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Search results 1 to 100 out of 256 for Capn1

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Type Details Score
Gene
823 | CAPN1
Type: gene
Organism: human
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Gene
406768 | capn1
Type: gene
Organism: zebrafish
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Gene
716618 | CAPN1
Type: gene
Organism: macaque, rhesus
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Gene
541455 | capn1
Type: gene
Organism: frog, western clawed
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Gene
29153 | Capn1
Type: gene
Organism: rat
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Gene
483745 | CAPN1
Type: gene
Organism: dog, domestic
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Gene
451317 | CAPN1
Type: gene
Organism: chimpanzee
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Gene
281661 | CAPN1
Type: gene
Organism: cattle
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Gene
693249 | CAPN1
Type: gene
Organism: chicken
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Protein Domain
IPR029643 | CAPN1
Type: Family
Description: Calpain-1 catalytic subunit (CAPN1, also known as mu-calpain) belongs to the calpain family, which consists of a group of Ca2+ dependent cysteine proteases that regulate functions of substrates by proteolysis [, ]. The most abundant members of the calpain familiy are CAPN1 and CAPN2. They form heterodimers, which are regulated by a small regulatory subunit (28kDa) encoded by the gene Capn4 []. Calpain-1 plays a role in regulating IgE-mediated mast cell activation []. Calpain-1 is also involved in mammary gland remodelling [].
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Protein Coding Gene
MGI:88263 | Capn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24467364 | J:212301
First Author: Arnandis T
Year: 2014
Journal: Biochem J
Title: Differential functions of calpain 1 during epithelial cell death and adipocyte differentiation in mammary gland involution.
Volume: 459
Issue: 2
Pages: 355-68
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Gene
728975 | CAPN1-AS1
Type: gene
Organism: human
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Publication
27320912 | J:238374
First Author: Wang Y
Year: 2016
Journal: Cell Rep
Title: Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans.
Volume: 16
Issue: 1
Pages: 79-91
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Publication
24760147 | -
First Author: Wu Z
Year: 2014
Journal: J Immunol
Title: Calpain-1 contributes to IgE-mediated mast cell activation.
Volume: 192
Issue: 11
Pages: 5130-9
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Protein
A0A494BAC4
Organism: Mus musculus/domesticus
Length: 79  
Fragment?: true
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Publication
18515801 | J:137992
First Author: Shimada M
Year: 2008
Journal: J Biol Chem
Title: In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation.
Volume: 283
Issue: 30
Pages: 21002-10
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Publication
24085852 | -
First Author: Jeong SY
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis.
Volume: 110
Issue: 42
Pages: E4007-15
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Publication
12843408 | -
First Author: Goll DE
Year: 2003
Journal: Physiol Rev
Title: The calpain system.
Volume: 83
Issue: 3
Pages: 731-801
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Protein
A0A494BAS0
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: true
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Protein
A0A494BB02
Organism: Mus musculus/domesticus
Length: 79  
Fragment?: true
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Protein
Q3UF24
Organism: Mus musculus/domesticus
Length: 543  
Fragment?: true
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Protein
O35350
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
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Protein
Q3TB79
Organism: Mus musculus/domesticus
Length: 699  
Fragment?: true
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Protein
Q80Y25
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
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Protein
Q3UDG8
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
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Protein
Q8C2J1
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
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Protein
Q3TI07
Organism: Mus musculus/domesticus
Length: 713  
Fragment?: false
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Publication
30874894 | J:294977
First Author: Cao T
Year: 2019
Journal: Basic Res Cardiol
Title: Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion.
Volume: 114
Issue: 3
Pages: 17
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Publication
16433929 | J:107240
 
First Author: Dutt P
Year: 2006
Journal: BMC Dev Biol
Title: m-Calpain is required for preimplantation embryonic development in mice.
Volume: 6
Pages: 3
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Publication
19781581 | J:164836
First Author: Mellgren RL
Year: 2009
Journal: Biochim Biophys Acta
Title: Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases.
Volume: 1793
Issue: 12
Pages: 1886-93
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Publication
10825211 | J:74966
First Author: Arthur JS
Year: 2000
Journal: Mol Cell Biol
Title: Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division.
Volume: 20
Issue: 12
Pages: 4474-81
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Publication
18840650 | J:141133
First Author: Undyala VV
Year: 2008
Journal: J Cell Sci
Title: The calpain small subunit regulates cell-substrate mechanical interactions during fibroblast migration.
Volume: 121
Issue: Pt 21
Pages: 3581-8
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Publication
12823437 | J:84147
First Author: Dunnwald M
Year: 2003
Journal: Exp Dermatol
Title: The ichq mutant mouse, a model for the human skin disorder harlequin ichthyosis: mapping, keratinocyte culture, and consideration of candidate genes involved in epidermal growth regulation.
Volume: 12
Issue: 3
Pages: 245-54
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Publication
33597260 | J:302341
 
