The testis anion transporter TAT1 (solute carrier family 26 member 8; SLC26A8) mediates chloride, sulfate and oxalate transport and is specifically expressed in male germ cells and mature sperms [, ]. It is essential for correct sperm tail differentiation and motility, and hence male fertility []. TAT1 and CFTR (cystic fibrosis transmembrane conductance regulator) seem to cooperate in the regulation of the Cl-/HCO3- fluxes required for motility and capacitation of sperm [].
