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Search results 101 to 150 out of 150 for Crb2

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Type Details Score
Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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HT Experiment
E-GEOD-50845 | Control vs CRB2 cKO retinas at early postnatal time points
Series Id: GSE50845
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
30239717 | J:268488
First Author: Quinn PM
Year: 2019
Journal: Hum Mol Genet
Title: Loss of CRB2 in Müller glial cells modifies a CRB1-associated retinitis pigmentosa phenotype into a Leber congenital amaurosis phenotype.
Volume: 28
Issue: 1
Pages: 105-123
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Publication
17190600 | -
First Author: Botuyan MV
Year: 2006
Journal: Cell
Title: Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.
Volume: 127
Issue: 7
Pages: 1361-73
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Publication
15550243 | -
First Author: Sanders SL
Year: 2004
Journal: Cell
Title: Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage.
Volume: 119
Issue: 5
Pages: 603-14
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DO Term
DOID:0111134 | focal segmental glomerulosclerosis 9
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DO Term
DOID:0111625 | ventriculomegaly - cystic kidney disease
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Publication
24035451 | -
First Author: Lu R
Year: 2013
Journal: Trends Biochem Sci
Title: Tudor: a versatile family of histone methylation 'readers'.
Volume: 38
Issue: 11
Pages: 546-55
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Protein Domain
IPR041297 | Crb2_Tudor
Type: Domain
Description: This is the tudor domain found in DNA repair protein Crb2. Structural and functional studies of Crb2 and its mammalian homologue 53BP1 indicate that the conserved tandem-Tudor domain of 53BP1 and Crb2 preferentially interacts with H4K20me2, though it also binds to H4K20me1 []. Furthermore, despite low amino acid sequence similarity, Crb2 is structurally related to 53BP1 in having two tudor domains and a conserved dimethyllysine-binding pocket, and that, like 53BP1, it directly binds H4-K20me2 [].
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Protein Domain
IPR025783 | Set9_fungi
Type: Family
Description: This entry represents fungal histone-lysine N-methyltransferase Set9 that belongs to the Suv4-20 family. This enzyme catalyzes mono-, di-, and trimethylation of H4K20. It participates in DNA damage response by giving a 'histone mark' required for the recruitment of the checkpoint protein Crb2 to sites of DNA damage [, ].
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Publication
19250904 | -
First Author: Wang Y
Year: 2009
Journal: Mol Cell
Title: Regulation of Set9-mediated H4K20 methylation by a PWWP domain protein.
Volume: 33
Issue: 4
Pages: 428-37
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Protein Domain
IPR040765 | Tudor_1_RapA
Type: Domain
Description: This is one of two Tudor-like domains found in the N-terminal region of RapA proteins. RapA is an abundant RNAP-associated protein of 110kDa molecular weight with ATPase activity.It forms a stable complex with the RNAP core enzyme, but not with the holoenzyme. The ATPase activity of RapA increases upon its binding to RNAP []. The N-terminal region of RapA contains two copies of a Tudor-like domains, both folded as a highly bent antiparallel β-sheet. This fold is also found in transcription factor NusG , ribosomal protein L24, human SMN (survival of motor neuron) protein, mammalian DNA repair factor 53BP1, putative fission yeast DNA repair factor Crb2 and bacterial transcription-repair coupling factor known as Mfd. The functional roles of the N-terminal region homologs in these proteins suggest that the Tudor-like domains of RapA may interact with both nucleic acids and RNAP [].
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Protein Domain
IPR040766 | Tudor_2_RapA
Type: Domain
Description: This is the second of two Tudor-like domains found in the N-terminal region of RapA proteins. RapA is an abundant RNAP-associated protein of 110kDa molecular weight with ATPase activity. It forms a stable complex with the RNAP core enzyme, but not with the holoenzyme. The ATPase activity of RapA increases upon its binding to RNAP []. The N-terminal region of RapA contains two copies of a Tudor-like domains, both folded as a highly bent antiparallel β-sheet. This fold is also found in transcription factor NusG , ribosomal protein L24, human SMN (survival of motor neuron) protein, mammalian DNA repair factor 53BP1, putative fission yeast DNA repair factor Crb2 and bacterial transcription-repair coupling factor known as Mfd. The functional roles of the N-terminal region homologs in these proteins suggest that the Tudor-like domains of RapA may interact with both nucleic acids and RNAP [].
