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Search results 101 to 200 out of 689 for Gata3

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Category: Publication
Type Details Score
Publication
First Author: Wei G
Year: 2011
Journal: Immunity
Title: Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types.
Volume: 35
Issue: 2
Pages: 299-311
Publication
First Author: Kohu K
Year: 2009
Journal: J Immunol
Title: The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3.
Volume: 183
Issue: 12
Pages: 7817-24
Publication
First Author: Hwang SS
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Transcription factor YY1 is essential for regulation of the Th2 cytokine locus and for Th2 cell differentiation.
Volume: 110
Issue: 1
Pages: 276-81
Publication
First Author: Yu Q
Year: 2009
Journal: Nat Immunol
Title: T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma.
Volume: 10
Issue: 9
Pages: 992-9
Publication
First Author: Li Y
Year: 2018
Journal: J Immunol
Title: Helminth-Induced Production of TGF-β and Suppression of Graft-versus-Host Disease Is Dependent on IL-4 Production by Host Cells.
Volume: 201
Issue: 10
Pages: 2910-2922
Publication
First Author: Horiuchi S
Year: 2011
Journal: J Immunol
Title: Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3.
Volume: 186
Issue: 11
Pages: 6378-89
Publication
First Author: Nozawa D
Year: 2009
Journal: Genes Cells
Title: GATA2-dependent and region-specific regulation of Gata2 transcription in the mouse midbrain.
Volume: 14
Issue: 5
Pages: 569-82
Publication
First Author: Xiao L
Year: 2016
Journal: Oncotarget
Title: The essential role of GATA transcription factors in adult murine prostate.
Volume: 7
Issue: 30
Pages: 47891-47903
Publication
First Author: Airik R
Year: 2005
Journal: Life Sci
Title: Gene expression analysis of Gata3-/- mice by using cDNA microarray technology.
Volume: 76
Issue: 22
Pages: 2559-68
Publication
First Author: Panayiotou E
Year: 2013
Journal: Gene Expr Patterns
Title: Pax6 is expressed in subsets of V0 and V2 interneurons in the ventral spinal cord in mice.
Volume: 13
Issue: 8
Pages: 328-34
Publication
First Author: Faas M
Year: 2021
Journal: Immunity
Title: IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation.
Volume: 54
Issue: 11
Pages: 2531-2546.e5
Publication
First Author: Maurice D
Year: 2007
Journal: EMBO J
Title: c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3.
Volume: 26
Issue: 15
Pages: 3629-40
Publication    
First Author: Tremblay M
Year: 2020
Journal: Elife
Title: Regulation of stem/progenitor cell maintenance by BMP5 in prostate homeostasis and cancer initiation.
Volume: 9
Publication
First Author: Ding Z
Year: 2022
Journal: Nat Commun
Title: Setd2 supports GATA3(+)ST2(+) thymic-derived Treg cells and suppresses intestinal inflammation.
Volume: 13
Issue: 1
Pages: 7468
Publication
First Author: Tenney AP
Year: 2023
Journal: Nat Genet
Title: Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis.
Volume: 55
Issue: 7
Pages: 1149-1163
Publication
First Author: Haugas M
Year: 2012
Journal: Hear Res
Title: Defects in sensory organ morphogenesis and generation of cochlear hair cells in Gata3-deficient mouse embryos.
Volume: 283
Issue: 1-2
Pages: 151-61
Publication
First Author: Duncan JS
Year: 2011
Journal: Int J Dev Biol
Title: Limited inner ear morphogenesis and neurosensory development are possible in the absence of GATA3.
Volume: 55
Issue: 3
Pages: 297-303
Publication  
First Author: Ramirez F
Year: 2013
Journal: BMC Genet
Title: The juvenile alopecia mutation (jal) maps to mouse Chromosome 2, and is an allele of GATA binding protein 3 (Gata3).
Volume: 14
Pages: 40
Publication
First Author: Walters BJ
Year: 2017
Journal: Cell Rep
Title: In Vivo Interplay between p27Kip1, GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice.
Volume: 19
Issue: 2
Pages: 307-320
Publication
First Author: Wang L
Year: 2008
Journal: Nat Immunol
Title: Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells.
Volume: 9
Issue: 10
Pages: 1122-30
Publication
First Author: Hosokawa H
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.
Volume: 110
Issue: 46
Pages: 18626-31
Publication
First Author: Braunstein M
Year: 2011
Journal: Mol Cell Biol
Title: HEB-deficient T-cell precursors lose T-cell potential and adopt an alternative pathway of differentiation.
Volume: 31
Issue: 5
Pages: 971-82
Publication
First Author: Home P
Year: 2017
Journal: Development
Title: Genetic redundancy of GATA factors in the extraembryonic trophoblast lineage ensures the progression of preimplantation and postimplantation mammalian development.
Volume: 144
Issue: 5
Pages: 876-888
Publication
First Author: Mantel PY
Year: 2007
Journal: PLoS Biol
Title: GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells.
Volume: 5
Issue: 12
Pages: e329
Publication
First Author: Pannu J
Year: 2015
Journal: PLoS One
Title: Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation.
Volume: 10
Issue: 2
Pages: e0117304
Publication
First Author: Mohri Y
Year: 2011
Journal: Dev Dyn
Title: Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3.
Volume: 240
Issue: 6
Pages: 1626-34
Publication  
First Author: Yu WM
Year: 2013
Journal: Elife
Title: A Gata3-Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing.
Volume: 2
Pages: e01341
Publication
First Author: Li X
Year: 2009
Journal: Dev Dyn
Title: Dynamic patterning at the pylorus: formation of an epithelial intestine-stomach boundary in late fetal life.
Volume: 238
Issue: 12
Pages: 3205-17
Publication
First Author: Yang M
Year: 2018
Journal: J Am Coll Cardiol
Title: Deficiency of GATA3-Positive Macrophages Improves Cardiac Function Following Myocardial Infarction or Pressure Overload Hypertrophy.
Volume: 72
Issue: 8
Pages: 885-904
Publication
First Author: Maeda A
Year: 2009
Journal: Dev Dyn
Title: Transcription factor GATA-3 is essential for lens development.
Volume: 238
Issue: 9
Pages: 2280-91
Publication  
First Author: Li Y
Year: 2014
Journal: BMC Biol
Title: LIM homeodomain transcription factor Isl1 directs normal pyloric development by targeting Gata3.
Volume: 12
Pages: 25
Publication
First Author: Wani MA
Year: 1998
Journal: Transgenic Res
Title: Loss of LKLF function results in embryonic lethality in mice.
Volume: 7
Issue: 4
Pages: 229-38
Publication
First Author: Nakahira M
Year: 2011
Journal: Int Immunol
Title: Requirement of GATA-binding protein 3 for II13 gene expression in IL-18-stimulated Th1 cells.
Volume: 23
Issue: 12
Pages: 761-72
Publication
First Author: Del Real MM
Year: 2013
Journal: Development
Title: Architecture of a lymphomyeloid developmental switch controlled by PU.1, Notch and Gata3.
Volume: 140
Issue: 6
Pages: 1207-19
Publication
First Author: Ptaschinski C
Year: 2017
Journal: J Immunol
Title: Hox5 Paralogous Genes Modulate Th2 Cell Function during Chronic Allergic Inflammation via Regulation of Gata3.
Volume: 199
Issue: 2
Pages: 501-509
Publication
First Author: van Hamburg JP
Year: 2008
Journal: Mol Immunol
Title: Cooperation of Gata3, c-Myc and Notch in malignant transformation of double positive thymocytes.
Volume: 45
Issue: 11
Pages: 3085-95
Publication
First Author: Bernardo GM
Year: 2010
Journal: Development
Title: FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis.
Volume: 137
Issue: 12
Pages: 2045-54
Publication
First Author: Grigorieva IV
Year: 2010
Journal: J Clin Invest
Title: Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2.
Volume: 120
Issue: 6
Pages: 2144-55
Publication
First Author: Zou MR
Year: 2014
Journal: J Biol Chem
Title: Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes.
Volume: 289
Issue: 25
Pages: 17620-33
Publication
First Author: Kurek D
Year: 2007
Journal: Development
Title: Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles.
Volume: 134
Issue: 2
Pages: 261-72
Publication
First Author: Lahti L
Year: 2016
Journal: Development
Title: Differentiation and molecular heterogeneity of inhibitory and excitatory neurons associated with midbrain dopaminergic nuclei.
Volume: 143
Issue: 3
Pages: 516-29
Publication
First Author: Jarick KJ
Year: 2022
Journal: Nature
Title: Non-redundant functions of group 2 innate lymphoid cells.
Volume: 611
Issue: 7937
Pages: 794-800
Publication
First Author: Kiwamoto T
Year: 2006
Journal: Am J Respir Crit Care Med
Title: Transcription factors T-bet and GATA-3 regulate development of airway remodeling.
Volume: 174
Issue: 2
Pages: 142-51
Publication
First Author: Chia I
Year: 2011
Journal: Development
Title: Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice.
Volume: 138
Issue: 10
Pages: 2089-97
Publication
First Author: Potvin E
Year: 2010
Journal: Mol Cell Biol
Title: Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3.
Volume: 30
Issue: 22
Pages: 5348-63
Publication
First Author: Lee DU
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3.
Volume: 101
Issue: 45
Pages: 16010-5
Publication
First Author: Yang Y
Year: 2011
Journal: J Clin Invest
Title: The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice.
Volume: 121
Issue: 4
Pages: 1373-85
Publication
First Author: Craven SE
Year: 2004
Journal: Development
Title: Gata2 specifies serotonergic neurons downstream of sonic hedgehog.
Volume: 131
Issue: 5
Pages: 1165-73
Publication
First Author: Farooqui-Kabir SR
Year: 2008
Journal: Cell Stress Chaperones
Title: Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression.
Volume: 13
Issue: 3
Pages: 297-312
Publication  
First Author: Jiao WE
Year: 2022
Journal: Int Immunopharmacol
Title: Notch2-dependent GATA3+ Treg cells alleviate allergic rhinitis by suppressing the Th2 cell response.
Volume: 112
Pages: 109261
Publication
First Author: Nishimura K
Year: 2017
Journal: PLoS One
Title: Dynamic Expression of Sox2, Gata3, and Prox1 during Primary Auditory Neuron Development in the Mammalian Cochlea.
Volume: 12
Issue: 1
Pages: e0170568
Publication
First Author: Saha B
Year: 2013
Journal: Mol Cell Biol
Title: EED and KDM6B coordinate the first mammalian cell lineage commitment to ensure embryo implantation.
Volume: 33
Issue: 14
Pages: 2691-705
Publication
First Author: Tsarovina K
Year: 2004
Journal: Development
Title: Essential role of Gata transcription factors in sympathetic neuron development.
Volume: 131
Issue: 19
Pages: 4775-86
Publication
First Author: Hosoya T
Year: 2009
Journal: J Exp Med
Title: GATA-3 is required for early T lineage progenitor development.
Volume: 206
Issue: 13
Pages: 2987-3000
Publication
First Author: Ogasawara T
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Development of chronic allergic responses by dampening Bcl6-mediated suppressor activity in memory T helper 2 cells.
Volume: 114
Issue: 5
Pages: E741-E750
Publication
First Author: Ono Y
Year: 1998
Journal: Mol Cell Biol
Title: TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3.
Volume: 18
Issue: 12
Pages: 6939-50
Publication
First Author: Wildner H
Year: 2008
Journal: Development
Title: Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage.
Volume: 135
Issue: 3
Pages: 473-81
Publication
First Author: Achim K
Year: 2012
Journal: Development
Title: Distinct developmental origins and regulatory mechanisms for GABAergic neurons associated with dopaminergic nuclei in the ventral mesodiencephalic region.
Volume: 139
Issue: 13
Pages: 2360-70
Publication
First Author: Martynova E
Year: 2019
Journal: Open Biol
Title: Transcriptomic analysis and novel insights into lens fibre cell differentiation regulated by Gata3.
Volume: 9
Issue: 12
Pages: 190220
Publication
First Author: Panayi H
Year: 2010
Journal: J Neurosci
Title: Sox1 is required for the specification of a novel p2-derived interneuron subtype in the mouse ventral spinal cord.
Volume: 30
Issue: 37
Pages: 12274-80
Publication
First Author: Udager AM
Year: 2014
Journal: Gastroenterology
Title: Proper development of the outer longitudinal smooth muscle of the mouse pylorus requires Nkx2-5 and Gata3.
Volume: 146
Issue: 1
Pages: 157-165.e10
Publication
First Author: Weiss AC
Year: 2014
Journal: Development
Title: Nephric duct insertion requires EphA4/EphA7 signaling from the pericloacal mesenchyme.
Volume: 141
Issue: 17
Pages: 3420-30
Publication
First Author: Tikker L
Year: 2020
Journal: J Neurosci
Title: Inactivation of the GATA Cofactor ZFPM1 Results in Abnormal Development of Dorsal Raphe Serotonergic Neuron Subtypes and Increased Anxiety-Like Behavior.
Volume: 40
Issue: 45
Pages: 8669-8682
Publication
First Author: Huber K
Year: 2013
Journal: Dev Biol
Title: The LIM-Homeodomain transcription factor Islet-1 is required for the development of sympathetic neurons and adrenal chromaffin cells.
Volume: 380
Issue: 2
Pages: 286-98
Publication
First Author: Ko LJ
Year: 1991
Journal: Mol Cell Biol
Title: Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer.
Volume: 11
Issue: 5
Pages: 2778-84
Publication
First Author: Hwang ES
Year: 2002
Journal: J Immunol
Title: Transcriptional regulation of GATA-3 by an intronic regulatory region and fetal liver zinc finger protein 1.
Volume: 169
Issue: 1
Pages: 248-53
Publication
First Author: Blanchard AD
Year: 2000
Journal: Eur J Immunol
Title: Identification and characterization of SKAT-2, a novel Th2-specific zinc finger gene.
Volume: 30
Issue: 11
Pages: 3100-10
Publication
First Author: Pai SY
Year: 2008
Journal: J Immunol
Title: Distinct structural requirements of GATA-3 for the regulation of thymocyte and Th2 cell differentiation.
Volume: 180
Issue: 2
Pages: 1050-9
Publication
First Author: Wang Y
Year: 2013
Journal: Nat Immunol
Title: GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling.
Volume: 14
Issue: 7
Pages: 714-22
Publication
First Author: Pai SY
Year: 2003
Journal: Immunity
Title: Critical roles for transcription factor GATA-3 in thymocyte development.
Volume: 19
Issue: 6
Pages: 863-75
Publication
First Author: Kouros-Mehr H
Year: 2008
Journal: Cancer Cell
Title: GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model.
Volume: 13
Issue: 2
Pages: 141-52
Publication
First Author: Taghon T
Year: 2007
Journal: Nat Immunol
Title: Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3.
Volume: 8
Issue: 8
Pages: 845-55
Publication
First Author: Karis A
Year: 2001
Journal: J Comp Neurol
Title: Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear.
Volume: 429
Issue: 4
Pages: 615-30
Publication
First Author: Hendriks RW
Year: 1999
Journal: Eur J Immunol
Title: Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus.
Volume: 29
Issue: 6
Pages: 1912-8
Publication
First Author: van Doorninck JH
Year: 1999
Journal: J Neurosci
Title: GATA-3 is involved in the development of serotonergic neurons in the caudal raphe nuclei.
Volume: 19
Issue: 12
Pages: RC12
Publication
First Author: Ting CN
Year: 1996
Journal: Nature
Title: Transcription factor GATA-3 is required for development of the T-cell lineage.
Volume: 384
Issue: 6608
Pages: 474-8
Publication
First Author: Tai TS
Year: 2013
Journal: J Immunol
Title: GATA-3 regulates the homeostasis and activation of CD8+ T cells.
Volume: 190
Issue: 1
Pages: 428-37
Publication
First Author: Pai SY
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells.
Volume: 101
Issue: 7
Pages: 1993-8
Publication
First Author: Asnagli H
Year: 2002
Journal: J Immunol
Title: Cutting edge: Identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human.
Volume: 168
Issue: 9
Pages: 4268-71
Publication
First Author: McElwee KJ
Year: 1999
Journal: Exp Dermatol
Title: Alopecia areata versus juvenile alopecia in C3H/HeJ mice: tools to dissect the role of inflammation in focal alopecia.
