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Search results 1 to 100 out of 516 for Cryab

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
101827485 | Cryab
Type: gene
Organism: hamster
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Gene
1410 | CRYAB
Type: gene
Organism: human
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Gene
479441 | CRYAB
Type: gene
Organism: dog, domestic
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Gene
396089 | CRYAB
Type: gene
Organism: chicken
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Gene
710747 | CRYAB
Type: gene
Organism: macaque, rhesus
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Gene
100494321 | cryab
Type: gene
Organism: frog, western clawed
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Gene
281719 | CRYAB
Type: gene
Organism: cattle
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Gene
key_80471 | CRYAB
Type: gene
Organism: rabbit, European
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Gene
25420 | Cryab
Type: gene
Organism: rat
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Gene
451543 | CRYAB
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:88516 | Cryab
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
16678848 | J:110933
First Author: Kadono T
Year: 2006
Journal: J Mol Cell Cardiol
Title: CRYAB and HSPB2 deficiency increases myocyte mitochondrial permeability transition and mitochondrial calcium uptake.
Volume: 40
Issue: 6
Pages: 783-9
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GXD Expression
GXD Expression
     
Probe: MGI:4949073
Assay Type: RT-PCR
Annotation Date: 2011-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603912
Stage: TS12
Assay Id: MGI:4949092
Age: embryonic day 8.25
Specimen Label: Cryab Sox17 -/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:4949073
Assay Type: RT-PCR
Annotation Date: 2011-05-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603912
Stage: TS12
Assay Id: MGI:4949092
Age: embryonic day 8.25
Specimen Label: Cryab Sox17+/+. Sox17-/+
Detected: true
Specimen Num: 1
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Publication
17873008 | J:132118
First Author: Benjamin IJ
Year: 2007
Journal: Am J Physiol Heart Circ Physiol
Title: CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice.
Volume: 293
Issue: 5
Pages: H3201-9
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Publication
15220483 | J:91433
First Author: Sanbe A
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis.
Volume: 101
Issue: 27
Pages: 10132-6
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Publication
16316967 | J:134030
First Author: Maloyan A
Year: 2005
Journal: Circulation
Title: Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy.
Volume: 112
Issue: 22
Pages: 3451-61
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Publication
21828004 | J:175982
First Author: Arac A
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Systemic augmentation of alphaB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation.
Volume: 108
Issue: 32
Pages: 13287-92
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Publication
14576194 | J:135117
First Author: Wang X
Year: 2003
Journal: Circ Res
Title: AlphaB-crystallin modulates protein aggregation of abnormal desmin.
Volume: 93
Issue: 10
Pages: 998-1005
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Publication
17568699 | J:123341
First Author: Ousman SS
Year: 2007
Journal: Nature
Title: Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination.
Volume: 448
Issue: 7152
Pages: 474-9
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Publication
16210548 | J:117506
First Author: Chen Q
Year: 2005
Journal: Circ Res
Title: Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake.
Volume: 97
Issue: 10
Pages: 1018-26
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Publication
18974385 | J:155270
First Author: Kumarapeli AR
Year: 2008
Journal: Circ Res
Title: Alpha B-crystallin suppresses pressure overload cardiac hypertrophy.
Volume: 103
Issue: 12
Pages: 1473-82
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Publication
28185662 | J:243140
 
