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Search results 201 to 228 out of 228 for Iqsec1

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Type Details Score
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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DO Term
DOID:0111674 | intellectual developmental disorder with short stature and behavioral abnormalities
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Allele
Tg(Aldh1l1-RHO/ADRA1,-lacZ)B36-3Mik | MGI:6361524
Name: transgene insertion B36-3, M I Kotlikoff
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:6361527 | B6.Cg-Tg(Aldh1l1-RHO/ADRA1,-lacZ)B36-3Mik/J
Attribute String: transgenic, mutant strain, congenic
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Publication
21686261 | -
First Author: Shoubridge C
Year: 2010
Journal: Small GTPases
Title: Subtle functional defects in the Arf-specific guanine nucleotide exchange factor IQSEC2 cause non-syndromic X-linked intellectual disability.
Volume: 1
Issue: 2
Pages: 98-103
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Publication
21198641 | J:170549
First Author: Fukaya M
Year: 2011
Journal: J Neurochem
Title: SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post-synaptic specializations of inhibitory synapses.
Volume: 116
Issue: 6
Pages: 1122-37
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Publication
24058294 | -
First Author: Aizel K
Year: 2013
Journal: PLoS Biol
Title: Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2.
Volume: 11
Issue: 9
Pages: e1001652
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Protein Domain
IPR033742 | IQSEC_PH
Type: Domain
Description: The IQSEC (IQ motif and SEC7 domain-containing protein), also called BRAG (Brefeldin A-resistant Arf-gunanine nucleotide exchange factor) family are a subset of Arf GEFs that have been shown to activate Arf6, which acts in the endocytic pathway to control the trafficking of a subset of cargo proteins including integrins. IQSEC family also have key roles in the function and organization of distinct excitatory and inhibitory synapses in the retina [, ]. The family consists of 3 members: IQSEC1 (also called BRAG2/GEP100), IQSEC2 (also called BRAG1), and IQSEC3 (also called SynArfGEF, BRAG3, or KIAA1110). IQSEC1 interacts with clathrin and modulates cell adhesion by regulating integrin surface expression and in addition to Arf6, it also activates the class II Arfs, Arf4 and Arf5 []. Mutations in IQSEC2 cause non-syndromic X-linked intellectual disability as well as reduced activation of Arf substrates (Arf1, Arf6) []. IQSEC3 regulates Arf6 at inhibitory synapses and associates with the dystrophin-associated glycoprotein complex and S-SCAM [].These IQSEC family members contain a IQ domain that may bind calmodulin, a PH domain that is thought to mediate membrane localization, and a SEC7 domain that can promote GEF activity on ARF []. The PH domain of BRAG2 has been shown to potentiate nucleotide exchange by binding to polyanionic membranes without marked phosphoinositides preference [].
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Publication
17850229 | -
First Author: Casanova JE
Year: 2007
Journal: Traffic
Title: Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors.
Volume: 8
Issue: 11
Pages: 1476-85
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Protein
Q3TES0
Organism: Mus musculus/domesticus
Length: 1195  
Fragment?: false
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Protein
A4GZ26
Organism: Mus musculus/domesticus
Length: 1479  
Fragment?: false
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Protein
Q3UHJ6
Organism: Mus musculus/domesticus
Length: 766  
Fragment?: false
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Protein
Q5DU25
Organism: Mus musculus/domesticus
Length: 1478  
Fragment?: false
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Protein
D3Z6V7
Organism: Mus musculus/domesticus
Length: 949  
Fragment?: false
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Protein
D3Z5I6
Organism: Mus musculus/domesticus
Length: 1154  
Fragment?: false
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Protein
E9QAD8
Organism: Mus musculus/domesticus
Length: 1488  
Fragment?: false
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Publication
34711305 | J:314125
   
First Author: Lee FK
Year: 2021
Journal: Elife
Title: Genetically engineered mice for combinatorial cardiovascular optobiology.
Volume: 10
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