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Search results 6201 to 6300 out of 7122 for App

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Hits by Strain

Type Details Score
Strain
Attribute String: transgenic, mutant strain, congenic
Strain
Attribute String: transgenic, mutant strain, congenic
Strain
Attribute String: congenic, mutant strain, transgenic
Strain
Attribute String: congenic, mutant strain, transgenic
Strain
Attribute String: transgenic, mutant strain, congenic
Strain
Attribute String: congenic, mutant strain, transgenic
Strain
Attribute String: transgenic, congenic
Publication
First Author: Adams AD
Year: 2024
Journal: Am J Obstet Gynecol
Title: Embryonic statistical analyses reveal 2 growth phenotypes in mouse models of Down syndrome.
Volume: 230
Issue: 2
Pages: 258.e1-258.e11
Publication
First Author: Starbuck JM
Year: 2014
Journal: Am J Med Genet A
Title: Overlapping trisomies for human chromosome 21 orthologs produce similar effects on skull and brain morphology of Dp(16)1Yey and Ts65Dn mice.
Volume: 164A
Issue: 8
Pages: 1981-1990
Publication
First Author: Fulton SL
Year: 2022
Journal: Nat Commun
Title: Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome.
Volume: 13
Issue: 1
Pages: 6384
Publication  
First Author: Guedj F
Year: 2016
Journal: Sci Rep
Title: An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome.
Volume: 6
Pages: 32353
Publication
First Author: Duchon A
Year: 2011
Journal: Mamm Genome
Title: Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome.
Volume: 22
Issue: 11-12
Pages: 674-84
Publication
First Author: Toiber D
Year: 2010
Journal: Neurobiol Dis
Title: Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations.
Volume: 40
Issue: 1
Pages: 348-59
Publication  
First Author: Nguyen TL
Year: 2018
Journal: Dis Model Mech
Title: Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A.
Volume: 11
Issue: 9
Publication
First Author: Tlili A
Year: 2013
Journal: Mol Genet Metab
Title: DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels.
Volume: 110
Issue: 3
Pages: 371-7
Publication
First Author: Sago H
Year: 2000
Journal: Pediatr Res
Title: Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome.
Volume: 48
Issue: 5
Pages: 606-13
Publication
First Author: Belichenko PV
Year: 2007
Journal: J Comp Neurol
Title: Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships.
Volume: 504
Issue: 4
Pages: 329-45
Publication      
First Author: Rastogi M
Year: 2024
Journal: Neuron
Title: Integrative multi-omic analysis reveals conserved cell-projection deficits in human Down syndrome brains.
Publication
First Author: Herault Y
Year: 2017
Journal: Dis Model Mech
Title: Rodent models in Down syndrome research: impact and future opportunities.
Volume: 10
Issue: 10
Pages: 1165-1186
Publication
First Author: Salehi A
Year: 2009
Journal: Sci Transl Med
Title: Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.
Volume: 1
Issue: 7
Pages: 7ra17
Publication
First Author: Victorino DB
Year: 2020
Journal: Invest Ophthalmol Vis Sci
Title: Quantitative Analysis of Retinal Structure and Function in Two Chromosomally Altered Mouse Models of Down Syndrome.
Volume: 61
Issue: 5
Pages: 25
Publication
First Author: Richtsmeier JT
Year: 2002
Journal: Am J Med Genet
Title: Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome.
Volume: 107
Issue: 4
Pages: 317-24
Publication
First Author: Xu JC
Year: 2013
Journal: EMBO J
Title: Usp16: key controller of stem cells in Down syndrome.
Volume: 32
Issue: 21
Pages: 2788-9
Publication
First Author: Colombi I
Year: 2024
Journal: iScience
Title: Heterogeneous subpopulations of GABA(A)R-responding neurons coexist across neuronal network scales and developmental stages in health and disease.
Volume: 27
Issue: 4
Pages: 109438
Publication  
First Author: Hijazi M
Year: 2013
Journal: Exp Neurol
Title: Overexpression of DYRK1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome.
Volume: 239
Pages: 229-34
Publication  
First Author: Navarro-Romero A
Year: 2019
Journal: Neurobiol Dis
Title: Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome.
