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Search results 1 to 100 out of 391 for Hic1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Hypermethylated in cancer 1 (HIC1) is a transcriptional repressor that modulates P53-dependent and E2F1-dependent cell growth control and is epigenetically inactivated in various human cancers []. It recognises and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3' []. It is a direct transcriptional repressor of ephrin-A1 and CXCR7, which are implicated in the pathogenesis of different cancers [, ]. HIC1 is also involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses []. HIC1 interacts with several different corepressors such as CTBP1, CTBP2 and MTA1 (a subunit of the NuRD complex) [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: true
Publication
First Author: Chen WY
Year: 2005
Journal: Cell
Title: Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.
Volume: 123
Issue: 3
Pages: 437-48
Publication
First Author: Zhang W
Year: 2010
Journal: Oncogene
Title: A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1.
Volume: 29
Issue: 17
Pages: 2467-76
Publication
First Author: Van Rechem C
Year: 2009
Journal: J Biol Chem
Title: Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1).
Volume: 284
Issue: 31
Pages: 20927-35
Publication
First Author: Van Rechem C
Year: 2010
Journal: Mol Cell Biol
Title: Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells.
Volume: 30
Issue: 16
Pages: 4045-59
Publication
First Author: Pinte S
Year: 2004
Journal: J Biol Chem
Title: The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties.
Volume: 279
Issue: 37
Pages: 38313-24
Publication
First Author: Burrows K
Year: 2017
Journal: Mucosal Immunol
Title: The transcriptional repressor HIC1 regulates intestinal immune homeostasis.
Volume: 10
Issue: 6
Pages: 1518-1528
Publication
First Author: Szczepny A
Year: 2018
Journal: Oncogene
Title: The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53.
Volume: 37
Issue: 14
Pages: 1939-1948
Publication
First Author: Briggs KJ
Year: 2008
Journal: Genes Dev
Title: Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma.
Volume: 22
Issue: 6
Pages: 770-85
Publication
First Author: Hao M
Year: 2017
Journal: J Pathol
Title: HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition.
Volume: 242
Issue: 4
Pages: 409-420
Publication
First Author: Arostegui M
Year: 2023
Journal: Cell Rep
Title: Hic1 identifies a specialized mesenchymal progenitor population in the embryonic limb responsible for bone superstructure formation.
Volume: 42
Issue: 4
Pages: 112325
Publication
First Author: Pospichalova V
Year: 2011
Journal: Genesis
Title: Generation of two modified mouse alleles of the Hic1 tumor suppressor gene.
Volume: 49
Issue: 3
Pages: 142-51
Publication
First Author: Scott RW
Year: 2019
Journal: Cell Stem Cell
Title: Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration.
Volume: 25
Issue: 6
Pages: 797-813.e9
Publication
First Author: Mohammad HP
Year: 2011
Journal: Oncogene
Title: Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice.
Volume: 30
Issue: 23
Pages: 2659-69
Publication
First Author: Chen WY
Year: 2003
Journal: Nat Genet
Title: Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors.
Volume: 33
Issue: 2
Pages: 197-202
Publication
First Author: Janeckova L
Year: 2015
Journal: Mol Cancer Res
Title: HIC1 Tumor Suppressor Loss Potentiates TLR2/NF-κB Signaling and Promotes Tissue Damage-Associated Tumorigenesis.
Volume: 13
Issue: 7
Pages: 1139-48
Publication
First Author: Chen W
Year: 2004
Journal: Cancer Cell
Title: Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis.
Volume: 6
Issue: 4
Pages: 387-98
Publication
First Author: Carter MG
Year: 2000
Journal: Hum Mol Genet
Title: Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome.
Volume: 9
Issue: 3
Pages: 413-9
Publication
First Author: Valenta T
Year: 2006
Journal: EMBO J
Title: HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies.
Volume: 25
Issue: 11
Pages: 2326-37
Publication
First Author: Burrows K
Year: 2018
Journal: PLoS Pathog
Title: HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis.
