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Search results 1 to 100 out of 2004 for Psen1

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Category: Publication
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Type Details Score
Publication
28617969 | J:273965
First Author: Song XW
Year: 2018
Journal: J Cell Physiol
Title: Conditionally targeted deletion of PSEN1 leads to diastolic heart dysfunction.
Volume: 233
Issue: 2
Pages: 1548-1557
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Publication
34939719 | J:331779
First Author: Song XW
Year: 2022
Journal: Cell Biol Int
Title: Cardiovascular-specific PSEN1 deletion leads to abnormalities in calcium homeostasis.
Volume: 46
Issue: 3
Pages: 475-487
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Publication
22723704 | J:185660
First Author: Zhang X
Year: 2012
Journal: J Neurosci
Title: A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.
Volume: 32
Issue: 25
Pages: 8633-48
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Publication
30042426 | J:266488
First Author: Sasaguri H
Year: 2018
Journal: Nat Commun
Title: Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID.
Volume: 9
Issue: 1
Pages: 2892
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Publication
12900443 | J:84596
First Author: Takahashi Y
Year: 2003
Journal: Development
Title: Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites.
Volume: 130
Issue: 18
Pages: 4259-68
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Publication
35486730 | J:338551
First Author: Lie PPY
Year: 2022
Journal: Sci Adv
Title: Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca(2+) efflux and disrupted by PSEN1 loss of function.
Volume: 8
Issue: 17
Pages: eabj5716
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Publication
21841774 | J:179786
First Author: Pratt KG
Year: 2011
Journal: Nat Neurosci
Title: Presenilin 1 regulates homeostatic synaptic scaling through Akt signaling.
Volume: 14
Issue: 9
Pages: 1112-4
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Publication
18729224 | J:138800
First Author: De Gasperi R
Year: 2008
Journal: Dev Dyn
Title: Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling.
Volume: 237
Issue: 9
Pages: 2405-14
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Publication
31217332 | J:278870
First Author: Ortega-Martinez S
Year: 2019
Journal: J Neurosci
Title: Deficits in Enrichment-Dependent Neurogenesis and Enhanced Anxiety Behaviors Mediated by Expression of Alzheimer's Disease-Linked Ps1 Variants Are Rescued by Microglial Depletion.
Volume: 39
Issue: 34
Pages: 6766-6780
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Publication
24694184 | J:285067
 
First Author: Guzmán EA
Year: 2014
Journal: Mol Neurodegener
Title: Abundance of Aβ₅-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease.
Volume: 9
Pages: 13
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Publication
37421950 | J:339320
First Author: Xiang J
Year: 2023
Journal: Cell
Title: Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies.
Volume: 186
Issue: 16
Pages: 3350-3367.e19
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Publication
37409006 | J:346956
 
First Author: Weigel TK
Year: 2023
Journal: Front Aging Neurosci
Title: Altered circadian behavior and light sensing in mouse models of Alzheimer's disease.
Volume: 15
Pages: 1218193
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Publication
35198070 | J:327457
First Author: Cai CZ
Year: 2022
Journal: Theranostics
Title: Enhancing autophagy maturation with CCZ1-MON1A complex alleviates neuropathology and memory defects in Alzheimer disease models.
Volume: 12
Issue: 4
Pages: 1738-1755
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Publication
31434879 | J:279495
First Author: Spangenberg E
Year: 2019
Journal: Nat Commun
Title: Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.
Volume: 10
Issue: 1
Pages: 3758
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Publication
32745992 | J:311234
 
First Author: Crapser JD
Year: 2020
Journal: EBioMedicine
Title: Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain.
Volume: 58
Pages: 102919
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34303222 | J:311302
 
First Author: Russo ML
Year: 2021
Journal: Neurobiol Aging
Title: Variability in sub-threshold signaling linked to Alzheimer's disease emerges with age and amyloid plaque deposition in mouse ventral CA1 pyramidal neurons.
Volume: 106
Pages: 207-222
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30635592 | J:275422
First Author: Creighton SD
Year: 2019
Journal: Sci Rep
Title: Dissociable cognitive impairments in two strains of transgenic Alzheimer's disease mice revealed by a battery of object-based tests.
Volume: 9
Issue: 1
Pages: 57
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32832679 | J:327386
First Author: Chen C
Year: 2020
Journal: Sci Adv
Title: Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer's disease mouse model.
Volume: 6
Issue: 31
Pages: eaba0466
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Publication
37308288 | J:337909
 
