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Search results 301 to 363 out of 363 for Hal

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0.024s

Type

Details

Score

Publication

33523841 | J:307619

First Author:	Navarro-Pando JM
Year:	2021
Journal:	Sci Adv
Title:	Inhibition of the NLRP3 inflammasome prevents ovarian aging.
Volume:	7
Issue:	1

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Publication

28249154 | J:265972

First Author:	Goldberg EL
Year:	2017
Journal:	Cell Rep
Title:	β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares.
Volume:	18
Issue:	9
Pages:	2077-2087

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Publication

35654037 | J:327624

First Author:	Panicker N
Year:	2022
Journal:	Neuron
Title:	Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease.
Volume:	110
Issue:	15
Pages:	2422-2437.e9

•

Publication

33931568 | J:341070

First Author:	Ren GM
Year:	2021
Journal:	Sci Immunol
Title:	Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases.
Volume:	6
Issue:	58

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Genotype

Symbol:	Il1r1/Il1r1 Nlrp3/Nlrp3<+> Lyz2/Lyz2<+>
Background:	involves: 129 * C57BL/6
Zygosity:	cn
Has Mutant Allele:	true

•

Genotype

Symbol:	Nlrp3/Nlrp3<+> Pycard/Pycard Lyz2/Lyz2<+>
Background:	involves: 129 * C57BL/6
Zygosity:	cn
Has Mutant Allele:	true

•

Protein

Q9D3I5

Organism:	Mus musculus/domesticus
Length:	151
Fragment?:	false

•

Publication

10220322 | -

First Author:	Schwede TF
Year:	1999
Journal:	Biochemistry
Title:	Crystal structure of histidine ammonia-lyase revealing a novel polypeptide modification as the catalytic electrophile.
Volume:	38
Issue:	17
Pages:	5355-61

•

Publication

6614592 | J:7181

First Author:	Juneja RK
Year:	1983
Journal:	Anim Blood Groups Biochem Genet
Title:	Genetic variation at a pig serum protein locus, Po-2 and its assignment to the Phi, Hal, S, H, Pgd linkage group.
Volume:	14
Issue:	1
Pages:	27-36

•

Publication

9671748 | J:49341

First Author:	Baross-Francis A
Year:	1998
Journal:	Proc Natl Acad Sci U S A
Title:	Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability.
Volume:	95
Issue:	15
Pages:	8739-43

•

Publication

23064362 | J:193548

First Author:	Tortola L
Year:	2012
Journal:	J Clin Invest
Title:	Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk.
Volume:	122
Issue:	11
Pages:	3965-76

•

Publication

27010854 | J:268803

First Author:	Wang C
Year:	2016
Journal:	Cell Death Dis
Title:	Poly-ADP-ribosylation-mediated degradation of ARTD1 by the NLRP3 inflammasome is a prerequisite for osteoclast maturation.
Volume:	7

Pages:	e2153

•

Publication

28687790 | J:253714

First Author:	Wang C
Year:	2017
Journal:	Sci Rep
Title:	Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells.
Volume:	7
Issue:	1
Pages:	4880

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Publication

27569535 | J:247029

First Author:	Agoro R
Year:	2016
Journal:	Eur J Immunol
Title:	IL-1R1-MyD88 axis elicits papain-induced lung inflammation.
Volume:	46
Issue:	11
Pages:	2531-2541

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Publication

28327619 | J:256437

First Author:	Harusato A
Year:	2017
Journal:	Mucosal Immunol
Title:	IL-36γ signaling controls the induced regulatory T cell-Th9 cell balance via NFκB activation and STAT transcription factors.
Volume:	10
Issue:	6
Pages:	1455-1467

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Publication

29760082 | J:263562

First Author:	Ngo VL
Year:	2018
Journal:	Proc Natl Acad Sci U S A
Title:	A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage.
Volume:	115
Issue:	22
Pages:	E5076-E5085

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Publication

26056255 | J:325815

First Author:	Yao Y
Year:	2015
Journal:	J Immunol
Title:	Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism.
Volume:	195
Issue:	2
Pages:	488-97

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Publication

28882883 | J:252638

First Author:	Nazir S
Year:	2017
Journal:	Blood
Title:	Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition.
Volume:	130
Issue:	24
Pages:	2664-2677

