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Search results 101 to 200 out of 264 for Tpx2

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Type Details Score
Protein Domain
IPR027330 | TPX2_central_dom
Type: Domain
Description: This entry represents the central domain found in the eukaryotic targeting protein for Xklp2 (TPX2) protein. TPX2 is a microtubule-associated protein that targets a plus end-directed motor (Xklp2) to the minus ends of microtubules in the mitotic spindle. This domain is close to the C-terminal of TPX2. The protein importin alpha regulates the activity of TPX2 by binding to the nuclear localisation signal in this domain [].
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Publication
10871281 | -
First Author: Wittmann T
Year: 2000
Journal: J Cell Biol
Title: TPX2, A novel xenopus MAP involved in spindle pole organization.
Volume: 149
Issue: 7
Pages: 1405-18
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Protein
A2APB8
Organism: Mus musculus/domesticus
Length: 745  
Fragment?: false
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Protein
Q9CT36
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: true
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Publication
8548825 | -
First Author: Boleti H
Year: 1996
Journal: Cell
Title: Xklp2, a novel Xenopus centrosomal kinesin-like protein required for centrosome separation during mitosis.
Volume: 84
Issue: 1
Pages: 49-59
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Protein
Q8BTJ3
Organism: Mus musculus/domesticus
Length: 745  
Fragment?: false
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Publication
14580337 | -
First Author: Bayliss R
Year: 2003
Journal: Mol Cell
Title: Structural basis of Aurora-A activation by TPX2 at the mitotic spindle.
Volume: 12
Issue: 4
Pages: 851-62
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Pathway
R-MMU-8854518 | AURKA Activation by TPX2
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Protein Coding Gene
MGI:1342328 | Dazl
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104667 | Hmmr
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q00547
Organism: Mus musculus/domesticus
Length: 794  
Fragment?: false
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Protein Domain
IPR044216 | WDL7
Type: Family
Description: This entry includes WDL7 from Arabidopsis and related proteins. WDL7 is a TPX2 C-terminal domain containing protein. Similar to WVD2 and other WVD2-like proteins, it contains the KLEEK-motif, which is typical for microtubule-binding proteins []. The function of WDL7 is not clear.
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Protein Domain
IPR044833 | WDL4/5/6
Type: Family
Description: In animals, Targeting Protein for Xklp2 (TPX2) is critical for mitotic spindle assembly. It has a highly conserved TPX2 central domain, an Aurora-A binding domain and a TPX2_C domain that contains a conserved pentapeptide KLEEK motif. However, in plants besides the TPX2 homologue (with three domains), several proteins were found with only the TPX2_C domain. This group of TPX2_C domain only proteins in plants has been named as WDL (or WVD2-like) proteins, as the first identified member is known as WVD2. These WDL proteins bind to microtubules; however, they have lost the function of targeting Xklp2 and were found to play roles in plant development and responses to environment cues [, ].This entry includes WDL4/5/6 from Arabidopsis.
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Publication
26134166 | -
First Author: Sun J
Year: 2015
Journal: Plant Physiol
Title: Ethylene Regulates the Arabidopsis Microtubule-Associated Protein WAVE-DAMPENED2-LIKE5 in Etiolated Hypocotyl Elongation.
Volume: 169
Issue: 1
Pages: 325-37
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Protein Domain
IPR015128 | Aurora-A-bd
Type: Domain
Description: The Aurora-A binding domain in TPX2 (targeting protein for Xklp2)binds to two distinct sites on the Aurora kinase: the upstream residues bind at the N-terminal lobe, whilst the downstream residues bind in an α-helical conformation between the N- and C-terminal lobes. The two Aurora-A binding motifs are connected by a flexible linker that is variable in length and sequence across species. Binding of the domain results strong activation of Aurora-A and protection from deactivating dephosphorylation by phosphatase PP1 [].
