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Search results 101 to 200 out of 229 for Clps

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Type Details Score
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Protein Domain
Type: Domain
Description: In the bacterial cytosol, ATP-dependent protein degradation is performed by several different chaperone-protease pairs, including ClpAP. ClpS directly influences the ClpAP machine by binding to the N-terminal domain of the chaperone ClpA. The degradation of ClpAP substrates, both SsrA-tagged proteins and ClpA itself, is specifically inhibited by ClpS. ClpS modifies ClpA substrate specificity, potentially redirecting degradation by ClpAP toward aggregated proteins [].ClpS is a small alpha/beta protein that consists of three α-helices connected to three antiparallel β-strands []. The protein has a globular shape, with a curved layer of three antiparallel α-helices over a twisted antiparallel β-sheet. Dimerization of ClpS may occur through its N-terminal domain. This short extended N-terminal region in ClpS is followed by the central seven-residue β-strand, which is flanked by two other β-strands in a small β-sheet.
Publication
First Author: Mouton L
Year: 2009
Journal: Res Microbiol
Title: Identification of a polymorphic collagen-like protein in the crustacean bacteria Pasteuria ramosa.
Volume: 160
Issue: 10
Pages: 792-9
Protein Domain
Type: Domain
Description: This domain is the conserved central region of bacterial collagen-like proteins (CLPs). Similar to animal collagens, bacterial CLPs contain the G-X-Y repeat motifs []. They are involved in pathogenicity, immune response elicitation and host-parasite interactions, possibly evolving as mimics of host proteins containing G-X-Y motifs [].
Publication
First Author: Inlay MA
Year: 2009
Journal: Genes Dev
Title: Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development.
Volume: 23
Issue: 20
Pages: 2376-81
Publication
First Author: Allman D
Year: 2003
Journal: Nat Immunol
Title: Thymopoiesis independent of common lymphoid progenitors.
Volume: 4
Issue: 2
Pages: 168-74
Publication
First Author: Dougan DA
Year: 2002
Journal: Mol Cell
Title: ClpS, a substrate modulator of the ClpAP machine.
Volume: 9
Issue: 3
Pages: 673-83
Publication
First Author: Nemeth MJ
Year: 2005
Journal: Blood
Title: Hmgb3 deficiency deregulates proliferation and differentiation of common lymphoid and myeloid progenitors.
Volume: 105
Issue: 2
Pages: 627-34
Publication
First Author: Ota N
Year: 2011
Journal: Nat Immunol
Title: IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium.
Volume: 12
Issue: 10
Pages: 941-8
Publication
First Author: Liu B
Year: 2019
Journal: J Exp Med
Title: Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription.
Volume: 216
Issue: 11
Pages: 2653-2668
Publication
First Author: Dias S
Year: 2005
Journal: J Exp Med
Title: Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors.
Volume: 201
Issue: 6
Pages: 971-9
Publication  
First Author: Edrees MAH
Year: 2019
Journal: Mol Immunol
Title: Ubc9 deficiency selectively impairs the functionality of common lymphoid progenitors (CLPs) during bone marrow hematopoiesis.
Volume: 114
Pages: 314-322
Publication
First Author: Ghaedi M
Year: 2016
Journal: Cell Rep
Title: Common-Lymphoid-Progenitor-Independent Pathways of Innate and T Lymphocyte Development.
Volume: 15
Issue: 3
Pages: 471-480
Publication
First Author: Borghesi L
Year: 2005
Journal: J Exp Med
Title: E47 is required for V(D)J recombinase activity in common lymphoid progenitors.
Volume: 202
Issue: 12
Pages: 1669-77
Publication
First Author: Sutherland TE
Year: 2014
Journal: Nat Immunol
Title: Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage.
Volume: 15
Issue: 12
Pages: 1116-25
Publication
First Author: Serwold T
Year: 2009
Journal: Blood
Title: Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis.
Volume: 113
Issue: 4
Pages: 807-15
Publication
First Author: Barber CL
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Reduced production of B-1-specified common lymphoid progenitors results in diminished potential of adult marrow to generate B-1 cells.
Volume: 108
Issue: 33
Pages: 13700-4
Publication  
First Author: Peña-Pérez L
Year: 2022
Journal: Front Immunol
Title: FOXO Dictates Initiation of B Cell Development and Myeloid Restriction in Common Lymphoid Progenitors.
Volume: 13
Pages: 880668
Publication
First Author: Itoh-Nakadai A
Year: 2014
Journal: Nat Immunol
Title: The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program.
