ADP-ribosylation factors (ARFs) function in diverse physiological and molecular activities []. This entry represents a group of GTPase-activating proteins (GAPs) for the ADP ribosylation factors (ARFs). This entry includes ACAP1-3 from animals, Age1 from budding yeasts []and AGD1-4 from plants. ACAP1 and ACAP2 are Arf6 GTPase-activating proteins that function coordinately in the cell periphery []. AGD1 is necessary for straight root hair growth in Arabidopsis [].
This entry represents the BAR domain found in ACAP3. BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions [].ACAP3 (ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 3) is predicted to be an Arf GTPase activating protein (GAP) based on its similarity to the Arf6-specific GAPs ACAP1 and ACAP2 []. The specific function of ACAP3 is still unknown. ACAP3 contains an N-terminal BAR domain, followed by a Pleckstrin homology (PH) domain, an Arf GAP domain, and C-terminal ankyrin (ANK) repeats.