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Publication
18786404 | -
First Author: Shaw G
Year: 2008
Journal: Structure
Title: Structure of RapA, a Swi2/Snf2 protein that recycles RNA polymerase during transcription.
Volume: 16
Issue: 9
Pages: 1417-27
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Publication
25646438 | -
First Author: Liu B
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for transcription reactivation by RapA.
Volume: 112
Issue: 7
Pages: 2006-10
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Publication
16987889 | J:114847
 
First Author: Richard M
Year: 2006
Journal: Hum Mol Genet
Title: Towards understanding CRUMBS function in retinal dystrophies.
Volume: 15 Spec No 2
Pages: R235-43
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Protein Domain
IPR039977 | Suv4-20/Set9
Type: Family
Description: This entry includes Suv4-20 family members and its fungal homologue known as Set9. They are a group of histone H4K20 methyltransferases.SET9 methylates 'Lys-20' of histone H4. H4 'Lys-20' methylation is apparently not involved in the regulation of gene expression or heterochromatin function, but participates in DNA damage response by giving a 'histone mark' required for the recruitment of the checkpoint protein Crb2 to sites of DNA damage [, ].Post-translational modification of the core histones H2A, H2B, H3 and H4 play an important part in chromatin biology. Histone H4 lysine 20 methylation (H4K20me) is critical for the biological processes that ensure genome integrity, such as DNA damage repair, DNA replication and chromatin compaction []. Suv4-20 family members are a group of histone H4K20 methyltransferases that play an important role in epigenetic regulation. Lower eukaryotes have a single Suv4-20, while mammals have two closely related Suv4-20 paralogs, SUV420H1 and SUV420H2 []. In mammals H4K20me2 is generated primarily by SUV420H1/KMT5B (which can also produce H4K20me3), while H4K20me3 is mostly generated by SUV420H2/KMT5C [].
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Protein
E0CXW4
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: false
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Protein
H3BJI9
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
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Protein
A0A494B976
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: true
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Protein
H3BJ94
Organism: Mus musculus/domesticus
Length: 87  
Fragment?: true
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Protein
H3BKZ5
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
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Protein
D3Z2F5
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: true
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Protein
D3YXL6
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
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Protein
F6XZN9
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: true
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Protein
Q8BLG0
Organism: Mus musculus/domesticus
Length: 1010  
Fragment?: false
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Protein
Q6PAR7
Organism: Mus musculus/domesticus
Length: 1023  
Fragment?: false
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Publication
24049080 | J:211428
First Author: Southall SM
Year: 2014
Journal: Nucleic Acids Res
Title: A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases.
Volume: 42
Issue: 1
Pages: 661-71
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Publication
21206904 | -
First Author: Tsang LW
Year: 2010
Journal: PLoS One
Title: Comparative analyses of SUV420H1 isoforms and SUV420H2 reveal differences in their cellular localization and effects on myogenic differentiation.
Volume: 5
Issue: 12
Pages: e14447
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Publication
23345616 | -
First Author: Jørgensen S
Year: 2013
Journal: Nucleic Acids Res
Title: Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity.
Volume: 41
Issue: 5
Pages: 2797-806
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Protein
Q3U8K7
Organism: Mus musculus/domesticus
Length: 883  
Fragment?: false
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Protein
Q6Q783
Organism: Mus musculus/domesticus
Length: 468  
Fragment?: false
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Protein
H3BLE5
Organism: Mus musculus/domesticus
Length: 423  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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