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Search results 301 to 389 out of 389 for Cyp2e1

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Type Details Score
Publication
9659577 | J:50744
First Author: Forkert PG
Year: 1998
Journal: Exp Lung Res
Title: Immunohistochemical detection of CYP2E1 and 2-S-glutathionyl acetate in murine lung tumors: diminished formation of reactive intermediates of 1,1-dichloroethylene.
Volume: 24
Issue: 4
Pages: 455-61
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Publication
9884311 | J:52490
First Author: Forkert PG
Year: 1999
Journal: Drug Metab Dispos
Title: Diminished CYP2E1 expression and formation of 2-S-glutathionyl acetate, a glutathione conjugate derived from 1,1-dichloroethylene epoxide, in murine lung tumors.
Volume: 27
Issue: 1
Pages: 68-73
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Publication
30463689 | J:270600
First Author: Ren J
Year: 2019
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Inhibition of CYP2E1 attenuates myocardial dysfunction in a murine model of insulin resistance through NLRP3-mediated regulation of mitophagy.
Volume: 1865
Issue: 1
Pages: 206-217
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Allele
Tg(CYP2E1)1Gonz | MGI:7354907
Name: transgene insertion 1, Frank J Gonzalez
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
29404441 | J:329819
First Author: Xu J
Year: 2017
Journal: Hepatol Commun
Title: The role of human cytochrome P450 2E1 in liver inflammation and fibrosis.
Volume: 1
Issue: 10
Pages: 1043-1057
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Publication
9784018 | -
First Author: Farker K
Year: 1998
Journal: Exp Toxicol Pathol
Title: Impact of CYP2E1 genotype in renal cell and urothelial cancer patients.
Volume: 50
Issue: 4-6
Pages: 425-31
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Protein Coding Gene
MGI:1921384 | Cyp2s1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3646735 | Cyp2b23
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88597 | Cyp2a5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88596 | Cyp2a4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88608 | Cyp2f2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3648316 | Cyp2a22
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:105055 | Cyp2a12
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P15392
Organism: Mus musculus/domesticus
Length: 494  
Fragment?: false
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Protein
P33267
Organism: Mus musculus/domesticus
Length: 491  
Fragment?: false
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Protein
P20852
Organism: Mus musculus/domesticus
Length: 494  
Fragment?: false
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Protein
P56593
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Protein
Q9DBX6
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Protein
E9Q593
Organism: Mus musculus/domesticus
Length: 491  
Fragment?: false
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Protein
B2RXZ2
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Protein
Q05421
Organism: Mus musculus/domesticus
Length: 493  
Fragment?: false
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Protein Coding Gene
MGI:1929474 | Cyp2d22
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919553 | Cyp2c65
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1917138 | Cyp2c66
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9JKY7
Organism: Mus musculus/domesticus
Length: 500  
Fragment?: false
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Protein
Q148B1
Organism: Mus musculus/domesticus
Length: 490  
Fragment?: false
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Protein
Q5GLZ0
Organism: Mus musculus/domesticus
Length: 490  
Fragment?: false
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Publication
19393728 | J:280009
First Author: Zhang F
Year: 2009
Journal: Toxicol Lett
Title: Delayed liver injury and impaired hepatocyte proliferation after carbon tetrachloride exposure in BPOZ2-deficient mice.
Volume: 188
Issue: 3
Pages: 201-7
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Publication
8110842 | J:17099
First Author: Sakuma T
Year: 1994
Journal: Biochim Biophys Acta
Title: Molecular cloning and sequence analysis of hamster CYP2E1.
Volume: 1217
Issue: 2
Pages: 229-31
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Publication
30555544 | J:271712
First Author: Zhang T
Year: 2018
Journal: Theranostics
Title: Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity.
Volume: 8
Issue: 19
Pages: 5246-5258
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Publication
14980704 | J:88957
First Author: Shertzer HG
Year: 2004
Journal: Free Radic Biol Med
Title: Cyp1a2 protects against reactive oxygen production in mouse liver microsomes.
Volume: 36
Issue: 5
Pages: 605-17
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Publication
22291093 | J:181870
First Author: Hur KY
Year: 2012
Journal: J Exp Med
Title: IRE1α activation protects mice against acetaminophen-induced hepatotoxicity.