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Publication
12586874 | -
First Author: Yuen CY
Year: 2003
Journal: Plant Physiol
Title: WVD2 and WDL1 modulate helical organ growth and anisotropic cell expansion in Arabidopsis.
Volume: 131
Issue: 2
Pages: 493-506
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Protein Domain
IPR027329 | TPX2_C
Type: Domain
Description: This entry represents a conserved region approximately 60 residues long within the eukaryotic targeting protein for Xklp2 (TPX2). Xklp2 is a kinesin-like protein localised on centrosomes throughout the cell cycle and on spindle pole microtubules during metaphase. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity [, ]. TPX2 is a microtubule-associated protein that mediates the binding of the C-terminal domain of Xklp2 to microtubules. It is phosphorylated during mitosis in a microtubule-dependent way [].
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Publication
17319849 | -
First Author: Perrin RM
Year: 2007
Journal: Plant J
Title: WVD2 is a novel microtubule-associated protein in Arabidopsis thaliana.
Volume: 49
Issue: 6
Pages: 961-71
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Publication
23653471 | -
First Author: Liu X
Year: 2013
Journal: Plant Cell
Title: Light-regulated hypocotyl elongation involves proteasome-dependent degradation of the microtubule regulatory protein WDL3 in Arabidopsis.
Volume: 25
Issue: 5
Pages: 1740-55
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Protein Domain
IPR044806 | WVD2/WDL1-3
Type: Family
Description: In animals, Targeting Protein for Xklp2 (TPX2) is critical for mitotic spindle assembly. It has a highly conserved TPX2 central domain, an Aurora-A binding domain and a TPX2_C domain that contains a conserved pentapeptide KLEEK motif. However, in plants besides the TPX2 homologue (with three domains), several proteins were found with only the TPX2_C domain. This group of TPX2_C domain only proteins in plants has been named as WDL (or WVD2-like) proteins, as the first identified member is known as WVD2. These WDL proteins bind to microtubules; however, they have lost the function of targeting Xklp2 and were found to play roles in plant development and responses to environment cues [, ].This entry includes WAVE-DAMPENED2 (WVD2) and WDL1/2/3. WVD2, and its closest paralogue WDL1, modulate both rotational polarity and anisotropic cell expansion during organ growth and also promote clockwise root and etiolated hypocotyls coiling, clockwise leaf curling, but left-handed petiole twisting [, ]. WDL3 stabilises microtubules, playing an important role in the regulation of hypocotyl cell elongation. WDL3 levels are regulated by an ubiquitin-26S proteasome-dependent pathway in response to light and functions as a negative regulator of hypocotyl cell elongation in the light [].
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Protein Coding Gene
MGI:1924066 | Sdccag8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:102722 | Pcnt
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97293 | Nedd1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2384917 | Cep290
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1926137 | Sfi1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:101834 | Tubg1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107440 | Cep131
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1921720 | Cep72
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1261794 | Haus4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1922546 | Cep43
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107812 | Tubb5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923401 | Cep76
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1918049 | Cep192
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2385076 | Haus1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1924386 | Cep78
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915725 | Ssna1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1098824 | Odf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913546 | Haus2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2139083 | Cep152
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1925427 | Ninl
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108084 | Cep250
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:101783 | Plk4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2384875 | Cdk5rap2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923389 | Haus6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2387633 | Haus3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2681869 | Cep135
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891414 | Cep41
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1934606 | Alms1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919159 | Haus5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1277958 | Pcm1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923728 | Haus8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915551 | Cep57
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2384878 | Cep164
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915371 | Cep70
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2158560 | Cep63
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1920988 | Haus7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1350328 | Ofd1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8K4E0
Organism: Mus musculus/domesticus
Length: 3251  
Fragment?: false
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Protein
