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Search results 1 to 100 out of 1271 for Ntrk1

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Type Details Score
Gene
4914 | NTRK1
Type: gene
Organism: human
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Gene
30546 | ntrk1
Type: gene
Organism: zebrafish
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Gene
719670 | NTRK1
Type: gene
Organism: macaque, rhesus
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Gene
100489637 | ntrk1
Type: gene
Organism: frog, western clawed
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Gene
59109 | Ntrk1
Type: gene
Organism: rat
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Gene
490404 | NTRK1
Type: gene
Organism: dog, domestic
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Gene
457408 | NTRK1
Type: gene
Organism: chimpanzee
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Gene
353111 | NTRK1
Type: gene
Organism: cattle
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Gene
396337 | NTRK1
Type: gene
Organism: chicken
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Protein Domain
IPR020461 | NTRK1
Type: Family
Description: Neurotrophins are a family of secreted proteins that regulate development, maintenance and function of vertebrate nervous systems. They act via two different classes of receptor: p75NTR (a member of the TNF receptor superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also known as tropomyosin-related kinases (Trks) []. NTRKs are multi-domain, transmembrane proteins - in addition to their cytoplasmic kinase domains, members of the family possess a number of extracellular leucine-rich repeat (LRR) and Ig-like C2-type regions. Ligand binding induces them to dimerise, resulting in activation of their cytoplasmic tyrosine kinase domains. The activated receptors couple to a variety of intracellular signalling cascades, including the Ras, phosphatidylinositol-3-kinase (PI-3 kinase), mitogen-activated protein (MAP) kinase, and phospholipase C (PLC)-gamma pathways []. NTRK1 (also termed TrkA) is a high-affinity receptor for nerve growth factor (NGF). The receptor is expressed in the dorsal root ganglia, trigeminal ganglia and sympathetic neurons of the peripheral nervous system, and in basal forebrain cholinergic neurons []. It is also expressed in peripheral sites, such as scalp skin []. Whereas p75NTR activation by NGF induces apoptosis, NTRK1 mediates the growth factor's cell survival-promoting effects [].
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Protein Coding Gene
MGI:97383 | Ntrk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
16919030 | -
First Author: Adly MA
Year: 2006
Journal: J Cutan Pathol
Title: Expression of nerve growth factor and its high-affinity receptor, tyrosine kinase A proteins, in the human scalp skin.
Volume: 33
Issue: 8
Pages: 559-68
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Publication
9547236 | -
First Author: Yoon SO
Year: 1998
Journal: J Neurosci
Title: Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival.
Volume: 18
Issue: 9
Pages: 3273-81
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Publication
17192812 | -
First Author: Lei L
Year: 2007
Journal: Cell Mol Life Sci
Title: Transcriptional regulation of Trk family neurotrophin receptors.
Volume: 64
Issue: 5
Pages: 522-32
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GXD Expression
GXD Expression
 
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271120
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450881
Age: embryonic day 12.5
Image: Ntrk1 - E12.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex.
Specimen Label: Ntrk1 - E12.5
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Scattered
Stage: TS22
Assay Id: MGI:4450881
Age: embryonic day 14.5
Image: Ntrk1 - E14.5
Note: There is weak, scattered staining in the postmitotic neurons in the cortical plate of the cerebral cortex.
Specimen Label: Ntrk1 - E14.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271220
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450881
Age: embryonic day 12.5
Image: Ntrk1 - E12.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex.
Specimen Label: Ntrk1 - E12.5
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3271222
Pattern: Scattered
Stage: TS22
Assay Id: MGI:4450881
Age: embryonic day 14.5
Image: Ntrk1 - E14.5
Note: There is weak, scattered staining in the postmitotic neurons in the intermediate zone of the cerebral cortex.
Specimen Label: Ntrk1 - E14.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754320
Pattern: Non-Uniform
Stage: TS20
Assay Id: MGI:4450881
Age: embryonic day 12.5
Image: Ntrk1 - E12.5
Note: There is strong staining in the ventricular zone of the prethalamus. Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus.
Specimen Label: Ntrk1 - E12.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1754322
Pattern: Non-Uniform
Stage: TS22
Assay Id: MGI:4450881
Age: embryonic day 14.5
Image: Ntrk1 - E14.5
Note: There is moderate staining in the ventricular zone of the prethalamus and moderate, scattered staining in the dorsal thalamus.