First Author: Lim EF
Year: 2017
Journal: Neurobiol Aging
Title: AlphaB-crystallin expression correlates with aging deficits in the peripheral nervous system.
Volume: 53
Pages: 138-149
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Publication
26878210 | J:231525
First Author: Ishikawa K
Year: 2016
Journal: Am J Pathol
Title: αB-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition.
Volume: 186
Issue: 4
Pages: 859-73
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Publication
26987815 | J:245447
First Author: Nahomi RB
Year: 2016
Journal: Biochem J
Title: αB-crystallin is essential for the TGF-β2-mediated epithelial to mesenchymal transition of lens epithelial cells.
Volume: 473
Issue: 10
Pages: 1455-69
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Publication
19129171 | J:146191
First Author: Hagemann TL
Year: 2009
Journal: Hum Mol Genet
Title: Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease.
Volume: 18
Issue: 7
Pages: 1190-9
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Publication
17389375 | J:120360
First Author: Maloyan A
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Exercise reverses preamyloid oligomer and prolongs survival in alphaB-crystallin-based desmin-related cardiomyopathy.
Volume: 104
Issue: 14
Pages: 5995-6000
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Publication
26542570 | J:226606
First Author: Makley LN
Year: 2015
Journal: Science
Title: Pharmacological chaperone for α-crystallin partially restores transparency in cataract models.
Volume: 350
Issue: 6261
Pages: 674-7
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Publication
11149910 | J:66889
First Author: Andley UP
Year: 2001
Journal: FASEB J
Title: Lens epithelial cells derived from alphaB-crystallin knockout mice demonstrate hyperproliferation and genomic instability.
Volume: 15
Issue: 1
Pages: 221-229
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Publication
14592939 | J:95610
First Author: Morrison LE
Year: 2004
Journal: Am J Physiol Heart Circ Physiol
Title: Roles for alphaB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse model.
Volume: 286
Issue: 3
Pages: H847-55
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Publication
18063749 | J:131311
First Author: Dimberg A
Year: 2008
Journal: Blood
Title: alphaB-crystallin promotes tumor angiogenesis by increasing vascular survival during tube morphogenesis.
Volume: 111
Issue: 4
Pages: 2015-23
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Publication
22781655 | J:188048
First Author: Dou G
Year: 2012
Journal: Free Radic Biol Med
Title: Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction.
Volume: 53
Issue: 5
Pages: 1111-22
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Publication
11687538 | J:72926
First Author: Brady JP
Year: 2001
Journal: Invest Ophthalmol Vis Sci
Title: AlphaB-crystallin in lens development and muscle integrity: a gene knockout approach.
Volume: 42
Issue: 12
Pages: 2924-34
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Publication
18227158 | J:133534
First Author: Whiston EA
Year: 2008
Journal: Infect Immun
Title: alphaB-crystallin protects retinal tissue during Staphylococcus aureus-induced endophthalmitis.
Volume: 76
Issue: 4
Pages: 1781-90
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Publication
23242137 | J:194407
First Author: Shao W
Year: 2013
Journal: Nature
Title: Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin.
Volume: 494
Issue: 7435
Pages: 90-4
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Publication
12826669 | J:85535
First Author: Bai F
Year: 2003
Journal: J Biol Chem
Title: Hyperproliferation and p53 status of lens epithelial cells derived from alphaB-crystallin knockout mice.
Volume: 278
Issue: 38
Pages: 36876-86
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Publication
11157875 | J:67216
First Author: Kannan R
Year: 2001
Journal: Invest Ophthalmol Vis Sci
Title: Regulation of GSH in alphaA-expressing human lens epithelial cell lines and in alphaA knockout mouse lenses.
Volume: 42
Issue: 2
Pages: 409-16
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Publication
16155124 | J:101419
First Author: Sanbe A
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.
Volume: 102
Issue: 38
Pages: 13592-7
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Publication
21541347 | J:172375
First Author: Sanbe A
Year: 2011
Journal: PLoS One
Title: Cardioprotective effect of nicorandil, a mitochondrial ATP-sensitive potassium channel opener, prolongs survival in HSPB5 R120G transgenic mice.
Volume: 6
Issue: 4
Pages: e18922
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Publication
20023214 | J:160799
First Author: Kase S
Year: 2010
Journal: Blood
Title: alphaB-crystallin regulation of angiogenesis by modulation of VEGF.
Volume: 115
Issue: 16
Pages: 3398-406
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Publication
21423662 | J:171699
First Author: Hishiya A
Year: 2011
Journal: PLoS One
Title: BAG3 directly interacts with mutated alphaB-crystallin to suppress its aggregation and toxicity.
Volume: 6
Issue: 3
Pages: e16828
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Publication
31369034 | J:279765
First Author: Molnar KS
Year: 2019
Journal: Invest Ophthalmol Vis Sci
Title: Mechanism of Action of VP1-001 in cryAB(R120G)-Associated and Age-Related Cataracts.
Volume: 60
Issue: 10
Pages: 3320-3331
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Publication
30497777 | J:291198
First Author: Guo YS
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Extracellular αB-crystallin modulates the inflammatory responses.
Volume: 508
Issue: 1
Pages: 282-288
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Publication
21379584 | J:171056
First Author: Ojha J
Year: 2011
Journal: PLoS One
Title: Behavioral defects in chaperone-deficient Alzheimer's disease model mice.
Volume: 6
Issue: 2
Pages: e16550
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Publication
14556987 | J:86896
First Author: Charukamnoetkanok P
Year: 2003
Journal: Immunol Lett
Title: Immunotolerance toward native alphaA-crystallin in knockout mice deficient in the functional protein.
Volume: 89
Issue: 2-3
Pages: 259-65
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Publication
30773991 | J:294389
First Author: Ma X
Year: 2019
Journal: J Am Heart Assoc
Title: Transcription Factor EB Activation Rescues Advanced αB-Crystallin Mutation-Induced Cardiomyopathy by Normalizing Desmin Localization.
Volume: 8
Issue: 4
Pages: e010866
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Publication
18191123 | J:132494
First Author: Yaung J
Year: 2008
Journal: Exp Eye Res
Title: Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia.
Volume: 86
Issue: 2
Pages: 355-65
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Publication
12546709 | J:86897
 
