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Search results 301 to 372 out of 372 for Vps35

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Type Details Score
Allele
Vps35l<Gt(OST137942)Lex> | MGI:4200737
 
Name: VPS35 endosomal protein sorting factor like; gene trap OST137942, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Vps35l<Gt(OST432522)Lex> | MGI:4315220
 
Name: VPS35 endosomal protein sorting factor like; gene trap OST432522, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Vps35l<Gt(EUCE00107e02)Hmgu> | MGI:4369830
 
Name: VPS35 endosomal protein sorting factor like; gene trap EUCE00107e02, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Vps35l<Gt(AK0502)Wtsi> | MGI:3876942
 
Name: VPS35 endosomal protein sorting factor like; gene trap AK0502, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Vps35l<Gt(AM0256)Wtsi> | MGI:4346317
 
Name: VPS35 endosomal protein sorting factor like; gene trap AM0256, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Vps35<tm1a(EUCOMM)Hmgu> | MGI:5296180
Name: VPS35 retromer complex component; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Strain
MGI:4839786 | B6;129P2-Vps35<Gt(RRK261)Byg>/Mmucd
Attribute String: gene trap, mutant stock
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Strain
MGI:5306888 | B6.129P2-Vps35<Gt(RRK261)Byg>
Attribute String: congenic, mutant strain, gene trap
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Allele
Vps35<Gt(AQ0265)Wtsi> | MGI:4345645
 
Name: VPS35 retromer complex component; gene trap AQ0265, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Vps35<tm1e(EUCOMM)Hmgu> | MGI:5296150
Name: VPS35 retromer complex component; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Strain
MGI:6866844 | C57BL/6NTac-Vps35<em1(IMPC)H>/Mmucd
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6335777 | C57BL/6NTac-Vps35<em1(IMPC)H>/H
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6408081 | C57BL/6N-Vps35<em1(IMPC)H>/H
Attribute String: coisogenic, targeted mutation
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Allele
Vps35<Gt(E219F03)Wrst> | MGI:3919088
 
Name: VPS35 retromer complex component; gene trap E219F03, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Vps35<tm1c(EUCOMM)Hmgu> | MGI:6197919
Name: VPS35 retromer complex component; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Vps35<Gt(AL0099)Wtsi> | MGI:4345471
 
Name: VPS35 retromer complex component; gene trap AL0099, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Vps35<tm1.2Mjff> | MGI:5466855
Name: VPS35 retromer complex component; targeted mutation 1.2,The Michael J Fox Foundation
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Vps35/Vps35
Background: B6.129P2-Vps35
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Vps35/Vps35
Background: C57BL/6N-Vps35/H
Zygosity: hm
Has Mutant Allele: true
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Publication
24819384 | -
 
First Author: Zavodszky E
Year: 2014
Journal: Nat Commun
Title: Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy.
Volume: 5
Pages: 3828
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Allele
Gt(ROSA)26Sor<tm1(CAG-VPS35*D620N)Lze> | MGI:6718577
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Li Zeng
Allele Type: Targeted
Attribute String: Conditional ready, Epitope tag, Humanized sequence, Inserted expressed sequence
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Allele
Vps35l<Gt(IST14224C10)Tigm> | MGI:5211097
 