Volume: 15
Issue: 12
Pages: 1171-80
Publication
First Author: Chen YL
Year: 2013
Journal: J Exp Med
Title: A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors.
Volume: 210
Issue: 12
Pages: 2515-22
Publication
First Author: Zeng H
Year: 2004
Journal: EMBO J
Title: Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells.
Volume: 23
Issue: 20
Pages: 4116-25
Publication
First Author: Gounari F
Year: 2002
Journal: Nat Immunol
Title: Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene.
Volume: 3
Issue: 5
Pages: 489-96
Publication
First Author: Hsu CL
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Antagonistic effect of CCAAT enhancer-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors.
Volume: 103
Issue: 3
Pages: 672-7
Publication
First Author: Fougeroux C
Year: 2021
Journal: Nat Commun
Title: Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity.
Volume: 12
Issue: 1
Pages: 324
Publication
First Author: McElroy K
Year: 2011
Journal: Res Microbiol
Title: Characterisation of a large family of polymorphic collagen-like proteins in the endospore-forming bacterium Pasteuria ramosa.
Volume: 162
Issue: 7
Pages: 701-14
Protein
Organism: Mus musculus/domesticus
Length: 849  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 859  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 850  
Fragment?: true
Publication
First Author: Nemeth MJ
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Hmgb3 regulates the balance between hematopoietic stem cell self-renewal and differentiation.
Volume: 103
Issue: 37
Pages: 13783-8
Publication
First Author: Vogt TK
Year: 2009
Journal: Blood
Title: Novel function for interleukin-7 in dendritic cell development.
Volume: 113
Issue: 17
Pages: 3961-8
Publication
First Author: Miller JP
Year: 2002
Journal: J Exp Med
Title: The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7.
Volume: 196
Issue: 5
Pages: 705-11
Publication
First Author: Yang GX
Year: 2005
Journal: J Immunol
Title: Plasmacytoid dendritic cells of different origins have distinct characteristics and function: studies of lymphoid progenitors versus myeloid progenitors.
Volume: 175
Issue: 11
Pages: 7281-7
Publication
First Author: Medina KL
Year: 2013
Journal: PLoS One
Title: Separation of plasmacytoid dendritic cells from B-cell-biased lymphoid progenitor (BLP) and Pre-pro B cells using PDCA-1.
Volume: 8
Issue: 10
Pages: e78408
Publication
First Author: Borghesi L
Year: 2004
Journal: J Exp Med
Title: B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors.
Volume: 199
Issue: 4
Pages: 491-502
Publication
First Author: Sanyal M
Year: 2007
Journal: Blood
Title: B-cell development fails in the absence of the Pbx1 proto-oncogene.
Volume: 109
Issue: 10
Pages: 4191-9
Publication
First Author: Yokota T
Year: 2015
Journal: Eur J Immunol
Title: Estrogen-inducible sFRP5 inhibits early B-lymphopoiesis in vivo, but not during pregnancy.
Volume: 45
Issue: 5
Pages: 1390-401
Publication
First Author: Liu B
Year: 2014
Journal: EMBO J
Title: PIAS1 SUMO ligase regulates the self-renewal and differentiation of hematopoietic stem cells.
Volume: 33
Issue: 2
Pages: 101-13
Publication
First Author: Yu Y
Year: 2012
Journal: J Exp Med
Title: Bcl11a is essential for lymphoid development and negatively regulates p53.
Volume: 209
Issue: 13
Pages: 2467-83
Publication
First Author: Kuo YH
Year: 2008
Journal: Blood
Title: Cbfbeta-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development.
Volume: 111
Issue: 3
Pages: 1543-51
Publication
First Author: Mansson R
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate.
Volume: 109
Issue: 51
Pages: 21028-33
Publication
First Author: Tsapogas P
Year: 2011
Journal: Blood
Title: IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors.
Volume: 118
Issue: 5
Pages: 1283-90
Publication
First Author: Zandi S
Year: 2008
Journal: J Immunol
Title: EBF1 is essential for B-lineage priming and establishment of a transcription factor network in common lymphoid progenitors.
Volume: 181
Issue: 5
Pages: 3364-72
Publication
First Author: Ishikawa F
Year: 2007
Journal: Blood
Title: The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways.
Volume: 110
Issue: 10
Pages: 3591-660
Publication
First Author: Gasco S
Year: 2016
Journal: Am J Physiol Cell Physiol
Title: Hematopoietic stem and progenitor cells as novel prognostic biomarkers of longevity in a murine model for amyotrophic lateral sclerosis.
