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Search results 301 to 358 out of 358 for Lgr6

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Type Details Score
Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:73796
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Function or Process or Component Unknown following Literature Review
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
10935549 | J:86876
First Author: Hsu SY
Year: 2000
Journal: Mol Endocrinol
Title: The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7.
Volume: 14
Issue: 8
Pages: 1257-71
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Allele
Lgr6<em1Smoc> | MGI:7290820
Name: leucine-rich repeat-containing G protein-coupled receptor 6; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6429108 | C57BL/6J-Lgr6<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Lgr6<em1Jleh> | MGI:6863874
Name: leucine-rich repeat-containing G protein-coupled receptor 6; endonuclease-mediated mutation 1, Jessica A Lechoczky
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Protein Domain
IPR043601 | Rspo_Fu-CRD_dom
Type: Domain
Description: The R-spondin (RSPO) family is a small group of four secreted proteins (RSPO1-RSPO4) that have pleiotropic functions in development and stem cell growth by strongly enhancing Wnt pathway activation. They contain an N-terminal secretory signal peptide sequence, two tandem furin-like cysteine-rich (Fu-CRD) domains, a thrombospondin type I repeat (TSP) domain, and a C-terminal basic amino acid-rich (BR) domain. Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4), LGR5, and LGR6 have been identified as receptors for RSPOs [].This entry represents the two tandem furin-like cysteine-rich domains found in R-spondin.
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Publication
16028069 | J:158050
First Author: Van Schoore G
Year: 2005
Journal: Histochem Cell Biol
Title: Expression pattern of the orphan receptor LGR4/GPR48 gene in the mouse.
Volume: 124
Issue: 1
Pages: 35-50
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Publication
23756652 | -
First Author: Wang D
Year: 2013
Journal: Genes Dev
Title: Structural basis for R-spondin recognition by LGR4/5/6 receptors.
Volume: 27
Issue: 12
Pages: 1339-44
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Publication
17804805 | -
First Author: Binnerts ME
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6.
Volume: 104
Issue: 37
Pages: 14700-5
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Publication
18842812 | J:215739
First Author: Kazanskaya O
Year: 2008
Journal: Development
Title: The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development.
Volume: 135
Issue: 22
Pages: 3655-64
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Publication
30329043 | -
First Author: Chen Z
Year: 2019
Journal: Carcinogenesis
Title: RSPO3 promotes the aggressiveness of bladder cancer via Wnt/β-catenin and Hedgehog signaling pathways.
Volume: 40
Issue: 2
Pages: 360-369
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Protein Domain
IPR042994 | RSPO3
Type: Family
Description: RSPO3 is a secreted protein that belongs to the R-spondin (RSPO) family. Interestingly, it is one of the two members (RSPO2 and RSPO3) of the family capable of potentiating WNT signaling in cells lacking all three LGRs (Leucine-rich repeat-containing G-protein-coupled receptor 4/5/6) []. RSPO3 promotes angioblast and vascular development []. It has been shown to promote bladder cancer progression via mediating the Wnt/beta-catenin and Hedgehog signaling pathways []. The R-spondin (RSPO) family is a small group of four secreted proteins (RSPO1-RSPO4) that have pleiotropic functions in development and stem cell growth by strongly enhancing Wnt pathway activation. They contain an N-terminal secretory signal peptide sequence, two tandem furin-like cysteine-rich (Fu-CRD) domains, a thrombospondin type I repeat (TSP) domain, and a C-terminal basic amino acid-rich (BR) domain. Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4), LGR5, and LGR6 have been identified as receptors for RSPOs [].
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Protein Domain
IPR042991 | RSPO1
Type: Family
Description: RSPO1 is a secreted protein that belongs to the R-spondin (RSPO) family. It regulates Wnt signalling by inhibiting internalization of LRP6 []. It also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signalling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signalling pathway []. The R-spondin (RSPO) family is a small group of four secreted proteins (RSPO1-RSPO4) that have pleiotropic functions in development and stem cell growth by strongly enhancing Wnt pathway activation. They contain an N-terminal secretory signal peptide sequence, two tandem furin-like cysteine-rich (Fu-CRD) domains, a thrombospondin type I repeat (TSP) domain, and a C-terminal basic amino acid-rich (BR) domain. Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4), LGR5, and LGR6 have been identified as receptors for RSPOs [].
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Publication
29405118 | J:259879
   
First Author: Lebensohn AM
Year: 2018
Journal: Elife
Title: R-spondins can potentiate WNT signaling without LGRs.
Volume: 7
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Publication
31737985 | J:311389
First Author: Kim DE
Year: 2020
Journal: Aging Cell
Title: Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin.
Volume: 19
Issue: 3
Pages: e13072
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Publication
30146491 | J:308689
First Author: Gyllborg D
Year: 2018
Journal: Stem Cell Reports
Title: The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation.
Volume: 11
Issue: 3
Pages: 651-664
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Publication
26123262 | -
First Author: Zebisch M
Year: 2015
Journal: J Struct Biol
Title: Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3.
Volume: 191
Issue: 2
Pages: 149-55
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Publication
19238248 | -
First Author: Ayadi L
Year: 2008
Journal: Bioinformation
Title: Molecular modelling of the TSR domain of R-spondin 4.
Volume: 3
Issue: 3
Pages: 119-23
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Publication
17041604 | J:116076
First Author: Blaydon DC
Year: 2006
Journal: Nat Genet
Title: The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia.
Volume: 38
Issue: 11
Pages: 1245-7
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Protein Domain
IPR042993 | RSPO2/4
Type: Family
Description: The R-spondin (RSPO) family is a small group of four secreted proteins (RSPO1-RSPO4) that have pleiotropic functions in development and stem cell growth by strongly enhancing Wnt pathway activation. They contain an N-terminal secretory signal peptide sequence, two tandem furin-like cysteine-rich (Fu-CRD) domains, a thrombospondin type I repeat (TSP) domain, and a C-terminal basic amino acid-rich (BR) domain. Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4), LGR5, and LGR6 have been identified as receptors for RSPOs [].RSPO2 is a secreted protein that belongs to the R-spondin (RSPO) family. Interestingly, it is one of the two members (RSPO2 and RSPO3) of the family capable of potentiating WNT signaling in cells lacking all three LGRs (Leucine-rich repeat-containing G-protein-coupled receptor 4/5/6) []. It plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form []. It has been shown to promote midbrain dopaminergic neurogenesis and differentiation in human stem cells []. Its structures in complex with the ectodomains of its receptors LGR5 and ZNRF3 have been revealed []. RSPO4 is a secreted protein that belongs to the R-spondin (RSPO) family. It has been associated with embryonic nail development [, ].
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Publication
29867341 | J:313109
 
First Author: Zhang Y
Year: 2018
Journal: Front Mol Neurosci
Title: Characterization of Lgr6+ Cells as an Enriched Population of Hair Cell Progenitors Compared to Lgr5+ Cells for Hair Cell Generation in the Neonatal Mouse Cochlea.
Volume: 11
Pages: 147
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Protein
Q8BJ73
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: false
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Protein
A0AUN1
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: true
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Protein
Q0P5Y9
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: false
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Publication
22575959 | J:184507
First Author: Hao HX
Year: 2012
Journal: Nature
Title: ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
Volume: 485
Issue: 7397
Pages: 195-200
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Protein
Q9Z132
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: false
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Protein
Q8BFU0
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: false
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Protein
Q2TJ95
Organism: Mus musculus/domesticus
Length: 277  
Fragment?: false
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Protein
B1ASC1
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: false
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Protein
A0A1L1SR88
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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