Specimen Label: Ntrk1 - E14.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1754324
Pattern: Non-Uniform
Stage: TS24
Assay Id: MGI:4450881
Age: embryonic day 16.5
Image: Ntrk1 - E16.5
Note: There is strong staining in the ventricular zone of the prethalamus. Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus.
Specimen Label: Ntrk1 - E16.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1753720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450881
Age: embryonic day 12.5
Image: Ntrk1 - E12.5
Note: Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs.
Specimen Label: Ntrk1 - E12.5
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1753722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450881
Age: embryonic day 14.5
Image: Ntrk1 - E14.5
Note: Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs.
Specimen Label: Ntrk1 - E14.5
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1691319
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4450881
Age: embryonic day 11.5
Image: Ntrk1 - E11.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex and the ganglionic eminences.
Specimen Label: Ntrk1 - E11.5
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3271820
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450881
Age: embryonic day 12.5
Image: Ntrk1 - E12.5
Note: Staining is either absent or ubiquitous in the mantle zone of the premam, mam and supramam zones and the TT.
Specimen Label: Ntrk1 - E12.5
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1690819
Pattern: Non-Uniform
Stage: TS19
Assay Id: MGI:4450881
Age: embryonic day 11.5
Image: Ntrk1 - E11.5
Note: There is strong staining in the VZ of the ventral POA, VMH & ARH nuclei, AVH, anterior & posterior IDs, premam & mam zones & TT. Staining is either absent or ubiquitous in the VZ of dorsal thalamus, prethalamus, dorsal POA, PVH nucleus & supramam zone.
Specimen Label: Ntrk1 - E11.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1753920
Pattern: Non-Uniform
Stage: TS20
Assay Id: MGI:4450881
Age: embryonic day 12.5
Image: Ntrk1 - E12.5
Note: There is strong staining in the ventricular zone of the ventral POA, PVH, VMH and ARH nuclei and the AVH and weak, scattered staining in the anterior and posterior IDs. Staining is either absent or ubiquitous in the ventricular zone of the dorsal POA.
Specimen Label: Ntrk1 - E12.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:1753922
Pattern: Non-Uniform
Stage: TS22
Assay Id: MGI:4450881
Age: embryonic day 14.5
Image: Ntrk1 - E14.5
Note: There is very strong staining in the VZ of the VMH & ARH nuclei, strong staining in the ventral POA, PVH nucleus & the AVH & weak, scattered staining in the anterior & posterior IDs. Staining is either absent or ubiquitous in the VZ of the dorsal POA.
Specimen Label: Ntrk1 - E14.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:1753924
Pattern: Non-Uniform
Stage: TS24
Assay Id: MGI:4450881
Age: embryonic day 16.5
Image: Ntrk1 - E16.5
Note: There is very strong staining in the ventricular zone of the VMH and ARH nuclei and strong staining in the AVH and DAH. Staining is either absent or ubiquitous in the ventricular zone of the dorsal and ventral POAs, the PVH, SCH and DMH nuclei and the PH.
Specimen Label: Ntrk1 - E16.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1691119
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4450881
Age: embryonic day 11.5
Image: Ntrk1 - E11.5
Note: Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone and cortical plate of the cerebral cortex and in the mantle zone of the ganglionic eminences.
Specimen Label: Ntrk1 - E11.5
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450881
Age: embryonic day 12.5
Image: Ntrk1 - E12.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex.
Specimen Label: Ntrk1 - E12.5
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3271020
Pattern: Non-Uniform
Stage: TS20
Assay Id: MGI:4450881
Age: embryonic day 12.5
Image: Ntrk1 - E12.5
Note: There is strong staining in the ventricular zone of the premam and mam zones and weak, scattered staining in the TT and supramam zone.
Specimen Label: Ntrk1 - E12.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3266520
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:4450881
Age: embryonic day 12.5
Image: Ntrk1 - E12.5
Note: Staining is either absent or ubiquitous in the ventricular and mantle zones of the ganglionic eminences.
