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Search results 1 to 100 out of 1378 for Uchl1

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
7345 | UCHL1
Type: gene
Organism: human
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Gene
514394 | UCHL1
Type: gene
Organism: cattle
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Gene
770302 | UCHL1
Type: gene
Organism: chicken
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Gene
325119 | uchl1
Type: gene
Organism: zebrafish
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Gene
701579 | UCHL1
Type: gene
Organism: macaque, rhesus
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Gene
496780 | uchl1
Type: gene
Organism: frog, western clawed
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Gene
29545 | Uchl1
Type: gene
Organism: rat
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Gene
479098 | UCHL1
Type: gene
Organism: dog, domestic
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Gene
461185 | UCHL1
Type: gene
Organism: chimpanzee
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Protein Domain
IPR030297 | UCHL1
Type: Family
Description: Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a deubiquitinase that has dual hydrolase and ligase activities []. It is the most abundant protein in brain lysates (1-2%), regulating the timing and the pattern of ubiquitination []. Mutations in the UCHL1 gene has been linked to neurodegenerative diseases [, ]. UCHL1 also pays a major role in oncogenesis [].
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Protein Coding Gene
MGI:103149 | Uchl1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
101410542 | UCHL1-DT
Type: gene
Organism: human
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Publication
23695785 | -
First Author: Jara JH
Year: 2013
Journal: Cell Biochem Biophys
Title: Could dysregulation of UPS be a common underlying mechanism for cancer and neurodegeneration? Lessons from UCHL1.
Volume: 67
Issue: 1
Pages: 45-53
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Publication
17586089 | -
First Author: Setsuie R
Year: 2007
Journal: Neurochem Int
Title: The functions of UCH-L1 and its relation to neurodegenerative diseases.
Volume: 51
Issue: 2-4
Pages: 105-11
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Publication
20949132 | -
First Author: Proctor CJ
Year: 2010
Journal: PLoS One
Title: Modelling the role of UCH-L1 on protein aggregation in age-related neurodegeneration.
Volume: 5
Issue: 10
Pages: e13175
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Publication
33137160 | J:296972
First Author: Gao H
Year: 2020
Journal: PLoS One
Title: UCHL1 regulates oxidative activity in skeletal muscle.
Volume: 15
Issue: 11
Pages: e0241716
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Protein
Q9R0P9
Organism: Mus musculus/domesticus
Length: 223  
Fragment?: false
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Protein
I7ENE7
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: true
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Protein
Q3TCH2
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: true
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Publication
35464088 | J:323853
 
First Author: Antony R
Year: 2022
Journal: Front Physiol
Title: UCHL1 Regulates Lipid and Perilipin 2 Level in Skeletal Muscle.
Volume: 13
Pages: 855193
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Publication
31356902 | J:280572
 
First Author: Gao H
Year: 2019
Journal: Life Sci
Title: UCHL1 regulates muscle fibers and mTORC1 activity in skeletal muscle.
Volume: 233
Pages: 116699
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Publication
23064229 | J:189219
First Author: Carrieri C
Year: 2012
Journal: Nature
Title: Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat.
Volume: 491
Issue: 7424
Pages: 454-7
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Publication
24994982 | J:288955
 
First Author: Coulombe J
Year: 2014
Journal: Front Aging Neurosci
Title: Loss of UCHL1 promotes age-related degenerative changes in the enteric nervous system.
Volume: 6
Pages: 129
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Publication
32451617 | J:319409
First Author: Hao L
Year: 2020
Journal: Histochem Cell Biol
Title: Gene UCHL1 expresses specifically in mouse uterine decidual cells in response to estrogen.
Volume: 154
Issue: 3
Pages: 275-286
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Publication
30760601 | J:274384
     
First Author: Liu H
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia.
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Publication
24879150 | J:321046
First Author: Costes S
Year: 2014
Journal: Autophagy
Title: UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy.
Volume: 10
Issue: 6
Pages: 1004-14
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Publication
25596590 | J:236769
First Author: Jara JH
Year: 2015
Journal: Cereb Cortex
Title: Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function.
Volume: 25
Issue: 11
Pages: 4259-72
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Publication
- | J:161692
     
