This entry contains Serp1/Serp2 and yeast Ysy6 stress-associated endoplasmic reticulum proteins. In humans, Serp1 (also known as RAMP4) interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. It has also been shown to protect unfolded target proteins against degradation during ER stress. It may facilitate glycosylation of target proteins after termination of ER stress and may modulate the use of N-glycosylation sites on target proteins [, ].
