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Search results 101 to 173 out of 173 for Rgs12

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Type Details Score
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
9168931 | J:40212
First Author: Snow BE
Year: 1997
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and expression analysis of rat Rgs12 and Rgs14.
Volume: 233
Issue: 3
Pages: 770-7
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Interaction Experiment
Willard MD (2007)
Description: Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation.
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Publication
11387333 | -
First Author: Kimple RJ
Year: 2001
Journal: J Biol Chem
Title: RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity.
Volume: 276
Issue: 31
Pages: 29275-81
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Allele
Rgs12<tm1Dski> | MGI:6389566
Name: regulator of G-protein signaling 12; targeted mutation 1, David Siderovski
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:6143693 | B6.Cg-Rgs12<tm1Dski>/Mmucd
Attribute String: mutant strain, congenic, targeted mutation
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Allele
Tg(Rgs12-EGFP)HW332Gsat | MGI:4847376
Name: transgene insertion HW332, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5003928 | STOCK Tg(Rgs12-EGFP)HW332Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Protein Domain
IPR037880 | RGS12_RGS
Type: Domain
Description: RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS12 protein. RGS12 is a member of the RA/RGS subfamily of RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis [, ]. RGS12 belongs to the R12 RGS subfamily, which includes RGS10 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q. RGS12 exist in multiple splice variants: RGS12s (short) contains the core RGS/RBD/GoLocodomains, while RGS12L (long) has additional N-terminal PDZ and PTB domains. RGS12 splice variants show distinct expression patterns, suggesting that they have discrete functions during mouse embryogenesis []. RGS12 also may play a critical role in coordinating Ras-dependent signals that are required for promoting and maintaining neuronal differentiation [].
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Publication
12223533 | -
First Author: Hollinger S
Year: 2002
Journal: Pharmacol Rev
Title: Cellular regulation of RGS proteins: modulators and integrators of G protein signaling.
Volume: 54
Issue: 3
Pages: 527-59
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Publication
16687250 | -
First Author: Willars GB
Year: 2006
Journal: Semin Cell Dev Biol
Title: Mammalian RGS proteins: multifunctional regulators of cellular signalling.
Volume: 17
Issue: 3
Pages: 363-76
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Publication
17881498 | J:128364
First Author: Yang S
Year: 2007
Journal: J Cell Sci
Title: Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiation.
Volume: 120
Issue: Pt 19
Pages: 3362-71
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Publication
8774883 | -
First Author: Hunt TW
Year: 1996
Journal: Nature
Title: RGS10 is a selective activator of G alpha i GTPase activity.
Volume: 383
Issue: 6596
Pages: 175-7
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Publication
15593368 | -
First Author: Waugh JL
Year: 2005
Journal: J Comp Neurol
Title: Regional, cellular, and subcellular localization of RGS10 in rodent brain.
Volume: 481
Issue: 3
Pages: 299-313
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Protein Domain
IPR037879 | RGS10_RGS
Type: Domain
Description: RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS10 protein. RGS10 is a member of the RGS proteins family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS10 is one of the smallest proteins of the RGS family; its structure is little more than the RGS domain. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis [, ]. RGS10 belongs to the R12 RGS subfamily, which includes RGS12 and RGS14, all of which are highly selective for G-alpha-i1 over G-alpha-q []. RGS10 exists in 2 splice isoforms, RGS10A and RGS10B. Although the expression of RGS10 is ubiquitous, the highest levels are found in the brain and immune system []. RGS10A is expressed in osteoclasts and is a key component in the RANKL signaling mechanism for osteoclast differentiation [].
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Protein
Q3TTW9
Organism: Mus musculus/domesticus
Length: 499  
Fragment?: false
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Protein
Q8CFD2
Organism: Mus musculus/domesticus
Length: 25  
Fragment?: true
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Publication
10470031 | -
First Author: Siderovski DP
Year: 1999
Journal: Trends Biochem Sci
Title: The GoLoco motif: a Galphai/o binding motif and potential guanine-nucleotide exchange factor.
Volume: 24
Issue: 9
Pages: 340-1
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Publication
11121039 | -
First Author: De Vries L
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Activator of G protein signaling 3 is a guanine dissociation inhibitor for Galpha i subunits.
Volume: 97
Issue: 26
Pages: 14364-9
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Publication
11024022 | -
First Author: Natochin M
Year: 2000
Journal: J Biol Chem
Title: AGS3 inhibits GDP dissociation from galpha subunits of the Gi family and rhodopsin-dependent activation of transducin.
Volume: 275
Issue: 52
Pages: 40981-5
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Publication
11976690 | -
First Author: Kimple RJ
Year: 2002
Journal: Nature
Title: Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits.