Specimen Label: Ntrk1 - E12.5
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3266522
Pattern: Non-Uniform
Stage: TS22
Assay Id: MGI:4450881
Age: embryonic day 14.5
Image: Ntrk1 - E14.5
Note: There is strong staining in the ventricular zone of the ganglionic eminences. Staining is either absent or ubiquitous in the mantle zone of the ganglionic eminences.
Specimen Label: Ntrk1 - E14.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3266524
Pattern: Non-Uniform
Stage: TS24
Assay Id: MGI:4450881
Age: embryonic day 16.5
Image: Ntrk1 - E16.5
Note: There is strong staining in the mantle zone of the ganglionic eminences. Staining is either absent or ubiquitous in the ventricular zone of the ganglionic eminences.
Specimen Label: Ntrk1 - E16.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1690619
Pattern: Non-Uniform
Stage: TS19
Assay Id: MGI:4450881
Age: embryonic day 11.5
Image: Ntrk1 - E11.5
Note: There is moderate staining in the MZ of the prethalamus. Staining is either absent or ubiquitous in the MZ of the dorsal thalamus, dorsal & ventral POAs, the PVH, VMH & ARH nuclei, the AVH, anterior & posterior IDs, premam, mam & supramam zones & the TT.
Specimen Label: Ntrk1 - E11.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1754124
Pattern: Non-Uniform
Stage: TS24
Assay Id: MGI:4450881
Age: embryonic day 16.5
Image: Ntrk1 - E16.5
Note: There is moderate staining in the mantle zone of the dorsal thalamus and weak staining in the prethalamus.
Specimen Label: Ntrk1 - E16.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3271124
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450881
Age: embryonic day 16.5
Image: Ntrk1 - E16.5
Note: There is moderate staining in the postmitotic neurons in the cortical plate of the cerebral cortex.
Specimen Label: Ntrk1 - E16.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3271224
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450881
Age: embryonic day 16.5
Image: Ntrk1 - E16.5
Note: There is moderate staining in the postmitotic neurons in the intermediate zone of the cerebral cortex.
Specimen Label: Ntrk1 - E16.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1753724
Pattern: Non-Uniform
Stage: TS24
Assay Id: MGI:4450881
Age: embryonic day 16.5
Image: Ntrk1 - E16.5
Note: There is strong staining in the mantle zone of the dorsal POA, DMH, VMH and ARH nuclei and the PH. Staining is either absent or ubiquitous in the mantle zone of the ventral POA, PVH and SCH nuclei, the AVH and the DAH.
Specimen Label: Ntrk1 - E16.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3271822
Pattern: Non-Uniform
Stage: TS22
Assay Id: MGI:4450881
Age: embryonic day 14.5
Image: Ntrk1 - E14.5
Note: There is weak, scattered staining in the mantle zone of the mam zone. Staining is either absent or ubiquitous in the mantle zone of the premam and supramam zones and the TT.
Specimen Label: Ntrk1 - E14.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3271824
Pattern: Non-Uniform
Stage: TS24
Assay Id: MGI:4450881
Age: embryonic day 16.5
Image: Ntrk1 - E16.5
Note: There is strong staining in the mantle zone of the premam zone and moderate staining in the mam and supramam zone.
Specimen Label: Ntrk1 - E16.5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4450881
Age: embryonic day 14.5
Image: Ntrk1 - E14.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex.
Specimen Label: Ntrk1 - E14.5
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754724
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:4450881
Age: embryonic day 16.5
Image: Ntrk1 - E16.5
Note: Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex.
Specimen Label: Ntrk1 - E16.5
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3271022
Pattern: Non-Uniform
Stage: TS22
Assay Id: MGI:4450881
Age: embryonic day 14.5
Image: Ntrk1 - E14.5
Note: There is very strong staining in the ventricular zone of the premam and mam zones and weak, scattered staining in the TT and supramam zone.
Specimen Label: Ntrk1 - E14.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Very strong
Sex: Not Specified
Emaps: EMAPS:3271024
Pattern: Non-Uniform
Stage: TS24
Assay Id: MGI:4450881
Age: embryonic day 16.5
Image: Ntrk1 - E16.5
Note: There is very strong staining in the ventricular zone of the premam and mam zones. Staining is either absent or ubiquitous in the ventricular zone of the supramam zone.
