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Search results 101 to 200 out of 286 for Eif2ak4

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Hits by Strain

Hits by Category

Type Details Score
GXD Expression
GXD Expression
     
Probe: MGI:4366298
Assay Type: Western blot
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:4366309
Age: postnatal
Specimen Label: Oo
Detected: true
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
     
Probe: MGI:4366296
Assay Type: Western blot
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:4366311
Age: postnatal
Specimen Label: Oo
Detected: true
Specimen Num: 1
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•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4366298
Assay Type: Western blot
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:4366312
Age: postnatal
Specimen Label: Oo
Detected: true
Specimen Num: 1
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•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4366299
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Absent
Sex: Female
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4366300
Age: postnatal day 25
Specimen Label: B
Detected: false
Specimen Num: 2
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•
•
GXD Expression
GXD Expression
     
Probe: MGI:4366301
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4366304
Age: postnatal day 25
Specimen Label: B
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
     
Probe: MGI:4366302
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4366305
Age: postnatal day 25
Specimen Label: B
Detected: true
Specimen Num: 4
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•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4366301
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4366306
Age: postnatal day 25
Specimen Label: B
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4366302
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4366307
Age: postnatal day 25
Specimen Label: B
Detected: true
Specimen Num: 4
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•
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•
•
GXD Expression
GXD Expression
   
Probe: MGI:6436589
Assay Type: RT-PCR
Annotation Date: 2020-06-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6436594
Age: embryonic day 18.5
Image: S1
Specimen Label: Brain
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
     
Probe: MGI:4366301
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366304
Age: postnatal day 25
Specimen Label: Ov PMSG
Detected: true
Specimen Num: 2
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•
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•
GXD Expression
GXD Expression
     
Probe: MGI:4366301
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366304
Age: postnatal day 25
Specimen Label: Ov hCG
Detected: true
Specimen Num: 3
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•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4366302
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366305
Age: postnatal day 25
Specimen Label: Ov PMSG
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4366302
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366305
Age: postnatal day 25
Specimen Label: Ov hCG
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4366301
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366306
Age: postnatal day 25
Specimen Label: Ov PMSG
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4366301
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366306
Age: postnatal day 25
Specimen Label: Ov hCG
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4366302
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366307
Age: postnatal day 25
Specimen Label: Ov PMSG
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4366302
Assay Type: RT-PCR
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366307
Age: postnatal day 25
Specimen Label: Ov hCG
Detected: true
Specimen Num: 3
•
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•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:4366296
Assay Type: Western blot
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366313
Age: postnatal
Specimen Label: C
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
     
Probe: MGI:4366296
Assay Type: Western blot
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366313
Age: postnatal
Specimen Label: PMSG
Detected: true
Specimen Num: 2
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•
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•
GXD Expression
GXD Expression
     
Probe: MGI:4366298
Assay Type: Western blot
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366314
Age: postnatal
Specimen Label: C
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
     
Probe: MGI:4366298
Assay Type: Western blot
Annotation Date: 2009-11-04
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:4366314
Age: postnatal
Specimen Label: PMSG
Detected: true
Specimen Num: 2
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Publication
31166980 | J:279071
First Author: Pereira CM
Year: 2019
Journal: PLoS One
Title: The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control.
Volume: 14
Issue: 6
Pages: e0217287
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Publication
28067447 | J:315881
First Author: Yoon J
Year: 2017
Journal: Mol Reprod Dev
Title: Importance of eIF2α phosphorylation as a protective mechanism against heat stress in mouse male germ cells.
Volume: 84
Issue: 3
Pages: 265-274
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Publication
27085088 | J:243940
   
First Author: Ishimura R
Year: 2016
Journal: Elife
Title: Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation.
Volume: 5
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Publication
27396336 | J:238675
First Author: Laeger T
Year: 2016
Journal: Cell Rep
Title: Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2.
Volume: 16
Issue: 3
Pages: 707-16
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Publication
24485657 | J:208777
First Author: Maurin AC
Year: 2014
Journal: Cell Rep
Title: Hypothalamic eIF2α signaling regulates food intake.
Volume: 6
Issue: 3
Pages: 438-44
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Publication
26936965 | J:252882
First Author: Wanders D
Year: 2016
Journal: Diabetes
Title: Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction.
Volume: 65
Issue: 6
Pages: 1499-510
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Publication
24130737 | J:209124
First Author: Loch D
Year: 2013
Journal: PLoS One
Title: Adiponectin enhances the responsiveness of the olfactory system.
Volume: 8
Issue: 10
Pages: e75716
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Publication
18996085 | J:143177
First Author: Alves VS
Year: 2009
Journal: Biochem Biophys Res Commun
Title: GCN2 activation and eIF2alpha phosphorylation in the maturation of mouse oocytes.
Volume: 378
Issue: 1
Pages: 41-4
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Publication
12176355 | J:227395
First Author: Deng J
Year: 2002
Journal: Curr Biol
Title: Activation of GCN2 in UV-irradiated cells inhibits translation.
Volume: 12
Issue: 15
Pages: 1279-86
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Publication
26102367 | J:227362
First Author: Lehman SL
Year: 2015
Journal: PLoS Genet
Title: Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress.
Volume: 11
Issue: 6
Pages: e1005212
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Publication
33186095 | J:298589
   