First Author: Sanna PP
Year: 2023
Journal: eNeuro
Title: A History of Repeated Alcohol Intoxication Promotes Cognitive Impairment and Gene Expression Signatures of Disease Progression in the 3xTg Mouse Model of Alzheimer's Disease.
Volume: 10
Issue: 7
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Publication
37060096 | J:335721
First Author: Wu D
Year: 2023
Journal: Mol Neurodegener
Title: Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation.
Volume: 18
Issue: 1
Pages: 23
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Publication
28826672 | J:271996
First Author: Wang ZH
Year: 2017
Journal: Mol Cell
Title: Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.
Volume: 67
Issue: 5
Pages: 812-825.e5
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29725016 | J:262986
First Author: Wang ZH
Year: 2018
Journal: Nat Commun
Title: C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease.
Volume: 9
Issue: 1
Pages: 1784
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Publication
23955714 | J:202038
First Author: Pietri M
Year: 2013
Journal: Nat Med
Title: PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases.
Volume: 19
Issue: 9
Pages: 1124-31
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26214837 | J:228830
First Author: Zenaro E
Year: 2015
Journal: Nat Med
Title: Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin.
Volume: 21
Issue: 8
Pages: 880-6
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31164420 | J:279242
First Author: Bahn G
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer's models.
Volume: 116
Issue: 25
Pages: 12516-12523
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31221985 | J:279897
First Author: Kastanenka KV
Year: 2019
Journal: Sci Rep
Title: Frequency-dependent exacerbation of Alzheimer's disease neuropathophysiology.
Volume: 9
Issue: 1
Pages: 8964
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28753475 | J:249747
 
First Author: Toussay X
Year: 2017
Journal: Neurobiol Aging
Title: Presenilin 1 mutation decreases both calcium and contractile responses in cerebral arteries.
Volume: 58
Pages: 201-212
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Publication
33846335 | J:311263
First Author: Kim K
Year: 2021
Journal: Nat Commun
Title: Therapeutic B-cell depletion reverses progression of Alzheimer's disease.
Volume: 12
Issue: 1
Pages: 2185
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34505007 | J:313520
First Author: Aguilar-Pineda JA
Year: 2021
Journal: iScience
Title: Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease.
Volume: 24
Issue: 9
Pages: 102993
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16079160 | J:100132
First Author: Wen PH
Year: 2005
Journal: Development
Title: Selective expression of presenilin 1 in neural progenitor cells rescues the cerebral hemorrhages and cortical lamination defects in presenilin 1-null mutant mice.
Volume: 132
Issue: 17
Pages: 3873-83
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Publication
26529393 | J:286210
First Author: Savastano A
Year: 2016
Journal: J Alzheimers Dis
Title: N-truncated Aβ2-X starting with position two in sporadic Alzheimer's disease cases and two Alzheimer mouse models.
Volume: 49
Issue: 1
Pages: 101-10
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28978359 | J:285070
First Author: Wirths O
Year: 2017
Journal: Alzheimers Res Ther
Title: N-truncated Aβ4-x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse models.
Volume: 9
Issue: 1
Pages: 80
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Publication
31042463 | J:284880
First Author: Deyts C
Year: 2019
Journal: Cell Rep
Title: APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model.
Volume: 27
Issue: 5
Pages: 1345-1355.e6
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19751708 | J:158791
 
First Author: Christensen DZ
Year: 2009
Journal: Brain Res
Title: Formic acid is essential for immunohistochemical detection of aggregated intraneuronal Abeta peptides in mouse models of Alzheimer's disease.
Volume: 1301
Pages: 116-25
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30867420 | J:273276
First Author: He Y
Year: 2019
Journal: Nat Commun
Title: Amyloid β oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate.
Volume: 10
Issue: 1
Pages: 1193
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Publication
35269588 | J:327470
 
First Author: Martínez-Iglesias O
Year: 2022
Journal: Int J Mol Sci
Title: Epigenetic Studies in the Male APP/BIN1/COPS5 Triple-Transgenic Mouse Model of Alzheimer's Disease.
Volume: 23
Issue: 5
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35426376 | J:323934
 
