Autophagy-related protein LC3C (also known as microtubule-associated proteins 1A/1B light chain 3C) is a member of the ATG8 family, LC3 subfamily []. It is an ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2 []. LC3C recruites all ATG8 family members to infecting bacteria such as Salmonella typhimurium [].