Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:4423910 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827583 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009638_06 |
|
Specimen Label: |
euxassay_009638_06 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4423910 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827583 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009638_07 |
|
Specimen Label: |
euxassay_009638_07 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4423910 |
Assay Type: |
RNA in situ |
Annotation Date: |
2010-09-14 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1679523 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:4827583 |
Age: |
embryonic day 14.5 |
Image: |
euxassay_009638_16 |
|
Specimen Label: |
euxassay_009638_16 |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3273028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691033 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1567043 |
|
Specimen Label: |
MRC Harwell_1567043 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3273028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691033 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1500596 |
|
Specimen Label: |
MRC Harwell_1500596 |
Detected: |
true |
Specimen Num: |
16 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1757728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691033 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1567044 |
|
Specimen Label: |
MRC Harwell_1567044 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3281228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691033 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1567043 |
|
Specimen Label: |
MRC Harwell_1567043 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6711819 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-05-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160519 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6711984 |
Age: |
embryonic day 6.5 |
Image: |
S3 -/- |
Note: |
Expressed in a resident of subdomains of early endosomes, existed separately with Dkk1. |
Specimen Label: |
S3 -/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6711819 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2021-05-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:160519 |
Pattern: |
Not Specified |
Stage: |
TS09 |
Assay Id: |
MGI:6711984 |
Age: |
embryonic day 6.5 |
Image: |
S3 WT |
Note: |
Expressed in a resident of subdomains of early endosomes, existed in close proximity with Dkk1. |
Specimen Label: |
S3 WT |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2991528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691033 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1567049 |
|
Specimen Label: |
MRC Harwell_1567049 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691033 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1567046 |
|
Specimen Label: |
MRC Harwell_1567046 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691033 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1567048 |
|
Specimen Label: |
MRC Harwell_1567048 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691033 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1567050 |
|
Specimen Label: |
MRC Harwell_1567050 |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:1796228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6691033 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1567049 |
|
Specimen Label: |
MRC Harwell_1567049 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7541042 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-10-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:381337 |
Pattern: |
Not Specified |
Stage: |
TS07 |
Assay Id: |
MGI:7541131 |
Age: |
embryonic day 5.5 |
Image: |
5c/d/e |
Note: |
Expressed in a dot-like pattern. |
Specimen Label: |
5c/d/e |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7541042 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-10-18 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:381337 |
Pattern: |
Not Specified |
Stage: |
TS07 |
Assay Id: |
MGI:7541131 |
Age: |
embryonic day 5.5 |
Image: |
5g/h/i |
Note: |
Diminished expression and exhibited a smear distribution pattern in mutant cells. |
Specimen Label: |
5g/h/i |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
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Isolation and sequence determination of cDNA encoding mouse rab 4 and candidate approach for the beige mutation in mice. |
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MGI Direct Data Submission |
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Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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Gene Ontology annotation based on Enzyme Commission mapping |
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Mouse Genome Database and National Center for Biotechnology Information Editorial Staff Collaboration |
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LocusLink Collaboration |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Bielli A |
Year: |
2001 |
Journal: |
Biochem Biophys Res Commun |
Title: |
The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1. |
Volume: |
281 |
Issue: |
5 |
Pages: |
1141-53 |
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Allele |
Name: |
RAB4A, member RAS oncogene family; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
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Publication |
First Author: |
Kachhap SK |
Year: |
2007 |
Journal: |
PLoS One |
Title: |
The N-Myc down regulated Gene1 (NDRG1) Is a Rab4a effector involved in vesicular recycling of E-cadherin. |
Volume: |
2 |
Issue: |
9 |
Pages: |
e844 |
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Publication |
First Author: |
Huber SK |
Year: |
2005 |
Journal: |
FEBS Lett |
Title: |
High resolution crystal structures of human Rab4a in its active and inactive conformations. |
Volume: |
579 |
Issue: |
13 |
Pages: |
2821-9 |
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Publication |
First Author: |
Karlsson S |
Year: |
2006 |
Journal: |
Mol Biol Cell |
Title: |
Loss of T-cell protein tyrosine phosphatase induces recycling of the platelet-derived growth factor (PDGF) beta-receptor but not the PDGF alpha-receptor. |
Volume: |
17 |
Issue: |
11 |
Pages: |
4846-55 |
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Publication |
First Author: |
Augustus AS |
Year: |
2008 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Substrate uptake and metabolism are preserved in hypertrophic caveolin-3 knockout hearts. |
Volume: |
295 |
Issue: |
2 |
Pages: |
H657-66 |
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Publication |
First Author: |
Katsura KA |
Year: |
2014 |
Journal: |
Matrix Biol |
Title: |
WDR72 models of structure and function: a stage-specific regulator of enamel mineralization. |
Volume: |
38 |
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Pages: |
48-58 |
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Publication |
First Author: |
Okuda T |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves. |
Volume: |
24 |
Issue: |
9 |
Pages: |
3949-56 |
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Publication |
First Author: |
Kalaydjieva L |
Year: |
2000 |
Journal: |
Am J Hum Genet |
Title: |
N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom. |
Volume: |
67 |
Issue: |
1 |
Pages: |
47-58 |
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Publication |
First Author: |
Stein S |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
NDRG1 is necessary for p53-dependent apoptosis. |
Volume: |
279 |
Issue: |
47 |
Pages: |
48930-40 |
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Protein Domain |
Type: |
Family |
Description: |
N-myc downstream regulated gene (NDRG) family members are characterised by an alpha/beta hydrolase-fold motif. NDRG proteins may function as tumour suppressors and may also play important roles in the development of neurological and electrophysiological diseases [, ]. This entry represents NDRG1. The C-terminal region of NDRG1 contains three 10-aa (GTRSRSHTSE) tandem repeats, which are absent in the other family members and may be crucial for its function. NDRG1 is implicated in placentation and is involved in the development of the urinary and reproductive organs of the embryos. NDRG1 also functions in mast cell inflammatory processes []. NDRG1 is expressed in Purkinje cells in the cerebellum and in the cytoplasm of myelinating Schwann cells in peripheral nerves []. NDRG1 has been links to several diseases, such as hereditary motor and sensory neuropathy-Lom (HMSNL) []and Schwann cell dysfunction []. The expression of NDRG1 is down-regulated in certain cancer types, but up-regulated in other cancer types. This suggests that NDRG1 has tissue-specific functions in various cancer types []. NDRG1 is necessary for p53-dependent apoptosis []. It is also a Rab4a effector involved in vesicular recycling of the adhesion molecule E-cadherin []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
53
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Fragment?: |
true |
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Publication |
First Author: |
Hwang J |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor. |
Volume: |
286 |
Issue: |
14 |
Pages: |
12450-60 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
394
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
394
|
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
394
|
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
174
|
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
119
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Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
394
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Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
155
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Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
157
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Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
141
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Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
394
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Fragment?: |
false |
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Publication |
First Author: |
Melotte V |
Year: |
2010 |
Journal: |
FASEB J |
Title: |
The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications. |
Volume: |
24 |
Issue: |
11 |
Pages: |
4153-66 |
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