Name: VPS35 endosomal protein sorting factor like; gene trap IST14224C10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Strain
MGI:5607778 | B6.Cg-Vps35<tm1.1Mjff>/J
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:7378803 | B6.Cg-Vps35<tm1.1Mjff>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5526108 | B6.Cg-Vps35<tm1.2Mjff>/J
Attribute String: congenic, targeted mutation, mutant strain
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Genotype
Genotype
Symbol: Vps35/Vps35 Tg(Vil1-cre/ERT2)23Syr/?
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Vps35l/Vps35l
Background: involves: C57BL/6N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Vps35l/Vps35l
Background: involves: C57BL/6N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Vps35/Vps35
Background: B6.Cg-Vps35
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Vps35/Vps35<+>
Background: C57BL/6N-Vps35/H
Zygosity: ht
Has Mutant Allele: true
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Protein Domain
IPR042491 | Vps35_C
Type: Homologous_superfamily
Description: This superfamily represents the α-helical C-terminal domain found in vacuolar protein sorting-associated protein 35 (Vps35) from eukaryotes.Vps35 is a core component of the retromer complex which functions in the endosome-to-Golgi retrieval cargo transport pathway [, ]. Vps35 is part of the a cargo-selective complex trimer (CSC) of the retromer, which is composed of Vps26, Vps29 and Vps35 and is responsible for binding to and sorting protein cargo []. Mutations in the Vps35 gene have been linked to Parkinson's disease []. Structurally, VPS35 forms a horseshoe-shaped, right-handed, α-helical solenoid [].
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Publication
9105038 | -
First Author: Seaman MN
Year: 1997
Journal: J Cell Biol
Title: Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products.
Volume: 137
Issue: 1
Pages: 79-92
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Genotype
Genotype
Symbol: Vps35/Vps35<+> Tg(APPSWE)2576Kha/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Vps35/Vps35<+>
Background: involves: C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Vps35/Vps35<+>
Background: B6.Cg-Vps35
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cx3cr1/Cx3cr1<+> Vps35/Vps35
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
24440570 | J:259423
 
First Author: Morabito MV
Year: 2014
Journal: Neurobiol Dis
Title: Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease.
Volume: 65
Pages: 188-92
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Publication
32737286 | J:303339
First Author: Muzio L
Year: 2020
Journal: Nat Commun
Title: Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis.
Volume: 11
Issue: 1
Pages: 3848
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Publication
11062004 | J:65471
First Author: Edgar AJ
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Human homologues of yeast vacuolar protein sorting 29 and 35.
Volume: 277
Issue: 3
Pages: 622-30
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Publication
31694921 | J:282176
First Author: Curnock R
Year: 2019
Journal: J Cell Biol
Title: TFEB controls retromer expression in response to nutrient availability.
Volume: 218
Issue: 12
Pages: 3954-3966
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Protein
E9PXS9
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: false
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Publication
12194858 | -
First Author: Babst M
Year: 2002
Journal: Dev Cell
Title: Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body.
Volume: 3
Issue: 2
Pages: 283-9
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Publication
15469844 | -
First Author: Teo H
Year: 2004
Journal: Dev Cell
Title: ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes.
Volume: 7
Issue: 4
Pages: 559-69
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Publication
15579210 | -
First Author: Wernimont AK
Year: 2004
Journal: BMC Struct Biol
Title: Crystal structure of subunit VPS25 of the endosomal trafficking complex ESCRT-II.
Volume: 4
Issue: 1
Pages: 10
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Protein Domain
IPR014041 | ESCRT-II_cplx_Vps25-sub_N
Type: Homologous_superfamily
Description: This superfamily represents the N-terminal winged helix domain of the vps25 subunit (vacuolar protein sorting-associated protein 25) of the endosome-associated complex ESCRT-II (Endosomal Sorting Complexes Required for Transport protein II). ESCRT (ESCRT-I, -II, -III) complexes orchestrate efficient sorting of ubiquitinated transmembrane receptors to lysosomes via multivesicular bodies (MVBs) []. ESCRT-II recruits the transport machinery for protein sorting at MVB []. In addition, the human ESCRT-II has been shown to form a complex with RNA polymerase II elongation factor ELL in order to exert transcriptional control activity. ESCRT-II transiently associates with the endosomal membrane and thereby initiates the formation of ESCRT-III, a membrane-associated protein complex that functions immediately downstream of ESCRT-II during sorting of MVB cargo. ESCRT-II in turn functions downstream of ESCRT-I, a protein complex that binds to ubiquitinated endosomal cargo [].ESCRT-II is a trilobal complex composed of two copies of vps25, one copy of vps22 and the C-terminal region of vps36. The crystal structure of vps25 revealed two winged-helix domains, the N-terminal domain of vps25 interacting with vps22 and vps35 [].
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Protein Domain
IPR008570 | ESCRT-II_cplx_Vps25-sub
Type: Family
Description: This entry represents the Vps25 subunit (vacuolar protein sorting-associated protein 25) of the endosome-associated complex ESCRT-II (Endosomal Sorting Complexes Required for Transport protein II). ESCRT (ESCRT-I, -II, -III) complexes orchestrate efficient sorting of ubiquitinated transmembrane receptors to lysosomes via multivesicular bodies (MVBs) []. ESCRT-II recruits the transport machinery for protein sorting at MVB []. In addition, the human ESCRT-II has been shown to form a complex with RNA polymerase II elongation factor ELL in order to exert transcriptional control activity. ESCRT-II transiently associates with the endosomal membrane and thereby initiates the formation of ESCRT-III, a membrane-associated protein complex that functions immediately downstream of ESCRT-II during sorting of MVB cargo. ESCRT-II in turn functions downstream of ESCRT-I, a protein complex that binds to ubiquitinated endosomal cargo [].ESCRT-II is a trilobal complex composed of two copies of vps25, one copy of vps22 and the C-terminal region of vps36. The crystal structure of vps25 revealed two winged-helix domains, the N-terminal domain of vps25 interacting with vps22 and vps35 [].
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Protein
Q9CQ80
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: false
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Protein
A2A4K0
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Protein
A2A4J8
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
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Protein
A8XY17
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Publication
20881129 | J:164876
First Author: Lane RF
Year: 2010
Journal: J Neurosci
Title: Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.
Volume: 30
Issue: 39
Pages: 13110-5
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Publication
30733594 | J:311353
First Author: Li JG
Year: 2020
Journal: Mol Psychiatry
Title: Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35.
Volume: 25
Issue: 10
Pages: 2630-2640
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Publication
25190809 | J:311816
First Author: Kang Y
Year: 2014
Journal: J Biol Chem
Title: A combined transgenic proteomic analysis and regulated trafficking of neuroligin-2.
Volume: 289
Issue: 42
Pages: 29350-64
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Publication
35776681 | J:327105
 
