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Search results 1 to 100 out of 162 for Sec63

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Type Details Score
Gene
11231 | SEC63
Type: gene
Organism: human
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Gene
541040 | SEC63
Type: gene
Organism: cattle
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Gene
421774 | SEC63
Type: gene
Organism: chicken
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Gene
436861 | sec63
Type: gene
Organism: zebrafish
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Gene
698863 | SEC63
Type: gene
Organism: macaque, rhesus
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Gene
100125094 | sec63
Type: gene
Organism: frog, western clawed
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Protein
Q80YG4
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
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Gene
475016 | SEC63
Type: gene
Organism: dog, domestic
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Gene
309858 | Sec63
Type: gene
Organism: rat
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Gene
462915 | SEC63
Type: gene
Organism: chimpanzee
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Protein Domain
IPR027137 | Sec63
Type: Family
Description: In Saccharomyces cerevisiae, Sec63 is a component of the Sec62/63 complex (includes Sec63p, Sec62p, Sec66p and Sec72p), which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex []. In humans, Sec63 is part of the multicomponent translocon that contains the trimeric SEC61 complex, SEC62 and SEC63. It is required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane [, ].Defects in SEC63 are a cause of polycystic liver disease (PCLD). PCLD is an autosomal dominant disorder and is characterised by the presence of multiple liver cysts of biliary epithelial origin [].
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Protein Coding Gene
MGI:2155302 | Sec63
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
22375059 | J:197701
First Author: Lang S
Year: 2012
Journal: J Cell Sci
Title: Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.
Volume: 125
Issue: Pt 8
Pages: 1958-69
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Protein
Q8K2U5
Organism: Mus musculus/domesticus
Length: 516  
Fragment?: true
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Publication
15133510 | -
First Author: Davila S
Year: 2004
Journal: Nat Genet
Title: Mutations in SEC63 cause autosomal dominant polycystic liver disease.
Volume: 36
Issue: 6
Pages: 575-7
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Protein
Q8VHE0
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
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Publication
25844898 | J:222413
First Author: Fedeles SV
Year: 2015
Journal: J Clin Invest
Title: Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity.
Volume: 125
Issue: 5
Pages: 1955-67
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Publication
11226176 | -
First Author: Young BP
Year: 2001
Journal: EMBO J
Title: Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo.
Volume: 20
Issue: 1-2
Pages: 262-71
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Publication
10543453 | -
First Author: Skowronek MH
Year: 1999
Journal: Biol Chem
Title: Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog.
Volume: 380
Issue: 9
Pages: 1133-8
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Publication
10799540 | -
First Author: Meyer HA
Year: 2000
Journal: J Biol Chem
Title: Mammalian Sec61 is associated with Sec62 and Sec63.
Volume: 275
Issue: 19
Pages: 14550-7
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Publication
30745418 | J:293109
     
First Author: Ishikawa Y
Year: 2019
Journal: J Am Soc Nephrol
Title: Spliced XBP1 Rescues Renal Interstitial Inflammation Due to Loss of Sec63 in Collecting Ducts.
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Publication
26303067 | J:293552
First Author: Hassan H
Year: 2016
Journal: J Am Soc Nephrol
Title: Essential Role of X-Box Binding Protein-1 during Endoplasmic Reticulum Stress in Podocytes.
Volume: 27
Issue: 4
Pages: 1055-65
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Publication
21685914 | J:188763
First Author: Fedeles SV
Year: 2011
Journal: Nat Genet
Title: A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation.
Volume: 43
Issue: 7
Pages: 639-47
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Protein Coding Gene
MGP_CAROLIEiJ_G0015282 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0017188 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0017165 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0017125 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0017127 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0016948 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2155302 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0017586 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0016527 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0016922 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017027 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017022 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017104 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017052 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0017623 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0016307 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0016590 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0030700 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016091 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1777828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133095
Specimen Label: MRC Harwell_2133095
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1777828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133097
Specimen Label: MRC Harwell_2133097
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133091
Note: kidney
Specimen Label: MRC Harwell_2133091
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3267828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133095
Specimen Label: MRC Harwell_2133095
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3267828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133097
Specimen Label: MRC Harwell_2133097
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1898428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133089
Specimen Label: MRC Harwell_2133089
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1753628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133095
Specimen Label: MRC Harwell_2133095
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1753628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133096
Specimen Label: MRC Harwell_2133096
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1753628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133097
Specimen Label: MRC Harwell_2133097
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3667028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133094
Specimen Label: MRC Harwell_2133094
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133095
Specimen Label: MRC Harwell_2133095
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133097
Specimen Label: MRC Harwell_2133097
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133095
Specimen Label: MRC Harwell_2133095
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133096
Specimen Label: MRC Harwell_2133096
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133097
Specimen Label: MRC Harwell_2133097
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133095
Specimen Label: MRC Harwell_2133095
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133096
Specimen Label: MRC Harwell_2133096
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133097
Specimen Label: MRC Harwell_2133097
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1610528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133098
Specimen Label: MRC Harwell_2133098
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1842628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133093
Specimen Label: MRC Harwell_2133093
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1750328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133086
Specimen Label: MRC Harwell_2133086
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133092
Specimen Label: MRC Harwell_2133092
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3599828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133088
Specimen Label: MRC Harwell_2133088
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3590528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133087
Specimen Label: MRC Harwell_2133087
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133090
Specimen Label: MRC Harwell_2133090
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133089
Specimen Label: MRC Harwell_2133089
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133095
Specimen Label: MRC Harwell_2133095
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133096
Specimen Label: MRC Harwell_2133096
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133097
Specimen Label: MRC Harwell_2133097
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692473
Age: postnatal adult
Image: MRC Harwell_2133089
Specimen Label: MRC Harwell_2133089
Detected: true
Specimen Num: 4
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Gene
100420287 | SEC63P2
Type: gene
Organism: human
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Gene
100420341 | SEC63P1
Type: gene
Organism: human
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Publication
12627228 | J:82658
First Author: Chalhoub N
Year: 2003
Journal: Nat Med
Title: Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human.
Volume: 9
Issue: 4
Pages: 399-406
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Publication
11707774 | J:72844
First Author: Chalhoub N
Year: 2001
Journal: Mamm Genome
Title: Physical and transcriptional map of the mouse Chromosome 10 proximal region syntenic to human 6q16-q21.
Volume: 12
Issue: 12
Pages: 887-92
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Publication
16472605 | J:125042
First Author: Pierreux CE
Year: 2006
Journal: Gastroenterology
Title: The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse.
Volume: 130
Issue: 2
Pages: 532-41
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:345476
       
First Author: Haiming Tang, Dustin Ebert, Matthias Blum, Robert Finn, Paul Thomas
Year: 2023
Title: TreeGrafter-generated GO annotations
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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