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Search results 301 to 370 out of 370 for Hspb1

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Type Details Score
HT Experiment
GSE134384 | The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Hspb1<em1Smoc> | MGI:7290268
Name: heat shock protein 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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GXD Expression
GXD Expression
Probe: MGI:7580670
Assay Type: Immunohistochemistry
Annotation Date: 2024-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1784128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7580681
Age: postnatal day 15
Image: 10B/C
Note: Coexpressed with Hspb1 (about 10% of the TDRD7 protein was co-localized with Hspb1 mRNA).
Specimen Label: 10B/C
Detected: true
Specimen Num: 1
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Strain
MGI:6428865 | C57BL/6J-Hspb1<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Protein
P14602
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Allele
Gt(ROSA)26Sor<em1(CAG-HSPB1)Juch> | MGI:6203656
Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Jun Chen
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence
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Protein
P14602-3
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
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Protein
P14602-2
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: false
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Allele
Hspb1<em1Mvw> | MGI:7614248
Name: heat shock protein 1; endonuclease-mediated mutation 1, Michael Wiles
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Publication
21785432 | J:174508
First Author: d'Ydewalle C
Year: 2011
Journal: Nat Med
Title: HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease.
Volume: 17
Issue: 8
Pages: 968-74
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Allele
Tg(Thy1-HSPB1*P182L)#Lvdb | MGI:5285201
Name: transgene insertion, Ludo Van Den Bosch
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Thy1-HSPB1*S135F)#Lvdb | MGI:5285200
Name: transgene insertion, Ludo Van Den Bosch
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:7614249 | C57BL/6J-Hspb1<em1Mvw>/Mmjax
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Tg(Thy1-HSPB1*S135F)#Lvdb/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-HSPB1*P182L)#Lvdb/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Protein Domain
IPR026773 | TCHP
Type: Family
Description: Trichoplein keratin filament-binding protein (TCHP) may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. It may regulate K8/K18 filament and desmosome organisation mainly at the apical or peripheral regions of simple epithelial cells []. In human, it acts as a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation [].
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Publication
15731013 | -
First Author: Nishizawa M
Year: 2005
Journal: J Cell Sci
Title: Identification of trichoplein, a novel keratin filament-binding protein.
Volume: 118
Issue: Pt 5
Pages: 1081-90
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Protein
Q3TVW5
Organism: Mus musculus/domesticus
Length: 497  
Fragment?: false
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Publication
18931701 | -
First Author: Vecchione A
Year: 2009
Journal: Oncogene
Title: MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer.
Volume: 28
Issue: 2
Pages: 257-69
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Protein Domain
IPR043597 | TPH_dom
Type: Domain
Description: This entry represents the trichohyalin-plectin-homology domain. This domain can be found in mitostatin (also known as trichoplein keratin filament-binding protein, TCHP) and related proteins [, ]. Trichoplein keratin filament-binding protein (TCHP) may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. It may regulate K8/K18 filament and desmosome organisation mainly at the apical or peripheral regions of simple epithelial cells []. In human, it acts as a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation [].
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Publication
28137866 | J:240938
First Author: Shi Y
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood-brain barrier disruption after ischemic brain injury.
Volume: 114
Issue: 7
Pages: E1243-E1252
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Protein
A0JLY1
Organism: Mus musculus/domesticus
Length: 547  
Fragment?: false
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Protein
Q9D9U9
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: false
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Protein
Q61884
Organism: Mus musculus/domesticus
Length: 491  
Fragment?: false
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Protein
V9GXM7
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: true
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Protein
E0CXX5
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: true
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Protein
V9GXE0
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: true
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Protein
B7ZN54
Organism: Mus musculus/domesticus
Length: 538  
Fragment?: false
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Protein
Q4KKZ3
Organism: Mus musculus/domesticus
Length: 361  
Fragment?: true
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Protein Domain
IPR043596 | CFAP53/TCHP
Type: Family
Description: This entry includes CFAP53 and TCHP.Cilia- and flagella-associated protein 53 (CFAP53), also known as coiled-coil domain-containing protein 11 (CCDC11), is a novel centriolar satellite protein essential for the assembly and function of motile cilia and establishment of left-right asymmetry [, ]. In zebrafish, it is required for cilia rotation specifically in Kupffer's vesicle, the zebrafish laterality organ [].Trichoplein keratin filament-binding protein (TCHP) may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. It may regulate K8/K18 filament and desmosome organisation mainly at the apical or peripheral regions of simple epithelial cells []. In human, it acts as a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation [].
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Protein
Q9D439
Organism: Mus musculus/domesticus
Length: 514  
Fragment?: false
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Protein
Q059Q0
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Publication
21641551 | J:176086
First Author: Tang D
Year: 2011
Journal: Cell Metab
Title: High-mobility group box 1 is essential for mitochondrial quality control.
Volume: 13
Issue: 6
Pages: 701-11
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Publication
17994014 | J:130775
First Author: Friedman MJ
Year: 2007
Journal: Nat Neurosci
Title: Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration.
Volume: 10
Issue: 12
Pages: 1519-28
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Publication
33870132 | J:316781
First Author: Sheehan BK
Year: 2021
Journal: iScience
Title: ATG9A regulates proteostasis through reticulophagy receptors FAM134B and SEC62 and folding chaperones CALR and HSPB1.
Volume: 24
Issue: 4
Pages: 102315
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Protein
F6Q720
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: true
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Protein
Q3TS07
Organism: Mus musculus/domesticus
Length: 50  
Fragment?: true
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Publication
26531781 | -
First Author: Noël ES
Year: 2016
Journal: Hum Mutat
Title: A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ Function.
Volume: 37
Issue: 2
Pages: 194-200
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Publication
26538025 | -
First Author: Silva E
Year: 2016
Journal: Mol Biol Cell
Title: Ccdc11 is a novel centriolar satellite protein essential for ciliogenesis and establishment of left-right asymmetry.
Volume: 27
Issue: 1
Pages: 48-63
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Publication
25504577 | -
First Author: Narasimhan V
Year: 2015
Journal: Hum Mutat
Title: Mutations in CCDC11, which encodes a coiled-coil containing ciliary protein, causes situs inversus due to dysmotility of monocilia in the left-right organizer.
Volume: 36
Issue: 3
Pages: 307-18
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Publication
20724476 | J:166791
First Author: Menon MB
Year: 2010
Journal: J Biol Chem
Title: p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins.
Volume: 285
Issue: 43
Pages: 33242-51
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Publication
22083493 | J:320710
First Author: Ciocca DR
Year: 2012
Journal: Histochem Cell Biol
Title: Absence of caveolin-1 alters heat shock protein expression in spontaneous mammary tumors driven by Her-2/neu expression.
Volume: 137
Issue: 2
Pages: 187-94
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Publication
29180567 | J:254128
 
