This entry represents a group of IGFBP (insulin-like growth fac-tor (IGF) binding proteins)-related proteins, which have been annotated as the CNN family [, ]. Members of the CCN family are composed of an N-terminal secretory signal peptide followed by four conserved domains with homology to insulin-like growth factor binding protein, von Willebrand factor type C repeat, thrombospondin type 1 repeat, and a C-terminal domain (CT) with heparin-binding motifs and sequence similarity to the C termini of von Willebrand factor and mucin. The CCN family includes CCN1 (CYR61) [], CCN2 (CTGF), CCN3 [], CCN4 (WISP-1) [], CCN5 (WISP-2), and CCN6 (WISP-3).