Volume: 125
Pages: 92-106
Publication
First Author: Siddiqui A
Year: 2008
Journal: Genes Brain Behav
Title: Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801.
Volume: 7
Issue: 7
Pages: 810-20
Publication
First Author: Adams AD
Year: 2021
Journal: Am J Obstet Gynecol
Title: Novel insights from fetal and placental phenotyping in 3 mouse models of Down syndrome.
Volume: 225
Issue: 3
Pages: 296.e1-296.e13
Publication      
First Author: Sierra C
Year: 2024
Journal: Mol Psychiatry
Title: The lncRNA Snhg11, a new candidate contributing to neurogenesis, plasticity, and memory deficits in Down syndrome.
Publication
First Author: Olson LE
Year: 2004
Journal: Dev Dyn
Title: Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes.
Volume: 230
Issue: 3
Pages: 581-9
Publication  
First Author: Moyer AJ
Year: 2023
Journal: Dis Model Mech
Title: Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome.
Volume: 16
Issue: 4
Publication  
First Author: Willuweit A
Year: 2021
Journal: Front Neurosci
Title: Comparison of the Amyloid Load in the Brains of Two Transgenic Alzheimer's Disease Mouse Models Quantified by Florbetaben Positron Emission Tomography.
Volume: 15
Pages: 699926
Publication
First Author: Lewis PA
Year: 2001
Journal: Biochim Biophys Acta
Title: Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptides.
Volume: 1537
Issue: 1
Pages: 58-62
Publication
First Author: Khan AA
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Neuroglobin attenuates beta-amyloid neurotoxicity in vitro and transgenic Alzheimer phenotype in vivo.
Volume: 104
Issue: 48
Pages: 19114-9
Publication
First Author: Terwel D
Year: 2008
Journal: Am J Pathol
Title: Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice.
Volume: 172
Issue: 3
Pages: 786-98
Publication
First Author: Daschil N
Year: 2015
Journal: Neurobiol Aging
Title: L-type calcium channel blockers and substance P induce angiogenesis of cortical vessels associated with beta-amyloid plaques in an Alzheimer mouse model.
Volume: 36
Issue: 3
Pages: 1333-41
Publication
First Author: Paolicelli RC
Year: 2017
Journal: Neuron
Title: TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss.
Volume: 95
Issue: 2
Pages: 297-308.e6
Strain
Attribute String: endonuclease-mediated mutation, congenic, mutant strain, targeted mutation
Strain
Attribute String: congenic, endonuclease-mediated mutation, mutant strain, targeted mutation
Strain
Attribute String: congenic, endonuclease-mediated mutation, mutant strain, targeted mutation
Strain
Attribute String: targeted mutation, mutant strain, endonuclease-mediated mutation, congenic
Strain
Attribute String: targeted mutation, mutant strain, endonuclease-mediated mutation, congenic
Strain
Attribute String: targeted mutation, mutant strain, endonuclease-mediated mutation, congenic
Strain
Attribute String: congenic, endonuclease-mediated mutation, mutant strain, targeted mutation
Strain
Attribute String: targeted mutation, mutant strain, endonuclease-mediated mutation, congenic
Strain
Attribute String: mutant strain, targeted mutation, endonuclease-mediated mutation
Strain
Attribute String: congenic, endonuclease-mediated mutation, mutant strain, targeted mutation
Strain
Attribute String: endonuclease-mediated mutation, mutant strain, targeted mutation
Strain
Attribute String: endonuclease-mediated mutation, targeted mutation, mutant strain
Strain
Attribute String: congenic, mutant strain, targeted mutation
Genotype
Symbol: Ts(17<16>)65Dn/? Del(16Cbr1-Fam3b)1Rhr/?
Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(APPSw)40Btla/Tg(APPSw)40Btla
Background: D2.129-Tg(APPSw)40Btla
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Apoe/Apoe Tg(Eno2-APP*751)10Cord/? Cdh18/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Apoe/Apoe Tg(Eno2-APP*751)10Cord/? Tg(GFAP-APOE_i3)37Hol/?
Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Omp/Omp Tg(tetO-APPSwInd)Dbo/?