First Author: Chelko SP
Year: 2021
Journal: Sci Transl Med
Title: Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy.
Volume: 13
Issue: 581
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Publication
22555453 | J:204792
First Author: Arnandis T
Year: 2012
Journal: Cell Death Differ
Title: Calpains mediate epithelial-cell death during mammary gland involution: mitochondria and lysosomal destabilization.
Volume: 19
Issue: 9
Pages: 1536-48
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Protein Coding Gene
MGP_CAROLIEiJ_G0022582 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0024736 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0024702 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0024675 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0024702 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0024470 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_88263 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0025149 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0023942 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0024442 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0024569 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0024535 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0024655 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0024565 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0025197 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0023688 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0024004 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0014076 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0023493 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
17332428 | J:133797
First Author: Galvez AS
Year: 2007
Journal: Circ Res
Title: Cardiomyocyte degeneration with calpain deficiency reveals a critical role in protein homeostasis.
Volume: 100
Issue: 7
Pages: 1071-8
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Publication
22665935 | J:189100
First Author: Randriamboavonjy V
Year: 2012
Journal: Blood
Title: Calpain inhibition stabilizes the platelet proteome and reactivity in diabetes.
Volume: 120
Issue: 2
Pages: 415-23
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Publication
11238954 | J:67798
First Author: Azam M
Year: 2001
Journal: Mol Cell Biol
Title: Disruption of the mouse mu-calpain gene reveals an essential role in platelet function.
Volume: 21
Issue: 6
Pages: 2213-20
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Publication
22870887 | J:191444
First Author: Wieschhaus A
Year: 2012
Journal: Biochem J
Title: Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology.
Volume: 448
Issue: 1
Pages: 141-52
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Publication
16461769 | J:111570
First Author: Marzia M
Year: 2006
Journal: J Biol Chem
Title: Calpain is required for normal osteoclast function and is down-regulated by calcitonin.
Volume: 281
Issue: 14
Pages: 9745-54
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Publication
20689063 | J:178202
First Author: Kang MY
Year: 2010
Journal: Circ Res
Title: Receptor-independent cardiac protein kinase Calpha activation by calpain-mediated truncation of regulatory domains.
Volume: 107
Issue: 7
Pages: 903-12
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Publication
30735788 | J:317453
 
First Author: Heysieattalab S
Year: 2020
Journal: Neurobiol Learn Mem
Title: Impaired cerebellar plasticity and eye-blink conditioning in calpain-1 knock-out mice.
Volume: 170
Pages: 106995
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Publication
28202907 | J:275306
 
First Author: Zhu G
Year: 2017
Journal: Sci Rep
Title: Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction.
Volume: 7
Pages: 42788
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Publication
25589756 | J:217727
First Author: Zhu G
Year: 2015
Journal: J Neurosci
Title: Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
Volume: 35
Issue: 2
Pages: 621-33
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Publication
16150618 | J:106359
First Author: Grammer M
Year: 2005
Journal: Neurobiol Learn Mem
Title: Lack of phenotype for LTP and fear conditioning learning in calpain 1 knock-out mice.
Volume: 84
Issue: 3
Pages: 222-7
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Publication
22367208 | J:184369
First Author: Yamada KH
Year: 2012
Journal: J Biol Chem
Title: Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress.
Volume: 287
Issue: 16
Pages: 13182-93
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Publication
29101791 | J:272782
 
First Author: Nwankwo JO
Year: 2017
Journal: Thromb Res
Title: Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease.
Volume: 160
Pages: 58-65
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Publication
30409431 | J:270469
First Author: Ishak R
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Defective rapid cell shape and transendothelial migration by calpain-1 null neutrophils.
Volume: 506
Issue: 4
Pages: 1065-1070
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Publication
29507101 | J:339472
First Author: Etwebi Z
Year: 2018
Journal: Hypertension
Title: Mechanistic Role of the Calcium-Dependent Protease Calpain in the Endothelial Dysfunction Induced by MPO (Myeloperoxidase).
Volume: 71
Issue: 4
Pages: 761-770
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Publication
25009256 | J:215307
First Author: Rao MV
Year: 2014
Journal: J Neurosci
Title: Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice.
Volume: 34
Issue: 28
Pages: 9222-34
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Publication
24441549 | J:209496
First Author: Li X
Year: 2014
Journal: Am J Physiol Heart Circ Physiol
Title: Cleavage of IκBα by calpain induces myocardial NF-κB activation, TNF-α expression, and cardiac dysfunction in septic mice.
Volume: 306
Issue: 6
Pages: H833-43
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Publication
22095979 | J:195971
First Author: Letavernier B
Year: 2012
Journal: Arterioscler Thromb Vasc Biol
Title: Calpains contribute to vascular repair in rapidly progressive form of glomerulonephritis: potential role of their externalization.
Volume: 32
Issue: 2
Pages: 335-42
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Publication
10661889 | J:60508
First Author: Tidball JG
Year: 2000
Journal: Int J Biochem Cell Biol
Title: Calpains and muscular dystrophies.
Volume: 32
Issue: 1
Pages: 1-5
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Publication
2209090 | J:10756
First Author: Moens PB
Year: 1990
Journal: Cytogenet Cell Genet
Title: In situ DNA sequence mapping with surface-spread mouse pachytene chromosomes.
Volume: 53
Issue: 4
Pages: 219-20
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Publication
19892928 | J:185866
First Author: Salazar JJ
Year: 2010
Journal: J Appl Physiol (1985)
Title: Inhibition of calpain prevents muscle weakness and disruption of sarcomere structure during hindlimb suspension.
Volume: 108
Issue: 1
Pages: 120-7
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GXD Expression
GXD Expression
       
