This family represents a group of LETM1-like mitochondrial inner membrane proteins, including LETM1/LETM2 from mammals and YLH47/MDM38 from yeastsLETM1 is a proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion []. LETM2 is preferentially expressed in testis and sperm. In humans, deletion of LETM1 causes Wolf-Hirschhorn syndrome []. MDM38 is involved in potassium homeostasis []and, with MBA1, it plays a role in ribosomal translation and protein insertion into the inner membrane [].
This entry represents the N-terminal region of the mammal LETM1-domain-containing protein LETM2, a mitochondrial protein that is expressed preferentially in spermatocytes and spermatozoa during developmental stages from spermatocyte to spermatozoon. LETM2 might contribute to the reorganisation of the inner and cristae membranes during spermatogenesis. Despite its name, it does not contain an EF-hand domain as LETM1, but it contains a putative leucine zipper coiled coil domain [, ].
