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Search results 101 to 200 out of 211 for Kcnq3

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Hits by Strain

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_05
Specimen Label: euxassay_008387_05
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_06
Specimen Label: euxassay_008387_06
Detected: true
Specimen Num: 6
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_07
Specimen Label: euxassay_008387_07
Detected: true
Specimen Num: 7
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_20
Specimen Label: euxassay_008387_20
Detected: true
Specimen Num: 20
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_21
Specimen Label: euxassay_008387_21
Detected: true
Specimen Num: 21
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_22
Specimen Label: euxassay_008387_22
Detected: true
Specimen Num: 22
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_23
Specimen Label: euxassay_008387_23
Detected: true
Specimen Num: 23
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691123
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_24
Specimen Label: euxassay_008387_24
Detected: true
Specimen Num: 24
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_03
Specimen Label: euxassay_008387_03
Detected: true
Specimen Num: 3
•
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_04
Specimen Label: euxassay_008387_04
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_05
Specimen Label: euxassay_008387_05
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_19
Specimen Label: euxassay_008387_19
Detected: true
Specimen Num: 19
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_20
Specimen Label: euxassay_008387_20
Detected: true
Specimen Num: 20
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_21
Specimen Label: euxassay_008387_21
Detected: true
Specimen Num: 21
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_22
Specimen Label: euxassay_008387_22
Detected: true
Specimen Num: 22
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1801023
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_23
Specimen Label: euxassay_008387_23
Detected: true
Specimen Num: 23
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_09
Specimen Label: euxassay_008387_09
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_10
Specimen Label: euxassay_008387_10
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_11
Specimen Label: euxassay_008387_11
Detected: true
Specimen Num: 11
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_13
Specimen Label: euxassay_008387_13
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_17
Specimen Label: euxassay_008387_17
Detected: true
Specimen Num: 17
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_18
Specimen Label: euxassay_008387_18
Detected: true
Specimen Num: 18
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4422445
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1625523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4825729
Age: embryonic day 14.5
Image: euxassay_008387_19
Specimen Label: euxassay_008387_19
Detected: true
Specimen Num: 19
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Publication
- | J:79250
   
First Author: Isbrandt D
Year: 2002
Journal: GenBank Submission
Title: Mus musculus potassium voltage-gated channel subfamily Q member 3 (Kcnq3) mRNA, complete cds
Pages: AY118171
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Publication
10854243 | J:62797
First Author: Watanabe H
Year: 2000
Journal: J Neurochem
Title: Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability.
Volume: 75
Issue: 1
Pages: 28-33
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Publication
27216573 | J:239919
 
First Author: Friedman AK
Year: 2016
Journal: Nat Commun
Title: KCNQ channel openers reverse depressive symptoms via an active resilience mechanism.
Volume: 7
Pages: 11671
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Publication
20885443 | J:186327
First Author: Zhou X
Year: 2011
Journal: Cell Death Differ
Title: Novel role of KCNQ2/3 channels in regulating neuronal cell viability.
Volume: 18
Issue: 3
Pages: 493-505
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Publication
23716673 | J:197397
First Author: Li S
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus.
Volume: 110
Issue: 24
Pages: 9980-5
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Publication
26312501 | J:226799
   
First Author: Li S
Year: 2015
Journal: Elife
Title: Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus.
Volume: 4
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Publication
19540314 | J:154528
First Author: Marowsky A
Year: 2009
Journal: Neuroscience
Title: Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism.
Volume: 163
Issue: 2
Pages: 646-61
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Publication
34509475 | J:329804
First Author: Chen X
Year: 2021
Journal: J Biol Chem
Title: The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels.
Volume: 297
Issue: 4
Pages: 101183
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Publication
30382937 | J:269758
   