Volume: 209
Issue: 2
Pages: 307-18
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Publication
26159875 | J:286806
First Author: Spruiell K
Year: 2015
Journal: J Pharmacol Exp Ther
Title: Pregnane X Receptor-Humanized Mice Recapitulate Gender Differences in Ethanol Metabolism but Not Hepatotoxicity.
Volume: 354
Issue: 3
Pages: 459-70
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Publication
19386791 | J:294925
First Author: Roede JR
Year: 2009
Journal: J Pharmacol Exp Ther
Title: Overexpression of peroxiredoxin 6 does not prevent ethanol-mediated oxidative stress and may play a role in hepatic lipid accumulation.
Volume: 330
Issue: 1
Pages: 79-88
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Publication
12466116 | J:80535
First Author: Yu C
Year: 2002
Journal: Am J Pathol
Title: Increased carbon tetrachloride-induced liver injury and fibrosis in FGFR4-deficient mice.
Volume: 161
Issue: 6
Pages: 2003-10
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Publication
22491424 | J:185717
First Author: Ni HM
Year: 2012
Journal: Toxicol Sci
Title: Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.
Volume: 127
Issue: 2
Pages: 438-50
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Publication
26003521 | J:309233
 
First Author: Latchoumycandane C
Year: 2015
Journal: Free Radic Biol Med
Title: Myeloperoxidase formation of PAF receptor ligands induces PAF receptor-dependent kidney injury during ethanol consumption.
Volume: 86
Pages: 179-90
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Publication
19499520 | J:149435
First Author: Njoku DB
Year: 2009
Journal: Eur J Immunol
Title: Suppressive and pro-inflammatory roles for IL-4 in the pathogenesis of experimental drug-induced liver injury.
Volume: 39
Issue: 6
Pages: 1652-63
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Publication
15654606 | J:311010
First Author: Kim YD
Year: 2005
Journal: Arch Toxicol
Title: Expression levels of hepatic cytochrome P450 enzymes in Aldh2-deficient mice following ethanol exposure: a pilot study.
Volume: 79
Issue: 4
Pages: 192-5
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Publication
15569633 | J:311012
 
First Author: Oyama T
Year: 2005
Journal: Front Biosci
Title: Tissue-distribution of aldehyde dehydrogenase 2 and effects of the ALDH2 gene-disruption on the expression of enzymes involved in alcohol metabolism.
Volume: 10
Pages: 951-60
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Publication
22490042 | J:243716
First Author: Bae SH
Year: 2012
Journal: Antioxid Redox Signal
Title: Peroxiredoxin III and sulfiredoxin together protect mice from pyrazole-induced oxidative liver injury.
Volume: 17
Issue: 10
Pages: 1351-61
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Publication
18952117 | J:145778
First Author: Gyamfi MA
Year: 2009
Journal: Toxicol Appl Pharmacol
Title: Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice.
Volume: 234
Issue: 2
Pages: 166-78
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Publication
16829625 | J:144689
First Author: Gyamfi MA
Year: 2006
Journal: J Pharmacol Exp Ther
Title: The role of retinoid X receptor alpha in regulating alcohol metabolism.
Volume: 319
Issue: 1
Pages: 360-8
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Publication
26474534 | J:256232
First Author: Chandrashekaran V
Year: 2016
Journal: Biochim Biophys Acta
Title: Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis.
Volume: 1862
Issue: 1
Pages: 32-45
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Publication
31076642 | J:287894
First Author: Zhong F
Year: 2019
Journal: Cell Res
Title: Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis.
Volume: 29
Issue: 7
Pages: 548-561
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Publication
23967274 | J:205850
First Author: Lian Y
Year: 2013
Journal: PLoS One
Title: Protective effects of metallothionein on isoniazid and rifampicin-induced hepatotoxicity in mice.
Volume: 8
Issue: 8
Pages: e72058
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Publication
27998724 | J:240187
First Author: Ronis M
Year: 2017
Journal: Am J Pathol
Title: Global Deletion of Glutathione S-Transferase A4 Exacerbates Developmental Nonalcoholic Steatohepatitis.
Volume: 187
Issue: 2
Pages: 418-430
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Publication
12060674 | J:77214
First Author: Martínez-Chantar ML
Year: 2002
Journal: FASEB J
Title: Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A.
Volume: 16
Issue: 10
Pages: 1292-4
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Publication
16831125 | J:116036
First Author: Lei XG
Year: 2006
Journal: Biochem J
Title: Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity.