First Author: Yamashita M
Year: 2018
Journal: Development
Title: Uhrf1 is indispensable for normal limb growth by regulating chondrocyte differentiation through specific gene expression.
Volume: 145
Issue: 1
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Publication
19399179 | J:148261
First Author: Sanbe A
Year: 2009
Journal: PLoS One
Title: Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy.
Volume: 4
Issue: 4
Pages: e5351
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Publication
32528249 | J:335339
 
First Author: Sadler E
Year: 2020
Journal: Front Cell Neurosci
Title: Cell-Specific Transcriptional Responses to Heat Shock in the Mouse Utricle Epithelium.
Volume: 14
Pages: 123
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Publication
18081892 | J:136539
First Author: Binet F
Year: 2008
Journal: Br J Haematol
Title: Arsenic trioxide induces de novo protein synthesis of annexin-1 in neutrophils: association with a heat shock-like response and not apoptosis.
Volume: 140
Issue: 4
Pages: 454-63
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Publication
35099007 | J:322813
 
First Author: Cui X
Year: 2022
Journal: Dis Model Mech
Title: Exercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway.
Volume: 15
Issue: 3
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Publication
19246516 | J:147580
First Author: Ninkina N
Year: 2009
Journal: Hum Mol Genet
Title: Gamma-synucleinopathy: neurodegeneration associated with overexpression of the mouse protein.
Volume: 18
Issue: 10
Pages: 1779-94
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Publication
27155571 | J:256885
First Author: Zhou Y
Year: 2016
Journal: Biochim Biophys Acta
Title: Lens ER-stress response during cataract development in Mip-mutant mice.
Volume: 1862
Issue: 8
Pages: 1433-42
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Publication
23555679 | J:199373
First Author: Tang MK
Year: 2013
Journal: PLoS One
Title: Promyelocytic leukemia (PML) protein plays important roles in regulating cell adhesion, morphology, proliferation and migration.
Volume: 8
Issue: 3
Pages: e59477
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Publication
19464326 | J:153470
First Author: Vos MJ
Year: 2009
Journal: Biochim Biophys Acta
Title: HSPB7 is a SC35 speckle resident small heat shock protein.
Volume: 1793
Issue: 8
Pages: 1343-53
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Publication
27567740 | J:236781
 
First Author: La Padula V
Year: 2016
Journal: Exp Neurol
Title: HSPB3 protein is expressed in motoneurons and induces their survival after lesion-induced degeneration.
Volume: 286
Pages: 40-49
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Publication
28595321 | J:243636
First Author: Kalmar B
Year: 2017
Journal: Hum Mol Genet
Title: Mitochondrial deficits and abnormal mitochondrial retrograde axonal transport play a role in the pathogenesis of mutant Hsp27-induced Charcot Marie Tooth Disease.
Volume: 26
Issue: 17
Pages: 3313-3326
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Publication
35095512 | J:319740
 
First Author: Wang W
Year: 2021
Journal: Front Pharmacol
Title: Paeonol Ameliorates Chronic Itch and Spinal Astrocytic Activation via CXCR3 in an Experimental Dry Skin Model in Mice.
Volume: 12
Pages: 805222
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Publication
29037376 | -
 