First Author: Terrey M
Year: 2020
Journal: Elife
Title: GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis.
Volume: 9
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Publication
19783659 | J:269837
First Author: Bunpo P
Year: 2009
Journal: J Biol Chem
Title: GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.
Volume: 284
Issue: 47
Pages: 32742-9
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Publication
21282364 | J:169781
First Author: Xiao F
Year: 2011
Journal: Diabetes
Title: Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways.
Volume: 60
Issue: 3
Pages: 746-56
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Publication
32504036 | J:292030
First Author: Yuan F
Year: 2020
Journal: Nat Commun
Title: Activation of GCN2/ATF4 signals in amygdalar PKC-δ neurons promotes WAT browning under leucine deprivation.
Volume: 11
Issue: 1
Pages: 2847
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Publication
25562323 | J:220564
First Author: Karner CM
Year: 2015
Journal: J Clin Invest
Title: Increased glutamine catabolism mediates bone anabolism in response to WNT signaling.
Volume: 125
Issue: 2
Pages: 551-62
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Publication
34954499 | J:321661
 
First Author: Yuan J
Year: 2022
Journal: Redox Biol
Title: Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation.
Volume: 49
Pages: 102224
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Publication
15894280 | J:99090
First Author: Munn DH
Year: 2005
Journal: Immunity
Title: GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.
Volume: 22
Issue: 5
Pages: 633-42
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Publication
27880901 | J:241241
First Author: Van de Velde LA
Year: 2016
Journal: Cell Rep
Title: Stress Kinase GCN2 Controls the Proliferative Fitness and Trafficking of Cytotoxic T Cells Independent of Environmental Amino Acid Sensing.
Volume: 17
Issue: 9
Pages: 2247-2258
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Publication
29337352 | J:264586
First Author: Zimmermann HR
Year: 2018
Journal: J Neurochem
Title: Genetic removal of eIF2α kinase PERK in mice enables hippocampal L-LTP independent of mTORC1 activity.
Volume: 146
Issue: 2
Pages: 133-144
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Publication
17343295 | J:120813
First Author: Manlapat AK
Year: 2007
Journal: Eur J Immunol
Title: Cell-autonomous control of interferon type I expression by indoleamine 2,3-dioxygenase in regulatory CD19+ dendritic cells.
Volume: 37
Issue: 4
Pages: 1064-71
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Publication
29570992 | J:261123
First Author: Longchamp A
Year: 2018
Journal: Cell
Title: Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production.
Volume: 173
Issue: 1
Pages: 117-129.e14
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Publication
29349768 | J:344405
First Author: Guo Y
Year: 2018
Journal: Protein Cell
Title: GCN2 deficiency protects mice from denervation-induced skeletal muscle atrophy via inhibiting FoxO3a nuclear translocation.
Volume: 9
Issue: 11
Pages: 966-970
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Publication
17710230 | J:127409
First Author: Sharma MD
Year: 2007
Journal: J Clin Invest
Title: Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase.
Volume: 117
Issue: 9
Pages: 2570-82
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Publication
31653831 | J:281437
First Author: Sonner JK
Year: 2019
Journal: Nat Commun
Title: Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology.
Volume: 10
Issue: 1
Pages: 4877
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Publication
24019515 | J:204908
First Author: She P
Year: 2013
Journal: J Biol Chem
Title: General control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in mice.
Volume: 288
Issue: 43
Pages: 31250-60
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Publication
28242759 | J:242508
First Author: Nikonorova IA
Year: 2017
Journal: J Biol Chem
Title: Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.
Volume: 292
Issue: 16
Pages: 6786-6798
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Publication
17475769 | J:127460
First Author: Mazroui R
Year: 2007
Journal: Mol Biol Cell
Title: Inhibition of the ubiquitin-proteasome system induces stress granule formation.
Volume: 18
Issue: 7
Pages: 2603-18
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Publication
20473272 | J:161314
First Author: Ye J
Year: 2010
Journal: EMBO J
Title: The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.
Volume: 29
Issue: 12
Pages: 2082-96
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Publication
21880833 | J:180041
First Author: Cai Q
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: Phosphorylation of eIF2α via the general control kinase, GCN2, modulates the ability of renal medullary cells to survive high urea stress.
Volume: 301
Issue: 6
Pages: F1202-7
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Publication
23900421 | J:203886
First Author: Xu X
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: GCN2 regulates the CCAAT enhancer binding protein beta and hepatic gluconeogenesis.
Volume: 305
Issue: 8
Pages: E1007-17
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Publication
25857264 | J:259334
First Author: D'Aniello C
Year: 2015
Journal: Cell Death Differ
Title: A novel autoregulatory loop between the Gcn2-Atf4 pathway and (L)-Proline [corrected] metabolism controls stem cell identity.
Volume: 22
Issue: 7
Pages: 1094-105
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Publication
25329545 | J:218404
First Author: Roobol A
Year: 2015
Journal: Biochem J
Title: p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.
Volume: 465
Issue: 2
Pages: 213-25
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Publication
26261340 | J:226640
First Author: Ravishankar B
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity.
Volume: 112
Issue: 34
Pages: 10774-9
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Publication
11389192 | J:69887
First Author: Kumar R
Year: 2001
Journal: J Neurochem
Title: Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK.
Volume: 77
Issue: 5
Pages: 1418-21
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Publication
26982722 | J:232715
First Author: Ravindran R
Year: 2016
Journal: Nature
Title: The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation.
Volume: 531
Issue: 7595
Pages: 523-527
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Publication
33887198 | J:309693
First Author: Yu D
Year: 2021
Journal: Cell Metab
Title: The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine.
Volume: 33
Issue: 5
Pages: 905-922.e6
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Publication
32329716 | J:291915
   