Volume: 14
Issue: 2
Pages: e1006869
Publication
First Author: Wang Y
Year: 2018
Journal: J Clin Invest
Title: HIC1 deletion promotes breast cancer progression by activating tumor cell/fibroblast crosstalk.
Volume: 128
Issue: 12
Pages: 5235-5250
Protein
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 733  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 714  
Fragment?: false
Publication  
First Author: Uchida A
Year: 2020
Journal: Development
Title: Development and function of smooth muscle cells is modulated by Hic1 in mouse testis.
Volume: 147
Issue: 13
Publication
First Author: Abbasi S
Year: 2020
Journal: Cell Stem Cell
Title: Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing.
Volume: 27
Issue: 3
Pages: 396-412.e6
Publication
First Author: Pinte S
Year: 2004
Journal: Oncogene
Title: Identification of a second G-C-rich promoter conserved in the human, murine and rat tumor suppressor genes HIC1.
Volume: 23
Issue: 22
Pages: 4023-31
Publication
First Author: Soliman H
Year: 2020
Journal: Cell Stem Cell
Title: Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors.
Volume: 26
Issue: 2
Pages: 205-220.e8
Publication
First Author: Arostegui M
Year: 2022
Journal: Nat Commun
Title: Cellular taxonomy of Hic1+ mesenchymal progenitor derivatives in the limb: from embryo to adult.
Volume: 13
Issue: 1
Pages: 4989
Publication  
First Author: Zhang X
Year: 2019
Journal: Redox Biol
Title: Ferroptosis is governed by differential regulation of transcription in liver cancer.
Volume: 24
Pages: 101211
Publication
First Author: Kajabadi N
Year: 2023
Journal: Dev Cell
Title: Activation of β-catenin in mesenchymal progenitors leads to muscle mass loss.
Volume: 58
Issue: 6
Pages: 489-505.e7
Publication
First Author: Grimm C
Year: 1999
Journal: Hum Mol Genet
Title: Isolation and embryonic expression of the novel mouse gene Hic1, the homologue of HIC1, a candidate gene for the Miller-Dieker syndrome.
Volume: 8
Issue: 4
Pages: 697-710
Publication
First Author: Lotto J
Year: 2023
Journal: Nat Commun
Title: Cell diversity and plasticity during atrioventricular heart valve EMTs.
Volume: 14
Issue: 1
Pages: 5567
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Guerardel C
Year: 2001
Journal: J Biol Chem
Title: Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53.
Volume: 276
Issue: 5
Pages: 3078-89
Publication
First Author: Deltour S
Year: 1998
Journal: Biochim Biophys Acta
Title: The carboxy-terminal end of the candidate tumor suppressor gene HIC-1 is phylogenetically conserved.
Volume: 1443
Issue: 1-2
Pages: 230-2
GXD Expression    
Probe: MGI:3694754
Assay Type: RT-PCR
Annotation Date: 2007-02-08
Strength: Present
Sex: Male
Emaps: EMAPS:1797220
Stage: TS20
Assay Id: MGI:3696016
Age: embryonic day 12.0
Image: 2
Specimen Label: XY Wnt4+/+
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3694754
Assay Type: RT-PCR
Annotation Date: 2007-02-08
Strength: Absent
Sex: Female
Emaps: EMAPS:1796220
Stage: TS20
Assay Id: MGI:3696016
Age: embryonic day 12.0
Image: 2
Specimen Label: XX Wnt4+/+
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3694754
Assay Type: RT-PCR
Annotation Date: 2007-02-08
Strength: Present
Sex: Female
Emaps: EMAPS:1796220
Stage: TS20
Assay Id: MGI:3696016
Age: embryonic day 12.0
Image: 2
Specimen Label: XX Wnt4-/-
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:6188993
Age: embryonic day 10.5
Image: 2
Specimen Label: E10.5
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603920
Stage: TS20
Assay Id: MGI:6188993
Age: embryonic day 12.5
Image: 2
Specimen Label: E12.5
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603922
Stage: TS22
Assay Id: MGI:6188993
Age: embryonic day 14.5
Image: 2
Specimen Label: E14.5
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:6188995
Age: postnatal adult
Image: 2
Specimen Label: Cortex
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:6188995
Age: postnatal adult
Image: 2
Specimen Label: Cerebellum
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:6188995
Age: postnatal adult
Image: 2
Specimen Label: Spinal cord
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:6188995
Age: postnatal adult
Image: 2
Specimen Label: Thymus
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:6188995
Age: postnatal adult
Image: 2
Specimen Label: Heart
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702128
Stage: TS28
Assay Id: MGI:6188995
Age: postnatal adult
Image: 2
Specimen Label: Stomach
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6188995
Age: postnatal adult
Image: 2
Specimen Label: Liver
