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Search results 401 to 500 out of 504 for Apex1

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:1997587
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823175
Age: embryonic day 14.5
Image: euxassay_005116_11
Specimen Label: euxassay_005116_11
Detected: true
Specimen Num: 11
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•
GXD Expression
GXD Expression
 
Probe: MGI:1997587
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823175
Age: embryonic day 14.5
Image: euxassay_005116_14
Specimen Label: euxassay_005116_14
Detected: true
Specimen Num: 14
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•
GXD Expression
GXD Expression
 
Probe: MGI:1997587
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823175
Age: embryonic day 14.5
Image: euxassay_005116_15
Specimen Label: euxassay_005116_15
Detected: true
Specimen Num: 15
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•
GXD Expression
GXD Expression
 
Probe: MGI:1997587
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823175
Age: embryonic day 14.5
Image: euxassay_005116_10
Specimen Label: euxassay_005116_10
Detected: true
Specimen Num: 10
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•
GXD Expression
GXD Expression
 
Probe: MGI:1997587
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823175
Age: embryonic day 14.5
Image: euxassay_005116_11
Specimen Label: euxassay_005116_11
Detected: true
Specimen Num: 11
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•
GXD Expression
GXD Expression
 
Probe: MGI:1997587
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823175
Age: embryonic day 14.5
Image: euxassay_005116_12
Specimen Label: euxassay_005116_12
Detected: true
Specimen Num: 12
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•
GXD Expression
GXD Expression
 
Probe: MGI:1997587
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823175
Age: embryonic day 14.5
Image: euxassay_005116_13
Specimen Label: euxassay_005116_13
Detected: true
Specimen Num: 13
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•
GXD Expression
GXD Expression
 
Probe: MGI:1997587
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823175
Age: embryonic day 14.5
Image: euxassay_005116_14
Specimen Label: euxassay_005116_14
Detected: true
Specimen Num: 14
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•
GXD Expression
GXD Expression
 
Probe: MGI:1997587
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823175
Age: embryonic day 14.5
Image: euxassay_005116_15
Specimen Label: euxassay_005116_15
Detected: true
Specimen Num: 15
•
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:1997587
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823175
Age: embryonic day 14.5
Image: euxassay_005116_16
Specimen Label: euxassay_005116_16
Detected: true
Specimen Num: 16
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:1997587
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823175
Age: embryonic day 14.5
Image: euxassay_005116_17
Specimen Label: euxassay_005116_17
Detected: true
Specimen Num: 17
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•
GXD Expression
GXD Expression
 
Probe: MGI:1997587
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823175
Age: embryonic day 14.5
Image: euxassay_005116_18
Specimen Label: euxassay_005116_18
Detected: true
Specimen Num: 18
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•
GXD Expression
GXD Expression
 
Probe: MGI:1997587
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4823175
Age: embryonic day 14.5
Image: euxassay_005116_19
Specimen Label: euxassay_005116_19
Detected: true
Specimen Num: 19
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•
GXD Expression
GXD Expression
 