First Author: Lara Ordóñez AJ
Year: 2022
Journal: Biol Open
Title: The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization.
Volume: 11
Issue: 8
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Publication
37900275 | J:342260
 
First Author: Meindl K
Year: 2023
Journal: Front Cell Dev Biol
Title: A missense mutation in Ehd1 associated with defective spermatogenesis and male infertility.
Volume: 11
Pages: 1240558
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Publication
23331060 | J:219175
First Author: Helfer E
Year: 2013
Journal: Biol Cell
Title: Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer.
Volume: 105
Issue: 5
Pages: 191-207
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Publication
17215868 | -
First Author: Gill DJ
Year: 2007
Journal: EMBO J
Title: Structural insight into the ESCRT-I/-II link and its role in MVB trafficking.
Volume: 26
Issue: 2
Pages: 600-12
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Publication
28847807 | J:252862
First Author: Wu S
Year: 2017
Journal: J Neurosci
Title: The Dopamine Transporter Recycles via a Retromer-Dependent Postendocytic Mechanism: Tracking Studies Using a Novel Fluorophore-Coupling Approach.
Volume: 37
Issue: 39
Pages: 9438-9452
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
11042159 | J:68323
First Author: Carninci P
Year: 2000
Journal: Genome Res
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume: 10
Issue: 10
Pages: 1617-30
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Publication
10349636 | J:80645
 
First Author: Carninci P
Year: 1999
Journal: Methods Enzymol
Title: High-efficiency full-length cDNA cloning.
Volume: 303
Pages: 19-44
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Publication
11076861 | J:68324
First Author: Shibata K
Year: 2000
Journal: Genome Res
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume: 10
Issue: 11
Pages: 1757-71
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Publication
16141073 | -
First Author: Katayama S
Year: 2005
Journal: Science
Title: Antisense transcription in the mammalian transcriptome.
Volume: 309
Issue: 5740
Pages: 1564-6
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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