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Search results 101 to 176 out of 176 for Tbrg1

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:975038
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3589023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828617
Age: embryonic day 14.5
Image: euxassay_001972_12
Specimen Label: euxassay_001972_12
Detected: true
Specimen Num: 12
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:975038
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3589023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828617
Age: embryonic day 14.5
Image: euxassay_001972_13
Specimen Label: euxassay_001972_13
Detected: true
Specimen Num: 13
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:975038
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3589023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828617
Age: embryonic day 14.5
Image: euxassay_001972_14
Specimen Label: euxassay_001972_14
Detected: true
Specimen Num: 14
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:975038
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3589023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828617
Age: embryonic day 14.5
Image: euxassay_001972_15
Specimen Label: euxassay_001972_15
Detected: true
Specimen Num: 15
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:975038
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3589023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828617
Age: embryonic day 14.5
Image: euxassay_001972_16
Specimen Label: euxassay_001972_16
Detected: true
Specimen Num: 16
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•
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:975038
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1870623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828617
Age: embryonic day 14.5
Image: euxassay_001972_05
Specimen Label: euxassay_001972_05
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:975038
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1870623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828617
Age: embryonic day 14.5
Image: euxassay_001972_06
Specimen Label: euxassay_001972_06
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:975038
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1870623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828617
Age: embryonic day 14.5
Image: euxassay_001972_13
Specimen Label: euxassay_001972_13
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:975038
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1870623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828617
Age: embryonic day 14.5
Image: euxassay_001972_15
Specimen Label: euxassay_001972_15
Detected: true
Specimen Num: 15
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:975038
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1870623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828617
Age: embryonic day 14.5
Image: euxassay_001972_16
Specimen Label: euxassay_001972_16
Detected: true
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:975038
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828617
Age: embryonic day 14.5
Image: euxassay_001972_05
Specimen Label: euxassay_001972_05
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:975038
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828617
Age: embryonic day 14.5
Image: euxassay_001972_06
Specimen Label: euxassay_001972_06
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:975038
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828617
Age: embryonic day 14.5
Image: euxassay_001972_07
Specimen Label: euxassay_001972_07
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:975038
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828617
Age: embryonic day 14.5
Image: euxassay_001972_08
Specimen Label: euxassay_001972_08
Detected: true
Specimen Num: 8
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:975038
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828617
Age: embryonic day 14.5
Image: euxassay_001972_10
Specimen Label: euxassay_001972_10
Detected: true
Specimen Num: 10
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:975038
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828617
Age: embryonic day 14.5
Image: euxassay_001972_11
Specimen Label: euxassay_001972_11
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:975038
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828617
Age: embryonic day 14.5
Image: euxassay_001972_12
Specimen Label: euxassay_001972_12
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:975038
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4828617
Age: embryonic day 14.5
Image: euxassay_001972_13
Specimen Label: euxassay_001972_13
Detected: true
Specimen Num: 13
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Publication
28811661 | J:253581
First Author: Pardo M
Year: 2017
Journal: Sci Rep
Title: Myst2/Kat7 histone acetyltransferase interaction proteomics reveals tumour-suppressor Niam as a novel binding partner in embryonic stem cells.
Volume: 7
Issue: 1
Pages: 8157
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Publication
7654366 | J:26127
First Author: Babalola GO
Year: 1995
Journal: Mol Reprod Dev
Title: Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta.
Volume: 41
Issue: 2
Pages: 133-9
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Publication
27568566 | J:239017
First Author: Steinmetz CC
Year: 2016
Journal: Cell Rep
Title: Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway.
Volume: 16
Issue: 10
Pages: 2711-2722
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Publication
15031102 | J:92177
First Author: Powles N
Year: 2004
Journal: Dev Biol
Title: Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization.
