The vertebrate DMRT (doublesex-and mab-3-related transcription factor) gene family encodes putative transcription factors related to the sexual regulators Doublesex (Drosophila melanogaster) and MAB-3 (Caenorhabditis elegans). They share a highly conserved DNA binding motif, the DM domain. This entry represents a domain found in the C-terminal of the DMRT C1 and C2 proteins. DMRTC1 (also known as DMRT8) is located on the X chromosome in placental mammals. It is related to DMRTC2 (DMRT7) but has lost the DM domain [].