First Author: Karst SY
Year: 2010
Journal: MGI Direct Data Submission
Title: Gracile axonal dystrophy 2 Jackson; a neuromuscular mutation in the Uchl1 gene
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Publication
34853443 | J:334041
First Author: Genç B
Year: 2022
Journal: Gene Ther
Title: Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons.
Volume: 29
Issue: 3-4
Pages: 178-192
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Publication
16965839 | J:128045
First Author: Setsuie R
Year: 2007
Journal: Neurochem Int
Title: Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant.
Volume: 50
Issue: 1
Pages: 119-29
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Publication
19141079 | J:172710
First Author: Yasuda T
Year: 2009
Journal: J Neurochem
Title: Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease.
Volume: 108
Issue: 4
Pages: 932-44
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Publication
24123561 | J:204976
First Author: Wiese CB
Year: 2013
Journal: Genesis
Title: A Uchl1-Histone2BmCherry:GFP-gpi BAC transgene for imaging neuronal progenitors.
Volume: 51
Issue: 12
Pages: 852-61
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Publication
10873389 | J:63229
First Author: Wang Y
Year: 2000
Journal: Genomics
Title: YAC/BAC-based physical and transcript mapping around the gracile axonal dystrophy (gad) locus identifies Uchl1, Pmx2b, Atp3a2, and Hip2 genes.
Volume: 66
Issue: 3
Pages: 333-6
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Publication
24662305 | J:212476
First Author: Read NC
Year: 2014
Journal: Biochim Biophys Acta
Title: Ubiquitin C-terminal hydrolase L1 deletion ameliorates glomerular injury in mice with ACTN4-associated focal segmental glomerulosclerosis.
Volume: 1842
Issue: 7
Pages: 1028-40
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Publication
22223688 | J:185332
First Author: Koyanagi S
Year: 2012
Journal: Reproduction
Title: Effects of ubiquitin C-terminal hydrolase L1 deficiency on mouse ova.
Volume: 143
Issue: 3
Pages: 271-9
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Publication
22212137 | J:183721
First Author: Zhang M
Year: 2012
Journal: J Neurochem
Title: Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1.
Volume: 120
Issue: 6
Pages: 1129-38
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Publication
32606430 | J:299810
First Author: Lei Q
Year: 2020
Journal: Sci Rep
Title: Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78).
Volume: 10
Issue: 1
Pages: 10604
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Publication
34508847 | J:318653
 
First Author: Mi Z
Year: 2021
Journal: Neuroscience
Title: Mutation of a Ubiquitin Carboxy Terminal Hydrolase L1 Lipid Binding Site Alleviates Cell Death, Axonal Injury, and Behavioral Deficits After Traumatic Brain Injury in Mice.
Volume: 475
Pages: 127-136
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Publication
22038515 | J:179012
First Author: Chu KY
Year: 2012
Journal: Diabetologia
Title: Ubiquitin C-terminal hydrolase L1 is required for pancreatic beta cell survival and function in lipotoxic conditions.
Volume: 55
Issue: 1
Pages: 128-40
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Publication
33159930 | J:301369
 
First Author: Mi Z
Year: 2021
Journal: Exp Neurol
Title: Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice.
Volume: 336
Pages: 113524
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Publication
35512140 | J:333871
First Author: Woodman MF
Year: 2022
Journal: Biol Reprod
Title: The requirement of ubiquitin C-terminal hydrolase L1 in mouse ovarian development and fertility†.
Volume: 107
Issue: 2
Pages: 500-513
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Publication
30257881 | J:269089
First Author: Hussain S
Year: 2018
Journal: Blood
Title: UCH-L1 bypasses mTOR to promote protein biosynthesis and is required for MYC-driven lymphomagenesis in mice.
Volume: 132
Issue: 24
Pages: 2564-2574
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Publication
35463782 | J:324184
 