Volume: 399
Issue: 3
Pages: 455-61
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Publication
28963035 | J:248834
First Author: Chowdhary V
Year: 2017
Journal: Am J Pathol
Title: miRNA-122 Protects Mice and Human Hepatocytes from Acetaminophen Toxicity by Regulating Cytochrome P450 Family 1 Subfamily A Member 2 and Family 2 Subfamily E Member 1 Expression.
Volume: 187
Issue: 12
Pages: 2758-2774
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Publication
22728710 | J:329067
First Author: He CY
Year: 2012
Journal: Acta Pharmacol Sin
Title: The dual role of osteopontin in acetaminophen hepatotoxicity.
Volume: 33
Issue: 8
Pages: 1004-12
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Publication
27501753 | J:238959
First Author: Akihara R
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress.
Volume: 478
Issue: 2
Pages: 765-71
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Publication
24269813 | J:211836
First Author: Wu W
Year: 2014
Journal: Biochem Biophys Res Commun
Title: Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease.
Volume: 443
Issue: 1
Pages: 68-73
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Publication
12829994 | J:105844
First Author: Ip E
Year: 2003
Journal: Hepatology
Title: Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice.
Volume: 38
Issue: 1
Pages: 123-32
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Publication
27406999 | J:301933
 
First Author: Kim SM
Year: 2016
Journal: Sci Rep
Title: CHIP(-/-)-Mouse Liver: Adiponectin-AMPK-FOXO-Activation Overrides CYP2E1-Elicited JNK1-Activation, Delaying Onset of NASH: Therapeutic Implications.
Volume: 6
Pages: 29423
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Publication
34390780 | J:313590
 
First Author: Yue R
Year: 2021
Journal: Free Radic Biol Med
Title: Activation of PPARα-catalase pathway reverses alcoholic liver injury via upregulating NAD synthesis and accelerating alcohol clearance.
Volume: 174
Pages: 249-263
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Publication
11238812 | J:68522
First Author: Yang CS
Year: 2001
Journal: J Nutr
Title: Mechanisms of inhibition of chemical toxicity and carcinogenesis by diallyl sulfide (DAS) and related compounds from garlic.
Volume: 131
Issue: 3s
Pages: 1041S-5S
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Publication
8801055 | J:33352
First Author: Delker DA
Year: 1996
Journal: Drug Metab Dispos
Title: A comparative study of hepatic and colonic metabolic enzymes in inbred mouse lines before and after treatment with the colon carcinogen, 1,2-dimethylhydrazine.
Volume: 24
Issue: 4
Pages: 408-13
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Publication
8914842 | J:36575
First Author: Chen W
Year: 1996
Journal: Arch Biochem Biophys
Title: Baculovirus expression and purification of human and rat cytochrome P450 2E1.
Volume: 335
Issue: 1
Pages: 123-30
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Publication
9176557 | J:41148
First Author: Carlson GP
Year: 1997
Journal: J Toxicol Environ Health
Title: Comparison of mouse strains for susceptibility to styrene-induced hepatotoxicity and pneumotoxicity.
Volume: 51
Issue: 2
Pages: 177-87
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Publication
10491286 | J:57873
First Author: Hu Y
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Structural and functional characterization of the 5'-flanking region of the rat and human cytochrome P450 2E1 genes: identification of a polymorphic repeat in the human gene.
Volume: 263
Issue: 2
Pages: 286-93
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Publication
12594235 | J:82213
First Author: Simpson K
Year: 2003
Journal: Lab Invest
Title: Stem cell factor attenuates liver damage in a murine model of acetaminophen-induced hepatic injury.
Volume: 83
Issue: 2
Pages: 199-206
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Publication
19638432 | J:153907
First Author: Liu F
Year: 2009
Journal: Toxicol Sci
Title: Comparative study on susceptibility to 1-bromopropane in three mice strains.
Volume: 112
Issue: 1
Pages: 100-10
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Publication
22766412 | J:191019
First Author: Xie XL
Year: 2012
Journal: Mutat Res
Title: Dammar resin, a non-mutagen, induces [corrected] oxidative stress and metabolic enzymes in the liver of gpt delta transgenic mouse which is different from a mutagen, 2-amino-3-methylimidazo[4,5-f]quinoline.
Volume: 748
Issue: 1-2
Pages: 29-35
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Publication
21929725 | J:192074
First Author: Knockaert L
Year: 2011
Journal: FEBS J
Title: Mechanisms of mitochondrial targeting of cytochrome P450 2E1: physiopathological role in liver injury and obesity.