First Author: Zou HY
Year: 2022
Journal: J Clin Invest
Title: Aberrant miR-339-5p/neuronatin signaling causes prodromal neuronal calcium dyshomeostasis in mutant presenilin mice.
Volume: 132
Issue: 8
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37028406 | J:334726
First Author: Li YD
Year: 2023
Journal: Cell Stem Cell
Title: Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer's disease.
Volume: 30
Issue: 4
Pages: 415-432.e6
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11070093 | J:65800
First Author: Grilli M
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically.
Volume: 97
Issue: 23
Pages: 12822-7
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Publication
23306558 | J:228263
First Author: Song H
Year: 2013
Journal: Cell Death Differ
Title: Critical role of presenilin-dependent γ-secretase activity in DNA damage-induced promyelocytic leukemia protein expression and apoptosis.
Volume: 20
Issue: 4
Pages: 639-48
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20971852 | J:167567
First Author: Wirths O
Year: 2010
Journal: J Biol Chem
Title: Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis.
Volume: 285
Issue: 53
Pages: 41517-24
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31213067 | J:277676
 
First Author: Findley CA
Year: 2019
Journal: ASN Neuro
Title: Amyloid Beta-Related Alterations to Glutamate Signaling Dynamics During Alzheimer's Disease Progression.
Volume: 11
Pages: 1759091419855541
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24305500 | J:286212
First Author: Reinert J
Year: 2014
Journal: J Alzheimers Dis
Title: Aβ38 in the brains of patients with sporadic and familial Alzheimer's disease and transgenic mouse models.
Volume: 39
Issue: 4
Pages: 871-81
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36012331 | J:327939
 
First Author: Saleh B
Year: 2022
Journal: Int J Mol Sci
Title: FAK-Mediated Signaling Controls Amyloid Beta Overload, Learning and Memory Deficits in a Mouse Model of Alzheimer's Disease.
Volume: 23
Issue: 16
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24278307 | J:209782
First Author: Guo Q
Year: 2013
Journal: PLoS One
Title: Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau.
Volume: 8
Issue: 11
Pages: e80706
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27100199 | J:239478
First Author: Veugelen S
Year: 2016
Journal: Neuron
Title: Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.
Volume: 90
Issue: 2
Pages: 410-6
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22753898 | J:190756
First Author: Coen K
Year: 2012
Journal: J Cell Biol
Title: Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells.
Volume: 198
Issue: 1
Pages: 23-35
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8755489 | J:34323
First Author: Thinakaran G
Year: 1996
Journal: Neuron
Title: Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
Volume: 17
Issue: 1
Pages: 181-90
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18760694 | J:149876
First Author: Choi SH
Year: 2008
Journal: Neuron
Title: Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation.
Volume: 59
Issue: 4
Pages: 568-80
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15212842 | J:102351
First Author: Jankowsky JL
Year: 2004
Journal: Neurobiol Aging
Title: APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1.
Volume: 25
Issue: 7
Pages: 885-92
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16148264 | J:116810
First Author: Cook DG
Year: 2005
Journal: J Neurophysiol
Title: Presenilin 1 deficiency alters the activity of voltage-gated Ca2+ channels in cultured cortical neurons.
Volume: 94
Issue: 6
Pages: 4421-9
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14980721 | J:89996
First Author: Yang Y
Year: 2004
Journal: Neuroscience
Title: Presenilin-1 deficiency impairs glutamate-evoked intracellular calcium responses in neurons.
Volume: 124
Issue: 3
Pages: 501-5
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21248114 | J:168562
First Author: Pratt KG
Year: 2011
Journal: J Neurosci
Title: A novel role for {gamma}-secretase: selective regulation of spontaneous neurotransmitter release from hippocampal neurons.
Volume: 31
Issue: 3
Pages: 899-906
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17596450 | J:122975
First Author: Lazarov O
Year: 2007
Journal: J Neurosci
Title: Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1.
Volume: 27
Issue: 26
Pages: 7011-20
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Publication
34758364 | J:321426
 
First Author: Si Y
Year: 2022
Journal: Behav Brain Res
Title: Noncognitive species-typical and home-cage behavioral alterations in conditional presenilin 1/presenilin 2 double knockout mice.
Volume: 418
Pages: 113652
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Publication
34292306 | J:321625
 
First Author: Wouters R
Year: 2021
Journal: J Cell Biol
Title: Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum.
Volume: 220
Issue: 9
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9160754 | J:40365
First Author: Shen J
Year: 1997
Journal: Cell
Title: Skeletal and CNS defects in Presenilin-1-deficient mice.
Volume: 89
Issue: 4
Pages: 629-39
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37143894 | J:337547
 
First Author: Tiberi A
Year: 2023
Journal: Front Cell Dev Biol
Title: Reduced levels of NGF shift astrocytes toward a neurotoxic phenotype.
Volume: 11
Pages: 1165125
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27069115 | J:233316
First Author: Yuede CM
Year: 2016
Journal: J Exp Med
Title: Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer's mouse model.
Volume: 213
Issue: 5
Pages: 677-85
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18304749 | J:135640
First Author: Pistell PJ
Year: 2008
Journal: Neuroscience
Title: Acquisition of conditioned taste aversion is impaired in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer's disease.
Volume: 152
Issue: 3
Pages: 594-600
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30059908 | J:264269
 
