of RNA polymerase II and III []. It is involved in sister chromatid cohesion [].
Proteins in this entry belong to the GPN-loop GTPase family [], including Npa3 (also known as Gpn1) and Gpn2/3 from budding yeasts. In humans, Npa3 homologue is known as XAB1; Gpn2 is known as GPN2/ATPBD1B; Gpn3 is known as Parcs. Npa3 plays an important part in transporting RNA polymerase II (RNAPII) to the nucleus. The binding of Npa3 with RNAPII is GTP-dependent []. Gpn2 and Gpn3 are putative GTPase that have a role in biogenesis of RNA polymerase II and III []. Npa3, Gpn2 and Gpn3 is involved in sister chromatid cohesion [, ].
