This group contains condensin-2 complex subunit D3. It is a regulatory subunit of the condensin-2 complex (contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2), a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis [, ].
This entry includes condensin subunit 1 (CND1) and condensin-2 complex subunit D3 (NCAPD3).CND1 is a regulatory subunit of the condensin complex (contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG), a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes []. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases [, , , ]. NCAPD3 is a regulatory subunit of the condensin-2 complex (contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2), a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis [].