Probe: MGI:7545044
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3820526
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7545050
Age: embryonic day 18.5
Image: 2O
Specimen Label: 2O
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:7545044
Assay Type: Immunohistochemistry
Annotation Date: 2023-11-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3820526
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:7545050
Age: embryonic day 18.5
Image: 2P
Note: Reduced expression compared with the wild-type.
Specimen Label: 2P
Detected: true
Specimen Num: 2
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Publication
18025127 | J:128500
First Author: Guikema JE
Year: 2007
Journal: J Exp Med
Title: APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.
Volume: 204
Issue: 12
Pages: 3017-26
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Publication
21216274 | J:171833
First Author: Rohrabaugh SL
Year: 2011
Journal: Exp Hematol
Title: Mad2 haploinsufficiency protects hematopoietic progenitor cells subjected to cell-cycle stress in vivo and to inhibition of redox function of Ape1/Ref-1 in vitro.
Volume: 39
Issue: 4
Pages: 415-23
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Publication
11454706 | J:70397
First Author: Meira LB
Year: 2001
Journal: Cancer Res
Title: Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress.
Volume: 61
Issue: 14
Pages: 5552-7
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Publication
11478795 | J:72154
First Author: Rodrigues-Lima F
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Sequence analysis identifies TTRAP, a protein that associates with CD40 and TNF receptor-associated factors, as a member of a superfamily of divalent cation-dependent phosphodiesterases.
Volume: 285
Issue: 5
Pages: 1274-9
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Publication
21172930 | J:173729
First Author: Pei DS
Year: 2011
Journal: Nucleic Acids Res
Title: A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta.
Volume: 39
Issue: 8
Pages: 3156-65
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Publication
23382073 | J:203324
First Author: Masani S
Year: 2013
Journal: Mol Cell Biol
Title: Apurinic/apyrimidinic endonuclease 1 is the essential nuclease during immunoglobulin class switch recombination.
Volume: 33
Issue: 7
Pages: 1468-73
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Publication
24927551 | J:212093
First Author: Stavnezer J
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation.
Volume: 111
Issue: 25
Pages: 9217-22
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Publication
15135726 | J:90034
First Author: Cistulli C
Year: 2004
Journal: DNA Repair (Amst)
Title: AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate.
Volume: 3
Issue: 6
Pages: 581-91
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Publication
20032196 | J:156951
First Author: Ray S
Year: 2010
Journal: Mol Endocrinol
Title: Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response.
Volume: 24
Issue: 2
Pages: 391-401
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Publication
9326930 | J:43195
First Author: Meira LB
Year: 1997
Journal: Nat Genet
Title: Genetic interaction between HAP1/REF-1 and p53.
Volume: 17
Issue: 2
Pages: 145
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Publication
10749126 | J:61421
First Author: Cheo DL
Year: 2000
Journal: Cancer Res
Title: Ultraviolet B radiation-induced skin cancer in mice defective in the Xpc, Trp53, and Apex (HAP1) genes: genotype-specific effects on cancer predisposition and pathology of tumors.
Volume: 60
Issue: 6
Pages: 1580-4
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Publication
21357694 | J:171127
First Author: Kothandapani A
Year: 2011
Journal: J Biol Chem
Title: Novel role of base excision repair in mediating cisplatin cytotoxicity.
Volume: 286
Issue: 16
Pages: 14564-74
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Publication
28404743 | J:252509
First Author: Hou X
Year: 2017
Journal: FASEB J
Title: Nuclear complex of glyceraldehyde-3-phosphate dehydrogenase and DNA repair enzyme apurinic/apyrimidinic endonuclease I protect smooth muscle cells against oxidant-induced cell death.
Volume: 31
Issue: 7
Pages: 3179-3192
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Publication
21228350 | J:169165
First Author: Guikema JE
Year: 2011
Journal: J Immunol
Title: Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge.
Volume: 186
Issue: 4
Pages: 1943-50
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Publication
23755229 | J:203203
First Author: Jung SB
Year: 2013
Journal: PLoS One
Title: Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain.
Volume: 8
Issue: 6
Pages: e65415
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Publication
12807961 | J:84043
First Author: Bonner AE
Year: 2003
Journal: J Med Genet
Title: Gene expression signatures identify novel regulatory pathways during murine lung development: implications for lung tumorigenesis.
Volume: 40
Issue: 6
Pages: 408-17
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Publication
17784788 | J:125220
First Author: Ward JO
Year: 2007
Journal: PLoS Genet
Title: Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over.
Volume: 3
Issue: 8
Pages: e139
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Publication
37373303 | J:337678
 
First Author: Moreli JB
Year: 2023
Journal: Int J Mol Sci
Title: The Role of Annexin A1 in DNA Damage Response in Placental Cells: Impact on Gestational Diabetes Mellitus.
Volume: 24
Issue: 12
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Publication
7656403 | J:25961
First Author: Ono Y
Year: 1995
Journal: Brain Res Dev Brain Res
Title: Developmental expression of APEX nuclease, a multifunctional DNA repair enzyme, in mouse brains.
Volume: 86
Issue: 1-2
Pages: 1-6
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Publication
24097111 | J:208661
First Author: Vuong BQ
Year: 2013
Journal: Nat Immunol
Title: A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination.
Volume: 14
Issue: 11
Pages: 1183-1189
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Publication
19997493 | J:161747
First Author: Goula AV
Year: 2009
Journal: PLoS Genet
Title: Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice.
Volume: 5
Issue: 12
Pages: e1000749
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Publication
14594818 | J:87555
First Author: Merluzzi S
Year: 2004
Journal: J Biol Chem
Title: CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism.
Volume: 279
Issue: 3
Pages: 1777-86
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Publication
20595612 | J:161356
First Author: Hajkova P
Year: 2010
Journal: Science
Title: Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway.
Volume: 329
Issue: 5987
Pages: 78-82
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Publication
20493910 | J:165356
First Author: Levros LC Jr
Year: 2010
Journal: Biochim Biophys Acta
Title: Characterization of nuclear factors modulating the apolipoprotein D promoter during growth arrest: implication of PARP-1, APEX-1 and ERK1/2 catalytic activities.
Volume: 1803
Issue: 9
Pages: 1062-71
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Publication
21425081 | J:170314
First Author: Albino D
Year: 2011
Journal: Int J Dev Biol
Title: Gene expression profiling identifies eleven DNA repair genes down-regulated during mouse neural crest cell migration.
Volume: 55
Issue: 1
Pages: 65-72
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Publication
20300987 | J:161421
 
