|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 119 out of 119 for Amn

<< First    < Previous  |  Next >    Last >>
0.019s

Categories

Hits by Strain

Hits by Category

Type Details Score
Author
Silva AMN
•
•
•
•
•
Strain
MGI:2161058 | STOCK Amn<amn>
Attribute String: mutant stock
•
•
•
•
•
Genotype
Genotype
Symbol: Amn/Amn
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Amn/Amn
Background: involves: 129S1/SvImJ * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Allele
Amn<em1(cre/ERT2)Fuzh> | MGI:7516282
Name: amnionless; endonuclease-mediated mutation 1, Fujian Zhang
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
•
•
•
•
•
Strain
MGI:7516501 | C57BL/6-Amn<em1(cre/ERT2)Fuzh>
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Genotype
Genotype
Symbol: Amn/Amn<+>
Background: C57BL/6-Amn
Zygosity: ht
Has Mutant Allele: true
•
•
•
•
•
Publication
28830894 | J:249116
First Author: Watt NT
Year: 2017
Journal: Diabetes
Title: Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance.
Volume: 66
Issue: 11
Pages: 2808-2821
•
•
•
•
•
Publication
29796592 | J:264008
First Author: Sengupta A
Year: 2018
Journal: Endocrinology
Title: Endothelial Insulin Receptor Restoration Rescues Vascular Function in Male Insulin Receptor Haploinsufficient Mice.
Volume: 159
Issue: 8
Pages: 2917-2925
•
•
•
•
•
Publication
33133093 | J:341802
 
First Author: Myers DR
Year: 2020
Journal: Front Immunol
Title: Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.
Volume: 11
Pages: 576310
•
•
•
•
•
Publication
37857886 | J:344188
First Author: Duarte TL
Year: 2024
Journal: Leukemia
Title: Iron overload induces dysplastic erythropoiesis and features of myelodysplasia in Nrf2-deficient mice.
Volume: 38
Issue: 1
Pages: 96-108
•
•
•
•
•
Publication
2690948 | -
First Author: Leung HB
Year: 1989
Journal: Biochemistry
Title: Structure and regulation of the AMP nucleosidase gene (amn) from Escherichia coli.
Volume: 28
Issue: 22
Pages: 8726-33
•
•
•
•
•
Publication
18344354 | J:136104
First Author: Fourcade S
Year: 2008
Journal: Hum Mol Genet
Title: Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy.
Volume: 17
Issue: 12
Pages: 1762-73
•
•
•
•
•
Protein Domain
IPR010944 | AMN-like
Type: Family
Description: AMP nucleosidase (AMN) catalyses the hydrolysis of AMP to form adenine and ribose 5-phosphate. It is only found in prokaryotes, where it plays a role in purine nucleoside salvage and intracellular AMP level regulation []. The gene for AMP nucleosidase from Escherichia coli (amn) encodes a protein of 483 amino acids. A comparison of the amino acid sequence for AMP nucleosidase with that for yeast AMP deaminase shows that there is a region where only six out of eight amino acids are identical but there is no other overall homology. AMN also showed little similarity to consensus sequences for adenylate binding sites even though the enzyme is known to have a catalytic site for AMP and regulatory sites for MgATP and phosphate [].The enzyme is a homohexamer, and each monomer has two domains: a catalytic domain and a putative regulatory domain. The overall topology of the catalytic domain and some features of the substrate binding site resemble those of the nucleoside phosphorylases. The structure of the regulatory domain consists of a long helix and a four-stranded sheet, but has a novel topology []. The majority of sequences in this entry are annotated as AMP nucleosidase. Their taxonomic range is restricted to the Bacteroidetes and Chlamydiae.
•
•
•
•
•
Protein Domain
IPR011271 | AMP_nucleosidase
Type: Family
Description: AMP nucleosidase (AMN) catalyses the hydrolysis of AMP to form adenine and ribose 5-phosphate. It is only found in prokaryotes, where it plays a role in purine nucleoside salvage and intracellular AMP level regulation []. The gene for AMP nucleosidase from Escherichia coli (amn) encodes a protein of 483 amino acids. A comparison of the amino acid sequence for AMP nucleosidase with that for yeast AMP deaminase shows that there is a region where only six out of eight amino acids are identical but there is no other overall homology. AMN also showed little similarity to consensus sequences for adenylate binding sites even though the enzyme is known to have a catalytic site for AMP and regulatory sites for MgATP and phosphate [].The enzyme is a homohexamer, and each monomer has two domains: a catalytic domain and a putative regulatory domain. The overall topology of the catalytic domain and some features of the substrate binding site resemble those of the nucleoside phosphorylases. The structure of the regulatory domain consists of a long helix and a four-stranded sheet, but has a novel topology [].
•
•
•
•
•
Publication
22095690 | J:180601
First Author: Schlüter A
Year: 2012
Journal: Hum Mol Genet
Title: Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophy.
Volume: 21
Issue: 5
Pages: 1062-77
•
•
•
•
•
Publication
26370417 | J:226851
First Author: Ruiz M
Year: 2015
Journal: Hum Mol Genet
Title: Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy.
Volume: 24
Issue: 24
Pages: 6861-76
•
•
•
•
•
Publication
15296732 | -
First Author: Zhang Y
Year: 2004
Journal: Structure
Title: Structure of Escherichia coli AMP nucleosidase reveals similarity to nucleoside phosphorylases.
Volume: 12
Issue: 8
Pages: 1383-94
•
•
•
•
•
Publication
17260006 | J:119497
First Author: Lu JF
Year: 2007
Journal: Lab Invest
Title: The role of peroxisomal ABC transporters in the mouse adrenal gland: the loss of Abcd2 (ALDR), Not Abcd1 (ALD), causes oxidative damage.
Volume: 87
Issue: 3
Pages: 261-72
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom