Intracellular chloride ion channel proteins (CLICs) has been shown to exist in both soluble and integral membrane forms. The CLIC family consists of six human members, and is a subgroup of the glutathione-S-transferase (GSTs) superfamily. Chloride intracellular channel protein 3 (CLIC3) was identified as a potential binding partner of a mitogen-activated protein kinase, suggesting that it may participate in cellular growth control [], but its role to date is unclear. The soluble form of CLIC3 possesses a GST-like form with a more open and polar active site than that of other CLIC proteins [].