Specimen Label: Ntrk1 - E16.5
Detected: true
Specimen Num: 4
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•
GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1754120
Pattern: Non-Uniform
Stage: TS20
Assay Id: MGI:4450881
Age: embryonic day 12.5
Image: Ntrk1 - E12.5
Note: There is moderate staining in the mantle zone of the prethalamus and weak staining in the dorsal thalamus.
Specimen Label: Ntrk1 - E12.5
Detected: true
Specimen Num: 2
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•
GXD Expression
GXD Expression
Probe: MGI:4442687
Assay Type: RNA in situ
Annotation Date: 2010-05-13
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1754122
Pattern: Non-Uniform
Stage: TS22
Assay Id: MGI:4450881
Age: embryonic day 14.5
Image: Ntrk1 - E14.5
Note: There is weak, scattered staining in the mantle zone of the dorsal thalamus. Staining is either absent or ubiquitous in the mantle zone of the prethalamus.
Specimen Label: Ntrk1 - E14.5
Detected: true
Specimen Num: 3
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Protein
Q3UFB7
Organism: Mus musculus/domesticus
Length: 799  
Fragment?: false
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Publication
7605062 | -
 
First Author: Bothwell M
Year: 1995
Journal: Annu Rev Neurosci
Title: Functional interactions of neurotrophins and neurotrophin receptors.
Volume: 18
Pages: 223-53
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Publication
11520916 | -
 
First Author: Huang EJ
Year: 2001
Journal: Annu Rev Neurosci
Title: Neurotrophins: roles in neuronal development and function.
Volume: 24
Pages: 677-736
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Publication
19357131 | J:152505
First Author: Kerr B
Year: 2009
Journal: Reproduction
Title: NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicular development in the mouse ovary.
Volume: 138
Issue: 1
Pages: 131-40
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Publication
33235206 | J:309176
First Author: Nakajima K
Year: 2020
Journal: Transl Psychiatry
Title: Ntrk1 mutation co-segregating with bipolar disorder and inherited kidney disease in a multiplex family causes defects in neuronal growth and depression-like behavior in mice.
Volume: 10
Issue: 1
Pages: 407
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GXD Expression
GXD Expression
   
Probe: MGI:6179390
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190978
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Ntrk1
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6179390
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190978
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Ntrk1
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6179390
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190978
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Ntrk1
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6179390
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190978
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Ntrk1
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6179390
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190978
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Ntrk1
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6179390
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190978
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Ntrk1
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6179390
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190978
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Ntrk1
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:7643374
Assay Type: RNA in situ
Annotation Date: 2024-05-29
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3671019
Stage: TS19
Assay Id: MGI:7643434
Age: embryonic day 11.5
Image: S4B
Note: Conditional ablation of Twist1 produces abnormal cellular aggregates. Expression of Ntrk1 was not detected in the aggregates.
Specimen Label: S4B
Detected: false
Specimen Num: 2
•
•
•
•
•
Publication
8145823 | J:17194
First Author: Smeyne RJ
Year: 1994
Journal: Nature
Title: Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.
Volume: 368
Issue: 6468
Pages: 246-9
•
•
•
•
•
Publication
9753121 | J:89430
First Author: de Castro F
Year: 1998
Journal: Eur J Neurosci
Title: Corneal innervation and sensitivity to noxious stimuli in trkA knockout mice.
Volume: 10
Issue: 1
Pages: 146-52
•
•
•
•
•
Publication
11516838 | J:85913
First Author: Matsuo S
Year: 2001
Journal: Neuroscience
Title: trkA modulation of developing somatosensory neurons in oro-facial tissues: tooth pulp fibers are absent in trkA knockout mice.
Volume: 105
Issue: 3
Pages: 747-60
•
•
•
•
•
Publication
10900332 | J:102970
First Author: García-Suárez O
Year: 2000
Journal: J Neuroimmunol
Title: TrkA is necessary for the normal development of the murine thymus.
Volume: 108
Issue: 1-2
Pages: 11-21
•
•
•
•
•
Publication
9315886 | J:43471
First Author: Fagan AM
Year: 1997
Journal: J Neurosci
Title: A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo.
Volume: 17
Issue: 20
Pages: 7644-54
•
•
•
•
•
Publication
7666178 | J:28575
First Author: Silos-Santiago I
Year: 1995
Journal: J Neurosci
Title: Non-TrkA-expressing small DRG neurons are lost in TrkA deficient mice.