First Author: Soh H
Year: 2018
Journal: Elife
Title: Deletion of KCNQ2/3 potassium channels from PV+ interneurons leads to homeostatic potentiation of excitatory transmission.
Volume: 7
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Publication
32610082 | J:308016
First Author: Markenscoff-Papadimitriou E
Year: 2020
Journal: Cell
Title: A Chromatin Accessibility Atlas of the Developing Human Telencephalon.
Volume: 182
Issue: 3
Pages: 754-769.e18
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Publication
23259949 | J:197655
First Author: Zhang J
Year: 2012
Journal: Neuron
Title: Activity-dependent transcriptional regulation of M-Type (Kv7) K(+) channels by AKAP79/150-mediated NFAT actions.
Volume: 76
Issue: 6
Pages: 1133-46
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Publication
15062102 | J:90089
First Author: Ballif BA
Year: 2004
Journal: Curr Biol
Title: Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons.
Volume: 14
Issue: 7
Pages: 606-10
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Publication
18077674 | J:130568
First Author: Kurrasch DM
Year: 2007
Journal: J Neurosci
Title: The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning.
Volume: 27
Issue: 50
Pages: 13624-34
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Publication
25798587 | J:232973
First Author: Hirst CS
Year: 2015
Journal: PLoS One
Title: Ion channel expression in the developing enteric nervous system.
Volume: 10
Issue: 3
Pages: e0123436
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Publication
35864088 | J:326958
First Author: Sapir T
Year: 2022
Journal: Nat Commun
Title: Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex.
Volume: 13
Issue: 1
Pages: 4209
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Publication
25979088 | J:242531
First Author: Bedogni F
Year: 2016
Journal: Cereb Cortex
Title: Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.
Volume: 26
Issue: 6
Pages: 2517-2529
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Publication
23431145 | J:196080
First Author: Elsen GE
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map.
Volume: 110
Issue: 10
Pages: 4081-6
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Publication
16985003 | J:119550
First Author: Harrell MD
Year: 2007
Journal: Physiol Genomics
Title: Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.
Volume: 28
Issue: 3
Pages: 273-83
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:346132
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
33863780 | J:337753
 
First Author: Hou B
Year: 2021
Journal: eNeuro
Title: Loss of KCNQ2 or KCNQ3 Leads to Multifocal Time-Varying Activity in the Neonatal Forebrain Ex Vivo.
Volume: 8
Issue: 3
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Publication
37305551 | J:346936
 
