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Search results 201 to 223 out of 223 for Mpg

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0.037s
Type Details Score
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication
First Author: Girard BM
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: Decrease in neuronal nicotinic acetylcholine receptor subunit and PSD-93 transcript levels in the male mouse MPG after cavernous nerve injury or explant culture.
Volume: 305
Issue: 10
Pages: F1504-12
GO Term
Protein
Organism: Mus musculus/domesticus
Length: 491  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: false
Allele
Name: transgene insertion 1, Leona D Samson
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Publication  
First Author: Broekema MF
Year: 2019
Journal: Mol Metab
Title: Natural helix 9 mutants of PPARĪ³ differently affect its transcriptional activity.
Volume: 20
Pages: 115-127
Publication
First Author: Allocca M
Year: 2017
Journal: Oncotarget
Title: PARP inhibitors protect against sex- and AAG-dependent alkylation-induced neural degeneration.
Volume: 8
Issue: 40
Pages: 68707-68720
Protein Domain
Type: Homologous_superfamily
Description: Methylpurine-DNA glycosylase (MPG, or alkyladenine DNA glycosylase (AAG)) is a base excision-repair protein, catalyzing the first step in base excision repair by cleaving damaged DNA bases within double-stranded DNA to produce an abasic site. MPG bends DNA by intercalating between the base pairs, causing the damaged base to flip out of the double helix and into the enzyme active site for cleavage. It is responsible for the hydrolysis of the deoxyribose N-glycosidic bond, excising 3-methyladenine and 3-methylguanine from damaged DNA [, , , , , , , , , , ]. Its action is induced by alkylating chemotherapeutics, as well as deaminated and lipid peroxidation-induced purine adducts []. MPG without an N-terminal extension excises hypoxanthine with one-third of the efficiency of full-length MPG under similar conditions, suggesting that is function may largely be attributable to the N-terminal extension [].Although AAG represents one of six DNA glycosylase classes, it lacks the helix-hairpin-helix active site motif associated with other base excision repair glycosylases and is structurally distinct from them.
Publication
First Author: Yasumatsu K
Year: 2012
Journal: J Physiol
Title: Umami taste in mice uses multiple receptors and transduction pathways.
Volume: 590
Issue: 5
Pages: 1155-70
Publication
First Author: Becerra R
Year: 2016
Journal: Am J Physiol Heart Circ Physiol
Title: Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart.
Volume: 311
Issue: 3
Pages: H713-24
Publication
First Author: Hariharan N
Year: 2011
Journal: Antioxid Redox Signal
Title: Oxidative stress stimulates autophagic flux during ischemia/reperfusion.
Volume: 14
Issue: 11
Pages: 2179-90
Publication
First Author: Kim NK
Year: 1998
Journal: Mol Cells
Title: Tissue-specific expression and activation of N-methylpurine-DNA glycosylase in thymic carcinomas of transgenic mice expressing the SV40 large T-antigen gene.
Volume: 8
Issue: 4
Pages: 383-7
Publication
First Author: Adhikari S
Year: 2006
Journal: J Biol Chem
Title: Magnesium, essential for base excision repair enzymes, inhibits substrate binding of N-methylpurine-DNA glycosylase.
Volume: 281
Issue: 40
Pages: 29525-32
Publication
First Author: Crombez L
Year: 2009
Journal: Nucleic Acids Res
Title: Targeting cyclin B1 through peptide-based delivery of siRNA prevents tumour growth.
Volume: 37
Issue: 14
Pages: 4559-69
Publication
First Author: Maegawa T
Year: 2018
Journal: Mamm Genome
Title: Congenic mapping and candidate gene analysis for streptozotocin-induced diabetes susceptibility locus on mouse chromosome 11.
Volume: 29
Issue: 3-4
Pages: 273-280
Publication
First Author: Kabir AM
Year: 2006
Journal: Am J Physiol Heart Circ Physiol
Title: Cardioprotection initiated by reactive oxygen species is dependent on activation of PKCepsilon.
Volume: 291
Issue: 4
Pages: H1893-9
Publication
First Author: Kielman MF
Year: 1996
Journal: Mamm Genome
Title: Characterization and localization of the mProx1 gene directly upstream of the mouse alpha-globin gene cluster: identification of a polymorphic direct repeat in the 5'UTR.
Volume: 7
Issue: 12
Pages: 877-80
Publication  
First Author: Chitaev NA
Year: 1998
Journal: J Cell Sci
Title: Molecular organization of the desmoglein-plakoglobin complex.
Volume: 111 ( Pt 14)
Pages: 1941-9
Publication
First Author: Palomeque J
Year: 2009
Journal: Circ Res
Title: Angiotensin II-induced oxidative stress resets the Ca2+ dependence of Ca2+-calmodulin protein kinase II and promotes a death pathway conserved across different species.
Volume: 105
Issue: 12
Pages: 1204-12