Volume: 8
Issue: 4
Pages: 354-5
Publication    
First Author: Rourk MH
Year: 1996
Journal: Annual Meeting for Investigative Dermatology
Title: Juvenile alopecia (jal): A new mouse mutation with curly hair and focal alopecia on Chromosome 13
Pages: Abstr # 489
Publication
First Author: Zhang DH
Year: 1999
Journal: Immunity
Title: Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3.
Volume: 11
Issue: 4
Pages: 473-82
Publication
First Author: George KM
Year: 1994
Journal: Development
Title: Embryonic expression and cloning of the murine GATA-3 gene.
Volume: 120
Issue: 9
Pages: 2673-86
Publication
First Author: Bull RJ
Year: 2002
Journal: Toxicol Appl Pharmacol
Title: Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene.
Volume: 182
Issue: 1
Pages: 55-65
Publication
First Author: Nawijn MC
Year: 2001
Journal: J Immunol
Title: Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice.
Volume: 167
Issue: 2
Pages: 715-23
Publication
First Author: Nawijn MC
Year: 2001
Journal: J Immunol
Title: Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo.
Volume: 167
Issue: 2
Pages: 724-32
Publication
First Author: Tamauchi H
Year: 2012
Journal: Immunobiology
Title: GATA-3 regulates contact hyperresponsiveness in a murine model of allergic dermatitis.
Volume: 217
Issue: 4
Pages: 446-54
Publication
First Author: Tai TS
Year: 2014
Journal: PLoS One
Title: Itm2a, a target gene of GATA-3, plays a minimal role in regulating the development and function of T cells.
Volume: 9
Issue: 5
Pages: e96535
Publication
First Author: Cui K
Year: 2023
Journal: Immunity
Title: Restraint of IFN-γ expression through a distal silencer CNS-28 for tissue homeostasis.
Volume: 56
Issue: 5
Pages: 944-958.e6
Publication
First Author: Zhong C
Year: 2016
Journal: Nat Immunol
Title: Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment.
Volume: 17
Issue: 2
Pages: 169-78
Publication
First Author: Thompson PK
Year: 2022
Journal: J Immunol
Title: Realization of the T Lineage Program Involves GATA-3 Induction of Bcl11b and Repression of Cdkn2b Expression.
Volume: 209
Issue: 1
Pages: 77-92
Publication
First Author: Asselin-Labat ML
Year: 2011
Journal: Mol Cell Biol
Title: Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14.
Volume: 31
Issue: 22
Pages: 4609-22
Publication  
First Author: Di Bonito M
Year: 2015
Journal: eNeuro
Title: Loss of Projections, Functional Compensation, and Residual Deficits in the Mammalian Vestibulospinal System of Hoxb1-Deficient Mice.
Volume: 2
Issue: 6
Publication
First Author: Betterman KL
Year: 2012
Journal: Am J Pathol
Title: Remodeling of the lymphatic vasculature during mouse mammary gland morphogenesis is mediated via epithelial-derived lymphangiogenic stimuli.
Volume: 181
Issue: 6
Pages: 2225-38
Publication
First Author: Kobayashi-Osaki M
Year: 2005
Journal: Mol Cell Biol
Title: GATA motifs regulate early hematopoietic lineage-specific expression of the Gata2 gene.
Volume: 25
Issue: 16
Pages: 7005-20
Publication
First Author: Caballero MT
Year: 2015
Journal: J Clin Invest
Title: TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization.
Volume: 125
Issue: 2
Pages: 571-82
Publication
First Author: Cook KD
Year: 2010
Journal: J Immunol
Title: TCR-dependent translational control of GATA-3 enhances Th2 differentiation.
Volume: 185
Issue: 6
Pages: 3209-16
Publication
First Author: Garcia-Frigola C
Year: 2003
Journal: Gene Expr Patterns
Title: Expression of the hyperpolarization-activated cyclic nucleotide-gated cation channel HCN4 during mouse heart development.
Volume: 3
Issue: 6
Pages: 777-83
Publication
First Author: Usui T
Year: 2006
Journal: J Exp Med
Title: T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription.
Volume: 203
Issue: 3
Pages: 755-66
Publication
First Author: Arceci RJ
Year: 1993
Journal: Mol Cell Biol
Title: Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart.
Volume: 13
Issue: 4
Pages: 2235-46