First Author: Chen KJ
Year: 2023
Journal: Front Mol Neurosci
Title: Behavioral and neuro-functional consequences of eliminating the KCNQ3 GABA binding site in mice.
Volume: 16
Pages: 1192628
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Protein Domain
IPR003948 | K_chnl_volt-dep_KCNQ3
Type: Family
Description: Potassium channels are the most diverse group of the ion channel family [, ]. They are important in shaping the action potential, and in neuronal excitability and plasticity []. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups []: the practically non-inactivating 'delayed' group and the rapidly inactivating 'transient' group.These are all highly similar proteins, with only small amino acid changes causing the diversity of the voltage-dependent gating mechanism, channel conductance and toxin binding properties. Each type of K+channel is activated by different signals and conditions depending on their type of regulation: some open in response to depolarisation of the plasma membrane; others in response to hyperpolarisation or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter, together with intracellular kinases; while others are regulated by GTP-binding proteins or other second messengers []. In eukaryotic cells, K+channels are involved in neural signalling and generation of the cardiac rhythm, act as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs) and may have a role in target cell lysis by cytotoxic T-lymphocytes []. In prokaryotic cells, they play a role in the maintenance of ionic homeostasis [].All K+channels discovered so far possess a core of alpha subunits, each comprising either one or two copies of a highly conserved pore loop domain (P-domain). The P-domain contains the sequence (T/SxxTxGxG), which has been termed the K+selectivity sequence. In families that contain one P-domain, four subunits assemble to form a selective pathway for K+across the membrane. However, it remains unclear how the 2 P-domain subunits assemble to form a selective pore. The functional diversity of these families can arise through homo- or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+channel subunits containing one pore domain can be assigned into one of two superfamilies: those that possess six transmembrane (TM) domains and those that possess only two TM domains. The six TM domain superfamily can be further subdivided into conserved gene families: the voltage-gated (Kv) channels; the KCNQ channels (originally known as KvLQT channels); the EAG-like K+channels; and three types of calcium (Ca)-activated K+channels (BK, IK and SK) []. The 2TM domain family comprises inward-rectifying K+channels. In addition, there are K+channel alpha-subunits that possess two P-domains. These are usually highly regulated K+selective leak channels.KCNQ channels (also known as KQT-like channels) differ from other voltage-gated 6 TM helix channels, chiefly in that they possess no tetramerisation domain. Consequently, they rely on interaction with accessory subunits, or form heterotetramers with other members of the family []. Currently, 5 members of the KCNQ family are known. These have been found to be widely distributed within the body, having been shown to be expressed in the heart, brain, pancreas, lung, placenta and ear. They were initially cloned as a result of a search for proteins involved in cardiac arhythmia. Subsequently, mutations in other KCNQ family members have been shown to be responsible for some forms of hereditary deafness []and benign familial neonatal epilepsy [].The KCNQ3 channel subunit is thought to form active channels by hetero- tetramerisation with KCNQ2, although some K+ channel activity does result from the expression of KCNQ3 alone []. Channel function is modulated by phosphorylation; experiments have demonstrated that an increase in intracellular cAMP concentration can enhance channel activity. Frameshift mutations in both KCNQ2 and KCNQ3 are associated with benign familial neonatal epilepsy [], a disorder in which infants suffer convulsions within the first 3 days of life. These symptoms usually disappear after about 3 months, but affected individuals have a higher than average chance of subsequently developing epilepsy (10-15%) in later life [].
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Publication
9872318 | -
First Author: Schroeder BC
Year: 1998
Journal: Nature
Title: Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy.
Volume: 396
Issue: 6712
Pages: 687-90
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Publication
16735477 | -
First Author: Chung HJ
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains.
Volume: 103
Issue: 23
Pages: 8870-5
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Protein
Q8K3F6
Organism: Mus musculus/domesticus
Length: 873  
Fragment?: false
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Publication
10838601 | -
First Author: Sanguinetti MC
Year: 2000
Journal: Trends Pharmacol Sci
Title: Maximal function of minimal K+ channel subunits.
Volume: 21
Issue: 6
Pages: 199-201
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Publication
8528244 | -
First Author: Wang Q
Year: 1996
Journal: Nat Genet
Title: Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias.
Volume: 12
Issue: 1
Pages: 17-23
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Publication
9430594 | -
First Author: Biervert C
Year: 1998
Journal: Science
Title: A potassium channel mutation in neonatal human epilepsy.
Volume: 279
Issue: 5349
Pages: 403-6
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Publication
12716895 | -
First Author: Lemaillet G
Year: 2003
Journal: J Biol Chem
Title: Identification of a conserved ankyrin-binding motif in the family of sodium channel alpha subunits.
Volume: 278
Issue: 30
Pages: 27333-9
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Publication
17311847 | -
First Author: Rasmussen HB
Year: 2007
Journal: J Cell Sci
Title: Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment.
Volume: 120
Issue: Pt 6
Pages: 953-63
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Publication
19112491 | -
First Author: Hill AS
Year: 2008
Journal: PLoS Genet
Title: Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates.
Volume: 4
Issue: 12
Pages: e1000317
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Protein Domain
IPR020969 | Ankyrin-G_BS
Type: Binding_site
Description: Interactions with ankyrin-G are crucial to the localisation of voltage-gated sodium channels (VGSCs) at the axon initial segment and for neurons to initiate action potentials. This conserved 9-amino acid motif ((V/A)P(I/L)AXXE(S/D)D) is required for ankyrin-G binding and functions to localise sodium channels to a variety of 'excitable' membrane domains both inside and outside of the nervous system []. This motif has also been identified in the potassium channel 6TM proteins KCNQ2 and KCNQ3 []that correspond to the M channels that exert a crucial influence over neuronal excitability. KCNQ2/KCNQ3 channels are preferentially localised to the surface of axons both at the axonal initial segment and more distally, and this axonal initial segment targeting of surface KCNQ channels is mediated by these ankyrin-G binding motifs of KCNQ2 and KCNQ3 []. KCNQ3 is a major determinant of M channel localisation to the AIS, rather than KCNQ2 []. Phylogenetic analysis reveals that anchor motifs evolved sequentially in chordates (NaV channel) and jawed vertebrates (KCNQ2/3) [].
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Publication
25649132 | J:221364
 
