The lipid-binding protein (LBP) family can be divided divided in four subfamiles. Subfamily I comprises proteins specific for vitamin A derivatives, and can be subdivided into the cellular retinoic acid-binding proteins (CRABP-I and II) and the cellular retinol-binding proteins (CRBP-I, II, III, and IV) [].This entry represents retinoic acid-binding protein 2 (CRABP-II). Both CRABP I and II are present in the cytoplasm, but CRABP-II is also found in the nucleus. CRABP-II transports retinoic acid (RA) to the nucleus, regulating the activation of nuclear RA receptors [, , ].