First Author: Wu P
Year: 2022
Journal: Front Cardiovasc Med
Title: Ubiquitin Carboxyl-Terminal Hydrolase L1 of Cardiomyocytes Promotes Macroautophagy and Proteostasis and Protects Against Post-myocardial Infarction Cardiac Remodeling and Heart Failure.
Volume: 9
Pages: 866901
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Protein Coding Gene
MGP_CAROLIEiJ_G0027261 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0029590 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0029558 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029506 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0029567 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029290 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_103149 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030021 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0028698 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029259 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029405 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029365 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029490 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029393 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030054 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028422 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0028778 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0017043 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028256 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10471497 | J:57318
First Author: Saigoh K
Year: 1999
Journal: Nat Genet
Title: Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice.
Volume: 23
Issue: 1
Pages: 47-51
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Publication
12559414 | J:81158
First Author: Marzban G
Year: 2002
Journal: Exp Gerontol
Title: Age-related alterations in the protein expression profile of C57BL/6J mouse pituitaries.
Volume: 37
Issue: 12
Pages: 1451-60
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Publication
14695319 | J:88434
First Author: Harada T
Year: 2004
Journal: Am J Pathol
Title: Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo.
Volume: 164
Issue: 1
Pages: 59-64
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Publication
18279321 | J:132716
First Author: Sakurai M
Year: 2008
Journal: Eur J Neurosci
Title: Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene.
Volume: 27
Issue: 3
Pages: 691-701
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Publication
26702068 | J:232584
First Author: Bedekovics T
Year: 2016
Journal: Blood
Title: UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.
Volume: 127
Issue: 12
Pages: 1564-74
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Publication
1451762 | J:3205
First Author: Yamazaki K
Year: 1992
Journal: Jikken Dobutsu
Title: Behavioral study on the gracile axonal dystrophy (GAD) mutant mouse.
Volume: 41
Issue: 4
Pages: 523-7
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Publication
20363052 | J:188246
First Author: Pfeffer M
Year: 2012
Journal: Neurobiol Aging
Title: Disturbed sleep/wake rhythms and neuronal cell loss in lateral hypothalamus and retina of mice with a spontaneous deletion in the ubiquitin carboxyl-terminal hydrolase L1 gene.
Volume: 33
Issue: 2
Pages: 393-403
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Publication
16177983 | J:104410
First Author: Wang YL
Year: 2006
Journal: Mol Reprod Dev
Title: Overexpression of ubiquitin carboxyl-terminal hydrolase L1 arrests spermatogenesis in transgenic mice.
Volume: 73
Issue: 1
Pages: 40-9
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Publication
3340629 | J:30954
First Author: Yamazaki K
Year: 1988
Journal: Proc Soc Exp Biol Med
Title: Gracile axonal dystrophy (GAD), a new neurological mutant in the mouse.
Volume: 187
Issue: 2
Pages: 209-15
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Publication
2558488 | J:30933
First Author: Mukoyama M
Year: 1989
Journal: Acta Neuropathol
Title: Neuropathology of gracile axonal dystrophy (GAD) mouse. An animal model of central distal axonopathy in primary sensory neurons.
Volume: 79
Issue: 3
Pages: 294-9
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Publication
8764939 | J:36121
First Author: Takagi A
Year: 1996
Journal: Virchows Arch
Title: Fine structural changes of muscle spindles in the gracile axonal dystrophy mutant mouse.
Volume: 428
Issue: 4-5
Pages: 289-96
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Publication
7504492 | J:15735
First Author: Yamazaki K
Year: 1993
Journal: Mol Chem Neuropathol
Title: Substance P-immunoreactive astrocytes in gracile sensory nervous tract of spinal cord in gracile axonal dystrophy mutant mouse.
Volume: 20
Issue: 1
Pages: 1-20
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Publication
22076440 | J:180215
First Author: Xilouri M
Year: 2012
Journal: Hum Mol Genet
Title: Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system.
Volume: 21
Issue: 4
Pages: 874-89
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Publication
- | J:20588
First Author: Suh JG
Year: 1994
Journal: Biomed Res
Title: Pathophysiological study of axonal degeneration in the gracile axonal dystrophy (gad) mutant mouse.
Volume: 15
Issue: 4
Pages: 241-246
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Publication
8474599 | J:28526
First Author: Miura H
Year: 1993
Journal: Neuropathol Appl Neurobiol
Title: Progressive degeneration of motor nerve terminals in GAD mutant mouse with hereditary sensory axonopathy.
Volume: 19
Issue: 1
Pages: 41-51
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Publication
7555927 | J:30227
First Author: Chandran AP
Year: 1995
Journal: Electromyogr Clin Neurophysiol
Title: Stimulus induced repetitive muscle potentials in the gracile axonal dystrophy (GAD) mouse.
Volume: 35
Issue: 4
Pages: 225-30
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Publication
8041506 | J:18673
First Author: Yamazaki K
Year: 1994
Journal: Neurosci Lett
Title: Methylcobalamin (methyl-B12) promotes regeneration of motor nerve terminals degenerating in anterior gracile muscle of gracile axonal dystrophy (GAD) mutant mouse.
Volume: 170
Issue: 1
Pages: 195-7
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Publication
19535597 | J:155638
First Author: Cartier AE
Year: 2009
Journal: J Neurosci
Title: Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1.
Volume: 29
Issue: 24
Pages: 7857-68
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Publication
20080621 | J:156538
First Author: Chen F
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction.
Volume: 107
Issue: 4
Pages: 1636-41
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Publication
34571914 | J:313709
 