Q6IRU7
Organism: Mus musculus/domesticus
Length: 790  
Fragment?: false
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Protein
Q0VEJ0
Organism: Mus musculus/domesticus
Length: 659  
Fragment?: false
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Protein
Q99NF3
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
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Protein
Q66JX5
Organism: Mus musculus/domesticus
Length: 399  
Fragment?: false
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Protein
Q8CEE0
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: false
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Protein
Q6IQY5
Organism: Mus musculus/domesticus
Length: 616  
Fragment?: false
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Protein
A2AUM9
Organism: Mus musculus/domesticus
Length: 1736  
Fragment?: false
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Protein
Q3UPP8
Organism: Mus musculus/domesticus
Length: 700  
Fragment?: false
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Protein
Q8K389
Organism: Mus musculus/domesticus
Length: 1822  
Fragment?: false
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Protein
Q62036
Organism: Mus musculus/domesticus
Length: 1060  
Fragment?: false
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Protein
P48725
Organism: Mus musculus/domesticus
Length: 2898  
Fragment?: false
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Protein
Q8QZX2
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Protein
Q9CQS9
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: false
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Protein
Q80Z25
Organism: Mus musculus/domesticus
Length: 1017  
Fragment?: false
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Protein
P33215
Organism: Mus musculus/domesticus
Length: 660  
Fragment?: false
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Protein
Q8BFT2
Organism: Mus musculus/domesticus
Length: 363  
Fragment?: false
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Protein
Q8BKT8
Organism: Mus musculus/domesticus
Length: 364  
Fragment?: false
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Protein
Q9R0L6
Organism: Mus musculus/domesticus
Length: 2025  
Fragment?: false
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Protein
Q64702
Organism: Mus musculus/domesticus
Length: 925  
Fragment?: false
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Protein
Q8BHX1
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
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Protein
Q6ZQ12
Organism: Mus musculus/domesticus
Length: 1394  
Fragment?: false
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Protein
A3KGV1
Organism: Mus musculus/domesticus
Length: 830  
Fragment?: false
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Protein
Q5DU05
Organism: Mus musculus/domesticus
Length: 1446  
Fragment?: false
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Protein
Q9D3R3
Organism: Mus musculus/domesticus
Length: 646  
Fragment?: false
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Protein
Q6A078
Organism: Mus musculus/domesticus
Length: 2472  
Fragment?: false
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Protein
Q6P5D4
Organism: Mus musculus/domesticus
Length: 1140  
Fragment?: false
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Protein
Q9D786
Organism: Mus musculus/domesticus
Length: 619  
Fragment?: false
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Protein
Q99L00
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
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Protein
Q60952
Organism: Mus musculus/domesticus
Length: 2414  
Fragment?: false
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Protein
Q80UF4
Organism: Mus musculus/domesticus
Length: 717  
Fragment?: false
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Protein
Q9JJ94
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
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Protein
Q3UZY0
Organism: Mus musculus/domesticus
Length: 1216  
Fragment?: false
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Protein
P99024
Organism: Mus musculus/domesticus
Length: 444  
Fragment?: false
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Protein
P83887
Organism: Mus musculus/domesticus
Length: 451  
Fragment?: false
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Protein
E9Q4Y4
Organism: Mus musculus/domesticus
Length: 2514  
Fragment?: false
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Protein
Q6NV99
Organism: Mus musculus/domesticus
Length: 933  
Fragment?: false
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Publication
32160543 | J:288247
First Author: Rohrberg J
Year: 2020
Journal: Cell Rep
Title: MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities.
Volume: 30
Issue: 10
Pages: 3368-3382.e7
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Publication
31495584 | J:281601
First Author: Vargas-Hurtado D
Year: 2019
Journal: Curr Biol
Title: Differences in Mitotic Spindle Architecture in Mammalian Neural Stem Cells Influence Mitotic Accuracy during Brain Development.
Volume: 29
Issue: 18
Pages: 2993-3005.e9
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Protein Coding Gene
MGI:2684927 | Cenpj
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1351660 | Csnk1e
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:894678 | Aurka
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2178217 | Akap9
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Cambridge CB2 3EH, United Kingdom