Volume: 15
Issue: 9
Pages: 5929-42
•
•
•
•
•
Publication
36730190 | J:338830
First Author: Connor B
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Transcytosis-mediated anterograde transport of TrkA receptors is necessary for sympathetic neuron development and function.
Volume: 120
Issue: 6
Pages: e2205426120
•
•
•
•
•
Publication
23462102 | J:258675
First Author: Miyamoto Y
Year: 2013
Journal: Sci Signal
Title: Akt and PP2A reciprocally regulate the guanine nucleotide exchange factor Dock6 to control axon growth of sensory neurons.
Volume: 6
Issue: 265
Pages: ra15
•
•
•
•
•
Publication
8764654 | J:34321
First Author: White FA
Year: 1996
Journal: J Neurosci
Title: Synchronous onset of NGF and TrkA survival dependence in developing dorsal root ganglia.
Volume: 16
Issue: 15
Pages: 4662-72
•
•
•
•
•
Publication
8994044 | J:38394
First Author: Schober A
Year: 1997
Journal: J Neurosci
Title: Reduced acetylcholinesterase (AChE) activity in adrenal medulla and loss of sympathetic preganglionic neurons in TrkA-deficient, but not TrkB-deficient, mice.
Volume: 17
Issue: 3
Pages: 891-903
•
•
•
•
•
Publication
24516396 | J:210892
First Author: Gorokhova S
Year: 2014
Journal: PLoS Genet
Title: Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor.
Volume: 10
Issue: 2
Pages: e1004081
•
•
•
•
•
Publication
8918886 | J:36756
First Author: Minichiello L
Year: 1996
Journal: Genes Dev
Title: TrkB and TrkC neurotrophin receptors cooperate in promoting survival of hippocampal and cerebellar granule neurons.
Volume: 10
Issue: 22
Pages: 2849-58
•
•
•
•
•
Publication
15530548 | J:101950
First Author: Ichikawa H
Year: 2004
Journal: Acta Histochem
Title: The development of myelinated nociceptors is dependent upon trks in the trigeminal ganglion.
Volume: 106
Issue: 5
Pages: 337-43
•
•
•
•
•
Publication
8815902 | J:35563
First Author: Fagan AM
Year: 1996
Journal: J Neurosci
Title: TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo.
Volume: 16
Issue: 19
Pages: 6208-18
•
•
•
•
•
Publication
11731452 | J:72722
First Author: Middleton G
Year: 2001
Journal: Development
Title: Populations of NGF-dependent neurones differ in their requirement for BAX to undergo apoptosis in the absence of NGF/TrkA signalling in vivo.
Volume: 128
Issue: 23
Pages: 4715-28
•
•
•
•
•
Publication
10719890 | J:60772
First Author: Patel TD
Year: 2000
Journal: Neuron
Title: Development of sensory neurons in the absence of NGF/TrkA signaling in vivo.
Volume: 25
Issue: 2
Pages: 345-57
•
•
•
•
•
Publication
9232598 | J:41896
First Author: Schimmang T
Year: 1997
Journal: Mech Dev
Title: Survival of inner ear sensory neurons in trk mutant mice.
Volume: 64
Issue: 1-2
Pages: 77-85
•
•
•
•
•
Publication
8575307 | J:30344
First Author: Minichiello L
Year: 1995
Journal: Development
Title: Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons.
Volume: 121
Issue: 12
Pages: 4067-75
•
•
•
•
•
Publication
10674466 | J:60480
First Author: Ichikawa H
Year: 2000
Journal: Neuroreport
Title: Developmental dependency of Meissner corpuscles on trkB but not trkA or trkC.
Volume: 11
Issue: 2
Pages: 259-62
•
•
•
•
•
Publication
11295244 | J:109307
First Author: Ichikawa H
Year: 2001
Journal: Brain Res Mol Brain Res
Title: Developmental dependency of Merkel endings on trks in the palate.
Volume: 88
Issue: 1-2
Pages: 171-5
•
•
•
•
•
Publication
20811452 | J:163998
First Author: Nikoletopoulou V
Year: 2010
Journal: Nature
Title: Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not.