First Author: Alpaugh WF
Year: 2021
Journal: Cells
Title: Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells.
Volume: 10
Issue: 9
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Publication
11819698 | J:74212
First Author: Li JC
Year: 2000
Journal: World J Gastroenterol
Title: Immunohistochemical study on gastroenteric nervous system in trisomy 16 mice:an animal model of Down syndrome.
Volume: 6
Issue: 6
Pages: 793-799
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Publication
7600671 | J:24541
First Author: Schofield JN
Year: 1995
Journal: Brain Res Dev Brain Res
Title: PGP9.5, a ubiquitin C-terminal hydrolase; pattern of mRNA and protein expression during neural development in the mouse.
Volume: 85
Issue: 2
Pages: 229-38
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Publication
7558041 | J:27398
First Author: Suh JG
Year: 1995
Journal: Genomics
Title: Mapping of the gracile axonal dystrophy (gad) gene to a region between D5Mit197 and D5Mit113 on proximal mouse chromosome 5.
Volume: 27
Issue: 3
Pages: 549-51
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Publication
14562616 | J:85447
First Author: Sekiguchi S
Year: 2003
Journal: Exp Anim
Title: Immunohistochemical analysis of protein gene product 9.5, a ubiquitin carboxyl-terminal hydrolase, during placental and embryonic development in the mouse.
Volume: 52
Issue: 4
Pages: 365-9
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Publication
11819726 | J:102708
First Author: Li JC
Year: 2001
Journal: World J Gastroenterol
Title: The development of colon innervation in trisomy 16 mice and Hirschsprung's disease.
Volume: 7
Issue: 1
Pages: 16-21
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Publication
24583340 | J:211573
First Author: Lohmann F
Year: 2014
Journal: Biochim Biophys Acta
Title: UCH-L1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation.
Volume: 1842
Issue: 7
Pages: 945-58
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Publication
30923110 | J:273818
First Author: Reinicke AT
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks.
Volume: 116
Issue: 16
Pages: 7963-7972
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Publication
28754552 | J:280754
First Author: Radón V
Year: 2018
Journal: Kidney Int
Title: Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney.
Volume: 93
Issue: 1
Pages: 110-127
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Publication
31492742 | J:279966
First Author: Reinicke AT
Year: 2019
Journal: J Immunol
Title: Deubiquitinating Enzyme UCH-L1 Promotes Dendritic Cell Antigen Cross-Presentation by Favoring Recycling of MHC Class I Molecules.
Volume: 203
Issue: 7
Pages: 1730-1742
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GXD Expression
GXD Expression
     
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Specimen Label: brain - total
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Specimen Label: cortex
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1755028
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Specimen Label: brain medulla
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Specimen Label: cerebellum
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Specimen Label: brainstem
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Specimen Label: olfactory bulb
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Specimen Label: spinal cord
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Specimen Label: eye
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1915328
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Specimen Label: harderian gland
Detected: false
Specimen Num: 9
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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