First Author: Boyle DL
Year: 2003
Journal: BMC Ophthalmol
Title: Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens.
Volume: 3
Pages: 3
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Publication
23590631 | J:201930
First Author: Andley UP
Year: 2013
Journal: Biochemistry
Title: Comparative proteomic analysis identifies age-dependent increases in the abundance of specific proteins after deletion of the small heat shock proteins αA- and αB-crystallin.
Volume: 52
Issue: 17
Pages: 2933-48
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Publication
17438522 | J:121617
 
First Author: Yaung J
Year: 2007
Journal: Mol Vis
Title: alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress.
Volume: 13
Pages: 566-77
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Publication
16675842 | J:111251
First Author: Xi JH
Year: 2006
Journal: FASEB J
Title: Alpha-crystallin expression affects microtubule assembly and prevents their aggregation.
Volume: 20
Issue: 7
Pages: 846-57
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Publication
32833997 | J:293900
First Author: Frankfater C
Year: 2020
Journal: PLoS One
Title: Alpha-crystallin mutations alter lens metabolites in mouse models of human cataracts.
Volume: 15
Issue: 8
Pages: e0238081
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Publication
29338044 | J:256727
First Author: Andley UP
Year: 2018
Journal: PLoS One
Title: Probing the changes in gene expression due to α-crystallin mutations in mouse models of hereditary human cataract.
Volume: 13
Issue: 1
Pages: e0190817
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Publication
20937869 | J:165515
First Author: Bousette N
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B.
Volume: 107
Issue: 43
Pages: 18481-6
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Publication
18621691 | J:137839
First Author: Tannous P
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Autophagy is an adaptive response in desmin-related cardiomyopathy.
Volume: 105
Issue: 28
Pages: 9745-50
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Publication
30389787 | J:268935
First Author: Lynch JM
Year: 2018
Journal: J Biol Chem
Title: Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells.
Volume: 293
Issue: 52
Pages: 20137-20156
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Publication
16439475 | J:106028
First Author: Morozov V
Year: 2006
Journal: Development
Title: Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice.
Volume: 133
Issue: 5
Pages: 813-21
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Publication
17893660 | J:125299
 
First Author: Bai F
Year: 2007
Journal: Mol Vis
Title: Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice.
Volume: 13
Pages: 1589-600
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Publication
37435054 | J:342762
 