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6188995
Age: postnatal adult
Image: 2
Specimen Label: Spleen
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287428
Stage: TS28
Assay Id: MGI:6188995
Age: postnatal adult
Image: 2
Specimen Label: Intestine
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:6188995
Age: postnatal adult
Image: 2
Specimen Label: Kidney
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:6188995
Age: postnatal adult
Image: 2
Specimen Label: Bladder
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:6188995
Age: postnatal adult
Image: 2
Specimen Label: Skeletal muscle
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3511228
Stage: TS28
Assay Id: MGI:6188995
Age: postnatal adult
Image: 2
Specimen Label: Adipose
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:6188995
Age: postnatal adult
Image: 2
Specimen Label: Bone marrow
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:6188995
Age: postnatal adult
Image: 2
Specimen Label: Testis
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:6188995
Age: postnatal adult
Image: 2
Specimen Label: Ovary
Detected: true
Specimen Num: 16
GXD Expression    
Probe: MGI:6188929
Assay Type: RT-PCR
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:6188995
Age: postnatal adult
Image: 2
Specimen Label: Placenta
Detected: true
Specimen Num: 17
GXD Expression      
Probe: MGI:218700
Assay Type: Northern blot
Annotation Date: 2019-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6356043
Age: postnatal adult
Specimen Label: lung
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6188988
Age: embryonic day 11.5
Image: 3b
Specimen Label: 3b
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:6188989
Assay Type: In situ reporter (knock in)
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1611819
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:6188991
Age: embryonic day 11.5
Image: 3l
Note: Expression is in mesenchyme adjacent to cartliage condensations.
Specimen Label: 3l
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3507291
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691621
Stage: TS21
Assay Id: MGI:3508341
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507291
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691627
Stage: TS27
Assay Id: MGI:3508341
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression
Probe: MGI:6188989
Assay Type: In situ reporter (knock in)
Annotation Date: 2018-07-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3558419
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:6188991
Age: embryonic day 11.5
Image: 3k
Note: Expression is in mesenchyme surrounding the nasal cavity.
Specimen Label: 3k
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:218700
Assay Type: RNA in situ
Annotation Date: 2019-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3558417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:6356044
Age: embryonic day 10.5
Specimen Label: 6a
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:218700
Assay Type: RNA in situ
Annotation Date: 2019-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3558419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6356044
Age: embryonic day 11.5
Specimen Label: 6b
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:218700
Assay Type: RNA in situ
Annotation Date: 2019-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3558419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6356044
Age: embryonic day 11.5
Specimen Label: 8a
Detected: true
Specimen Num: 19
GXD Expression  
Probe: MGI:218700
Assay Type: RNA in situ
Annotation Date: 2019-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3558419
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:6356044
Age: embryonic day 11.5
Note: Expression is adjacent to budding epithelia.
Specimen Label: 8c
Detected: true
Specimen Num: 20
GXD Expression  
Probe: MGI:218700
Assay Type: RNA in situ
Annotation Date: 2019-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3558422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6356044
Age: embryonic day 14.5
Note: Expression is adjacent to budding epithelia.
Specimen Label: 8e
Detected: true
Specimen Num: 22
GXD Expression  
Probe: MGI:218700
Assay Type: RNA in situ
Annotation Date: 2019-08-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3558422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6356044
Age: embryonic day 14.5
Note: Expression is adjacent to budding epithelia.
Specimen Label: 8f
Detected: true
Specimen Num: 23