This entry includes homologues of yeast Sfi1 in higher eukaryotes, where it plays a role in the dynamic structure of centrosome-associated contractile fibres via its interaction with CETN2 [, ]. The structure of the human centrin 2/hSfi1 complex has been solved [].
This is a domain of fungal spindle pole body proteins that play a role in spindle body duplication. They contain binding sites for calmodulin-like proteins called centrins []which are present in microtubule-organising centres.
This C-terminal domain of spindle-body-associated protein Sfi1 has an important role to play in the bridge-splitting during bi-polar spindle assembly, and this separation event possibly requires interaction with integral components of the nuclear envelope, such as the Mps2-Bbp1 complex []. Centrally to this domain is a region carrying centrin-binding repeats with repeating units containing tryptophan, .