First Author: Chou C
Year: 2023
Journal: Front Cardiovasc Med
Title: A novel αB-crystallin R123W variant drives hypertrophic cardiomyopathy by promoting maladaptive calcium-dependent signal transduction.
Volume: 10
Pages: 1223244
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Publication
23395094 | J:195775
First Author: Liu L
Year: 2013
Journal: Am J Pathol
Title: Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization.
Volume: 182
Issue: 4
Pages: 1412-24
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Publication
27724964 | J:255328
First Author: Qiu J
Year: 2016
Journal: J Neuroinflammation
Title: Sinomenine activates astrocytic dopamine D2 receptors and alleviates neuroinflammatory injury via the CRYAB/STAT3 pathway after ischemic stroke in mice.
Volume: 13
Issue: 1
Pages: 263
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Publication
19538478 | J:343388
First Author: Manukyan I
Year: 2010
Journal: J Cell Mol Med
Title: Cross-talk between calcineurin/NFAT and Jak/STAT signalling induces cardioprotective alphaB-crystallin gene expression in response to hypertrophic stimuli.
Volume: 14
Issue: 6B
Pages: 1707-16
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Publication
20959464 | J:167581
First Author: Cheng C
Year: 2010
Journal: J Biol Chem
Title: Altered chaperone-like activity of alpha-crystallins promotes cataractogenesis.
Volume: 285
Issue: 52
Pages: 41187-93
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Protein Coding Gene
MGP_CAROLIEiJ_G0032195 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0034789 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0034770 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0034698 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0034762 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0034472 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_88516 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0035282 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0033794 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0034444 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0034603 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0034544 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0034684 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0034587 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0035303 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0033499 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033907 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015063 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0033334 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
7838723 | J:23039
First Author: Frederikse PH
Year: 1994
Journal: Nucleic Acids Res
Title: Structure and alternate tissue-preferred transcription initiation of the mouse alpha B-crystallin/small heat shock protein gene.
Volume: 22
Issue: 25
Pages: 5686-94
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Publication
2725488 | J:9803
First Author: Dubin RA
Year: 1989
Journal: Mol Cell Biol
Title: Expression of the murine alpha B-crystallin gene is not restricted to the lens.
Volume: 9
Issue: 3
Pages: 1083-91
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Publication
21445271 | J:171679
First Author: Andley UP
Year: 2011
Journal: PLoS One
Title: A knock-in mouse model for the R120G mutation of αB-crystallin recapitulates human hereditary myopathy and cataracts.
Volume: 6
Issue: 3
Pages: e17671
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Publication
24874187 | J:217342
First Author: Zhou P
Year: 2014
Journal: PLoS One
Title: Protection of retina by αB crystallin in sodium iodate induced retinal degeneration.
Volume: 9
Issue: 5
Pages: e98275
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Publication
22289178 | J:200485
First Author: Mishra S
Year: 2012
Journal: FEBS Lett
Title: Cataract-linked γD-crystallin mutants have weak affinity to lens chaperones α-crystallins.
Volume: 586
Issue: 4
Pages: 330-6
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Publication
11156955 | J:67569
First Author: Ray PS
Year: 2001
Journal: FASEB J
Title: Transgene overexpression of alphaB crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusion.
Volume: 15
Issue: 2
Pages: 393-402
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Publication
11245977 | J:68021
First Author: Avivi A
Year: 2001
Journal: Gene
Title: The lens protein alpha-B-crystallin of the blind subterranean mole-rat: high homology with sighted mammals.
Volume: 264
Issue: 1
Pages: 45-9
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Publication
3862098 | J:19955
First Author: Quax-Jeuken Y
Year: 1985
Journal: Proc Natl Acad Sci U S A
Title: Complete structure of the alpha B-crystallin gene: conservation of the exon-intron distribution in the two nonlinked alpha-crystallin genes.
Volume: 82
Issue: 17
Pages: 5819-23
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Publication
2539261 | J:44594
First Author: Iwaki T
Year: 1989
Journal: Cell
Title: Alpha B-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain.
Volume: 57
Issue: 1
Pages: 71-8
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Publication
1875925 | J:32364
First Author: Dubin RA
Year: 1991
Journal: Mol Cell Biol
Title: Expression of the murine alpha B-crystallin gene in lens and skeletal muscle: identification of a muscle-preferred enhancer.
Volume: 11
Issue: 9
Pages: 4340-9
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Publication
8413303 | J:15148
First Author: Gopal-Srivastava R
Year: 1993
Journal: Mol Cell Biol
Title: The murine alpha B-crystallin/small heat shock protein enhancer: identification of alpha BE-1, alpha BE-2, alpha BE-3, and MRF control elements.
Volume: 13
Issue: 11
Pages: 7144-52
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Publication
8165144 | J:18395
First Author: Gopal-Srivastava R
Year: 1994
Journal: Nucleic Acids Res
Title: Identification of a lens-specific regulatory region (LSR) of the murine alpha B-crystallin gene.
Volume: 22
Issue: 7
Pages: 1281-6
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Publication
8524275 | J:29888
First Author: Gopal-Srivastava R
Year: 1995
Journal: Mol Cell Biol
Title: Regulation of the murine alpha B-crystallin/small heat shock protein gene in cardiac muscle.
Volume: 15
Issue: 12
Pages: 7081-90
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Publication
8875078 | J:35178
First Author: Haynes JI 2nd
Year: 1996
Journal: Dev Dyn
Title: Spatial and temporal activity of the alpha B-crystallin/small heat shock protein gene promoter in transgenic mice.
Volume: 207
Issue: 1
Pages: 75-88
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Publication
8961256 | J:36868
First Author: Scheier B
Year: 1996
Journal: Mol Cell Endocrinol
Title: Glucocorticoids regulate the expression of the stressprotein alpha B-crystallin.
Volume: 123
Issue: 2
Pages: 187-98
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Publication
17293452 | J:125939
First Author: Li Y
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Tissue-specific activity of the blind mole rat and the two nucleotide-mutated mouse alphaB-crystallin promoter in transgenic mice.
Volume: 104
Issue: 8
Pages: 2608-13
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Publication
21640763 | J:177749
First Author: Adhikari AS
Year: 2011
Journal: Biochim Biophys Acta
Title: αB-crystallin, a small heat shock protein, modulates NF-κB activity in a phosphorylation-dependent manner and protects muscle myoblasts from TNF-α induced cytotoxicity.
Volume: 1813
Issue: 8
Pages: 1532-42
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Publication
26718604 | J:231174
 
First Author: Quraishe S
Year: 2016
Journal: Neuroscience
Title: Selective and compartmentalized myelin expression of HspB5.
Volume: 316
Pages: 130-42
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