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Search results 201 to 291 out of 291 for Corin

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Type Details Score
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
UniProt Feature
Begin: 122
Description: Cleavage; by CORIN
Type: site
End: 123
Publication  
First Author: Niu Y
Year: 2023
Journal: Front Cardiovasc Med
Title: Corin deficiency impairs cardiac function in mouse models of heart failure.
Volume: 10
Pages: 1164524
Publication
First Author: Knappe S
Year: 2004
Journal: J Biol Chem
Title: Identification of domain structures in the propeptide of corin essential for the processing of proatrial natriuretic peptide.
Volume: 279
Issue: 33
Pages: 34464-71
Protein
Organism: Mus musculus/domesticus
Length: 1047  
Fragment?: false
Allele
Name: corin, serine peptidase; targeted mutation 1, David Enshell-Seijffers
Allele Type: Targeted
Attribute String: Inducible, Recombinase
Allele
Name: corin, serine peptidase; targeted mutation 2, Bruce A Morgan
Allele Type: Targeted
Attribute String: Recombinase
Publication
First Author: Qi X
Year: 2011
Journal: J Biol Chem
Title: Human corin isoforms with different cytoplasmic tails that alter cell surface targeting.
Volume: 286
Issue: 23
Pages: 20963-9
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Corin/Corin<+>
Background: involves: 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Protein Domain
Type: Domain
Description: The cysteine-rich domain (CRD) is an essential component of corin, a type II transmembrane serine protease which functions as the convertase of the pro-atrial natriuretic peptide (pro-ANP) in the heart []. Corin contains two CRDs in its extracellular region, which play an important role in recognition of the physiological substrate, pro-ANP. This entry represents the first (N-terminal) CRD [].
Protein Domain
Type: Domain
Description: The cysteine-rich domain (CRD) is an essential component of corin, a type II transmembrane serine protease which functions as the convertase of the pro-atrial natriuretic peptide (pro-ANP) in the heart []. Corin contains two CRDs in its extracellular region, which play an important role in recognition of the physiological substrate, pro-ANP. This entry represents the second (C-terminal) CRD [].
Genotype
Symbol: Chd4/Chd4 Corin/Corin
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Ctnnb1/Ctnnb1 Corin/Corin<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Corin/Corin<+> Ctnnb1/Ctnnb1 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Tripathi R
Year: 2017
Journal: PLoS One
Title: Enhanced heart failure, mortality and renin activation in female mice with experimental dilated cardiomyopathy.
Volume: 12
Issue: 12
Pages: e0189315
Publication
First Author: Sales KU
Year: 2011
Journal: PLoS One
Title: Expression and genetic loss of function analysis of the HAT/DESC cluster proteases TMPRSS11A and HAT.
Volume: 6
Issue: 8
Pages: e23261
Protein Domain
Type: Domain
Description: The frizzled (fz) domain is an extracellular domain of about 120 amino acids.It was first identified in the alpha-1 chain of type XVIII collagen and in members of the Frizzled family of seven transmembrane (7TM) proteins which act as receptors for secreted Wingless (Wg)/Wnt glycoproteins []. In addition to these proteins, one or two copies of the fz domain are also found [, , , , ]in:The Frzb family; secreted frizzled-like proteins.Smoothened; another 7TM receptor involved in hedgehog signaling.Carboxpeptidase Z (CPZ).Transmembrane serine protease corin (atrial natriuretic peptide-converting enzyme).Two receptor tyrosine kinases (RTKs) subfamilies, the Ror family and the muscle-specific kinase (MuSK) family.As the fz domain contains 10 cysteines which are largely conserved, it has also been called cysteine-rich domain (CRD) []. The fz domain also contains several other highly conserved residues, for example, a basic amino acid follows C6, and a conserved proline residues lies four residues C-terminal to C9 []. The crystal structure of a fz domain shows that it is predominantly α-helical with all cysteines forming disulphide bonds. In addition to helical regions, two short β-strands at the N terminus form a minimal β-sheet with the second beta sheet passing through a knot created by disulphide bonds [].Several fz domains have been shown to be both necessary and sufficient for Wg/Wnt ligand binding, strongly suggesting that the fz domain is a Wg/Wnt interacting domain [, ].
