Type |
Details |
Score |
Strain |
Attribute String: |
transgenic, mutant strain, congenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, mutant strain, congenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, mutant strain, congenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, congenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams AD |
Year: |
2024 |
Journal: |
Am J Obstet Gynecol |
Title: |
Embryonic statistical analyses reveal 2 growth phenotypes in mouse models of Down syndrome. |
Volume: |
230 |
Issue: |
2 |
Pages: |
258.e1-258.e11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Starbuck JM |
Year: |
2014 |
Journal: |
Am J Med Genet A |
Title: |
Overlapping trisomies for human chromosome 21 orthologs produce similar effects on skull and brain morphology of Dp(16)1Yey and Ts65Dn mice. |
Volume: |
164A |
Issue: |
8 |
Pages: |
1981-1990 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fulton SL |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome. |
Volume: |
13 |
Issue: |
1 |
Pages: |
6384 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guedj F |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome. |
Volume: |
6 |
|
Pages: |
32353 |
|
•
•
•
•
•
|
Publication |
First Author: |
Duchon A |
Year: |
2011 |
Journal: |
Mamm Genome |
Title: |
Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome. |
Volume: |
22 |
Issue: |
11-12 |
Pages: |
674-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Toiber D |
Year: |
2010 |
Journal: |
Neurobiol Dis |
Title: |
Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations. |
Volume: |
40 |
Issue: |
1 |
Pages: |
348-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen TL |
Year: |
2018 |
Journal: |
Dis Model Mech |
Title: |
Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A. |
Volume: |
11 |
Issue: |
9 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Tlili A |
Year: |
2013 |
Journal: |
Mol Genet Metab |
Title: |
DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels. |
Volume: |
110 |
Issue: |
3 |
Pages: |
371-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sago H |
Year: |
2000 |
Journal: |
Pediatr Res |
Title: |
Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome. |
Volume: |
48 |
Issue: |
5 |
Pages: |
606-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Belichenko PV |
Year: |
2007 |
Journal: |
J Comp Neurol |
Title: |
Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. |
Volume: |
504 |
Issue: |
4 |
Pages: |
329-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rastogi M |
Year: |
2024 |
Journal: |
Neuron |
Title: |
Integrative multi-omic analysis reveals conserved cell-projection deficits in human Down syndrome brains. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Herault Y |
Year: |
2017 |
Journal: |
Dis Model Mech |
Title: |
Rodent models in Down syndrome research: impact and future opportunities. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1165-1186 |
|
•
•
•
•
•
|
Publication |
First Author: |
Salehi A |
Year: |
2009 |
Journal: |
Sci Transl Med |
Title: |
Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome. |
Volume: |
1 |
Issue: |
7 |
Pages: |
7ra17 |
|
•
•
•
•
•
|
Publication |
First Author: |
Victorino DB |
Year: |
2020 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Quantitative Analysis of Retinal Structure and Function in Two Chromosomally Altered Mouse Models of Down Syndrome. |
Volume: |
61 |
Issue: |
5 |
Pages: |
25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Richtsmeier JT |
Year: |
2002 |
Journal: |
Am J Med Genet |
Title: |
Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome. |
Volume: |
107 |
Issue: |
4 |
Pages: |
317-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu JC |
Year: |
2013 |
Journal: |
EMBO J |
Title: |
Usp16: key controller of stem cells in Down syndrome. |
Volume: |
32 |
Issue: |
21 |
Pages: |
2788-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Colombi I |
Year: |
2024 |
Journal: |
iScience |
Title: |
Heterogeneous subpopulations of GABA(A)R-responding neurons coexist across neuronal network scales and developmental stages in health and disease. |
Volume: |
27 |
Issue: |
4 |
Pages: |
109438 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hijazi M |
Year: |
2013 |
Journal: |
Exp Neurol |
Title: |
Overexpression of DYRK1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome. |
Volume: |
239 |
|
Pages: |
229-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Navarro-Romero A |
Year: |
2019 |
Journal: |
Neurobiol Dis |
Title: |
Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome. |
Volume: |
125 |
|
Pages: |
92-106 |
|
•
•
•
•
•
|
Publication |
First Author: |
Siddiqui A |
Year: |
2008 |
Journal: |
Genes Brain Behav |
Title: |
Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801. |
Volume: |
7 |
Issue: |
7 |
Pages: |