Volume: 416
Issue: 6883
Pages: 878-81
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Protein Domain
IPR003109 | GoLoco_motif
Type: Conserved_site
Description: In heterotrimeric G-protein signalling, cell surface receptors (GPCRs) arecoupled to membrane-associated heterotrimers comprising a GTP-hydrolysing subunit G-alpha and a G-beta/G-gamma dimer. The inactive form contains the alpha subunit bound to GDP and complexes with the beta and gamma subunit. When the ligand is associated to thereceptor, GDP is displaced from G-alpha and GTP is bound. GTP/G-alpha complex dissociates from the trimer and associates to an effector until the intrinsic GTPase activity of G-alpha returns the protein to GDP bound form. Reassociation of GDP bound G-alpha with G-beta/G-gamma dimer terminates the signal. Several mechanisms regulate the signal output at different stage of the G-protein cascade. Two classes of intracellular proteins act as inhibitors of G protein activation: GTPase activating proteins (GAPs), which enhance GTP hydrolysis (see ),and guanine dissociation inhibitors (GDIs), which inhibit GDP dissociation.The GoLoco or G-protein regulatory (GPR) motif found in various G-proteinregulators [, ]acts as a GDI on G-alpha(i) [, ].The crystal structure of the GoLoco motif in complex with G-alpha(i) has been solved []. It consists of three small alpha helices. The highly conserved Asp-Gln-Arg triad within the GoLoco motif participates directly in GDP binding by extending the arginine side chain into the nucleotide binding pocket, highly reminiscent of the catalytic arginine finger employed in GTPase-activating protein (see ). This addition of an arginine in the binding pocket affects the interaction of GDP with G-alpha and therefore is certainly important for the GoLoco GDI activity [].Some proteins known to contain a GoLoco motif are listed below:Mammalian regulators of G-protein signalling 12 and 14 (RGS12 and RGS14), multifaceted signal transduction regulators.Loco, the drosophila RGS12 homologue.Mammalian Purkinje-cell protein-2 (Pcp2). It may function as a cell-type specific modulator for G protein-mediated cell signalling. It is uniquely expressed in cerebellar Purkinje cells and in retinal bipolar neurons.Eukaryotic Rap1GAP. A GTPase activator for the nuclear ras-related regulatory protein RAP-1A.Drosophila protein Rapsynoid (also known as Partner of Inscuteable, Pins) and its mammalian homologues AGS3 and LGN. They form a G-protein regulator family that also contains TPR repeats.
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Protein
D3Z0G6
Organism: Mus musculus/domesticus
Length: 733  
Fragment?: false
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Protein
D3Z0G7
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: false
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Protein
E9Q1K7
Organism: Mus musculus/domesticus
Length: 723  
Fragment?: false
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Protein
Q9D677
Organism: Mus musculus/domesticus
Length: 723  
Fragment?: false
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Protein
D3Z0G5
Organism: Mus musculus/domesticus
Length: 803  
Fragment?: false
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Protein
G3UYL4
Organism: Mus musculus/domesticus
Length: 55  
Fragment?: true
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Protein
E9Q652
Organism: Mus musculus/domesticus
Length: 1451  
Fragment?: false
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Protein
Q6IR34
Organism: Mus musculus/domesticus
Length: 673  
Fragment?: false
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Protein
P12660
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: false
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Protein
Q3U1Z5
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
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Protein
Q8VDU0
Organism: Mus musculus/domesticus
Length: 679  
Fragment?: false
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Protein
A2ALS5
Organism: Mus musculus/domesticus
Length: 663  
Fragment?: false
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Protein
Q0VGT5
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
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Protein
A8IK50
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: false
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Protein
A0A0R4IZX8
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: false
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Protein
A0A140LHG1
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: false
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Protein
F6SX81
Organism: Mus musculus/domesticus
Length: 497  
Fragment?: true
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Protein
A2AIV3
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: false
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Protein
A2ALS4
Organism: Mus musculus/domesticus
Length: 729  
Fragment?: false
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Protein
A0A140LI57
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: false
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Protein
Q3UPG3
Organism: Mus musculus/domesticus
Length: 679  
Fragment?: false
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Protein
Q8R0E6
Organism: Mus musculus/domesticus
Length: 496  
Fragment?: true
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Protein
O35443
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: false
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Protein
A2ALS2
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: true
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Publication
10606204 | -
First Author: Ponting CP
Year: 1999
Journal: J Mol Med (Berl)
Title: Raf-like Ras/Rap-binding domains in RGS12- and still-life-like signalling proteins.
Volume: 77
Issue: 10
Pages: 695-8
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Protein
A2ALS3
Organism: Mus musculus/domesticus
Length: 240  
Fragment?: true
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Protein
Q9CQE5
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Protein
Q32MD7
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Protein
P97492
Organism: Mus musculus/domesticus
Length: 547  
Fragment?: false
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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