Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
•
•
|
Publication |
First Author: |
Davey JR |
Year: |
2012 |
Journal: |
Traffic |
Title: |
TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes. |
Volume: |
13 |
Issue: |
10 |
Pages: |
1429-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bulek K |
Year: |
2019 |
Journal: |
J Immunol |
Title: |
IL-17A Recruits Rab35 to IL-17R to Mediate PKCĪ±-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility. |
Volume: |
202 |
Issue: |
5 |
Pages: |
1540-1548 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marat AL |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery. |
Volume: |
285 |
Issue: |
14 |
Pages: |
10627-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rahajeng J |
Year: |
2012 |
Journal: |
Traffic |
Title: |
MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a. |
Volume: |
13 |
Issue: |
1 |
Pages: |
82-93 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
47
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
61
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
47
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
277
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
413
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes proteins containing an N-terminal tripartite DENN domain, including DENND1A (also known as connecdenn 1), DENND1B (connecdenn 2) and DENND1C (connecdenn 3). These proteins act as guanine-nucleotide exchange factors for Rab35 through the DENN domain. Inactive GDP-bound RAB35 is converted into its active GTP-bound form by the exchange of GDP to GTP. The DENN domains of DENND1A and DENND1B, but not DENND1C, bind Rab35, indicating that binding and activation are separate. The C-termini of DENND1A, DENND1B and DENND1C differ significantly, but each binds to clathrin and to the clathrin adaptor AP-2. This is a means to regulate clathrin-mediated endocytosis of synaptic vesicles and exit from early endosomes []. |
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•
•
•
•
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Publication |
First Author: |
Fukuda M |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. |
Volume: |
277 |
Issue: |
14 |
Pages: |
12432-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Itoh T |
Year: |
2006 |
Journal: |
Genes Cells |
Title: |
Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. |
Volume: |
11 |
Issue: |
9 |
Pages: |
1023-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kuroda TS |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. |
Volume: |
277 |
Issue: |
11 |
Pages: |
9212-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Steger M |
Year: |
2017 |
Journal: |
Elife |
Title: |
Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. |
Volume: |
6 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Novo D |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels. |
Volume: |
9 |
Issue: |
1 |
Pages: |
5069 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wheeler DB |
Year: |
2015 |
Journal: |
Science |
Title: |
Identification of an oncogenic RAB protein. |
Volume: |
350 |
Issue: |
6257 |
Pages: |
211-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fukuda M |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. |
Volume: |
278 |
Issue: |
17 |
Pages: |
15373-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jalabert A |
Year: |
2021 |
Journal: |
Sci Rep |
Title: |
Profiling of ob/ob mice skeletal muscle exosome-like vesicles demonstrates combined action of miRNAs, proteins and lipids to modulate lipid homeostasis in recipient cells. |
Volume: |
11 |
Issue: |
1 |
Pages: |
21626 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nirujogi RS |
Year: |
2021 |
Journal: |
Biochem J |
Title: |
Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites. |
Volume: |
478 |
Issue: |
2 |
Pages: |
299-326 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lara OrdĆ³Ć±ez AJ |
Year: |
2022 |
Journal: |
Biol Open |
Title: |
The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization. |
Volume: |
11 |
Issue: |
8 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Sakane A |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Rab13 small G protein and junctional Rab13-binding protein (JRAB) orchestrate actin cytoskeletal organization during epithelial junctional development. |
Volume: |
287 |
Issue: |
51 |
Pages: |
42455-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamamura R |
Year: |
2008 |
Journal: |
Mol Biol Cell |
Title: |
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions. |
Volume: |
19 |
Issue: |
3 |
Pages: |
971-83 |
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•
•
•
•
•
|
Publication |
First Author: |
Sakane A |
Year: |
2013 |
Journal: |
Genes Cells |
Title: |
Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins. |
Volume: |
18 |
Issue: |
9 |
Pages: |
810-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abou-Zeid N |
Year: |
2011 |
Journal: |
Mol Biol Cell |
Title: |
MICAL-like1 mediates epidermal growth factor receptor endocytosis. |
