Nuclear receptor coactivator 4, also known as ARA70, is a coactivator for the androgen receptor (AR) []and can function as a ligand-enhanced coactivator of PPARgamma. AR can suppress PPARgamma-ARA70 transactivation, suggesting cross-talk between PPARgamma- and AR-mediated responses in adipocytes []. NCOA4 has been identified as a selective cargo receptor for the autophagic turnover of ferritinin, a critical process for regulation of iron homeostasis [, ].