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Protein

P35492

Organism:	Mus musculus/domesticus
Length:	657
Fragment?:	false

•

Protein

Q8CE60

Organism:	Mus musculus/domesticus
Length:	657
Fragment?:	false

•

Protein

B2RXW1

Organism:	Mus musculus/domesticus
Length:	657
Fragment?:	false

•

Publication

8204579 | -

First Author:	Langer M
Year:	1994
Journal:	Biochemistry
Title:	Identification of serine-143 as the most likely precursor of dehydroalanine in the active site of histidine ammonia-lyase. A study of the overexpressed enzyme by site-directed mutagenesis.
Volume:	33
Issue:	21
Pages:	6462-7

•

Publication

8050576 | -

First Author:	Schuster B
Year:	1994
Journal:	FEBS Lett
Title:	Serine-202 is the putative precursor of the active site dehydroalanine of phenylalanine ammonia lyase. Site-directed mutagenesis studies on the enzyme from parsley (Petroselinum crispum L.).
Volume:	349
Issue:	2
Pages:	252-4

•

Publication

2120224 | -

First Author:	Taylor RG
Year:	1990
Journal:	J Biol Chem
Title:	Cloning and expression of rat histidase. Homology to two bacterial histidases and four phenylalanine ammonia-lyases.
Volume:	265
Issue:	30
Pages:	18192-9

•

Publication

7961661 | -

First Author:	Taylor RG
Year:	1994
Journal:	J Biol Chem
Title:	Site-directed mutagenesis of conserved serines in rat histidase. Identification of serine 254 as an essential active site residue.
Volume:	269
Issue:	44
Pages:	27473-7

•

Protein Domain

IPR022313 | Phe/His_NH3-lyase_AS

Type:

Active_site

Description:

This entry represents the active site of phenylalanine ammonia-lyase (PAL; ) and the mechanistically related protein histidine ammonia lyase (HAL; ). Both contain a catalytic Ala-Ser-Gly triad that is post-translationally cyclised []. PAL is a key biosynthetic catalyst in phenylpropanoid assembly in plants and fungi, and is involved in the biosynthesis of a wide variety of secondary metabolites such as flavanoids, furanocoumarin phytoalexins and cell wall components. These compounds are important for normal growth and in responses to environmental stress. PAL catalyses the removal of an ammonia group from phenylalanine to form trans-cinnamate. HAL catalyses the first step in histidine degradation, the removal of an ammonia group from histidine to produce urocanic acid. The core domain in PAL and Hal share about 30% sequence identity, with PAL containing an additional approximately 160 residues extending from the common fold [].The two types of enzymes are functionally and structurally related []. They are the only enzymes which are known to have the modified amino acid dehydro-alanine (DHA) in their active site. A serine residue has been shown [, , ]to be the precursor of this essential electrophilic moiety. The region around the active site serine is well conserved and has been used as the signature pattern for this entry.

•

Publication

12502351 | -

First Author:	Moore BS
Year:	2002
Journal:	J Nat Prod
Title:	Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone.
Volume:	65
Issue:	12
Pages:	1956-62

•

Publication

15350127 | -

First Author:	Calabrese JC
Year:	2004
Journal:	Biochemistry
Title:	Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.
Volume:	43
Issue:	36
Pages:	11403-16

•

Publication

16478474 | -

First Author:	Pilbák S
Year:	2006
Journal:	FEBS J
Title:	The essential tyrosine-containing loop conformation and the role of the C-terminal multi-helix region in eukaryotic phenylalanine ammonia-lyases.
Volume:	273
Issue:	5
Pages:	1004-19

•

Publication

29120743 | J:278147

First Author:	Liu H
Year:	2017
Journal:	Cell Host Microbe
Title:	Staphylococcus aureus Epicutaneous Exposure Drives Skin Inflammation via IL-36-Mediated T Cell Responses.
Volume:	22
Issue:	5
Pages:	653-666.e5

•

Publication

33798492 | J:332510

First Author:	Wang G
Year:	2021
Journal:	Cell Host Microbe
Title:	Bacteria induce skin regeneration via IL-1β signaling.
Volume:	29
Issue:	5
Pages:	777-791.e6

•

Publication

22387558 | J:183090

First Author:	Norton JT
Year:	2012
Journal:	J Immunol
Title:	Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1.
Volume:	188
Issue:	7
Pages:	2977-80

•

Publication

19501000 | J:150054

First Author:	Brydges SD
Year:	2009
Journal:	Immunity
Title:	Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.
Volume:	30
Issue:	6
Pages:	875-87

•

Protein

F8WH73

Organism:	Mus musculus/domesticus
Length:	167
Fragment?:	false

•

Publication

9221926 | J:41519

First Author:	Shearman LP
Year:	1997
Journal:	Brain Res Mol Brain Res
Title:	Haloperidol regulates neurotensin gene expression in striatum of c-fos-deficient mice.
Volume:	47
Issue:	1-2
Pages:	275-85