Volume: 311
Issue: 6
Pages: C910-C919
Publication
First Author: Lu X
Year: 2018
Journal: J Cell Biochem
Title: An epididymis-specific secretory protein Clpsl2 critically regulates sperm motility, acrosomal integrity, and male fertility.
Volume: 119
Issue: 6
Pages: 4760-4774
Protein
Organism: Mus musculus/domesticus
Length: 1757  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1755  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1755  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1755  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1757  
Fragment?: false
Publication
First Author: Zenker M
Year: 2005
Journal: Nat Genet
Title: Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).
Volume: 37
Issue: 12
Pages: 1345-50
Publication
First Author: Chitturi J
Year: 2018
Journal: PLoS Genet
Title: The UBR-1 ubiquitin ligase regulates glutamate metabolism to generate coordinated motor pattern in Caenorhabditis elegans.
Volume: 14
Issue: 4
Pages: e1007303
Publication
First Author: Vicente J
Year: 2019
Journal: New Phytol
Title: Distinct branches of the N-end rule pathway modulate the plant immune response.
Volume: 221
Issue: 2
Pages: 988-1000
Protein Domain
Type: Domain
Description: UBR box family is a unique class of E3 ligases that recognise N-degrons or structurally related determinants for ubiquitin-dependent proteolysis. They belong to the N-end rule pathway which relates the identity of the N-terminal residue of a protein with its half-life, recognising destabilising ones. Some of the functions of this pathway include the control of peptide import, the fidelity of chromosome segregation, the regulation of apoptosis, as well as regulation of meiosis in yeasts and metazoans, leaf senescence in plants, and cardiovascular development in mammals []. These proteins contain an N-terminal UBR box (a substrate-binding domain), which is highly conserved among UBR family members, a cysteine- and histidine-rich RING (RING-H2) domain, which is present in a larger class of E3 ubiquitin ligases and some additional domains that vary among UBR family members, like these described in UBR1 []: ClpS, a region of sequence similarity to prokaryotic ClpS which acts as an accessory subunit that contributes to recognition of degrons by the ATP-dependent protease ClpAP, a BRR (basic residue-rich region), a conserved motif that contributes to the binding of yeast UBR1 to the E2 enzyme RAD6, and conserved regions [, , ].This entry represents the C-terminal domain which includes a conserved region found in E3 ubiquitin-protein ligase UBR1, 2, 3 from animals, UBR1/11 from fission yeast, and also in PRT6 from Arabidopsis thaliana [].
Protein Domain
Type: Domain
Description: O-Glycosyl hydrolases () are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrateand a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [, ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.The glycosyl hydrolases family 18 (GH18) is widely distributed in all kingdoms and contains hydrolytic enzymes with chitinase or endo-N-acetyl-beta-D-glucosaminidase (ENGase) activity as well as chitinase-like lectins (chi-lectins/proteins (CLPs). Chitinases () are hydrolytic enzymes that cleave the beta-1,4-bond releasing oligomeric, dimeric (chitobiose) or monomeric (N-actetylglucosamine, GlcNAc) products. ENGases () hydrolyze the beta-1,4 linkage in the chitobiose core of N-linked glycans from glycoproteins leaving one GlcNAc residue on the substrate. CLPs do not display chitinase activity but some of them have been reported to have specific functions and carbohydrate binding property []. This family also includes glycoproteins from mammals, such as oviduct-specific glycoproteins.The catalytic domain of GH18s has a common (beta/alpha)8 triosephosphate isomerase (TIM)-barrel structure, which consists of a barrel-like framework made from eight internal parallel β-strands that are alternately connected by eight exterior α-helices. The active site motif DxxDxDxE is essential for the activity of the GH18 catalytic domain. [, , ].
Publication
First Author: Kurkewich JL
Year: 2017
Journal: PLoS Genet
Title: The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis.
Volume: 13
Issue: 7
Pages: e1006887
Publication  
First Author: Ohno M
Year: 2014
Journal: BMC Mol Biol
Title: Establishment of a quantitative PCR system for discriminating chitinase-like proteins: catalytically inactive breast regression protein-39 and Ym1 are constitutive genes in mouse lung.
Volume: 15
Pages: 23
Publication
First Author: Schimpl M
Year: 2012
Journal: Biochem J
Title: Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties.
Volume: 446
Issue: 1
Pages: 149-57
Publication
First Author: Stals I
Year: 2012
Journal: PLoS One
Title: High resolution crystal structure of the endo-N-Acetyl-β-D-glucosaminidase responsible for the deglycosylation of Hypocrea jecorina cellulases.