810-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams AD |
Year: |
2021 |
Journal: |
Am J Obstet Gynecol |
Title: |
Novel insights from fetal and placental phenotyping in 3 mouse models of Down syndrome. |
Volume: |
225 |
Issue: |
3 |
Pages: |
296.e1-296.e13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sierra C |
Year: |
2024 |
Journal: |
Mol Psychiatry |
Title: |
The lncRNA Snhg11, a new candidate contributing to neurogenesis, plasticity, and memory deficits in Down syndrome. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Olson LE |
Year: |
2004 |
Journal: |
Dev Dyn |
Title: |
Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes. |
Volume: |
230 |
Issue: |
3 |
Pages: |
581-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moyer AJ |
Year: |
2023 |
Journal: |
Dis Model Mech |
Title: |
Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome. |
Volume: |
16 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Willuweit A |
Year: |
2021 |
Journal: |
Front Neurosci |
Title: |
Comparison of the Amyloid Load in the Brains of Two Transgenic Alzheimer's Disease Mouse Models Quantified by Florbetaben Positron Emission Tomography. |
Volume: |
15 |
|
Pages: |
699926 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lewis PA |
Year: |
2001 |
Journal: |
Biochim Biophys Acta |
Title: |
Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptides. |
Volume: |
1537 |
Issue: |
1 |
Pages: |
58-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Khan AA |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Neuroglobin attenuates beta-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivo. |
Volume: |
104 |
Issue: |
48 |
Pages: |
19114-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Terwel D |
Year: |
2008 |
Journal: |
Am J Pathol |
Title: |
Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice. |
Volume: |
172 |
Issue: |
3 |
Pages: |
786-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Daschil N |
Year: |
2015 |
Journal: |
Neurobiol Aging |
Title: |
L-type calcium channel blockers and substance P induce angiogenesis of cortical vessels associated with beta-amyloid plaques in an Alzheimer mouse model. |
Volume: |
36 |
Issue: |
3 |
Pages: |
1333-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Paolicelli RC |
Year: |
2017 |
Journal: |
Neuron |
Title: |
TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss. |
Volume: |
95 |
Issue: |
2 |
Pages: |
297-308.e6 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
endonuclease-mediated mutation, congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, endonuclease-mediated mutation, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, endonuclease-mediated mutation, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, endonuclease-mediated mutation, congenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, endonuclease-mediated mutation, congenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, endonuclease-mediated mutation, congenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, endonuclease-mediated mutation, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, endonuclease-mediated mutation, congenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, targeted mutation, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, endonuclease-mediated mutation, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
endonuclease-mediated mutation, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
endonuclease-mediated mutation, targeted mutation, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Ts(17<16>)65Dn/? Del(16Cbr1-Fam3b)1Rhr/? |
Background: |
involves: 129S6/SvEvTac * C57BL/6 * DBA/2J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(APPSw)40Btla/Tg(APPSw)40Btla |
Background: |
D2.129-Tg(APPSw)40Btla |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe Tg(Eno2-APP*751)10Cord/? Cdh18/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * CBA |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe Tg(Eno2-APP*751)10Cord/? Tg(GFAP-APOE_i3)37Hol/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * CBA |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Omp/Omp Tg(tetO-APPSwInd)Dbo/? |
Background: |
involves: 129 * 129P2/OlaHsd * C3H/HeJ * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Or10a4/Or10a4<+> Omp/Omp<+> Tg(tetO-APPSwInd)Dbo/? |
Background: |
involves: 129 * 129P2/OlaHsd * C3H/HeJ * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Camk2a-tTA)1Mmay/? Tg(PDGFB-APPSwInd)J9Lms/? Tg(tetO-MAPT*A152T)L1Lms/? |
Background: |
involves: C57BL/6 * C57BL/6J * DBA/2 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tbx5/Tbx5<+> Ts(17<16>)65Dn/? |
Background: |
involves: C3H * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Brwd1/Brwd1<+> Ts(17<16>)65Dn/? |
Background: |
involves: C3H/HeJ * C57BL/6J * DBA/2J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Del(17Scaf8-Pde10a)2Yey/+ Ts(17<16>)65Dn/? |