Background: involves: 129 * 129P2/OlaHsd * C3H/HeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Or10a4/Or10a4<+> Omp/Omp<+> Tg(tetO-APPSwInd)Dbo/?
Background: involves: 129 * 129P2/OlaHsd * C3H/HeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Camk2a-tTA)1Mmay/? Tg(PDGFB-APPSwInd)J9Lms/? Tg(tetO-MAPT*A152T)L1Lms/?
Background: involves: C57BL/6 * C57BL/6J * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tbx5/Tbx5<+> Ts(17<16>)65Dn/?
Background: involves: C3H * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Brwd1/Brwd1<+> Ts(17<16>)65Dn/?
Background: involves: C3H/HeJ * C57BL/6J * DBA/2J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Del(17Scaf8-Pde10a)2Yey/+ Ts(17<16>)65Dn/?
Background: involves: 129S7/SvEvBrd * DBA/2J
Zygosity: cx
Has Mutant Allele: true
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Genotype
Symbol: Apoe/Apoe
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Choi H
Year: 2015
Journal: Biol Reprod
Title: Reduced Fertility and Altered Epididymal and Sperm Integrity in Mice Lacking ADAM7.
Volume: 93
Issue: 3
Pages: 70
Publication
First Author: Czarnek M
Year: 2020
Journal: Mol Neurobiol
Title: Proteolytic Processing of Neuregulin 2.
Volume: 57
Issue: 4
Pages: 1799-1813
Publication
First Author: Frade JM
Year: 2005
Journal: J Neurosci
Title: Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding.
Volume: 25
Issue: 6
Pages: 1407-11
Publication      
First Author: Seldin MF
Year: 1999
Journal: Database Release
Title: Seldin Interspecific Backcross Mapping Data
Protein
Organism: Mus musculus/domesticus
Length: 514  
Fragment?: false
Publication
First Author: Rustenhoven J
Year: 2021
Journal: Cell
Title: Functional characterization of the dural sinuses as a neuroimmune interface.
Volume: 184
Issue: 4
Pages: 1000-1016.e27
Publication
First Author: Crowe SE
Year: 2014
Journal: J Comp Neurol
Title: Longitudinal in vivo two-photon fluorescence imaging.
Volume: 522
Issue: 8
Pages: 1708-27
Publication
First Author: Sakae N
Year: 2016
Journal: J Neurosci
Title: ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology.
Volume: 36
Issue: 13
Pages: 3848-59
Publication
First Author: Ezra Y
Year: 2003
Journal: Neuroscience
Title: Apolipoprotein E4 decreases whereas apolipoprotein E3 increases the level of secreted amyloid precursor protein after closed head injury.
Volume: 121
Issue: 2
Pages: 315-25
Publication
First Author: Fitz NF
Year: 2020
Journal: Mol Neurodegener
Title: Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice.
Volume: 15
Issue: 1
Pages: 41
Publication
First Author: Haure-Mirande JV
Year: 2017
Journal: Acta Neuropathol
Title: Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.
Volume: 134
Issue: 5
Pages: 769-788
Publication
First Author: Ali T
Year: 2021
Journal: Mol Neurodegener
Title: Adiponectin-mimetic novel nonapeptide rescues aberrant neuronal metabolic-associated memory deficits in Alzheimer's disease.
Volume: 16
Issue: 1
Pages: 23
Publication  
First Author: Stephens GS
Year: 2020
Journal: Front Neurosci
Title: Genes Bound by ΔFosB in Different Conditions With Recurrent Seizures Regulate Similar Neuronal Functions.
Volume: 14
Pages: 472
Publication
First Author: Lei M
Year: 2019
Journal: J Neurosci
Title: Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.
Volume: 39
Issue: 48
Pages: 9645-9659
Publication  
First Author: Tohumeken S
Year: 2023
Journal: Neurobiol Dis
Title: Neuronal deletion of nSMase2 reduces the production of Aβ and directly protects neurons.
Volume: 177
Pages: 105987
Publication
First Author: Shen R
Year: 2020
Journal: Transl Neurodegener
Title: Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.
Volume: 9
Issue: 1
Pages: 26
Publication
First Author: Xiao Q
Year: 2015
Journal: J Neurosci
Title: Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.