First Author: Azimi M
Year: 2018
Journal: Differentiation
Title: Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens.
Volume: 102
Pages: 40-52
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33314529 | J:331908
First Author: Audrain M
Year: 2021
Journal: Alzheimers Dement
Title: Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice.
Volume: 17
Issue: 2
Pages: 149-163
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16303255 | J:105507
First Author: Spencer JP
Year: 2006
Journal: Neuroscience
Title: Transgenic mice over-expressing human beta-amyloid have functional nicotinic alpha 7 receptors.
Volume: 137
Issue: 3
Pages: 795-805
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15261108 | J:91273
First Author: Howlett DR
Year: 2004
Journal: Brain Res
Title: Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.
Volume: 1017
Issue: 1-2
Pages: 130-6
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23259730 | J:309717
 
First Author: De Gasperi R
Year: 2012
Journal: BMC Biochem
Title: Presenilin-1 regulates the constitutive turnover of the fibronectin matrix in endothelial cells.
Volume: 13
Pages: 28
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19936202 | J:155410
First Author: Willuweit A
Year: 2009
Journal: PLoS One
Title: Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease.
Volume: 4
Issue: 11
Pages: e7931
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15519767 | J:94236
First Author: Wen PH
Year: 2004
Journal: Neurosci Lett
Title: Neural progenitor cells do not differentiate prematurely in presenilin-1 null mutant mice.
Volume: 371
Issue: 2-3
Pages: 249-54
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21239495 | J:170632
First Author: Greenough MA
Year: 2011
Journal: J Biol Chem
Title: Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity.
Volume: 286
Issue: 11
Pages: 9776-86
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17088253 | J:118134
First Author: Priller C
Year: 2007
Journal: J Biol Chem
Title: Mutant presenilin 1 alters synaptic transmission in cultured hippocampal neurons.
Volume: 282
Issue: 2
Pages: 1119-27
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31142678 | J:275647
 
First Author: Habets RA
Year: 2019
Journal: Sci Transl Med
Title: Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition.
Volume: 11
Issue: 494
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33450722 | J:305544
 
First Author: Cheng Z
Year: 2021
Journal: Neurobiol Aging
Title: Presenilin 1 mutation likely contributes to U1 small nuclear RNA dysregulation and Alzheimer's disease-like symptoms.
Volume: 100
Pages: 1-10
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30089166 | J:269173
First Author: Cummings M
Year: 2018
Journal: PLoS One
Title: Presenilin1 regulates Th1 and Th17 effector responses but is not required for experimental autoimmune encephalomyelitis.
Volume: 13
Issue: 8
Pages: e0200752
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17233641 | J:116798
First Author: Reiserer RS
Year: 2007
Journal: Genes Brain Behav
Title: Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.
Volume: 6
Issue: 1
Pages: 54-65
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32522344 | J:293057
 
First Author: Kuroda E
Year: 2020
Journal: Neuroscience
Title: Mouse Bone Marrow-derived Microglia-like Cells Secrete Transforming Growth Factor-β1 and Promote Microglial Aβ Phagocytosis and Reduction of Brain Aβ.
Volume: 438
Pages: 217-228
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37213691 | J:338490
 
First Author: Demuth H
Year: 2023
Journal: Front Mol Neurosci
Title: Deletion of p75(NTR) rescues the synaptic but not the inflammatory status in the brain of a mouse model for Alzheimer's disease.
Volume: 16
Pages: 1163087
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23747948 | J:199082
First Author: Frost JL
Year: 2013
Journal: Am J Pathol
Title: Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models.
Volume: 183
Issue: 2
Pages: 369-81
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30120949 | J:270232
 