First Author: Singh MK
Year: 2017
Journal: J Therm Biol
Title: The small heat shock protein Hsp27: Present understanding and future prospects.
Volume: 69
Pages: 149-154
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Publication
9325325 | -
First Author: Piotrowicz RS
Year: 1997
Journal: J Biol Chem
Title: Basolateral membrane-associated 27-kDa heat shock protein and microfilament polymerization.
Volume: 272
Issue: 41
Pages: 25920-7
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Publication
20010861 | -
First Author: Bektas M
Year: 2010
Journal: J Invest Dermatol
Title: What's in a name?: Heat shock protein 27 and keratinocyte differentiation.
Volume: 130
Issue: 1
Pages: 10-2
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Publication
15706088 | -
First Author: Arrigo AP
Year: 2005
Journal: Antioxid Redox Signal
Title: Hsp27 consolidates intracellular redox homeostasis by upholding glutathione in its reduced form and by decreasing iron intracellular levels.
Volume: 7
Issue: 3-4
Pages: 414-22
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Publication
17375066 | -
First Author: Perrin V
Year: 2007
Journal: Mol Ther
Title: Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease.
Volume: 15
Issue: 5
Pages: 903-11
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Publication
18573886 | -
First Author: Sinsimer KS
Year: 2008
Journal: Mol Cell Biol
Title: Chaperone Hsp27, a novel subunit of AUF1 protein complexes, functions in AU-rich element-mediated mRNA decay.
Volume: 28
Issue: 17
Pages: 5223-37
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Publication
19411251 | -
First Author: Hayes D
Year: 2009
Journal: J Biol Chem
Title: Phosphorylation dependence of hsp27 multimeric size and molecular chaperone function.
Volume: 284
Issue: 28
Pages: 18801-7
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Publication
18007587 | -
First Author: Sur R
Year: 2008
Journal: J Invest Dermatol
Title: Hsp27 regulates pro-inflammatory mediator release in keratinocytes by modulating NF-kappaB signaling.
Volume: 128
Issue: 5
Pages: 1116-22
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Publication
17467701 | -
First Author: Arrigo AP
Year: 2007
Journal: FEBS Lett
Title: Hsp27 (HspB1) and alphaB-crystallin (HspB5) as therapeutic targets.
Volume: 581
Issue: 19
Pages: 3665-74
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Protein Domain
IPR037876 | ACD_HspB1
Type: Domain
Description: This entry represents the alpha crystallin domain (ACD) found in mammalian Hsp27 (also denoted HspB1 in human).Small heat shock proteins (sHsps) are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits [, ]. They are characterised by the presence of an alpha crystallin domain (ACD) [].Hsp27 shows enhanced synthesis in response to stress. It is a molecular chaperone which interacts with a large number of different proteins. It is found in many types of human cells including breast, uterus, cervix, platelets and cancer cells. Hsp27 has diverse cellular functions including chaperoning, regulation of actin polymerization, keratinocyte differentiation, regulation of inflammatory pathways in keratinocytes, and protection from oxidative stress through modulating glutathione levels [, , , ]. It is also a subunit of AUF1-containing protein complexes []. Hsp27 has been linked to several transduction pathways regulating cellular functions including differentiation, cell growth, development, and apoptosis []. Its activity can be regulated by phosphorylation. Its unphosphorylated state is a high molecular weight aggregated form (100-800kDa) composed of up to 24 subunits, which forms as a result of multiple interactions within the ACD, and is required for chaperone function and resistance to oxidative stress. Upon phosphorylation these large aggregates rapidly disassociate to smaller oligomers and chaperone activity is modified [].High constitutive levels of Hsp27 have been detected in various cancer cells, in particular those of carcinoma origin []. Over-expression of Hsp27 has a protective effect against various diseases-processes, including Huntington's disease []. Mutations in Hsp27 have been associated with a form of distal hereditary motor neuropathy type II and Charcot-Marie-Tooth disease type 2 [].
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Publication
32929361 | J:313550
First Author: Qie C
Year: 2020
Journal: Theranostics
Title: Single-cell RNA-Seq reveals the transcriptional landscape and heterogeneity of skin macrophages in Vsir-/- murine psoriasis.
Volume: 10
Issue: 23
Pages: 10483-10497
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Publication
29187369 | J:283129
First Author: Nie X
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: Pharmacological and genetic inhibition of downstream targets of p38 MAPK in experimental nephrotic syndrome.
Volume: 314
Issue: 4
Pages: F602-F613
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Publication
12475175 | -
First Author: Haslbeck M
Year: 2002
Journal: Cell Mol Life Sci
Title: sHsps and their role in the chaperone network.
Volume: 59
Issue: 10
Pages: 1649-57
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Publication
16205709 | -
First Author: Haslbeck M
Year: 2005
Journal: Nat Struct Mol Biol
Title: Some like it hot: the structure and function of small heat-shock proteins.
Volume: 12
Issue: 10
Pages: 842-6
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Protein
Q545F4
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Publication
11875128 | -
First Author: Narberhaus F
Year: 2002
Journal: Microbiol Mol Biol Rev
Title: Alpha-crystallin-type heat shock proteins: socializing minichaperones in the context of a multichaperone network.
Volume: 66
Issue: 1
Pages: 64-93; table of contents
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