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3288022
Stage: TS22
Assay Id: MGI:4361682
Age: embryonic day 14.0
Specimen Label: E14
Specimen Num: 1
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GXD Expression
GXD Expression
       
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3288024
Stage: TS24
Assay Id: MGI:4361682
Age: embryonic day 16.0
Specimen Label: E16
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3288026
Stage: TS26
Assay Id: MGI:4361682
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289727
Stage: TS27
Assay Id: MGI:4361682
Age: postnatal day 1
Specimen Label: PN1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289728
Stage: TS28
Assay Id: MGI:4361682
Age: postnatal day 7
Specimen Label: PN7
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
       
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3287822
Stage: TS22
Assay Id: MGI:4361686
Age: embryonic day 14.0
Specimen Label: E14
Specimen Num: 1
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GXD Expression
GXD Expression
       
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3287824
Stage: TS24
Assay Id: MGI:4361686
Age: embryonic day 16.0
Specimen Label: E16
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287826
Stage: TS26
Assay Id: MGI:4361686
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289727
Stage: TS27
Assay Id: MGI:4361686
Age: postnatal day 1
Specimen Label: PN1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289728
Stage: TS28
Assay Id: MGI:4361686
Age: postnatal day 7
Specimen Label: PN7
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
       
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3288022
Stage: TS22
Assay Id: MGI:4361687
Age: embryonic day 14.0
Specimen Label: E14
Specimen Num: 1
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GXD Expression
GXD Expression
       
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3288024
Stage: TS24
Assay Id: MGI:4361687
Age: embryonic day 16.0
Specimen Label: E16
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3288026
Stage: TS26
Assay Id: MGI:4361687
Age: embryonic day 18.0
Specimen Label: E18
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289727
Stage: TS27
Assay Id: MGI:4361687
Age: postnatal day 1
Specimen Label: PN1
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:4361645
Assay Type: RT-PCR
Annotation Date: 2009-10-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3289728
Stage: TS28
Assay Id: MGI:4361687
Age: postnatal day 7
Specimen Label: PN7
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7380427
Assay Type: Western blot
Annotation Date: 2022-11-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:7380698
Age: embryonic day 12.5
Image: 3
Specimen Label: E12.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7380427
Assay Type: Western blot
Annotation Date: 2022-11-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:7380698
Age: embryonic day 14.5
Image: 3
Specimen Label: E14.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7380427
Assay Type: Western blot
Annotation Date: 2022-11-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:7380698
Age: embryonic day 16.5
Image: 3
Specimen Label: E16.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7380427
Assay Type: Western blot
Annotation Date: 2022-11-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:7380698
Age: embryonic day 17.5
Image: 3
Specimen Label: E17.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7380427
Assay Type: Western blot
Annotation Date: 2022-11-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:7380698
Age: embryonic day 18.5
Image: 3
Specimen Label: E18.5
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7380427
Assay Type: Western blot
Annotation Date: 2022-11-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:7380698
Age: postnatal adult
Image: 3
Specimen Label: adult
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3287822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:4361694
Age: embryonic day 14.0
Note: Expression was weak in outer enamel epithelium.
Specimen Label: Table 1 E14
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3287824
Pattern: Regionally restricted
Stage: TS24
Assay Id: MGI:4361694
Age: embryonic day 16.0
Note: Expression was weak in the outer enamel epithelium.
Specimen Label: Table 1 E16
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3287826
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:4361694
Age: embryonic day 18.0
Note: Expression was weak in outer enamel epithelium and inner enamel epithelium.
Specimen Label: Table 1 E18
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:4361649
Assay Type: Immunohistochemistry
Annotation Date: 2009-10-20
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3287922
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4361694
Age: embryonic day 14.0
Specimen Label: Table 1 E14
Detected: true
Specimen Num: 11
•
•
•
•
•




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