Volume: 268
Issue: 1
Pages: 24-38
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein Domain
IPR003889 | FYrich_C
Type: Domain
Description: The "FY-rich"domain N-terminal (FYRN) and "FY-rich"domain C-terminal (FYRC) sequence motifs are two poorly characterised phenylalanine/tyrosine-rich regions of around 50 and 100 amino acids, respectively, that arefound in a variety of chromatin-associated proteins [, , , ]. They areparticularly common in histone H3K4 methyltransferases most notably in afamily of proteins that includes human mixed lineage leukemia (MLL) and theDrosophila melanogaster protein trithorax. Both of these enzymes play a keyrole in the epigenetic regulation of gene expression during development, andthe gene coding for MLL is frequently rearranged in infant and secondarytherapy-related acute leukemias. They are also found in transforming growthfactor beta regulator 1 (TBRG1), a growth inhibitory protein induced in cellsundergoing arrest in response to DNA damage and transforming growth factor(TGF)-beta1. As TBRG1 has been shown to bind to both the tumor suppressorp14ARF and MDM2, a key regulator of p53, it is also known as nuclearinteractor of ARF and MDM2 (NIAM). In most proteins, the FYRN and FYRC regionsare closely juxtaposed, however, in MLL and its homologues they are fardistant. To be fully active, MLL must be proteolytically processed bytaspase1, which cleaves the protein between the FYRN and FYRC regions []. TheN-terminal and C-terminal fragments remain associated after proteolysisapparently as a result of an interaction between the FYRN and FYRC regions.How proteolytic processing regulates the activity of MLL is not known.Intriguingly, the FYRN and FYRC motifs of a second family of histone H3K4methyltransferases, represented by MLL2 and MLL4 in humans and TRR inDrosophila melanogaster, are closely juxtaposed. FYRN and FYRC motifs arefound in association with modules that create or recognise histonemodifications in proteins from a wide range of eukaryotes, and it is likelythat in these proteins they have a conserved role related to some aspect ofchromatin biology [].The FYRN and FYRC regions are not separate independently folded domains, butare components of a distinct protein module, The FYRN and FYRC motifs bothform part of a single folded module (the FYR domain), which adopts an alpha+beta fold consisting of a six-stranded antiparallel β-sheet followed byfour consecutive α-helices. The FYRN region correspondsto β-strands 1-4 and their connecting loops, whereas the FYRC motif maps toβ-strand 5, β-strand 6 and helices alpha1 to alpha4. Most of theconserved tyrosine and phenylalanine residues, after which these motifs arenamed are involved in interactions that stabilise the fold. Proteins such asMLL, in which the FYRN and FYRC regions are separated by hundreds of aminoacids, are expected to contain FYR domains with a large insertion between twoof the strands of the β-sheet (strands 4 and 5) [].
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Protein Domain
IPR003888 | FYrich_N
Type: Domain
Description: The "FY-rich"domain N-terminal (FYRN) and "FY-rich"domain C-terminal (FYRC) sequence motifs are two poorly characterised phenylalanine/tyrosine-rich regions of around 50 and 100 amino acids, respectively, that arefound in a variety of chromatin-associated proteins [, , , ]. They areparticularly common in histone H3K4 methyltransferases most notably in afamily of proteins that includes human mixed lineage leukemia (MLL) and theDrosophila melanogaster protein trithorax. Both of these enzymes play a keyrole in the epigenetic regulation of gene expression during development, andthe gene coding for MLL is frequently rearranged in infant and secondarytherapy-related acute leukemias. They are also found in transforming growthfactor beta regulator 1 (TBRG1), a growth inhibitory protein induced in cellsundergoing arrest in response to DNA damage and transforming growth factor(TGF)-beta1. As TBRG1 has been shown to bind to both the tumor suppressorp14ARF and MDM2, a key regulator of p53, it is also known as nuclearinteractor of ARF and MDM2 (NIAM). In most proteins, the FYRN and FYRC regionsare closely juxtaposed, however, in MLL and its homologues they are fardistant. To be fully active, MLL must be proteolytically processed bytaspase1, which cleaves the protein between the FYRN and FYRC regions []. TheN-terminal and C-terminal fragments remain associated after proteolysisapparently as a result of an interaction between the FYRN and FYRC regions.How proteolytic processing regulates the activity of MLL is not known.Intriguingly, the FYRN and FYRC motifs of a second family of histone H3K4methyltransferases, represented by MLL2 and MLL4 in humans and TRR inDrosophila melanogaster, are closely juxtaposed. FYRN and FYRC motifs arefound in association with modules that create or recognise histonemodifications in proteins from a wide range of eukaryotes, and it is likelythat in these proteins they have a conserved role related to some aspect ofchromatin biology [].The FYRN and FYRC regions are not separate independently folded domains, butare components of a distinct protein module, The FYRN and FYRC motifs bothform part of a single folded module (the FYR domain), which adopts an alpha+beta fold consisting of a six-stranded antiparallel β-sheet followed byfour consecutive α-helices. The FYRN region correspondsto β-strands 1-4 and their connecting loops, whereas the FYRC motif maps toβ-strand 5, β-strand 6 and helices alpha1 to alpha4. Most of theconserved tyrosine and phenylalanine residues, after which these motifs arenamed are involved in interactions that stabilise the fold. Proteins such asMLL, in which the FYRN and FYRC regions are separated by hundreds of aminoacids, are expected to contain FYR domains with a large insertion between twoof the strands of the β-sheet (strands 4 and 5) [].
