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Search results 1 to 1 out of 1 for Cables2

Category restricted to ProteinDomain (x)

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Categories

Category: ProteinDomain
Type Details Score
Protein Domain
Type: Family
Description: This group represents protein CABLES (CDK5 and ABL1 enzyme substrate), including CABLES1 and CABLES2 [, ]. CABLES1 is a cyclin-dependent kinase binding protein, primarily involved in cell cycle regulation []. CABLES1 binds to different functional domains of p53 and p73 and modifies their cell death-inducing activities []. It may be a tumour suppressor in human ovarian cancer []. CABLES2 is involved in both p53-mediated and p53-independent apoptotic pathways [].