First Author: Fidzinski P
Year: 2015
Journal: Nat Commun
Title: KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations.
Volume: 6
Pages: 6254
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Publication
29748663 | J:262937
First Author: Manville RW
Year: 2018
Journal: Nat Commun
Title: Direct neurotransmitter activation of voltage-gated potassium channels.
Volume: 9
Issue: 1
Pages: 1847
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Publication
20534576 | J:195336
First Author: Tzingounis AV
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus.
Volume: 107
Issue: 22
Pages: 10232-7
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Publication
35691372 | J:333540
 
First Author: Jing J
Year: 2022
Journal: Exp Neurol
Title: Removal of KCNQ2 from parvalbumin-expressing interneurons improves anti-seizure efficacy of retigabine.
Volume: 355
Pages: 114141
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Publication
28283543 | J:252684
First Author: Neverisky DL
Year: 2017
Journal: FASEB J
Title: KCNQ-SMIT complex formation facilitates ion channel-solute transporter cross talk.
Volume: 31
Issue: 7
Pages: 2828-2838
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Publication
21849543 | J:254146
First Author: Roepke TA
Year: 2011
Journal: J Neurosci
Title: Fasting and 17β-estradiol differentially modulate the M-current in neuropeptide Y neurons.
Volume: 31
Issue: 33
Pages: 11825-35
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Publication
21562284 | J:244567
First Author: Zhang J
Year: 2011
Journal: J Neurosci
Title: AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels.
Volume: 31
Issue: 19
Pages: 7199-211
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Publication
2451788 | J:9129
First Author: Tempel BL
Year: 1988
Journal: Nature
Title: Cloning of a probable potassium channel gene from mouse brain.
Volume: 332
Issue: 6167
Pages: 837-9
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Publication
1772658 | -
First Author: Perney TM
Year: 1991
Journal: Curr Opin Cell Biol
Title: The molecular biology of K+ channels.
Volume: 3
Issue: 4
Pages: 663-70
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Publication
1879548 | -
First Author: Luneau C
Year: 1991
Journal: FEBS Lett
Title: Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.
Volume: 288
Issue: 1-2
Pages: 163-7
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Publication
1373731 | J:931
First Author: Attali B
Year: 1992
Journal: J Biol Chem
Title: Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.
Volume: 267
Issue: 12
Pages: 8650-7
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Publication
2448635 | -
First Author: Schwarz TL
Year: 1988
Journal: Nature
Title: Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila.
Volume: 331
Issue: 6152
Pages: 137-42
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Publication
2555158 | -
First Author: Stühmer W
Year: 1989
Journal: EMBO J
Title: Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.
Volume: 8
Issue: 11
Pages: 3235-44
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Publication
11178249 | -
First Author: Miller C
Year: 2000
Journal: Genome Biol
Title: An overview of the potassium channel family.
Volume: 1
Issue: 4
Pages: REVIEWS0004
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Publication
29265344 | J:273036
First Author: Vanhoof-Villalba SL
Year: 2018
Journal: Epilepsia
Title: Pharmacogenetics of KCNQ channel activation in 2 potassium channelopathy mouse models of epilepsy.
Volume: 59
Issue: 2
Pages: 358-368
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Publication
23977150 | J:205838
First Author: Robbins J
Year: 2013
Journal: PLoS One
Title: Effects of KCNQ2 gene truncation on M-type Kv7 potassium currents.
Volume: 8
Issue: 8
Pages: e71809
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Protein
F6UC55
Organism: Mus musculus/domesticus
Length: 795  
Fragment?: true
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Protein
B7ZBV9
Organism: Mus musculus/domesticus
Length: 870  
Fragment?: false
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Protein
A0A0G2JFQ2
Organism: Mus musculus/domesticus
Length: 842  
Fragment?: false
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Protein
Q3UY10
Organism: Mus musculus/domesticus
Length: 726  
Fragment?: true
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Protein
B7ZBV3
Organism: Mus musculus/domesticus
Length: 726  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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