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Search results 101 to 191 out of 191 for Pak4

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Type Details Score
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1721422
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1646922
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736222
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1683322
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1700022
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1832122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876522
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Note: Expression was not detected in the immune system.
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1741222
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3599822
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280922
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1833322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3287022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1821522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1702122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1738322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: MH1476; Specimen C1523
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3724883
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:2672022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421534
Age: embryonic day 14.5
Image: MH1476; Specimen C1523
Note: Expression was weak in whisker follicle.
Specimen Label: MH1476; Specimen C1523
Detected: true
Specimen Num: 1
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•
Publication
14517284 | J:85956
First Author: Li X
Year: 2003
Journal: Mol Cell Biol
Title: Targeted disruption of the gene for the PAK5 kinase in mice.
Volume: 23
Issue: 20
Pages: 7134-42
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•
Publication
16300676 | J:104456
 
First Author: Michaud EJ
Year: 2005
Journal: BMC Genomics
Title: Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice.
Volume: 6
Pages: 164
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•
Publication
23509247 | J:194236
First Author: Dolan BM
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.
Volume: 110
Issue: 14
Pages: 5671-6
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Publication
26002917 | J:239366
First Author: Chintala H
Year: 2015
Journal: Development
Title: The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase-1 and Notch signaling.
Volume: 142
Issue: 13
Pages: 2364-74
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Publication
24472646 | J:229358
 
First Author: Teo ZL
Year: 2014
Journal: Exp Eye Res
Title: Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation.
Volume: 121
Pages: 130-42
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Publication
26273529 | J:227247
 
First Author: Brommage R
Year: 2014
Journal: Bone Res
Title: High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.
Volume: 2
Pages: 14034
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Publication
- | J:165963
     
First Author: Centre for Modeling Human Disease
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Centre for Modeling Human Disease (Cmhd), Institute of Biomaterials & Biomedical Engineering, University of Toronto
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Publication
14621295 | J:86686
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 4
Pages: 167-80
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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•
•
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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HT Experiment
GSE200913 | Effect of Pak4 deficiency on transcriptome in liver of mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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UniProt Feature
UniProt Feature
Begin: 143
Description: Phosphoserine; by PAK4
Type: modified residue
End: 143
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UniProt Feature
UniProt Feature
Begin: 895
Description: Phosphoserine; by PAK4
Type: modified residue
End: 895
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Publication
36301793 | J:330575
First Author: Yamada S
Year: 2022
Journal: PLoS Genet
Title: Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal development.
Volume: 18
Issue: 10
Pages: e1010438
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Publication
30685413 | J:271221
 
First Author: Liu X
Year: 2019
Journal: Cancer Lett
Title: miR-193a-3p inhibition of the Slug activator PAK4 suppresses non-small cell lung cancer aggressiveness via the p53/Slug/L1CAM pathway.
Volume: 447
Pages: 56-65
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Publication
11413130 | -
First Author: Dan C
Year: 2001
Journal: J Biol Chem
Title: Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin.
Volume: 276
Issue: 34
Pages: 32115-21
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Publication
26607847 | -
 
First Author: Baskaran Y
Year: 2015
Journal: Nat Commun
Title: An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1.
Volume: 6
Pages: 8681
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Publication
21381077 | -
First Author: Nekrasova T
Year: 2011
Journal: J Cell Biochem
Title: PAK4 is required for regulation of the cell-cycle regulatory protein p21, and for control of cell-cycle progression.
Volume: 112
Issue: 7
Pages: 1795-806
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Publication
30485810 | J:270789
First Author: Lee S
Year: 2018
Journal: Cell Rep
Title: Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity.
Volume: 25
Issue: 9
Pages: 2417-2430.e5
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Protein
Q3U261
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: true
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Protein
Q8CG12
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: true
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Publication
31225512 | -
First Author: Keller L
Year: 2019
Journal: Cell Stress
Title: Biology and clinical relevance of EpCAM.
Volume: 3
Issue: 6
Pages: 165-180
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Publication
22819673 | J:190580
First Author: Lei Z
Year: 2012
Journal: Dev Biol
Title: EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins.
Volume: 371
Issue: 2
Pages: 136-45
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Publication
20651236 | -
First Author: Nakatsukasa M
Year: 2010
Journal: Am J Pathol
Title: Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy.
Volume: 177
Issue: 3
Pages: 1344-55
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Publication
18281513 | -
First Author: Wang J
Year: 2008
Journal: Mol Cancer Ther
Title: Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers.
Volume: 7
Issue: 2
Pages: 280-5
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Publication
31177095 | -
First Author: Mori Y
Year: 2019
Journal: J Biol Chem
Title: Trophoblast cell surface antigen 2 (Trop-2) phosphorylation by protein kinase C α/δ (PKCα/δ) enhances cell motility.
Volume: 294
Issue: 30
Pages: 11513-11524
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Publication
30628064 | -
First Author: Yahyazadeh Mashhadi SM
Year: 2019
Journal: J Cell Physiol
Title: Shedding light on the EpCAM: An overview.
Volume: 234
Issue: 8
Pages: 12569-12580
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Publication
23536555 | -
First Author: Trerotola M
Year: 2013
Journal: Cancer Res
Title: Trop-2 promotes prostate cancer metastasis by modulating β(1) integrin functions.
Volume: 73
Issue: 10
Pages: 3155-67
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Protein Domain
IPR043406 | EPCAM/Trop-2
Type: Family
Description: This entry includes transmembrane glycoprotein EpCAM (epithelial cell adhesion molecule, also known as Trop-1) and Trop-2 (also known as tumor-associated calcium signal transducer 2, TACSTD2). They belong to the tumour-associated calcium signal transducer (TACSTD) family. They have been reported to directly interact with claudin-1 and claudin-7 [, , ]. EpCAM mediates homotypic cell contacts in epithelia tissues and regulates cell proliferation and cancer stemness. It has been used as a diagnostic marker for circulating tumour cells (CTCs) in the blood []. EpCAM has been shown to contribute to formation of intestinal barrier by recruiting claudins to cell-cell junctions []. Mutations in the EpCAM gene lead to congenital tufting enteropathy, severe intestinal epithelium homeostasis disorders, and Lynch syndrome []. Trop-2 is highly expressed in a variety of epithelial cancer cells. It has been identified as an oncogene leading to invasiveness and tumorigenesis []. It has been shown to regulate integrin-dependent signalling for cell-substrate adhesion and cell migration. It also modulates Rac1 GTPase activity and induces activation of PAK4 [].
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Publication
18675265 | J:141962
First Author: Nekrasova T
Year: 2008
Journal: Dev Biol
Title: Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion.
Volume: 322
Issue: 1
Pages: 95-108
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Publication
23593460 | J:200575
First Author: Furnari MA
Year: 2013
Journal: PLoS One
Title: Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice.
Volume: 8
Issue: 4
Pages: e61321
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Publication
36586159 | J:333156
 
First Author: Yamada S
Year: 2023
Journal: Biochem Biophys Res Commun
Title: Inka2 expression in smooth muscle cells and its involvement in cell migration.
Volume: 643
Pages: 55-60
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Publication
27486147 | J:240343
First Author: Barry DM
Year: 2016
Journal: Circ Res
Title: Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II.
Volume: 119
Issue: 7
Pages: 810-26
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Protein
Q99JW5
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
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Protein
Q8BGV3
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false
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Protein
A0A3Q4EHR5
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: true
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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