First Author: Wang M
Year: 2018
Journal: Neurosci Lett
Title: Beta-secretase/BACE1 promotes APP endocytosis and processing in the endosomes and on cell membrane.
Volume: 685
Pages: 63-67
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23833557 | J:202532
First Author: Lee JE
Year: 2013
Journal: Exp Neurobiol
Title: An update of animal models of Alzheimer disease with a reevaluation of plaque depositions.
Volume: 22
Issue: 2
Pages: 84-95
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27425031 | J:255474
First Author: Kamphuis W
Year: 2016
Journal: Biochim Biophys Acta
Title: Transcriptional profiling of CD11c-positive microglia accumulating around amyloid plaques in a mouse model for Alzheimer's disease.
Volume: 1862
Issue: 10
Pages: 1847-60
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25741723 | J:219929
First Author: Xia D
Year: 2015
Journal: Neuron
Title: Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.
Volume: 85
Issue: 5
Pages: 967-81
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15009636 | J:107993
First Author: Yang Y
Year: 2004
Journal: J Neurochem
Title: Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake.
Volume: 88
Issue: 6
Pages: 1361-72
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28855626 | J:255802
First Author: Baglietto-Vargas D
Year: 2017
Journal: Sci Rep
Title: Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer's disease.
Volume: 7
Issue: 1
Pages: 10085
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16307858 | J:128243
First Author: Wirths O
Year: 2006
Journal: Exp Gerontol
Title: Decreased plasma cholesterol levels during aging in transgenic mouse models of Alzheimer's disease.
Volume: 41
Issue: 2
Pages: 220-4
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8986743 | J:83861
First Author: Citron M
Year: 1997
Journal: Nat Med
Title: Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.
Volume: 3
Issue: 1
Pages: 67-72
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9883847 | J:51950
First Author: Guo Q
Year: 1999
Journal: Nat Med
Title: Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.
Volume: 5
Issue: 1
Pages: 101-6
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Publication
10764737 | J:62820
First Author: Chan SL
Year: 2000
Journal: J Biol Chem
Title: Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons.
Volume: 275
Issue: 24
Pages: 18195-200
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Publication
26455952 | J:232370
First Author: Kim S
Year: 2015
Journal: Neurobiol Aging
Title: Reduction of increased calcineurin activity rescues impaired homeostatic synaptic plasticity in presenilin 1 M146V mutant.
Volume: 36
Issue: 12
Pages: 3239-3246
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Publication
12390529 | J:79892
First Author: Milhavet O
Year: 2002
Journal: J Neurochem
Title: Involvement of Gadd153 in the pathogenic action of presenilin-1 mutations.
Volume: 83
Issue: 3
Pages: 673-81
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Publication
18068871 | J:152964
First Author: Wang Y
Year: 2009
Journal: Neurobiol Aging
Title: Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices.
Volume: 30
Issue: 7
Pages: 1061-8
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Publication
23726841 | J:199100
First Author: Chu TH
Year: 2013
Journal: Cancer Lett
Title: miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII.
Volume: 337
Issue: 1
Pages: 115-24
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14724250 | J:87452
First Author: Stutzmann GE
Year: 2004
Journal: J Neurosci
Title: Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability.
Volume: 24
Issue: 2
Pages: 508-13
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Publication
10811821 | J:62231
First Author: Leissring MA
Year: 2000
Journal: J Cell Biol
Title: Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice.
Volume: 149
Issue: 4
Pages: 793-8
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Publication
10526115 | J:57847
First Author: Zhu H
Year: 1999
Journal: Brain Res
Title: Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation.
Volume: 842
Issue: 1
Pages: 224-9
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Publication
18205190 | J:156283
First Author: Wang G
Year: 2008
Journal: Glia
Title: Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes.
Volume: 56
Issue: 4
Pages: 449-56
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12064358 | J:106192
First Author: LaFontaine MA
Year: 2002
Journal: Neurochem Res
Title: Oxidative stress in synaptosomal proteins from mutant presenilin-1 knock-in mice: implications for familial Alzheimer's disease.
Volume: 27
Issue: 5
Pages: 417-21
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10662826 | J:60290
First Author: Mattson MP
Year: 2000
Journal: J Neurosci
Title: Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis.
Volume: 20
Issue: 4
Pages: 1358-64
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Publication
11578614 | J:72044
First Author: Xie J
Year: 2001
Journal: Brain Res
Title: Aberrant induction of Par-4 is involved in apoptosis of hippocampal neurons in presenilin-1 M146V mutant knock-in mice.
Volume: 915
Issue: 1
Pages: 1-10
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Publication
10097174 | J:54086
First Author: Guo Q
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation.
Volume: 96
Issue: 7
Pages: 4125-30
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Publication
10037473 | J:53132
First Author: Guo Q
Year: 1999
Journal: J Neurochem
Title: Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.
Volume: 72
Issue: 3
Pages: 1019-29
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18466334 | J:139367
First Author: Malik B
Year: 2008
Journal: J Neurochem
Title: Cell cycle-driven neuronal apoptosis specifically linked to amyloid peptide Abeta1-42 exposure is not exacerbated in a mouse model of presenilin-1 familial Alzheimer's disease.
Volume: 106
Issue: 2
Pages: 912-6
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