This entry represents calcium-responsive transcription factor (CaRF, also known as amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) []. CaRF acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. It binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence [].
This entry represents the minimal version of the CRISPR polymerase domain. It is predicted to generate cyclic nucleotides, potentially sensed by CARF domains which in turn activate various effector domain including HEPN RNases, CARF sensor and effectors are found in conserved genome contexts. It is part of a broader class of conflict systems reliant on the production of second messenger nucleotide or nucleotide derivatives. This implicates CRISPR polymerase of the Type III CRISPR/Cas systems in a nucleotide synthetase functional role [].