Protein Domain
Type: Homologous_superfamily
Description: This entry represents the frizzled domain superfamily.The frizzled (fz) domain is an extracellular domain of about 120 amino acids.It was first identified in the alpha-1 chain of type XVIII collagen and in members of the Frizzled family of seven transmembrane (7TM) proteins which act as receptors for secreted Wingless (Wg)/Wnt glycoproteins []. In addition to these proteins, one or two copies of the fz domain are also found [, , , , ]in:The Frzb family; secreted frizzled-like proteins.Smoothened; another 7TM receptor involved in hedgehog signaling.Carboxpeptidase Z (CPZ).Transmembrane serine protease corin (atrial natriuretic peptide-converting enzyme).Two receptor tyrosine kinases (RTKs) subfamilies, the Ror family and the muscle-specific kinase (MuSK) family.As the fz domain contains 10 cysteines which are largely conserved, it has also been called cysteine-rich domain (CRD) []. The fz domain also contains several other highly conserved residues, for example, a basic amino acid follows C6, and a conserved proline residues lies four residues C-terminal to C9 []. The crystal structure of a fz domain shows that it is predominantly α-helical with all cysteines forming disulphide bonds. In addition to helical regions, two short β-strands at the N terminus form a minimal β-sheet with the second beta sheet passing through a knot created by disulphide bonds [].Several fz domains have been shown to be both necessary and sufficient for Wg/Wnt ligand binding, strongly suggesting that the fz domain is a Wg/Wnt interacting domain [, ].
Publication
First Author: Rehn M
Year: 1995
Journal: J Biol Chem
Title: Identification of three N-terminal ends of type XVIII collagen chains and tissue-specific differences in the expression of the corresponding transcripts. The longest form contains a novel motif homologous to rat and Drosophila frizzled proteins.
Volume: 270
Issue: 9
Pages: 4705-11
Protein
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: true
Publication
First Author: Bhanot P
Year: 1996
Journal: Nature
Title: A new member of the frizzled family from Drosophila functions as a Wingless receptor.
Volume: 382
Issue: 6588
Pages: 225-30
Publication
First Author: Xu YK
Year: 1998
Journal: Curr Biol
Title: The Frizzled CRD domain is conserved in diverse proteins including several receptor tyrosine kinases.
Volume: 8
Issue: 12
Pages: R405-6
Publication
First Author: Rehn M
Year: 1998
Journal: Trends Biochem Sci
Title: The frizzled motif: in how many different protein families does it occur?
Volume: 23
Issue: 11
Pages: 415-7
Publication
First Author: Masiakowski P
Year: 1998
Journal: Curr Biol
Title: The Wnt receptor CRD domain is also found in MuSK and related orphan receptor tyrosine kinases.
Volume: 8
Issue: 12
Pages: R407
Publication
First Author: Saldanha J
Year: 1998
Journal: Protein Sci
Title: Identification of a Frizzled-like cysteine rich domain in the extracellular region of developmental receptor tyrosine kinases.
Volume: 7
Issue: 8
Pages: 1632-5
Publication
First Author: Lin K
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling.
Volume: 94
Issue: 21
Pages: 11196-200
Protein
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1774  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 666  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 642  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 685  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 592  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 654  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 365  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 439  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1774  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 357  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 750  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 801  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 937  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 944  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 870  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 944  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 878  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 893  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 870  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 944  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 944  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 932  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 860  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 878  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 937  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 893  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 860  
Fragment?: false
Publication
First Author: Dann CE
Year: 2001
Journal: Nature
Title: Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.
Volume: 412
Issue: 6842
Pages: 86-90
Publication
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7