This entry includes fission yeast Rap1 and its homologue, TERF2IP (telomeric repeat-binding factor 2-interacting protein 1) from animals.TERF2IP is a telomere-interacting protein that plays a role in protecting telomeres from initiating homology directed repair (HDR) []. It is recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. It can also be recruited to extratelomeric 5'-TTAGGG-3' sites and regulates gene expression [].In Schizosaccharomyces pombe, Rap1 is involved in the regulation of telomere length and telomere position effect (TPE) []. It is also involved in chromosomal bouquet formation [].