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Publication
20506279 | -
First Author: García-Alai MM
Year: 2010
Journal: Protein Sci
Title: The structure of the FYR domain of transforming growth factor beta regulator 1.
Volume: 19
Issue: 7
Pages: 1432-8
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Publication
9247308 | J:42245
First Author: Prasad R
Year: 1997
Journal: Oncogene
Title: Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax.
Volume: 15
Issue: 5
Pages: 549-60
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Publication
12482972 | -
First Author: Hsieh JJ
Year: 2003
Journal: Mol Cell Biol
Title: Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization.
Volume: 23
Issue: 1
Pages: 186-94
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Protein
Q3TPB7
Organism: Mus musculus/domesticus
Length: 342  
Fragment?: false
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Publication
10838566 | -
First Author: Balciunas D
Year: 2000
Journal: Trends Biochem Sci
Title: Evidence of domain swapping within the jumonji family of transcription factors.
Volume: 25
Issue: 6
Pages: 274-6
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Publication
11779830 | -
First Author: Doerks T
Year: 2002
Journal: Genome Res
Title: Systematic identification of novel protein domain families associated with nuclear functions.
Volume: 12
Issue: 1
Pages: 47-56
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Protein
Q3UWY2
Organism: Mus musculus/domesticus
Length: 865  
Fragment?: true
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Protein
G3UWZ3
Organism: Mus musculus/domesticus
Length: 1524  
Fragment?: true
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Protein
Q3TU00
Organism: Mus musculus/domesticus
Length: 563  
Fragment?: true
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Protein
G3UY45
Organism: Mus musculus/domesticus
Length: 1748  
Fragment?: true
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Protein
Q6ZPP4
Organism: Mus musculus/domesticus
Length: 1520  
Fragment?: true
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Protein
Q6P6H8
Organism: Mus musculus/domesticus
Length: 442  
Fragment?: true
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Protein
Q8CHH1
Organism: Mus musculus/domesticus
Length: 1744  
Fragment?: true
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Protein
P55200
Organism: Mus musculus/domesticus
Length: 3966  
Fragment?: false
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Protein
Q6PDK2
Organism: Mus musculus/domesticus
Length: 5588  
Fragment?: false
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Protein
Q8BRH4
Organism: Mus musculus/domesticus
Length: 4903  
Fragment?: false
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Protein
O08550
Organism: Mus musculus/domesticus
Length: 2713  
Fragment?: false
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Protein
F8WJ40
Organism: Mus musculus/domesticus
Length: 2721  
Fragment?: false
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Protein
A0A0A0MQ73
Organism: Mus musculus/domesticus
Length: 5588  
Fragment?: false
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Protein
Q6PHU4
Organism: Mus musculus/domesticus
Length: 2013  
Fragment?: true
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Protein
F8WI37
Organism: Mus musculus/domesticus
Length: 4904  
Fragment?: false
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Protein
F6W623
Organism: Mus musculus/domesticus
Length: 2014  
Fragment?: true
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Protein
Q5DTR3
Organism: Mus musculus/domesticus
Length: 762  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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