Volume: |
22 |
Issue: |
18 |
Pages: |
3431-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nishimura N |
Year: |
2008 |
Journal: |
Methods Enzymol |
Title: |
Identification and characterization of JRAB/MICAL-L2, a junctional Rab13-binding protein. |
Volume: |
438 |
|
Pages: |
141-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sharma M |
Year: |
2010 |
Journal: |
Commun Integr Biol |
Title: |
MICAL-L1: An unusual Rab effector that links EHD1 to tubular recycling endosomes. |
Volume: |
3 |
Issue: |
2 |
Pages: |
181-3 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
MICAL (molecule Interacting with CasL) family is a group of multifunctional proteins that contain the calponin homology (CH), a LIM and a coiled-coil (CC) domains []. They interact with receptors on the target cells, help recruiting other proteins, and promote the modulation of their activity with respect to the downstream events []. There is only one MICAL protein found in Drosophila [], while there are 5 MICAL (MICAL1/2/3, MICAL-like1/2) isoforms found in vertebrates []. Drosophila MICAL and vertebrate MICAL1/2/3 contain an extra N-terminal FAD (flavin adenine dinucleotide binding monooxygenase) domain, whose structure resembles that of a flavo-enzyme, p-hydroxybenzoate hydroxylase []. Drosophila MICAL has an NADPH-dependent actin depolymerising activity []. Vertebrate MICALs are also shown to be effectors of small Rab GTPases, which play important roles in vesicular trafficking []. MICAL-like protein 1 (MICAL-L1) interacts with small G proteins and regulates endocytic recycling of receptors [, ]. It forms a complex with Rab13 that regulates EGFR trafficking at late endocytic pathways []. MICAL-L1 also forms a complex with Arf6 that regulates Rab8a function. MICAL-L1 can be regulated by Rab35 [].MICAL-like protein 2 (MICAL-L2, also known as JRAB) interacts with Rab13 []and Rab8 to regulate the endocytic recycling of occludin, claudin and E-cadherin to the plasma membrane. It may thereby regulate the establishment of tight junctions and adherens junctions []. MICAL-L2/JRAB also regulates the reorganisation of the actin cytoskeleton through interactions with actinin-1, actinin-4, and filamentous actin [], and via filamins during cell spreading []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
103
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
105
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
70
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
94
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
845
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
224
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1016
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
766
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
786
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
352
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
926
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
895
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Terman JR |
Year: |
2002 |
Journal: |
Cell |
Title: |
MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. |
Volume: |
109 |
Issue: |
7 |
Pages: |
887-900 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nadella M |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Structure and activity of the axon guidance protein MICAL. |
Volume: |
102 |
Issue: |
46 |
Pages: |
16830-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rahajeng J |
Year: |
2010 |
Journal: |
World J Biol Chem |
Title: |
Important relationships between Rab and MICAL proteins in endocytic trafficking. |
Volume: |
1 |
Issue: |
8 |
Pages: |
254-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki T |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
MICAL, a novel CasL interacting molecule, associates with vimentin. |
Volume: |
277 |
Issue: |
17 |
Pages: |
14933-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vanoni MA |
Year: |
2013 |
Journal: |
Int J Mol Sci |
Title: |
MICAL, the flavoenzyme participating in cytoskeleton dynamics. |
Volume: |
14 |
Issue: |
4 |
Pages: |
6920-59 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
870
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1009
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
992
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
324
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1617-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
1999 |
Journal: |
Methods Enzymol |
Title: |
High-efficiency full-length cDNA cloning. |
Volume: |
303 |
|
Pages: |
19-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibata K |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1757-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katayama S |
Year: |
2005 |
Journal: |
Science |
Title: |
Antisense transcription in the mammalian transcriptome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1564-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
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•
•
•
•
•
|