First Author: Mann W
Year: 2010
Journal: Methods Mol Biol
Title: Single cell RT-PCR on mouse embryos: a general approach for developmental biology.
Volume: 630
Pages: 3-12
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Publication
32548123 | J:299723
 
First Author: Kafer GR
Year: 2020
Journal: Front Cell Dev Biol
Title: A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis.
Volume: 8
Pages: 416
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Publication
24793032 | J:212924
First Author: Katyal S
Year: 2014
Journal: Nat Neurosci
Title: Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes.
Volume: 17
Issue: 6
Pages: 813-21
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Publication
18784354 | J:145796
First Author: May A
Year: 2009
Journal: Biol Reprod
Title: Multiplex rt-PCR expression analysis of developmentally important genes in individual mouse preimplantation embryos and blastomeres.
Volume: 80
Issue: 1
Pages: 194-202
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Publication
32123907 | J:286844
First Author: Kim J
Year: 2020
Journal: Nucleic Acids Res
Title: Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation.
Volume: 48
Issue: 7
Pages: 3678-3691
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Publication
30538199 | J:269212
First Author: Dumitrache LC
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors.
Volume: 115
Issue: 52
Pages: E12285-E12294
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Publication
36459087 | J:331692
   
First Author: Xin Y
Year: 2022
Journal: Elife
Title: m(6)A epitranscriptomic modification regulates neural progenitor-to-glial cell transition in the retina.
Volume: 11
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Publication
- | J:94077
     
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Pathway
R-MMU-110357 | Displacement of DNA glycosylase by APEX1
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Protein Coding Gene
MGI:97073 | Mpg
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1918976 | Smug1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1313275 | Nthl1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1917853 | Mutyh
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109352 | Ung
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1333850 | Mbd4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P97931
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: false
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Protein
O35980
Organism: Mus musculus/domesticus
Length: 300  
Fragment?: false
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Protein
Q99P21
Organism: Mus musculus/domesticus
Length: 515  
Fragment?: false
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Protein
Q04841
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: false
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Protein
Q9Z2D7
Organism: Mus musculus/domesticus
Length: 554  
Fragment?: false
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Protein
Q6P5C5
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
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Protein Coding Gene
MGI:108247 | Tdg
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1097693 | Ogg1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
O08760
Organism: Mus musculus/domesticus
Length: 345  
Fragment?: false
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Protein
P28352
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false
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Protein
P56581
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: false
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Publication
12967653 | -
First Author: Caldecott KW
Year: 2003
Journal: DNA Repair (Amst)
Title: XRCC1 and DNA strand break repair.
Volume: 2
Issue: 9
Pages: 955-69
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Publication
15987676 | -
First Author: Beernink PT
Year: 2005
Journal: J Biol Chem
Title: Specificity of protein interactions mediated by BRCT domains of the XRCC1 DNA repair protein.
Volume: 280
Issue: 34
Pages: 30206-13
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Publication
33330937 | -
First Author: Hammel M
Year: 2021
Journal: Nucleic Acids Res
Title: An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex.
Volume: 49
Issue: 1
Pages: 306-321
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Protein Domain
IPR045080 | BRCT_XRCC1_rpt1
Type: Domain
Description: XRCC1 plays a key role in multiple DNA repair pathways by acting as a scaffold that binds to both DNA single strand breaks and gaps, poly (ADP-ribose) and to numerous DNA repair enzymes. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1 [, ]. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This entry corresponds to the first (central) BRCT domain []. This domain has been shown to interact with poly(ADP-ribosyl)ated (PARylated) PARP1. Inactivation of the central X1BR1 domain results in DNA damage hypersensitivity due to a defect in S phase-dependent DNA repair [].
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Publication
19556307 | J:151678
First Author: Sabouri Z
Year: 2009
Journal: Int Immunol
Title: Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.
Volume: 21
Issue: 8
Pages: 947-55
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Publication
21652643 | J:183051
First Author: Cuneo MJ
Year: 2011
Journal: Nucleic Acids Res
Title: The structural basis for partitioning of the XRCC1/DNA ligase III-α BRCT-mediated dimer complexes.
Volume: 39
Issue: 17
Pages: 7816-27
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Publication
29750271 | J:263805
First Author: Li M
Year: 2018
Journal: Nucleic Acids Res
Title: APE1 deficiency promotes cellular senescence and premature aging features.
Volume: 46
Issue: 11
Pages: 5664-5677
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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