Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism []. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases, but they have lost conserved histidines involved in zinc binding and consequently their catalytic activity.This entry represents a carbonic anhydrase-related domain found in tyrosine phosphatase receptors type gamma (Ptprg) [, ]and type zeta (Ptprz), which mediate cell adhesion and signaling during development []. Ptprg is a regulator of spinal cord neurogenesis []. Ptprz negatively regulates oligodendrocyte differentiation and myelination [].