Volume: 7
Issue: 7
Pages: e40854
Publication
First Author: Madhuprakash J
Year: 2013
Journal: Int J Biochem Mol Biol
Title: Structure of chitinase D from Serratia proteamaculans reveals the structural basis of its dual action of hydrolysis and transglycosylation.
Volume: 4
Issue: 4
Pages: 166-78
Publication
First Author: Li T
Year: 2016
Journal: PLoS Genet
Title: Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination.
Volume: 12
Issue: 5
Pages: e1006054
Protein
Organism: Mus musculus/domesticus
Length: 950  
Fragment?: true
Publication
First Author: Lee CG
Year: 2012
Journal: Proc Am Thorac Soc
Title: Chitinase-like proteins in lung injury, repair, and metastasis.
Volume: 9
Issue: 2
Pages: 57-61
Publication
First Author: Terwisscha van Scheltinga AC
Year: 1996
Journal: J Mol Biol
Title: The 1.8 A resolution structure of hevamine, a plant chitinase/lysozyme, and analysis of the conserved sequence and structure motifs of glycosyl hydrolase family 18.
Volume: 262
Issue: 2
Pages: 243-57
Publication
First Author: Tzelepis GD
Year: 2012
Journal: Fungal Genet Biol
Title: Functional analysis of glycoside hydrolase family 18 and 20 genes in Neurospora crassa.
Volume: 49
Issue: 9
Pages: 717-30
Publication
First Author: Badariotti F
Year: 2011
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: Identification of three singular glycosyl hydrolase family 18 members from the oyster Crassostrea gigas: Structural characterization, phylogenetic analysis and gene expression.
Volume: 158
Issue: 1
Pages: 56-63
Publication
First Author: Patil DN
Year: 2013
Journal: PLoS One
Title: Structural investigation of a novel N-acetyl glucosamine binding chi-lectin which reveals evolutionary relationship with class III chitinases.
Volume: 8
Issue: 5
Pages: e63779
Publication
First Author: Junges Â
Year: 2014
Journal: PLoS One
Title: Genomic analyses and transcriptional profiles of the glycoside hydrolase family 18 genes of the entomopathogenic fungus Metarhizium anisopliae.
Volume: 9
Issue: 9
Pages: e107864
Publication
First Author: Tsuji H
Year: 2010
Journal: FEBS J
Title: Kinetic and crystallographic analyses of the catalytic domain of chitinase from Pyrococcus furiosus- the role of conserved residues in the active site.
Volume: 277
Issue: 12
Pages: 2683-95
Protein Domain
Type: Active_site
Description: The glycosyl hydrolases family 18 (GH18) [E1]is widely distributed in all kingdoms, including viruses, bacteria, plants, fungi and animals. The GH18 family contains hydrolytic enzymes with chitinase or endo-N-acetyl-beta-D-glucosaminidase (ENGase) activity as well as chitinase like lectins (chi-lectins/proteins (CLPs). Chitinases (EC 3.2.1.14) are hydrolytic enzymes that cleave the beta-1,4-bond releasing oligomeric, dimeric (chitobiose) or monomeric (N-actetylglucosamine, GlcNAc) products. ENGases (EC ) hydrolyse the beta-1,4 linkage in the chitobiose core of N-linked glycans from glycoproteins leaving one GlcNAc residue on the substrate. CLPs do not display chitinase activity but some of them have been reported to have specific functions and carbohydrate binding property. The catalytic domain of GH18s may be connected to one or several substrate binding modules (CBMs), which enhance binding of enzymes to insoluble substrates. Certain GH18s also contain peptide signals for localization such as an N-terminal secretion peptide, a C-terminal glycosyl-phosphatidylinositol (GPI) anchor signal for attachment to the plasma-membrane, or N- or O-linked glycosylation sites for oligosaccharide modifications [, , , , , , , , ].The catalytic domain of GH18s has a common (beta/alpha)8 triosephosphate isomerase (TIM)-barrel structure, which consists of a barrel-like framework made from eight internal parallel β-strands that are alternately connected by eight exterior alpha helices. The active site motifDxxDxDxE is essential for the activity of the GH18 catalytic domain. The Glu (E) in this motif acts as the catalytic proton donor, and the last Asp (D(3))is supposed to contribute to the stabilization of the essential distortion of the substrate [, , , , ].This entry represents the active site of GH18.
Protein
Organism: Mus musculus/domesticus
Length: 58  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 297  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 366  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 473  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 366  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 402  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 721  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: false