Background: |
involves: 129S7/SvEvBrd * DBA/2J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Choi H |
Year: |
2015 |
Journal: |
Biol Reprod |
Title: |
Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7. |
Volume: |
93 |
Issue: |
3 |
Pages: |
70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Czarnek M |
Year: |
2020 |
Journal: |
Mol Neurobiol |
Title: |
Proteolytic Processing of Neuregulin 2. |
Volume: |
57 |
Issue: |
4 |
Pages: |
1799-1813 |
|
•
•
•
•
•
|
Publication |
First Author: |
Frade JM |
Year: |
2005 |
Journal: |
J Neurosci |
Title: |
Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding. |
Volume: |
25 |
Issue: |
6 |
Pages: |
1407-11 |
|
•
•
•
•
•
|
Publication |
First Author: |
Seldin MF |
Year: |
1999 |
Journal: |
Database Release |
Title: |
Seldin Interspecific Backcross Mapping Data |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
514
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Rustenhoven J |
Year: |
2021 |
Journal: |
Cell |
Title: |
Functional characterization of the dural sinuses as a neuroimmune interface. |
Volume: |
184 |
Issue: |
4 |
Pages: |
1000-1016.e27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Crowe SE |
Year: |
2014 |
Journal: |
J Comp Neurol |
Title: |
Longitudinal in vivo two-photon fluorescence imaging. |
Volume: |
522 |
Issue: |
8 |
Pages: |
1708-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sakae N |
Year: |
2016 |
Journal: |
J Neurosci |
Title: |
ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology. |
Volume: |
36 |
Issue: |
13 |
Pages: |
3848-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ezra Y |
Year: |
2003 |
Journal: |
Neuroscience |
Title: |
Apolipoprotein E4 decreases whereas apolipoprotein E3 increases the level of secreted amyloid precursor protein after closed head injury. |
Volume: |
121 |
Issue: |
2 |
Pages: |
315-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fitz NF |
Year: |
2020 |
Journal: |
Mol Neurodegener |
Title: |
Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice. |
Volume: |
15 |
Issue: |
1 |
Pages: |
41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Haure-Mirande JV |
Year: |
2017 |
Journal: |
Acta Neuropathol |
Title: |
Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology. |
Volume: |
134 |
Issue: |
5 |
Pages: |
769-788 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ali T |
Year: |
2021 |
Journal: |
Mol Neurodegener |
Title: |
Adiponectin-mimetic novel nonapeptide rescues aberrant neuronal metabolic-associated memory deficits in Alzheimer's disease. |
Volume: |
16 |
Issue: |
1 |
Pages: |
23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stephens GS |
Year: |
2020 |
Journal: |
Front Neurosci |
Title: |
Genes Bound by ΔFosB in Different Conditions With Recurrent Seizures Regulate Similar Neuronal Functions. |
Volume: |
14 |
|
Pages: |
472 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lei M |
Year: |
2019 |
Journal: |
J Neurosci |
Title: |
Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease. |
Volume: |
39 |
Issue: |
48 |
Pages: |
9645-9659 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tohumeken S |
Year: |
2023 |
Journal: |
Neurobiol Dis |
Title: |
Neuronal deletion of nSMase2 reduces the production of Aβ and directly protects neurons. |
Volume: |
177 |
|
Pages: |
105987 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shen R |
Year: |
2020 |
Journal: |
Transl Neurodegener |
Title: |
Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease. |
Volume: |
9 |
Issue: |
1 |
Pages: |
26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xiao Q |
Year: |
2015 |
Journal: |
J Neurosci |
Title: |
Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis. |
Volume: |
35 |
Issue: |
35 |
Pages: |
12137-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luo R |
Year: |
2020 |
Journal: |
Autophagy |
Title: |
Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model. |
Volume: |
16 |
Issue: |
1 |
Pages: |
52-69 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bold CS |
Year: |
2022 |
Journal: |
J Neurosci |
Title: |
APPsα Rescues Tau-Induced Synaptic Pathology. |
Volume: |
42 |
Issue: |
29 |
Pages: |
5782-5802 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawarabayashi T |
Year: |
1996 |
Journal: |
Neurobiol Aging |
Title: |
Accumulation of beta-amyloid fibrils in pancreas of transgenic mice. |
Volume: |
17 |
Issue: |
2 |
Pages: |
215-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martinez TP |
Year: |
2024 |
Journal: |
eNeuro |
Title: |
Amyloid-β-induced dendritic spine elimination requires Ca(2+)-permeable AMPA receptors, AKAP-Calcineurin-NFAT signaling, and the NFAT target gene Mdm2. |
Volume: |
11 |
Issue: |
3 |
|
|
•
•
•
•
•
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Publication |
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