Volume: 278
Issue: 22
Pages: 4252-60
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Publication
24183702 | J:205205
First Author: Jackson AF
Year: 2014
Journal: Toxicol Appl Pharmacol
Title: Case study on the utility of hepatic global gene expression profiling in the risk assessment of the carcinogen furan.
Volume: 274
Issue: 1
Pages: 63-77
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Publication
26493931 | J:227919
First Author: Zhang F
Year: 2015
Journal: Toxicol Appl Pharmacol
Title: Effects of sexually dimorphic growth hormone secretory patterns on arachidonic acid metabolizing enzymes in rodent heart.
Volume: 289
Issue: 3
Pages: 495-506
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Publication
25424544 | J:275699
First Author: Yoo HS
Year: 2015
Journal: J Toxicol Environ Health A
Title: Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects.
Volume: 78
Issue: 1
Pages: 15-31
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Publication
25244648 | J:278566
First Author: Possamai LA
Year: 2015
Journal: Liver Int
Title: The role of intestinal microbiota in murine models of acetaminophen-induced hepatotoxicity.
Volume: 35
Issue: 3
Pages: 764-73
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Publication
- | J:37999
First Author: Pinkerton KE
Year: 1996
Journal: Inhal Toxicol
Title: Quantitative histology and cytochrome P-450 immunocytochemistry of the lung parenchyma following 6 months of exposure of strain A/J mice to cigarette sidestream smoke.
Volume: 8
Issue: 9
Pages: 927-945
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Protein Domain
IPR008070 | Cyt_P450_E_grp-I_CYP2E-like
Type: Family
Description: Cytochrome P450 enzymes are a superfamily of haem-containing mono-oxygenases that are found in all kingdoms of life, and which show extraordinary diversity in their reaction chemistry. In mammals, these proteins are found primarily in microsomes of hepatocytes and other cell types, where they oxidise steroids, fatty acids and xenobiotics, and are important for the detoxification and clearance of various compounds, as well as for hormone synthesis and breakdown, cholesterol synthesis and vitamin D metabolism. In plants, these proteins are important for the biosynthesis of several compounds such as hormones, defensive compounds and fatty acids. In bacteria, they are important for several metabolic processes, such as the biosynthesis of antibiotic erythromycin in Saccharopolyspora erythraea (Streptomyces erythraeus).Cytochrome P450 enzymes use haem to oxidise their substrates, using protons derived from NADH or NADPH to split the oxygen so asingle atom can be added to a substrate. They also require electrons, which they receive from a variety of redox partners. In certain cases, cytochrome P450 can be fused to its redox partner to produce a bi-functional protein, such as with P450BM-3 from Bacillus megaterium [], which has haem and flavin domains.Organisms produce many different cytochrome P450 enzymes (at least 58 in humans), which together with alternative splicing can provide a wide array of enzymes with different substrate and tissue specificities. Individual cytochrome P450 proteins follow the nomenclature: CYP, followed by a number (family), then a letter (subfamily), and another number (protein); e.g. CYP3A4 is the fourth protein in family 3, subfamily A. In general, family members should share >40% identity, while subfamily members should share >55% identity.Cytochrome P450 proteins can also be grouped by two different schemes. One scheme was based on a taxonomic split: class I (prokaryotic/mitochondrial) and class II (eukaryotic microsomes). The other scheme was based on the number of components in the system: class B (3-components) and class E (2-components). These classes merge to a certain degree. Most prokaryotes and mitochondria (and fungal CYP55) have 3-component systems (class I/class B) - a FAD-containing flavoprotein (NAD(P)H-dependent reductase), an iron-sulphur protein and P450. Most eukaryotic microsomes have 2-component systems (class II/class E) - NADPH:P450 reductase (FAD and FMN-containing flavoprotein) and P450. There are exceptions to this scheme, such as 1-component systems that resemble class E enzymes [, , ]. The class E enzymes can be further subdivided into five sequence clusters, groups I-V, each of which may contain more than one cytochrome P450 family (eg, CYP1 and CYP2 are both found in group I).The divergence of the cytochrome P450 superfamily into B- and E-classes, and further divergence into stable clusters within the E-class, appears to be very ancient, occurring before the appearance of eukaryotes.This entry represents the CYP2E family from group I, class E, cytochrome P450 proteins, as well as other CYP2 family proteins. The CYP2 family comprises 15 subfamilies (A-H, J-N, P and Q). The first five (A-E) are present in mammalian liver, but in differing amounts and with different inducibilities. These five subfamilies show varied substrate specificities, with some degree of overlap. CYP2E1 metabolises several therapeutic drugs, precarcinogens and solvents to reactive metabolites, and as such is appears involved in cancer susceptibility [].