•

Publication

31127135 | J:278639

First Author:	Guma E
Year:	2019
Journal:	Sci Rep
Title:	Role of D3 dopamine receptors in modulating neuroanatomical changes in response to antipsychotic administration.
Volume:	9
Issue:	1
Pages:	7850

•

Publication

27702890 | J:238630

First Author:	Lin WH
Year:	2016
Journal:	Proc Natl Acad Sci U S A
Title:	Hypoxia-activated cytotoxic agent tirapazamine enhances hepatic artery ligation-induced killing of liver tumor in HBx transgenic mice.
Volume:	113
Issue:	42
Pages:	11937-11942

•

Publication

21245496 | J:171014

First Author:	Dugan CM
Year:	2011
Journal:	Toxicol Sci
Title:	Natural killer cells mediate severe liver injury in a murine model of halothane hepatitis.
Volume:	120
Issue:	2
Pages:	507-18

•

Publication

29704613 | J:307738

First Author:	Guma E
Year:	2018
Journal:	Neuroimage
Title:	Regional brain volume changes following chronic antipsychotic administration are mediated by the dopamine D2 receptor.
Volume:	176

Pages:	226-238

•

Publication

- | J:49722

First Author:	Moussa NM
Year:	1998
Journal:	M S Med Sci
Title:	The role of the Agouti protein in the yellow mouse obesity syndrome.
Volume:	14
Issue:	8-9
Pages:	898-906

•

Protein

Q99NH2

Organism:	Mus musculus/domesticus
Length:	1333
Fragment?:	false

•

Protein

Q9CSB4

Organism:	Mus musculus/domesticus
Length:	1203
Fragment?:	false

•

Protein

Q5SV55

Organism:	Mus musculus/domesticus
Length:	1141
Fragment?:	false

•

Protein

B7ZNY3

Organism:	Mus musculus/domesticus
Length:	1319
Fragment?:	false

•

Protein

A5D6P2

Organism:	Mus musculus/domesticus
Length:	1334
Fragment?:	false

•

Protein

G3XA13

Organism:	Mus musculus/domesticus
Length:	1333
Fragment?:	false

•

Protein

E0CXR8

Organism:	Mus musculus/domesticus
Length:	990
Fragment?:	true

•

Protein

Q8BPQ4

Organism:	Mus musculus/domesticus
Length:	741
Fragment?:	false

•

Protein

E9PYJ2

Organism:	Mus musculus/domesticus
Length:	741
Fragment?:	false

•

Protein

E0CX45

Organism:	Mus musculus/domesticus
Length:	943
Fragment?:	true

•

Protein

F6TSJ9

Organism:	Mus musculus/domesticus
Length:	984
Fragment?:	true

•

Protein

Q8BPQ6

Organism:	Mus musculus/domesticus
Length:	721
Fragment?:	false

•

Protein

F6S7Z1

Organism:	Mus musculus/domesticus
Length:	1324
Fragment?:	true

•

Protein

E0CY24

Organism:	Mus musculus/domesticus
Length:	1247
Fragment?:	false

•

Protein

E0CXL4

Organism:	Mus musculus/domesticus
Length:	1289
Fragment?:	false

•

Protein

F6UGU7

Organism:	Mus musculus/domesticus
Length:	919
Fragment?:	true

•

Protein

E0CZ83

Organism:	Mus musculus/domesticus
Length:	1094
Fragment?:	true

•

Protein

B2RUK1

Organism:	Mus musculus/domesticus
Length:	1304
Fragment?:	false

•

Protein

E0CZE2

Organism:	Mus musculus/domesticus
Length:	1024
Fragment?:	true

•

Protein

Q5SV54

Organism:	Mus musculus/domesticus
Length:	1104
Fragment?:	false

•

Publication

30937919 | J:346788

First Author:	Schwartz C
Year:	2019
Journal:	Allergy
Title:	Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL-1β.
Volume:	74
Issue:	10
Pages:	1920-1933

•

Publication

22297845 | J:181354

First Author:	Henao-Mejia J
Year:	2012
Journal:	Nature
Title:	Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Volume:	482
Issue:	7384
Pages:	179-85

•

Publication

- | J:38102

First Author:	Peters J
Year:	1996
Journal:	Mouse Genome
Title:	New Gene Symbols
Volume:	94
Issue:	4
Pages:	700-14

•

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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Search results 301 to 363 out of 363 for Hal

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