First Author: Alvarez-Castelao B
Year: 2020
Journal: Elife
Title: The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition.
Volume: 9
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Publication
25133427 | J:215910
First Author: Laeger T
Year: 2014
Journal: J Clin Invest
Title: FGF21 is an endocrine signal of protein restriction.
Volume: 124
Issue: 9
Pages: 3913-22
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Publication
25131199 | J:234894
First Author: Harputlugil E
Year: 2014
Journal: Cell Rep
Title: The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo.
Volume: 8
Issue: 4
Pages: 1160-70
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Publication
19567830 | J:150809
First Author: Cobbold SP
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Infectious tolerance via the consumption of essential amino acids and mTOR signaling.
Volume: 106
Issue: 29
Pages: 12055-60
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Publication
29449374 | J:262786
First Author: Nikonorova IA
Year: 2018
Journal: J Biol Chem
Title: Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver.
Volume: 293
Issue: 14
Pages: 5005-5015
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Publication
20559319 | J:186345
First Author: Peidis P
Year: 2011
Journal: Cell Death Differ
Title: Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death.
Volume: 18
Issue: 1
Pages: 145-54
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Publication
27103515 | J:235030
 
First Author: Yang W
Year: 2016
Journal: Neurobiol Aging
Title: Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease.
Volume: 41
Pages: 19-24
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Publication
18287093 | J:136544
First Author: Thiaville MM
Year: 2008
Journal: J Biol Chem
Title: MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells.
Volume: 283
Issue: 16
Pages: 10848-57
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Publication
11106749 | J:99455
First Author: Harding HP
Year: 2000
Journal: Mol Cell
Title: Regulated translation initiation controls stress-induced gene expression in mammalian cells.
Volume: 6
Issue: 5
Pages: 1099-108
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Publication
12667446 | J:137331
First Author: Harding HP
Year: 2003
Journal: Mol Cell
Title: An integrated stress response regulates amino acid metabolism and resistance to oxidative stress.
Volume: 11
Issue: 3
Pages: 619-33
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Publication
35228694 | J:333732
First Author: Raines LN
Year: 2022
Journal: Nat Immunol
Title: PERK is a critical metabolic hub for immunosuppressive function in macrophages.
Volume: 23
Issue: 3
Pages: 431-445
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Publication
23443666 | J:197825
First Author: Souza-Fonseca-Guimaraes F
Year: 2013
Journal: J Biol Chem
Title: Interferon-γ and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING).
Volume: 288
Issue: 15
Pages: 10715-21
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Publication
24248597 | J:329767
First Author: Liu H
Year: 2014
Journal: Mol Cell Biol
Title: GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology.
Volume: 34
Issue: 3
Pages: 428-38
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Publication
24790153 | J:318806
First Author: Bhatt S
Year: 2014
Journal: J Immunol
Title: All-trans retinoic acid induces arginase-1 and inducible nitric oxide synthase-producing dendritic cells with T cell inhibitory function.
Volume: 192
Issue: 11
Pages: 5098-108
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Publication
19366986 | J:149490
First Author: Sharma MD
Year: 2009
Journal: Blood
Title: Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes.
Volume: 113
Issue: 24
Pages: 6102-11
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Publication
19499519 | J:149436
First Author: Vinay DS
Year: 2009
Journal: Eur J Immunol
Title: Origins and functional basis of regulatory CD11c+CD8+ T cells.
Volume: 39
Issue: 6
Pages: 1552-63
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Publication
31522764 | J:282578
First Author: Pathak SS
Year: 2019
Journal: Neuron
Title: The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4.
Volume: 104
Issue: 4
Pages: 724-735.e6
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Publication
19828695 | J:155467
First Author: Jasperson LK
Year: 2009
Journal: Blood
Title: Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality.
Volume: 114
Issue: 24
Pages: 5062-70
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Publication
26123823 | J:251645
 
First Author: Lehman SL
Year: 2015
Journal: Sci Rep
Title: Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma.
Volume: 5
Pages: 11781
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Publication
32373236 | J:309301
First Author: Li Y
Year: 2020
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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