Volume: 35
Issue: 35
Pages: 12137-51
Publication
First Author: Luo R
Year: 2020
Journal: Autophagy
Title: Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model.
Volume: 16
Issue: 1
Pages: 52-69
Publication
First Author: Bold CS
Year: 2022
Journal: J Neurosci
Title: APPsα Rescues Tau-Induced Synaptic Pathology.
Volume: 42
Issue: 29
Pages: 5782-5802
Publication
First Author: Kawarabayashi T
Year: 1996
Journal: Neurobiol Aging
Title: Accumulation of beta-amyloid fibrils in pancreas of transgenic mice.
Volume: 17
Issue: 2
Pages: 215-22
Publication  
First Author: Martinez TP
Year: 2024
Journal: eNeuro
Title: Amyloid-β-induced dendritic spine elimination requires Ca(2+)-permeable AMPA receptors, AKAP-Calcineurin-NFAT signaling, and the NFAT target gene Mdm2.
Volume: 11
Issue: 3
Publication  
First Author: Medina CS
Year: 2019
Journal: Front Cell Neurosci
Title: Decoupling the Effects of the Amyloid Precursor Protein From Amyloid-β Plaques on Axonal Transport Dynamics in the Living Brain.
Volume: 13
Pages: 501
Publication
First Author: Song S
Year: 2008
Journal: J Cell Biol
Title: E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity.
Volume: 182
Issue: 4
Pages: 675-84
Publication
First Author: Adorno M
Year: 2013
Journal: Nature
Title: Usp16 contributes to somatic stem-cell defects in Down's syndrome.
Volume: 501
Issue: 7467
Pages: 380-4
Publication
First Author: Jensen MM
Year: 2015
Journal: Neurobiol Aging
Title: Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease.
Volume: 36
Issue: 4
Pages: 1629-1638
Publication  
First Author: Sherman KM
Year: 2022
Journal: Bone
Title: Low bone mass and impaired fracture healing in mouse models of Trisomy21 (Down syndrome).
Volume: 162
Pages: 116471
Publication
First Author: Gao Y
Year: 2023
Journal: Cell
Title: β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function.
Volume: 186
Issue: 5
Pages: 1026-1038.e20
Publication
First Author: Holtzman DM
Year: 1999
Journal: J Clin Invest
Title: Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease.
Volume: 103
Issue: 6
Pages: R15-R21
Publication
First Author: Hartman RE
Year: 2002
Journal: J Neurosci
Title: Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease.
Volume: 22
Issue: 23
Pages: 10083-7
Publication
First Author: Bales KR
Year: 2009
Journal: J Neurosci
Title: Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.
Volume: 29
Issue: 21
Pages: 6771-9
Publication
First Author: Koistinaho M
Year: 2002
Journal: Stroke
Title: Expression of human apolipoprotein E downregulates amyloid precursor protein-induced ischemic susceptibility.
Volume: 33
Issue: 7
Pages: 1905-10
Publication  
First Author: Zhao L
Year: 2016
Journal: Neurobiol Aging
Title: Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.
Volume: 44
Pages: 159-172
Publication
First Author: Castellano JM
Year: 2011
Journal: Sci Transl Med
Title: Human apoE isoforms differentially regulate brain amyloid-β peptide clearance.
Volume: 3
Issue: 89
Pages: 89ra57
Publication
First Author: Raber J
Year: 2000
Journal: Nature
Title: Apolipoprotein E and cognitive performance.
Volume: 404
Issue: 6776
Pages: 352-4
Publication
First Author: Bien-Ly N
Year: 2015
Journal: Neuron
Title: Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies.
Volume: 88
Issue: 2
Pages: 289-97
Publication
First Author: Wahrle SE
Year: 2008
Journal: J Clin Invest
Title: Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.
Volume: 118
Issue: 2
Pages: 671-82
Publication
First Author: Fagan AM
Year: 2002
Journal: Neurobiol Dis
Title: Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease.
Volume: 9
Issue: 3
Pages: 305-18
Publication
First Author: Fedoriw AM
Year: 2015
Journal: Development
Title: Key mediators of somatic ATR signaling localize to unpaired chromosomes in spermatocytes.
Volume: 142
Issue: 17
Pages: 2972-80