Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2, also known as IMP-2) is a ubiquitously expressed RNA-binding protein that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs) []. It is involved in the stimulation of insulin action and has a role in metabolic homeostasis []. SNPs in IGF2BP2 gene are implicated in susceptibility to type 2 diabetes []. IGF2BP2 also plays an important role in cellular motility; it regulates the expression of PINCH-2, an important mediator of cell adhesion and motility, and MURF-3, a microtubule-stabilizing protein, through direct binding to their mRNAs []. IGF2BP2 may be involved in the regulation of mRNA stability through the interaction with the AU-rich element-binding factor AUF1 []. IGF2BP2 belongs to the IGF2BP family, which includes IGF2BP1, IGF2BP2, and IGF2BP3. They have different functions, such as cell polarisation, migration, morphology, metabolism, proliferation and differentiation []. They contain four hnRNP K-homology (KH) domains, two RNA recognition motifs (RRMs) and a RGG RNA-binding domain.
This entry represents the RNA recognition motif 1 (RRM1) of IGF2BP2.Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2, also known as IMP-2) is a ubiquitously expressed RNA-binding protein that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs) []. It is involved in the stimulation of insulin action and has a role in metabolic homeostasis []. SNPs in IGF2BP2 gene are implicated in susceptibility to type 2 diabetes []. IGF2BP2 also plays an important role in cellular motility; it regulates the expression of PINCH-2, an important mediator of cell adhesion and motility, and MURF-3, a microtubule-stabilizing protein, through direct binding to their mRNAs []. IGF2BP2 may be involved in the regulation of mRNA stability through the interaction with the AU-rich element-binding factor AUF1 []. IGF2BP2 belongs to the IGF2BP family, which includes IGF2BP1, IGF2BP2, and IGF2BP3. They have different functions, such as cell polarisation, migration, morphology, metabolism, proliferation and differentiation []. They contain four hnRNP K-homology (KH) domains, two RNA recognition motifs (RRMs) and a RGG RNA-binding domain.