Volume: 467
Issue: 7311
Pages: 59-63
•
•
•
•
•
Publication
27698470 | J:336592
 
First Author: Nakajima K
Year: 2016
Journal: Sci Rep
Title: Exome sequencing in the knockin mice generated using the CRISPR/Cas system.
Volume: 6
Pages: 34703
•
•
•
•
•
Publication
8898237 | J:36236
First Author: Piñon LG
Year: 1996
Journal: Development
Title: Timing of neuronal death in trkA, trkB and trkC mutant embryos reveals developmental changes in sensory neuron dependence on Trk signalling.
Volume: 122
Issue: 10
Pages: 3255-61
•
•
•
•
•
Publication
16037097 | J:102679
First Author: von Bohlen und Halbach O
Year: 2005
Journal: FASEB J
Title: Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra.
Volume: 19
Issue: 12
Pages: 1740-2
•
•
•
•
•
Publication
25242222 | J:218052
First Author: Gaillard S
Year: 2014
Journal: Neuron
Title: GINIP, a Gαi-interacting protein, functions as a key modulator of peripheral GABAB receptor-mediated analgesia.
Volume: 84
Issue: 1
Pages: 123-136
•
•
•
•
•
Publication
37470475 | J:339286
 
First Author: Schubert L
Year: 2023
Journal: Biol Open
Title: A functional sgRNA-CRISPR screening method for generating murine RET and NTRK1 rearranged oncogenes.
Volume: 12
Issue: 8
•
•
•
•
•
Publication
12117822 | J:77445
First Author: Cronk KM
Year: 2002
Journal: Development
Title: Diverse dependencies of developing Merkel innervation on the trkA and both full-length and truncated isoforms of trkC.
Volume: 129
Issue: 15
Pages: 3739-50
•
•
•
•
•
Publication
21102451 | J:170255
First Author: Vaegter CB
Year: 2011
Journal: Nat Neurosci
Title: Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
Volume: 14
Issue: 1
Pages: 54-61
•
•
•
•
•
Publication
18162309 | J:141631
First Author: Andres R
Year: 2008
Journal: Neurosci Lett
Title: Regulation of sympathetic neuron differentiation by endogenous nerve growth factor and neurotrophin-3.
Volume: 431
Issue: 3
Pages: 241-6
•
•
•
•
•
Publication
20064392 | J:157721
First Author: Bourane S
Year: 2009
Journal: Neuron
Title: Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling.
Volume: 64
Issue: 6
Pages: 857-70
•
•
•
•
•
Publication
15247919 | J:92099
First Author: Moqrich A
Year: 2004
Journal: Nat Neurosci
Title: Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate.
Volume: 7
Issue: 8
Pages: 812-8
•
•
•
•
•
Publication
9331334 | J:43425
First Author: Fundin BT
Year: 1997
Journal: Dev Biol
Title: Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR.
Volume: 190
Issue: 1
Pages: 94-116
•
•
•
•
•
Publication
15260993 | J:91949
First Author: Kuruvilla R
Year: 2004
Journal: Cell
Title: A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling.
Volume: 118
Issue: 2
Pages: 243-55
•
•
•
•
•
Publication
9640332 | J:107715
First Author: Rice FL
Year: 1998
Journal: Dev Biol
Title: Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR.
Volume: 198
Issue: 1
Pages: 57-81
•
•
•
•
•
Publication
15376326 | J:93853
First Author: Sedý J
Year: 2004
Journal: Dev Dyn
Title: Pacinian corpuscle development involves multiple Trk signaling pathways.
Volume: 231
Issue: 3
Pages: 551-63
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•
•
•
•
Publication
37143894 | J:337547
 
First Author: Tiberi A
Year: 2023
Journal: Front Cell Dev Biol
Title: Reduced levels of NGF shift astrocytes toward a neurotoxic phenotype.
Volume: 11
Pages: 1165125
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•
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Allele
Ntrk1<tm1.2Tkato> | MGI:6779991
Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1.2, Tadafumi Kato
Allele Type: Targeted
Attribute String: Not Specified
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Allele
Ntrk1<tm1.1Tkato> | MGI:6779990
Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1.1, Tadafumi Kato
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Protein Coding Gene
MGP_CAROLIEiJ_G0025140 | -
Type: protein_coding_gene
Organism: Mus caroli
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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