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Publication
35145060 | J:333656
First Author: Ye H
Year: 2022
Journal: Cell Death Dis
Title: Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy.
Volume: 13
Issue: 2
Pages: 143
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Publication
26447219 | J:281896
First Author: Alhasson F
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: NKT cell modulates NAFLD potentiation of metabolic oxidative stress-induced mesangial cell activation and proximal tubular toxicity.
Volume: 310
Issue: 1
Pages: F85-F101
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Publication
12117783 | J:77740
First Author: Takagi T
Year: 2002
Journal: Carcinogenesis
Title: Hemizygous mice for the angiotensin II type 2 receptor gene have attenuated susceptibility to azoxymethane-induced colon tumorigenesis.
Volume: 23
Issue: 7
Pages: 1235-41
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Publication
28026023 | J:241887
First Author: Müller MF
Year: 2017
Journal: J Pathol
Title: Effects of long-term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice.
Volume: 241
Issue: 5
Pages: 649-660
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Publication
32877213 | J:307085
First Author: Chen X
Year: 2020
Journal: Am J Physiol Gastrointest Liver Physiol
Title: High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis.
Volume: 319
Issue: 5
Pages: G626-G635
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Publication
33967806 | J:345811
 
First Author: Ding H
Year: 2021
Journal: Front Pharmacol
Title: Effects of Real-Ambient PM(2.5) Exposure on Lung Damage Modulated by Nrf2(-/).
Volume: 12
Pages: 662664
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Publication
21572097 | J:174997
First Author: Bajt ML
Year: 2011
Journal: Toxicol Sci
Title: Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.
Volume: 122
Issue: 2
Pages: 598-605
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Publication
21277885 | J:170938
First Author: Bhave VS
Year: 2011
Journal: Toxicol Appl Pharmacol
Title: Secretory phospholipase Aâ‚‚-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2.
Volume: 251
Issue: 3
Pages: 173-80
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Publication
31492698 | J:284775
First Author: Kwon D
Year: 2019
Journal: Mol Pharmacol
Title: Induction via Functional Protein Stabilization of Hepatic Cytochromes P450 upon gp78/Autocrine Motility Factor Receptor (AMFR) Ubiquitin E3-Ligase Genetic Ablation in Mice: Therapeutic and Toxicological Relevance.
Volume: 96
Issue: 5
Pages: 641-654
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Publication
30294325 | J:294487
 
First Author: McCullough RL
Year: 2018
Journal: Front Immunol
Title: Anaphylatoxin Receptors C3aR and C5aR1 Are Important Factors That Influence the Impact of Ethanol on the Adipose Secretome.
Volume: 9
Pages: 2133
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Publication
10463382 | J:57136
First Author: Bernauer U
Year: 1999
Journal: Arch Toxicol
Title: CYP2E1-dependent benzene toxicity: the role of extrahepatic benzene metabolism.
Volume: 73
Issue: 4-5
Pages: 189-96
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Protein
A0A1B0GSV7
Organism: Mus musculus/domesticus
Length: 434  
Fragment?: false
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Protein
Q0PGA0
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: false
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Protein
Q0PGA1
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: false
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Publication
16042601 | -
First Author: McLean KJ
Year: 2005
Journal: Biochem Soc Trans
Title: Biodiversity of cytochrome P450 redox systems.
Volume: 33
Issue: Pt 4
Pages: 796-801
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Publication
17023115 | -
First Author: Munro AW
Year: 2007
Journal: Biochim Biophys Acta
Title: Cytochrome P450--redox partner fusion enzymes.
Volume: 1770
Issue: 3
Pages: 345-59
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15128046 | J:87417
First Author: Nelson DR
Year: 2004
Journal: Pharmacogenetics
Title: Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.
Volume: 14
Issue: 1
Pages: 1-18
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8637843 | -
First Author: Degtyarenko KN
Year: 1995
Journal: Protein Eng
Title: Structural domains of P450-containing monooxygenase systems.
Volume: 8
Issue: 8
Pages: 737-47
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